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  1. Article ; Online: Editorial: Advances in cardiovascular medicine: debates and controversies.

    Pal, Nirvik / Kim, Christin

    Current opinion in anaesthesiology

    2022  Volume 36, Issue 1, Page(s) 1–4

    Language English
    Publishing date 2022-12-22
    Publishing country United States
    Document type Journal Article
    ZDB-ID 645203-6
    ISSN 1473-6500 ; 0952-7907
    ISSN (online) 1473-6500
    ISSN 0952-7907
    DOI 10.1097/ACO.0000000000001216
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    Zs.A 2564: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (2.OG)
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  2. Article ; Online: Thrombotic Microangiopathic Anemia After Cardiac Surgery.

    Sweeney, Craig A / Quader, Mohammed / Kim, Christin

    Journal of cardiothoracic and vascular anesthesia

    2023  Volume 38, Issue 3, Page(s) 784–787

    MeSH term(s) Humans ; Anemia, Hemolytic ; Cardiac Surgical Procedures/adverse effects ; Thrombosis
    Language English
    Publishing date 2023-11-26
    Publishing country United States
    Document type Case Reports
    ZDB-ID 1067317-9
    ISSN 1532-8422 ; 1053-0770
    ISSN (online) 1532-8422
    ISSN 1053-0770
    DOI 10.1053/j.jvca.2023.11.033
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    Zs.A 2203: Show issues Location:
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  3. Article ; Online: The Do Not Resuscitate (DNR) order in the perioperative setting: practical considerations.

    Kim, Christin / Keneally, Ryan

    Current opinion in anaesthesiology

    2021  Volume 34, Issue 2, Page(s) 141–144

    Abstract: Purpose of review: Addressing patients' Do Not Resuscitate (DNR) status in the perioperative setting is important for shared patient decision-making. Although the inherently resuscitative nature of anesthesia and surgery may pose an ethical quandary for ...

    Abstract Purpose of review: Addressing patients' Do Not Resuscitate (DNR) status in the perioperative setting is important for shared patient decision-making. Although the inherently resuscitative nature of anesthesia and surgery may pose an ethical quandary for clinicians tasked with caring for the patient, anesthesiologist-led efforts need to evaluate all aspects of the DNR order and operative procedures.
    Recent findings: Approximately 15% of patients undergoing surgical procedures have a preexisting DNR order (Margolis et al., 1995) [1]. American Society of Anesthesiologists (ASA) and the American College of Surgeons (ACS) do not support automatic reversal of the DNR order in the perioperative setting. Citing patient self-determination and autonomy, these societies advocate for a thoughtful discussion where a patient or legal designee may make an informed decision regarding resuscitation in the perioperative setting. Although studies have suggested increased perioperative mortality among patients with a preexisting DNR order, this data remains largely inconclusive.
    Summary: Efforts must be made to address the DNR order in the perioperative setting. The fundamental tenets of medical ethics, nonmaleficence, beneficence, and patient autonomy can help to guide this oftentimes challenging discussion.
    MeSH term(s) Anesthesia ; Anesthesiology ; Ethics, Medical ; Humans ; Resuscitation Orders
    Language English
    Publishing date 2021-03-04
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 645203-6
    ISSN 1473-6500 ; 0952-7907
    ISSN (online) 1473-6500
    ISSN 0952-7907
    DOI 10.1097/ACO.0000000000000974
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  4. Article ; Online: Extracorporeal cardiopulmonary resuscitation: is it futile?

    Kim, Christin / Vigneshwar, Mythili / Nicolato, Patricia

    Current opinion in anaesthesiology

    2022  Volume 35, Issue 2, Page(s) 190–194

    Abstract: Purpose of review: Extracorporeal cardiopulmonary resuscitation (ECPR) is a treatment modality used to restore end-organ perfusion in the setting of refractory cardiac arrest in patients receiving cardiopulmonary resuscitation (CPR). Despite advances in ...

    Abstract Purpose of review: Extracorporeal cardiopulmonary resuscitation (ECPR) is a treatment modality used to restore end-organ perfusion in the setting of refractory cardiac arrest in patients receiving cardiopulmonary resuscitation (CPR). Despite advances in medicine, survival from cardiac arrest remains low with conventional CPR. The body of literature relating to ECPR is limited to retrospective studies and case series, with data that are inconsistent. Routine use of ECPR is not currently endorsed by the American Heart Association.
    Recent findings: In several single-center retrospective studies, ECPR was associated with a higher level of return of spontaneous circulation and survival to hospital discharge, when compared with conventional CPR. However, data from larger population-based registry studies have not reproduced these findings. Implementation of ECPR is a complex endeavor that requires specialized, multidisciplinary expertise to be successful.
    Summary: ECPR may be considered as an adjunct to CPR in cases of refractory cardiac arrest. The success of ECPR relies on specialized expertise, thoughtful patient selection, and timely initiation.
    MeSH term(s) Cardiopulmonary Resuscitation ; Extracorporeal Membrane Oxygenation ; Humans ; Out-of-Hospital Cardiac Arrest/therapy ; Retrospective Studies
    Language English
    Publishing date 2022-01-20
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 645203-6
    ISSN 1473-6500 ; 0952-7907
    ISSN (online) 1473-6500
    ISSN 0952-7907
    DOI 10.1097/ACO.0000000000001097
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  5. Book ; Online ; Thesis: Die Modulation der kutanen Durchblutung unter blauem LED-Licht der Wellenlänge 453 nm und dessen Auswirkung auf die Zellvitalität

