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Article ; Online: Development of Automated Delivery Quality Assurance Analysis Software for Helical Tomotherapy.

Yoon, Y H / Shin, Han-Back / Han, M C / Kim, Hojin / Kim, D W / Hong, Chae-Seon / Kim, Jihun / Kim, J S

Technology in cancer research & treatment

2023 Volume 22, Page(s) 15330338231175781

Abstract: Background: To develop a fully automated in-house gamma analysis software for the "Cheese" phantom-based delivery quality assurance (QA) of helical tomotherapy plans.: Methods: The developed in-house software was designed to automate several ... ...

Abstract	Background: To develop a fully automated in-house gamma analysis software for the "Cheese" phantom-based delivery quality assurance (QA) of helical tomotherapy plans. Methods: The developed in-house software was designed to automate several procedures, which need to be manually performed using commercial software packages. The region of interest for the analysis was automatically selected by cropping out film edges and thresholding dose values (>10% of the maximum dose). The film-measured dose was automatically aligned to the computed dose using an image registration algorithm. An optimal film scaling factor was determined to maximize the percentage of pixels passing gamma (gamma passing rate) between the measured and computed doses (3%/3 mm criteria). This gamma analysis was repeated by introducing setup uncertainties in the anterior-posterior direction. For 73 tomotherapy plans, the gamma analysis results using the developed software were compared to those analyzed by medical physicists using a commercial software package. Results: The developed software successfully automated the gamma analysis for the tomotherapy delivery quality assurance. The gamma passing rate (GPR) calculated by the developed software was higher than that by the clinically used software by 3.0%, on average. While, for 1 of the 73 plans, the GPR by the manual gamma analysis was higher than 90% (pass/fail criteria), the gamma analysis using the developed software resulted in fail (GPR < 90%). Conclusions: The use of automated and standardized gamma analysis software can improve both the clinical efficiency and veracity of the analysis results. Furthermore, the gamma analyses with various film scaling factors and setup uncertainties will provide clinically useful information for further investigations.
MeSH term(s)	Humans ; Radiotherapy, Intensity-Modulated ; Software ; Algorithms ; Gamma Rays ; Phantoms, Imaging
Language	English
Publishing date	2023-05-25
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2146365-7
ISSN	1533-0338 ; 1533-0346
ISSN (online)	1533-0338
ISSN	1533-0346
DOI	10.1177/15330338231175781
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Zs.A 5871: Show issues

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Article ; Online: Sonography-guided ethanol ablation of a remnant solid component after radio-frequency ablation of benign solid thyroid nodules: a preliminary study.

Kim, D W

AJNR. American journal of neuroradiology

2012 Volume 33, Issue 6, Page(s) 1139–1143

Abstract: Background and purpose: No study has previously examined the feasibility of using EA to remove any peripherally located, solid components remaining after treatment of benign solid thyroid nodules by RFA. The aim of this study was to assess the efficacy ... ...

Abstract	Background and purpose: No study has previously examined the feasibility of using EA to remove any peripherally located, solid components remaining after treatment of benign solid thyroid nodules by RFA. The aim of this study was to assess the efficacy of EA in removing remnant solid components following the incomplete ablation of benign solid thyroid nodules by RFA. Materials and methods: During a 1-year period, RFA was performed in 18 benign solid thyroid nodules in 17 patients. EA was subsequently performed on 8 of these nodules. The success rate of EA, size and vascularity of the remaining solid components, amount of injected ethanol, degree of intranodular echo staining just after ethanol injection, and number of EA sessions were assessed. Results: Of 18 post-RFA nodules, 8 nodules were subsequently treated with EA because of incomplete ablation, as defined by the presence of peripherally located vascularized solid components. On follow-up US, 2 nodules showed marked hypoechogenicity and no vascularity of the remaining solid components, while 3 nodules showed considerably decreased echogenicity and vascularity of the remaining solid components. Three nodules showed no significant decrease or mild decrease in the echogenicity and vascularity of the remaining solid components. No serious complications were observed during or after RFA or EA, with the exception of 1 patient who experienced diffuse glandular hemorrhage during these procedures. Conclusions: EA was effectively used to remove incompletely ablated components of benign solid thyroid nodules remaining after RFA.
MeSH term(s)	Adolescent ; Adult ; Catheter Ablation/methods ; Child ; Combined Modality Therapy ; Ethanol/therapeutic use ; Female ; Humans ; Male ; Middle Aged ; Neoplasm, Residual ; Pilot Projects ; Sclerosing Solutions/therapeutic use ; Thyroid Nodule/diagnosis ; Thyroid Nodule/therapy ; Treatment Outcome ; Ultrasonography, Interventional/methods ; Young Adult
Chemical Substances	Sclerosing Solutions ; Ethanol (3K9958V90M)
Keywords	covid19
Language	English
Publishing date	2012-01-19
Publishing country	United States
Document type	Clinical Trial ; Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	603808-6
ISSN	1936-959X ; 0195-6108
ISSN (online)	1936-959X
ISSN	0195-6108
DOI	10.3174/ajnr.A2904
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Zs.A 1580: Show issues

