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  1. Article ; Online: NAMPT-Driven M2 Polarization of Tumor-Associated Macrophages Leads to an Immunosuppressive Microenvironment in Colorectal Cancer.

    Hong, Sun Mi / Lee, A-Yeon / Kim, Byeong-Ju / Lee, Jeong-Eun / Seon, Su-Yeon / Ha, Yu-Jin / Ng, Jestlin Tianthing / Yoon, Gyesoon / Lim, Su Bin / Morgan, Michael J / Cha, Jong-Ho / Lee, Dakeun / Kim, You-Sun

    Advanced science (Weinheim, Baden-Wurttemberg, Germany)

    2024  Volume 11, Issue 14, Page(s) e2303177

    Abstract: Nicotinamide phosphoribosyltransferase (NAMPT) is a metabolic enzyme with key roles in inflammation. Previous studies have examined the consequences of its upregulated expression in cancer cells themselves, but studies are limited with respect to its ... ...

    Abstract Nicotinamide phosphoribosyltransferase (NAMPT) is a metabolic enzyme with key roles in inflammation. Previous studies have examined the consequences of its upregulated expression in cancer cells themselves, but studies are limited with respect to its role in the other cells within the tumor microenvironment (TME) during colorectal cancer (CRC) progression. Using single-cell RNA sequencing (scRNA-seq) data, it is founded that NAMPT is highly expressed in SPP1
    MeSH term(s) Animals ; Humans ; Mice ; Colorectal Neoplasms/pathology ; Macrophages/metabolism ; Nicotinamide Phosphoribosyltransferase/metabolism ; Signal Transduction ; Tumor Microenvironment ; Tumor-Associated Macrophages
    Chemical Substances Nicotinamide Phosphoribosyltransferase (EC 2.4.2.12) ; nicotinamide phosphoribosyltransferase, mouse (EC 2.4.2.12)
    Language English
    Publishing date 2024-02-02
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 2808093-2
    ISSN 2198-3844 ; 2198-3844
    ISSN (online) 2198-3844
    ISSN 2198-3844
    DOI 10.1002/advs.202303177
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: LCK-Mediated RIPK3 Activation Controls Double-Positive Thymocyte Proliferation and Restrains Thymic Lymphoma by Regulating the PP2A-ERK Axis.

    Hwang, Sung-Min / Ha, Yu-Jin / Koo, Gi-Bang / Noh, Hyun-Jin / Lee, A-Yeon / Kim, Byeong-Ju / Hong, Sun Mi / Morgan, Michael J / Eyun, Seong-Il / Lee, Dakeun / Roe, Jae-Seok / Lee, Youngsoo / Kim, You-Sun

    Advanced science (Weinheim, Baden-Wurttemberg, Germany)

    2022  Volume 9, Issue 32, Page(s) e2204522

    Abstract: Receptor-interacting protein kinase 3 (RIPK3) is the primary regulator of necroptotic cell death. RIPK3 expression is often silenced in various cancer cells, which suggests that it may have tumor suppressor properties. However, the exact mechanism by ... ...

    Abstract Receptor-interacting protein kinase 3 (RIPK3) is the primary regulator of necroptotic cell death. RIPK3 expression is often silenced in various cancer cells, which suggests that it may have tumor suppressor properties. However, the exact mechanism by which RIPK3 negatively regulates cancer development and progression remains unclear. This report indicates that RIPK3 acts as a potent regulator of the homeostatic proliferation of CD4
    MeSH term(s) Animals ; Mice ; Cell Proliferation ; Extracellular Signal-Regulated MAP Kinases/metabolism ; Lymphocyte Specific Protein Tyrosine Kinase p56(lck)/metabolism ; Lymphoma/metabolism ; Mice, Knockout ; Protein Phosphatase 2/metabolism ; Receptor-Interacting Protein Serine-Threonine Kinases/metabolism ; Thymocytes/metabolism ; Thymus Neoplasms/metabolism
    Chemical Substances Extracellular Signal-Regulated MAP Kinases (EC 2.7.11.24) ; Lymphocyte Specific Protein Tyrosine Kinase p56(lck) (EC 2.7.10.2) ; Protein Phosphatase 2 (EC 3.1.3.16) ; Receptor-Interacting Protein Serine-Threonine Kinases (EC 2.7.11.1) ; Ripk3 protein, mouse (EC 2.7.11.1)
    Language English
    Publishing date 2022-09-25
    Publishing country Germany
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2808093-2
    ISSN 2198-3844 ; 2198-3844
    ISSN (online) 2198-3844
    ISSN 2198-3844
    DOI 10.1002/advs.202204522
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Transplantation of human Wharton's jelly-derived mesenchymal stem cells highly expressing TGFβ receptors in a rabbit model of disc degeneration.

