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  1. Article ; Online: Bidirectional association between psoriasis and inflammatory bowel disease in a paediatric population: a nationwide study in South Korea.

    Kim, D H / Cho, S I

    Journal of the European Academy of Dermatology and Venereology : JEADV

    2022  Volume 36, Issue 8, Page(s) e654–e656

    MeSH term(s) Child ; Humans ; Incidence ; Inflammatory Bowel Diseases/complications ; Inflammatory Bowel Diseases/epidemiology ; Psoriasis/complications ; Psoriasis/epidemiology ; Republic of Korea/epidemiology
    Language English
    Publishing date 2022-04-07
    Publishing country England
    Document type Letter
    ZDB-ID 1128828-0
    ISSN 1468-3083 ; 0926-9959
    ISSN (online) 1468-3083
    ISSN 0926-9959
    DOI 10.1111/jdv.18121
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Diagnostic accuracy of a decision-support software for the detection of intracranial large-vessel occlusion in CT angiography.

    Andralojc, L E / Kim, D H / Edwards, A J

    Clinical radiology

    2023  Volume 78, Issue 4, Page(s) e313–e318

    Abstract: Aim: To investigate the real-world clinical performance of the decision-support software "e-CTA" (e-Stroke Suite, Brainomix Limited, Oxford UK) for the detection of acute intracranial large-vessel occlusion (LVO) on computed tomography (CT) angiography ... ...

    Abstract Aim: To investigate the real-world clinical performance of the decision-support software "e-CTA" (e-Stroke Suite, Brainomix Limited, Oxford UK) for the detection of acute intracranial large-vessel occlusion (LVO) on computed tomography (CT) angiography at a UK district general hospital.
    Materials and methods: The retrospective study included 300 consecutive CT angiograms of the head and neck performed between 8 March 2021 and 20 May 2021. e-CTA findings were recorded and compared with the radiologist report. Cases in which there was disagreement between e-CTA and the radiologist were reviewed by a sub-specialist vascular radiologist as the reference standard.
    Results: The incidence of intracranial LVO was 7%. e-CTA correctly identified 18 of 21 intracranial proximal LVOs (86%). There were 34 false positives. The sensitivity was 0.86 (95% confidence interval [CI], 0.64-0.97), with specificity of 0.88 (95% CI, 0.83-0.91). The positive predictive value was 0.35 (95% CI, 0.27-0.43). The negative predictive value was 0.99 (95% CI, 0.96-1.00).
    Conclusion: Sensitivity, specificity, and negative predictive values were similar to those reported in the literature (Seker et al., Int J Stroke. 2021; 17:77-82); however, the positive predictive value for e-CTA was significantly lower. In practice, this meant that over half of all reported occlusions by the software were false positives. Radiologists should be aware of these metrics in order to assign appropriate weight to software findings when formulating a report. Differences in population demographics, scanners, CT protocols, and incidence are all factors potentially influencing software accuracy. Local validation testing may help provide accuracy metrics more relevant to individual institutions.
    MeSH term(s) Humans ; Computed Tomography Angiography/methods ; Retrospective Studies ; Tomography, X-Ray Computed/methods ; Stroke/diagnostic imaging ; Software ; Angiography ; Cerebral Angiography/methods ; Sensitivity and Specificity
    Language English
    Publishing date 2023-01-11
    Publishing country England
    Document type Journal Article
    ZDB-ID 391227-9
    ISSN 1365-229X ; 0009-9260
    ISSN (online) 1365-229X
    ISSN 0009-9260
    DOI 10.1016/j.crad.2022.10.017
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Conference proceedings: Underwater endoscopic mucosal resection for gastric tumours

    Kim, J. W. / Kim, H. S. / Park, S. Y. / Kim, D. H.

    Endoscopy

    2024  Volume 56, Issue S 02

    Event/congress ESGE Days 2024, Berlin, Germany, 2024-04-25
    Language English
    Publishing date 2024-04-01
    Publisher Georg Thieme Verlag KG
    Publishing place Stuttgart ; New York
    Document type Article ; Conference proceedings
    ZDB-ID 80120-3
    ISSN 1438-8812 ; 0013-726X
    ISSN (online) 1438-8812
    ISSN 0013-726X
    DOI 10.1055/s-0044-1783608
    Database Thieme publisher's database

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  4. Article: Clinical predictors of polyps recurring in patients with chronic rhinosinusitis and nasal polyps: a systematic review and meta-analysis.