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Article ; Conference proceedings: Adenomas per colonoscopy is superior to adenoma detection rate as a quality indicator of colonoscopy

Suh, Y. S. / Koo, J. S. / Kim, D. W. / Shin, H. K. / Kim, J. W. / Choi, D. K. / Park, K. H.

Endoscopy

2024 Volume 56, Issue S 02

Event/congress	ESGE Days 2024, Berlin, Germany, 2024-04-25
Language	English
Publishing date	2024-04-01
Publisher	Georg Thieme Verlag KG
Publishing place	Stuttgart ; New York
Document type	Article ; Conference proceedings
ZDB-ID	80120-3
ISSN	1438-8812 ; 0013-726X
ISSN (online)	1438-8812
ISSN	0013-726X
DOI	10.1055/s-0044-1782833
Database	Thieme publisher's database

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Zs.A 669: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
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Article ; Online: Anatomical study of the anterior interosseous nerve.

Jeon, A / Lee, M / Kim, D W / Kwon, O-Y / Lee, J-H

Folia morphologica

2021 Volume 81, Issue 3, Page(s) 574–578

Abstract: Background: The aim of this study is to investigate the location of nerves that innervate the flexor digitorum profundus (FDP), the flexor pollicis longus (FPL) and the pronator quadratus muscles. It also investigates the change in nerve location with ... ...

Abstract	Background: The aim of this study is to investigate the location of nerves that innervate the flexor digitorum profundus (FDP), the flexor pollicis longus (FPL) and the pronator quadratus muscles. It also investigates the change in nerve location with hand movement. Materials and methods: We studied 30 adult cadavers (17 males and 13 females) with a mean age of 69.5 years (range: 60-95 years). The reference line was from the humeral epicondylar line to the styloid process line of both the radius and ulnar bones. This study measured the anterior interosseous nerve (AIN) branch outpoint and the innervated muscle nerve entry point to the muscle belly. It also examines nerve position changes as related to making a fist. Results: The reference line mean distance was 24.1 ± 1.2 cm. The median nerve branched into the AIN at 18.0 ± 4.0%. We found the most densely distributed section of the nerves' entry point to the muscle belly to be at a distance of 30% to 40% for the FDP and from 30% to 40% for the FPL. Except for the FPL, the nerve branch outpoints and the FDP moved by 3.0%, depending upon hand movements. Conclusions: The results of this study show that it will be necessary to consider the anatomy of the nerve location as it enters the muscle belly as well as how it changes with movement.
MeSH term(s)	Aged ; Aged, 80 and over ; Cadaver ; Female ; Forearm ; Hand ; Humans ; Male ; Median Nerve/anatomy & histology ; Middle Aged ; Muscle, Skeletal/innervation
Language	English
Publishing date	2021-08-06
Publishing country	Poland
Document type	Journal Article
ZDB-ID	419361-1
ISSN	1644-3284 ; 0015-5659
ISSN (online)	1644-3284
ISSN	0015-5659
DOI	10.5603/FM.a2021.0078
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Zs.A 577: Show issues

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Article ; Online: Perigastric varices detected in a gastrointestinal bleeding study with