    Kotte, Kim Christin [Verfasser]

    2019  

    Author's details Kim Christin Kotte
    Keywords Medizin, Gesundheit ; Medicine, Health
    Subject code sg610
    Language German
    Publisher Universitäts- und Landesbibliothek der Heinrich-Heine-Universität Düsseldorf
    Publishing place Düsseldorf
    Document type Book ; Online ; Thesis
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  6. Book ; Online ; Thesis: Komplikationen im Rahmen von Transkatheter-Aortenklappen-Implantationen

    Meertens, Max Maria [Verfasser] / Schmidt, Tobias [Akademischer Betreuer] / Honselmann genannt Humme, Kim Christin [Akademischer Betreuer]

    2023  

    Author's details Max Maria Meertens ; Akademische Betreuer: Tobias Schmidt, Kim Christin Honselmann genannt Humme
    Keywords Medizin, Gesundheit ; Medicine, Health
    Subject code sg610
    Language German
    Publisher Zentrale Hochschulbibliothek Lübeck
    Publishing place Lübeck
    Document type Book ; Online ; Thesis
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  7. Book ; Online ; Thesis: Lebensqualität und Mortalität von Intensivpatienten mit Pneumonie und/oder Sepsis. Prognosestellung durch klinische Parameter

    Honselmann, Kim Christin [Verfasser]

    2015  

    Author's details Kim Christin Honselmann genannt Humme
    Keywords Medizin, Gesundheit ; Medicine, Health
    Subject code sg610
    Language German
    Publisher Zentrale Hochschulbibliothek Lübeck
    Publishing place Lübeck
    Document type Book ; Online ; Thesis
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  8. Article ; Online: Roadmap: one anesthesiology department's strategic approach to COVID-19.

    Coombs, Alice A Tolbert / Lawson, Tamara / Daniel, Ronsard / Kim, Christin / Rashid, Megan M

    Current opinion in anaesthesiology

    2020  Volume 34, Issue 1, Page(s) 54–61

    Abstract: Purpose of review: The COVID-19 pandemic has driven transformation in every aspect of the healthcare delivery system. The unpredictable onset and magnitude of COVID-19 infections resulted in wide gaps in preparedness for healthcare systems. The ... ...

    Abstract Purpose of review: The COVID-19 pandemic has driven transformation in every aspect of the healthcare delivery system. The unpredictable onset and magnitude of COVID-19 infections resulted in wide gaps in preparedness for healthcare systems. The development of protocols to address both scarcity of resources and staff protection continues to be essential for risk mitigation.
    Recent findings: The northeast region of the United States had a rapid early surge of COVID-19 infections leading to the exhaustion of critical care capacity. In addition, northeastern hospitals experienced decrease in elective surgical interventions, including organ transplantation. Limited availability of COVID-19 testing and personal protective equipment further fueled the pandemic. This commentary highlights a comprehensive innovative approach to addressing the operating room and hospital demands, as well as the shortages in resources and staffing during the pandemic.
    Summary: The VCU Department of Anesthesiology operated at 40% of its regular operating room volume throughout the COVID-19 pandemic because of the increased demand from emergency cases. The delay in the peak surge allowed Virginia Commonwealth University, Department of Anesthesiology to develop a comprehensive infrastructure resulting in resulting is maximal workforce risk mitigation.
    MeSH term(s) Anesthesia Department, Hospital/organization & administration ; COVID-19/prevention & control ; COVID-19 Testing/statistics & numerical data ; Hospitals, University/organization & administration ; Humans ; Occupational Exposure/prevention & control ; Pandemics ; Personal Protective Equipment/supply & distribution ; United States
    Language English
    Publishing date 2020-09-15
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 645203-6
    ISSN 1473-6500 ; 0952-7907
    ISSN (online) 1473-6500
    ISSN 0952-7907
    DOI 10.1097/ACO.0000000000000950
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    Zs.A 2564: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  9. Article ; Online: Delayed Onset of Central Diabetes Insipidus With Ketamine Sedation: A Report of 2 Cases.