    Ahn, Jongchan / Park, Eun-Mi / Kim, Byeong Ju / Kim, Jin-Soo / Choi, Bogyu / Lee, Soo-Hong / Han, Inbo

    Stem cell research & therapy

    2015  Volume 6, Page(s) 190

    Abstract: Introduction: Mesenchymal stem cells (MSCs) are widely considered to hold promise for the treatment of intervertebral disc (IVD) degeneration. However, variation in the therapeutic efficacy of MSCs is a major problem and the derivation of MSCs for use ... ...

    Abstract Introduction: Mesenchymal stem cells (MSCs) are widely considered to hold promise for the treatment of intervertebral disc (IVD) degeneration. However, variation in the therapeutic efficacy of MSCs is a major problem and the derivation of MSCs for use in IVD regeneration has not been optimized. Additionally, no data are available on the efficacy of Wharton's Jelly-derived MSC (WJ-MSC) transplantation in an animal model of IVD degeneration.
    Methods: This study evaluated the effectiveness of a cross-linked hyaluronic acid (XHA) scaffold loaded with human WJ-MSCs, according to their expression levels of transforming growth factor-β receptor I/activin-like kinase receptor 5 (TβRI/ALK5) and TβRII, for IVD regeneration in a rabbit model. We compared the degree of IVD regeneration between rabbits transplanted with a XHA scaffold loaded with WJ-MSCs highly and lowly expressing TβRI/ALK5 and TβRII (MSC-highTR and MSC-lowTR, respectively) using magnetic resonance imaging (MRI) and histological analysis.
    Results: At 12 weeks after transplantation, T2-weighted MRI analysis showed significant restoration of the disc water content in rabbits treated with a MSC-highTR-loaded XHA scaffold in comparison to rabbits treated with the scaffold alone or a MSC-lowTR-loaded XHA scaffold. In addition, morphological and histological analyses revealed that IVD regeneration was highest in rabbits transplanted with a MSC-highTR-loaded XHA scaffold.
    Conclusion: Taken together, our results suggest that a MSC-highTR-loaded XHA scaffold supports IVD regeneration more effectively than a MSC-lowTR-loaded XHA scaffold. This study supports the potential clinical use of MSC-highTR-loaded XHA scaffolds to halt IVD degeneration or to enhance IVD regeneration.
    MeSH term(s) Animals ; Humans ; Hyaluronic Acid/pharmacology ; Intervertebral Disc Degeneration/therapy ; Mesenchymal Stem Cell Transplantation ; Mesenchymal Stromal Cells/cytology ; Mesenchymal Stromal Cells/drug effects ; Mesenchymal Stromal Cells/metabolism ; Rabbits ; Receptors, Transforming Growth Factor beta/genetics ; Receptors, Transforming Growth Factor beta/metabolism ; Tissue Scaffolds/chemistry
    Chemical Substances Receptors, Transforming Growth Factor beta ; Hyaluronic Acid (9004-61-9)
    Language English
    Publishing date 2015-10-02
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2548671-8
    ISSN 1757-6512 ; 1757-6512
    ISSN (online) 1757-6512
    ISSN 1757-6512
    DOI 10.1186/s13287-015-0183-1
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: Breeding Temperate Japonica Rice Varieties Adaptable to Tropical Regions: Progress and Prospects

    Pacleb, Myrish / Jeong, O-Young / Lee, Jeom-Sig / Padolina, Thelma / Braceros, Rustum / Pautin, Lenie / Torollo, Gideon / Sana, Elbert E. / Del-Amen, Jesson Y. / Baek, Man-Kee / Jo, Sumin / Hyun, Woong-Jo / Park, Hyun-Su / Jeong, Jong-Min / Lee, Ji-Youn / Cho, Jun-Hyeon / Lee, Jeong-Heui / Lee, Sais-Beul / Choi, Il-Ryong /
    Kim, Sung-Ryul / Lee, Jae-Sung / Sreenivasulu, Nese / Ko, Jong-Cheol / Lee, Joum-Ho / Kim, Byeong-Ju / Kim, Ki-Young / Park, Dong-Soo

    Agronomy. 2021 Nov. 08, v. 11, no. 11

    2021  

    Abstract: Temperate japonica rice is mainly cultivated in temperate regions. Many temperate japonica varieties have a superior grain quality that is preferred in Northeast Asian countries such as Japan, Korea, and China. The changes in consumers’ preferences in ... ...