Kim, M H / Park, S-A / Kim, D-W

Revista espanola de medicina nuclear e imagen molecular

2018 Volume 38, Issue 3, Page(s) 186–187

Title translation	Varices perigástricas detectadas en un estudio de hemorragia digestiva mediante SPECT/TC con hematíes marcados con
MeSH term(s)	Aged ; Erythrocytes ; Esophageal and Gastric Varices/complications ; Esophageal and Gastric Varices/diagnostic imaging ; Female ; Gastrointestinal Hemorrhage/diagnostic imaging ; Gastrointestinal Hemorrhage/etiology ; Humans ; Radiopharmaceuticals ; Single Photon Emission Computed Tomography Computed Tomography/methods ; Technetium Tc 99m Sulfur Colloid
Chemical Substances	Radiopharmaceuticals ; Technetium Tc 99m Sulfur Colloid (556Q0P6PB1)
Language	Spanish
Publishing date	2018-10-23
Publishing country	Spain
Document type	Case Reports ; Journal Article
ISSN	2253-8089
ISSN (online)	2253-8089
DOI	10.1016/j.remn.2018.07.001
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Article ; Online: Infinite deflectometry enabling 2π-steradian measurement range.

Graves, L R / Quach, H / Choi, H / Kim, D W

Optics express

2019 Volume 27, Issue 5, Page(s) 7602–7615

Abstract: We present a novel deflectometry implementation termed Infinite Deflectometry. The technique provides a full aperture surface reconstruction sag map of freeform surfaces, including previously challenging to measure optics such as highly convex surfaces. ... ...

Abstract	We present a novel deflectometry implementation termed Infinite Deflectometry. The technique provides a full aperture surface reconstruction sag map of freeform surfaces, including previously challenging to measure optics such as highly convex surfaces. The method relies on the creation of a virtual source enclosure around the tested optic, which creates a virtual 2π-steradian measurement range. To demonstrate the performance, a fast f/1.26 convex optical surface was measured with a commercial interferometer and with the Infinite Deflectometry system. After removing Zernike terms 1 through 37, the metrology tests resulted in absolute RMS surface values of 18.48 nm and 16.26 nm, respectively. Additionally, a freeform Alvarez lens was measured with the new technique and measured 22.34 m of surface sag RMS after piston, tip/tilt, and defocus had been removed. The result deviated by 488 nm RMS from a profilometer measurement while standard interferometry failed to measure the Alvarez lens due to its non-nulled wavefront dynamic range limitation.
Language	English
Publishing date	2019-03-15
Publishing country	United States
Document type	Journal Article
ZDB-ID	1491859-6
ISSN	1094-4087 ; 1094-4087
ISSN (online)	1094-4087
ISSN	1094-4087
DOI	10.1364/OE.27.007602
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Article ; Online: Emphasis on Repair, Not Just Avoidance of Injury, Facilitates Prudent Stereotactic Ablative Radiotherapy.

Kim, D W Nathan / Medin, Paul M / Timmerman, Robert D

Seminars in radiation oncology

2017 Volume 27, Issue 4, Page(s) 378–392

Abstract: Stereotactic ablative radiotherapy (SAbR) is a potent, hypofractionated treatment against cancer which puts adjacent normal tissue in potential peril. Accurate delineation of normal tissue injury risks from SAbR has been challenging, and lack of clear ... ...

Abstract	Stereotactic ablative radiotherapy (SAbR) is a potent, hypofractionated treatment against cancer which puts adjacent normal tissue in potential peril. Accurate delineation of normal tissue injury risks from SAbR has been challenging, and lack of clear understanding of SAbR tolerance continues to limit its potential. In this review, we contend that SAbR effects on normal tissue could be akin to a surgical "wound," and that adequate wound repair of organs at risk is an essential component of effective SAbR therapy. To mitigate risks of clinical relevance from an SAbR wound, in addition to the traditional views on architectural organization and functional organization of an organ at risk, one should also consider the organ's predominant wound healing tendencies. We also propose that avoidance of SAbR injury to organs at risk must involve careful thought to minimize risk factors that could further impair wound healing. It is imperative that efforts aimed at determining appropriate dose constraints based on predicted SAbR wound injury repair mechanisms for a particular organ to be studied as a critically important step to furthering our understanding of SAbR-related normal tissue tolerances. This can be best achieved through thoughtful design of prospective phase I dose-escalation studies.
Language	English
Publishing date	2017-10
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	1146999-7
ISSN	1532-9461 ; 1053-4296
ISSN (online)	1532-9461
ISSN	1053-4296
DOI	10.1016/j.semradonc.2017.04.007
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Zs.A 3654: Show issues

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Article: Aspirin Use Is Associated With Improved Outcomes in Inflammatory Breast Cancer Patients.