    Herity, Leah B / Baker, Cassandra / Kim, Christin / Lowe, Denise K / Cahoon, William D

    Journal of pharmacy practice

    2019  Volume 34, Issue 2, Page(s) 314–318

    Abstract: Ketamine is being prescribed with greater frequency due to an emphasis on multimodal analgesia. With increasing use, uncommon adverse effects associated with ketamine are likely to surface. Limited reports of transient central diabetes insipidus (DI) ... ...

    Abstract Ketamine is being prescribed with greater frequency due to an emphasis on multimodal analgesia. With increasing use, uncommon adverse effects associated with ketamine are likely to surface. Limited reports of transient central diabetes insipidus (DI) occurring early after initiation (ie, within 10 hours) of ketamine have been reported. We present 2 cases of delayed onset (32 hours or more after initiation), ketamine-induced, transient central DI in patients cannulated for venovenous extracorporeal membranous oxygenation. No other causes of central DI were determined based upon physical examination or laboratory data, and both patients responded to treatment with desmopressin/vasopressin. The Naranjo adverse drug reaction probability scale noted a probable causation for each case. These cases demonstrate the possibility of a rare but serious complication of ketamine. Improvement after discontinuation of ketamine and administration of desmopressin/vasopressin appear to support a drug-effect association.
    MeSH term(s) Anesthesia ; Diabetes Insipidus, Neurogenic/chemically induced ; Diabetes Insipidus, Neurogenic/diagnosis ; Diabetes Insipidus, Neurogenic/drug therapy ; Diabetes Mellitus ; Extracorporeal Membrane Oxygenation ; Humans ; Ketamine/adverse effects
    Chemical Substances Ketamine (690G0D6V8H)
    Language English
    Publishing date 2019-10-24
    Publishing country United States
    Document type Case Reports ; Journal Article
    ZDB-ID 1027474-1
    ISSN 1531-1937 ; 0897-1900
    ISSN (online) 1531-1937
    ISSN 0897-1900
    DOI 10.1177/0897190019882266
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    Zs.A 2893: Show issues Location:
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  10. Article ; Online: Establishment and Molecular Characterization of Two Patient-Derived Pancreatic Ductal Adenocarcinoma Cell Lines as Preclinical Models for Treatment Response.

    Braun, Rüdiger / Lapshyna, Olha / Watzelt, Jessica / Drenckhan, Maren / Künstner, Axel / Färber, Benedikt / Hael, Ahmed Ahmed Mohammed / Bolm, Louisa / Honselmann, Kim Christin / Konukiewitz, Björn / Castven, Darko / Spielmann, Malte / Gorantla, Sivahari Prasad / Busch, Hauke / Marquardt, Jens-Uwe / Keck, Tobias / Wellner, Ulrich Friedrich / Ungefroren, Hendrik

    Cells

    2023  Volume 12, Issue 4

    Abstract: The prognosis of pancreatic ductal adenocarcinoma (PDAC) is exceedingly poor. Although surgical resection is the only curative treatment option, multimodal treatment is of the utmost importance, as only about 20% of tumors are primarily resectable at the ...

    Abstract The prognosis of pancreatic ductal adenocarcinoma (PDAC) is exceedingly poor. Although surgical resection is the only curative treatment option, multimodal treatment is of the utmost importance, as only about 20% of tumors are primarily resectable at the time of diagnosis. The choice of chemotherapeutic treatment regimens involving gemcitabine and FOLFIRINOX is currently solely based on the patient's performance status, but, ideally, it should be based on the tumors' individual biology. We established two novel patient-derived primary cell lines from surgical PDAC specimens. LuPanc-1 and LuPanc-2 were derived from a pT3, pN1, G2 and a pT3, pN2, G3 tumor, respectively, and the clinical follow-up was fully annotated. STR-genotyping revealed a unique profile for both cell lines. The population doubling time of LuPanc-2 was substantially longer than that of LuPanc-1 (84 vs. 44 h). Both cell lines exhibited a typical epithelial morphology and expressed moderate levels of CK7 and E-cadherin. LuPanc-1, but not LuPanc-2, co-expressed E-cadherin and vimentin at the single-cell level, suggesting a mixed epithelial-mesenchymal differentiation. LuPanc-1 had a missense mutation (p.R282W) and LuPanc-2 had a frameshift deletion (p.P89X) in
    MeSH term(s) Humans ; Pancreatic Neoplasms/pathology ; Transforming Growth Factor beta1/metabolism ; Antineoplastic Combined Chemotherapy Protocols ; Cell Line, Tumor ; Carcinoma, Pancreatic Ductal/pathology ; Gemcitabine ; Cadherins/metabolism ; Pancreatic Neoplasms
    Chemical Substances Transforming Growth Factor beta1 ; Gemcitabine ; Cadherins
    Language English
    Publishing date 2023-02-11
    Publishing country Switzerland
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2661518-6
    ISSN 2073-4409 ; 2073-4409
    ISSN (online) 2073-4409
    ISSN 2073-4409
    DOI 10.3390/cells12040587
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