    Kim, D H / Han, J S / Kim, G J / Basurrah, M A / Hwang, S H

    Rhinology

    2023  Volume 61, Issue 6, Page(s) 482–497

    Abstract: Background: Identification of perioperative risk factors for recurrent nasal polyps (RNPs) is important for selection of further treatment and determination of appropriate follow-up period. However, the relative prognostic significance of these risk ... ...

    Abstract Background: Identification of perioperative risk factors for recurrent nasal polyps (RNPs) is important for selection of further treatment and determination of appropriate follow-up period. However, the relative prognostic significance of these risk factors has not been investigated.
    Methodology: We compared the nasal symptoms, endoscopic polyp and Lund-Mackey computed tomography scores, and the laboratory and pathological findings of RNP and non-RNP patients. The risk of bias was assessed using the Newcastle-Ottawa scale.
    Results: Patients with poor nasal symptom scores and olfactory dysfunctions and high Lund-Mackey computed tomography scores were at higher risk of postoperative RNPs, as were those with allergic conditions and elevated tissue and serum eosinophil levels. The tissue neutrophil counts/percentages were significantly lower in the RNP than the other group. The tissue eosinophil level was of higher diagnostic utility than the serum eosinophil level. The RNP diagnostic odds ratio afforded by the tissue eosinophil count or percentage was 54.1247. The area under the receiver operating characteristic curve was 0.936. The sensitivity and specificity were 0.8809 and 0.8834, respectively.
    Conclusion: The tissue eosinophil level reliably predicts RNP after endoscopic sinus surgery.
    MeSH term(s) Humans ; Nasal Polyps/complications ; Nasal Polyps/surgery ; Nasal Polyps/diagnosis ; Rhinitis/complications ; Rhinitis/surgery ; Rhinitis/diagnosis ; Sinusitis/complications ; Sinusitis/surgery ; Sinusitis/diagnosis ; Eosinophils ; Smell ; Chronic Disease
    Language English
    Publishing date 2023-07-15
    Publishing country Netherlands
    Document type Meta-Analysis ; Systematic Review ; Journal Article
    ZDB-ID 80336-4
    ISSN 0300-0729
    ISSN 0300-0729
    DOI 10.4193/Rhin23.136
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: A SEER analysis of survival and prognostic factors in merkel cell carcinoma of the head and neck region.

    Go, C C / Kim, D H / Briceño, C A

    International journal of oral and maxillofacial surgery

    2021  Volume 51, Issue 3, Page(s) 314–322

    Abstract: While Merkel cell carcinoma (MCC) of the head and neck is highly malignant, it remains poorly characterized due to its rarity. The purpose of this study was to examine prognostic factors for overall survival (OS) and disease-specific survival (DSS) in ... ...

    Abstract While Merkel cell carcinoma (MCC) of the head and neck is highly malignant, it remains poorly characterized due to its rarity. The purpose of this study was to examine prognostic factors for overall survival (OS) and disease-specific survival (DSS) in patients with MCC of the head and neck region. The Surveillance, Epidemiology and End Results registry was reviewed for patients diagnosed between 1984 and 2016 with histologically confirmed, primary MCC of the head and neck region. A total of 2818 patients met the inclusion criteria, with a median age at diagnosis of 77 years. At five and 10 years, respectively, the OS was 42.4% and 25.1% and the DSS was 67.9% and 64.1%. Multivariate Cox analysis indicated that predictors of decreased DSS included age at diagnosis ≥75 years, white race, increasing tumor spread, lymph node involvement and either the lip or the scalp/neck as a primary site. When adjusting for the aforementioned factors, tumor depth was not found to be a prognostic factor for DSS. We anticipate these results will help clinicians to counsel patients regarding expectations and potential prognosis.
    MeSH term(s) Carcinoma, Merkel Cell/pathology ; Head and Neck Neoplasms/pathology ; Head and Neck Neoplasms/therapy ; Humans ; Neoplasm Staging ; Prognosis ; Retrospective Studies ; SEER Program ; Skin Neoplasms/pathology
    Language English
    Publishing date 2021-06-03
    Publishing country Denmark
    Document type Journal Article
    ZDB-ID 353721-3
    ISSN 1399-0020 ; 0901-5027
    ISSN (online) 1399-0020
    ISSN 0901-5027
    DOI 10.1016/j.ijom.2021.05.014
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Conference proceedings: CHARLSON COMORBIDITY INDEX PREDICTS COLONIC DIVERTICULAR REBLEEDING

    You, H.-S. / Kim, D.H. / Park, S.-Y.