    Abstract Temperate japonica rice is mainly cultivated in temperate regions. Many temperate japonica varieties have a superior grain quality that is preferred in Northeast Asian countries such as Japan, Korea, and China. The changes in consumers’ preferences in Southeast Asia and Western countries has contributed to increasing the demand for temperate japonica. Most temperate japonica varieties developed in temperate regions typically exhibit extra-early flowering under the short-day conditions in the tropics, which usually results in severely reduced yields. Since 1992, we have been developing temperate japonica varieties that can adapt to tropical environments to meet the increasing demand for temperate japonica rice, having released six varieties in the Philippines. Especially, the yield of one of the temperate japonica varieties, Japonica 7, was comparable to the yields of leading indica varieties in the Philippines. Here, we discuss the current breeding initiatives and future plans for the development of tropical-region-bred temperate japonica rice.
    Keywords Japan ; Philippines ; agronomy ; grain quality ; rice ; China ; Korean Peninsula
    Language English
    Dates of publication 2021-1108
    Publishing place Multidisciplinary Digital Publishing Institute
    Document type Article
    ZDB-ID 2607043-1
    ISSN 2073-4395
    ISSN 2073-4395
    DOI 10.3390/agronomy11112253
    Database NAL-Catalogue (AGRICOLA)

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  5. Article ; Online: Parent-reported ISAAC written questionnaire may underestimate the prevalence of asthma in children aged 10-12 years.

    Kim, Myoung Hee / Kwon, Ji-Won / Kim, Hyo Bin / Song, Younghwa / Yu, Jinho / Kim, Woo-Kyung / Kim, Byeong-Ju / Lee, So Yeon / Kim, Kyoung-Won / Ji, Hye-Mi / Kim, Kyu-Earn / Shin, Yee-Jin / Kim, Ho / Hong, Soo-Jong

    Pediatric pulmonology

    2012  Volume 47, Issue 1, Page(s) 36–43

    Abstract: Objectives: The aim of the present study was to compare the validity of the International Study of Asthma and Allergies in Childhood (ISAAC) written (WQ) and audiovisual questionnaires (AVQ 3.0) in two age-groups (10-12 and 13-15 years, respectively).!## ...

    Abstract Objectives: The aim of the present study was to compare the validity of the International Study of Asthma and Allergies in Childhood (ISAAC) written (WQ) and audiovisual questionnaires (AVQ 3.0) in two age-groups (10-12 and 13-15 years, respectively).
    Methods: The 13-15 year olds performed the self-completed the WQ and AVQ on the same day. The 10-12 year olds performed the self-completed the AVQ and the parent-completed WQ was completed by their parents. The methacholine challenge test was conducted in 10-12 year olds from one elementary school.
    Results: In 10-12 year olds, the AVQ detected a generally higher prevalence of asthma symptoms than WQ. In 13-15 year olds, this was reversed. In 10-12 year olds, poor agreement was found between the parent-completed WQ and the self-reported AVQ. In 13-15 year olds, moderate agreement was found between the self-reported WQ and AVQ. Low sensitivity was found, in predicting bronchial hyper-responsiveness (BHR) for all questions of both WQ and AVQ in 10-12 year olds. However, the AVQ had slightly higher sensitivity than WQ, with the exception of wheeze ever, although it was not statistically significant.
    Conclusion: The ISAAC AVQ may be another effective instrument for assessing the prevalence of asthma symptoms in children aged 10-12 years, whereas the parent-reported-WQ may underestimate the prevalence of asthma symptoms in this age-group.
    MeSH term(s) Adolescent ; Asthma/diagnosis ; Asthma/epidemiology ; Bronchoconstrictor Agents ; Child ; Humans ; Methacholine Chloride ; Parents ; Predictive Value of Tests ; Prevalence ; Reproducibility of Results ; Surveys and Questionnaires/standards
    Chemical Substances Bronchoconstrictor Agents ; Methacholine Chloride (0W5ETF9M2K)
    Language English
    Publishing date 2012-01
    Publishing country United States
    Document type Comparative Study ; Journal Article ; Validation Studies
    ZDB-ID 632784-9
    ISSN 1099-0496 ; 8755-6863
    ISSN (online) 1099-0496
    ISSN 8755-6863
    DOI 10.1002/ppul.21512
    Database MEDical Literature Analysis and Retrieval System OnLINE

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