    Endoscopy

    2022  Volume 54, Issue S 01

    Event/congress ESGE Days 2022, Prague, Czech Republic, 2022-04-28
    Language English
    Publishing date 2022-04-01
    Publisher Georg Thieme Verlag KG
    Publishing place Stuttgart ; New York
    Document type Article ; Conference proceedings
    ZDB-ID 80120-3
    ISSN 1438-8812 ; 0013-726X
    ISSN (online) 1438-8812
    ISSN 0013-726X
    DOI 10.1055/s-0042-1744756
    Database Thieme publisher's database

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  7. Article: [Effects of SGI-1027 on Formation and Elimination of PrP^(Sc) in Prion-Infected Cells].

    Li, J J / Ryou, C S / Kim, D-H

    Molekuliarnaia biologiia

    2020  Volume 54, Issue 3, Page(s) 469–473

    Abstract: Recently, SGI-1027, a well-known inhibitor of DNA-methyl transferases (DNMTs), was reported to effectively reduce formation of pathogenic PrP^(Sc) in prion-infected cells. Herein, we confirm the elimination of PrP^(Sc) in chronic wasting disease (CWD) ... ...

    Abstract Recently, SGI-1027, a well-known inhibitor of DNA-methyl transferases (DNMTs), was reported to effectively reduce formation of pathogenic PrP^(Sc) in prion-infected cells. Herein, we confirm the elimination of PrP^(Sc) in chronic wasting disease (CWD) prion-infected neurons by SGI-1027, and pinpoint the binding region of human prion protein to SGI-1027. SGI-1027 is broadly functional against various prion disease types, including human prions. Previously, the inhibitory effects of SGI-1027 on DNMT function is well tested in various cell culture models. While neither treatment with a DNMTs enhancer S-adenosyl-L-methionine (SAM), nor with their inhibitor, 5-azacytidine, prevented PrP^(Sc) propagation, SGI-1027 did. Our study suggest that the anti-prion effects of SGI-1027 are a result of its direct interaction with PrP^(C), which effectively interferes with the pathogenic conformational change of PrP^(C) to PrP^(Sc). We conclude that SGI-1027 driven suppression of pathogenic PrP^(Sc) is independent of DNMT.
    MeSH term(s) Aminoquinolines/pharmacology ; Animals ; Cells, Cultured ; Humans ; Prion Diseases ; Prions/drug effects ; Pyrimidines/pharmacology ; Wasting Disease, Chronic
    Chemical Substances Aminoquinolines ; Prions ; Pyrimidines ; SGI-1027
    Language Russian
    Publishing date 2020-06-22
    Publishing country Russia (Federation)
    Document type Journal Article
    ZDB-ID 213542-5
    ISSN 0026-8984
    ISSN 0026-8984
    DOI 10.31857/S0026898420030118
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Lacticaseibacillus paracasei

    Yun, S-W / Kim, J-K / Han, M J / Kim, D-H

    Beneficial microbes

    2021  Volume 12, Issue 6, Page(s) 541–551

    Abstract: The gut microbiota communicates with the brain through microbiota-gut-brain (MGB) and hypothalamus-pituitary-adrenal (HPA) axes and other pathways. Excessive expression of interleukin (IL)-6 is closely associated with the occurrence of the psychiatric ... ...

    Abstract The gut microbiota communicates with the brain through microbiota-gut-brain (MGB) and hypothalamus-pituitary-adrenal (HPA) axes and other pathways. Excessive expression of interleukin (IL)-6 is closely associated with the occurrence of the psychiatric disorders depression and dementia. Therefore, to understand whether IL-6 expression-suppressing probiotics could alleviate psychiatric disorders, we isolated IL-6 expression-inhibiting
    MeSH term(s) Animals ; Brain-Derived Neurotrophic Factor/metabolism ; Cognitive Dysfunction/therapy ; Colitis/therapy ; Depression/therapy ; Escherichia coli/pathogenicity ; Gastrointestinal Microbiome ; Interleukin-1beta/metabolism ; Interleukin-6/metabolism ; Lactobacillus paracasei ; Mice ; Mice, Inbred C57BL ; NF-kappa B/metabolism ; Probiotics/therapeutic use ; Tumor Necrosis Factor-alpha/metabolism
    Chemical Substances Brain-Derived Neurotrophic Factor ; IL1B protein, mouse ; Interleukin-1beta ; Interleukin-6 ; NF-kappa B ; Tumor Necrosis Factor-alpha ; interleukin-6, mouse
    Language English
    Publishing date 2021-09-13
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 2561259-1
    ISSN 1876-2891 ; 1876-2883
    ISSN (online) 1876-2891
    ISSN 1876-2883
    DOI 10.3920/BM2020.0109
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article: Letter to the Editor: Utility of Serial Patient Reported Outcomes Measurement Information System (PROMIS®) Physical Function Assessment in a Geriatrics Outpatient Clinic.

    Newmeyer, N / Zhong, L / Cheslock, M / Sison, S D M / Raman, V / Whyman, J D / Kim, D H

    The Journal of frailty & aging

    2023  Volume 12, Issue 4, Page(s) 329–330

    MeSH term(s) Humans ; Aged ; Patient Reported Outcome Measures ; Ambulatory Care Facilities ; Information Systems
    Language English
    Publishing date 2023-11-27
    Publishing country France
    Document type Letter ; Research Support, N.I.H., Extramural
    ZDB-ID 2856228-8
    ISSN 2273-4309 ; 2260-1341
    ISSN (online) 2273-4309
    ISSN 2260-1341
    DOI 10.14283/jfa.2023.32
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  10. Article: Using a Claims-Based Frailty Index to Investigate Frailty, Survival, and Healthcare Expenditures among Older Adults Hospitalized for COVID-19 at an Academic Medical Center.

    Keeney, T / Flom, M / Ding, J / Sy, M / Leung, K / Kim, D H / Orav, J / Vogeli, C / Ritchie, C S

    The Journal of frailty & aging

    2023  Volume 12, Issue 2, Page(s) 150–154

    Abstract: Background: Frailty is associated with mortality in older adults hospitalized with COVID-19, yet few studies have quantified healthcare utilization and spending following COVID-19 hospitalization.: Objective: To evaluate whether survival and follow- ... ...

    Abstract Background: Frailty is associated with mortality in older adults hospitalized with COVID-19, yet few studies have quantified healthcare utilization and spending following COVID-19 hospitalization.
    Objective: To evaluate whether survival and follow-up healthcare utilization and expenditures varied as a function of claims-based frailty status for older adults hospitalized with COVID-19.
    Design: Retrospective cohort study.
    Participants: 136 patients aged 65 and older enrolled in an Accountable Care Organization (ACO) risk contract at an academic medical center and hospitalized for COVID-19 between March 11, 2020 - June 3, 2020.
    Measurements: We linked a COVID-19 Registry with administrative claims data to quantify a frailty index and its relationship to mortality, healthcare utilization, and expenditures over 6 months following hospital discharge. Kaplan Meier curves and Cox Proportional Hazards models were used to evaluate survival by frailty. Kruskal-Wallis tests were used to compare utilization. A generalized linear model with a gamma distribution was used to evaluate differences in monthly Medicare expenditures.
    Results: Much of the cohort was classified as moderate to severely frail (65.4%), 24.3% mildly frail, and 10.3% robust or pre-frail. Overall, 27.2% (n=37) of the cohort died (n=26 during hospitalization, n=11 after discharge) and survival did not significantly differ by frailty. Among survivors, inpatient hospitalizations during the 6-month follow-up period varied significantly by frailty (p=0.02). Mean cost over follow-up was $856.37 for the mild and $4914.16 for the moderate to severe frailty group, and monthly expenditures increased with higher frailty classification (p <.001).
    Conclusions: In this cohort, claims-based frailty was not significantly associated with survival but was associated with follow-up hospitalizations and Medicare expenditures.
    MeSH term(s) Aged ; Humans ; United States/epidemiology ; Health Expenditures ; Medicare ; Frail Elderly ; Retrospective Studies ; COVID-19 ; Frailty ; Delivery of Health Care ; Academic Medical Centers
    Language English
    Publishing date 2023-03-22
    Publishing country France
    Document type Journal Article
    ZDB-ID 2856228-8
    ISSN 2273-4309 ; 2260-1341
    ISSN (online) 2273-4309
    ISSN 2260-1341
    DOI 10.14283/jfa.2023.15
    Database MEDical Literature Analysis and Retrieval System OnLINE

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