Johns, Christopher / Yen, Allen / Rahimi, Asal / Liu, Yu-Lun / Leitch, Ann Marilyn / Spangler, Ann / Alluri, Prasanna / Nwachukwu, Chika / Wooldridge, Rachel / Farr, Deborah / Kim, D W Nathan

Journal of breast cancer

2023 Volume 26, Issue 1, Page(s) 14–24

Abstract: Purpose: Inflammatory breast cancer (IBC) is the most aggressive form of breast cancer and has a high propensity for distant metastases. Our previous data suggested that aspirin (acetylsalicylic acid, ASA) use may be associated with reduced risk of ... ...

Abstract	Purpose: Inflammatory breast cancer (IBC) is the most aggressive form of breast cancer and has a high propensity for distant metastases. Our previous data suggested that aspirin (acetylsalicylic acid, ASA) use may be associated with reduced risk of distant metastases in aggressive breast cancer; however, there are no reported studies on the potential benefit of ASA use in patients with IBC. Methods: Data from patients with non-metastatic IBC treated between 2000-2017 at two institutions, were reviewed. Overall survival (OS), disease-free survival (DFS), and distant metastasis-free survival (DMFS) were performed using Kaplan-Meier analysis. Univariate and multivariable logistic regression models were used to identify significant associated factors. Results: Of 59 patients meeting the criteria for analysis and available for review, 14 ASA users were identified. ASA users demonstrated increased OS ( Conclusion: ASA use during remission was associated with significantly improved OS and DMFS in patients with IBC. These results suggest that ASA may provide survival benefits to patients with IBC. Prospective clinical trials of ASA use in patients with high-risk IBC in remission should be considered.
Language	English
Publishing date	2023-01-25
Publishing country	Korea (South)
Document type	Journal Article
ZDB-ID	2559753-X
ISSN	2092-9900 ; 1738-6756
ISSN (online)	2092-9900
ISSN	1738-6756
DOI	10.4048/jbc.2023.26.e3
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Zs.A 6866: Show issues

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Article ; Online: Aspirin use is associated with improvement in distant metastases outcome in patients with residual disease after neoadjuvant chemotherapy.

Johns, Christopher / Montalvo, Steven K / Cauble, M'Kay / Liu, Yu-Lun / All, Sean / Rahimi, Asal S / Alluri, Prasanna G / Leitch, Marilyn / Unni, Nisha / Wooldridge, Rachel / Farr, Deborah / Nwachukwu, Chika / Kim, D W Nathan

Breast cancer research and treatment

2023 Volume 199, Issue 2, Page(s) 381–387

Abstract: Purpose: Aspirin (ASA) use has been correlated with improved outcomes in high-risk patients at risk for distant metastases. Breast cancer (BC) patients with residual disease, particularly nodal disease (ypN +) after neoadjuvant chemotherapy (NAC), are ... ...

Abstract	Purpose: Aspirin (ASA) use has been correlated with improved outcomes in high-risk patients at risk for distant metastases. Breast cancer (BC) patients with residual disease, particularly nodal disease (ypN +) after neoadjuvant chemotherapy (NAC), are high-risk patients portending worse outcomes. We hypothesized that ASA use can reduce distant metastases and improve outcomes in these patients. Methods: Patients at our institutions from 2005 to 2018, with BC who did not achieve complete response (pCR) after NAC were reviewed (IRB protocol STU- 052012-019). Data, including evidence of ASA use, and clinico-pathologic parameters were analyzed. Survival outcomes were obtained (Kaplan Meier analysis) and univariate (UVA) and multivariable (MVA) Cox proportional hazards regression analyses were performed. Results: 637 did not achieve pCR (ypN+ = 422). 138 were ASA users. Median follow-up for the control and ASA group were 3.8 (IQR 2.2-6.3) and 3.8 (IQR 2.5-6.4) years, respectively. Majority were stage II/III. 387 were hormone receptor positive, 191 HER2 +, and 157 triple negative. On UVA, ASA use, PR status, pathologic and clinical stage showed significance for DMFS, and disease-free survival (DFS). On MVA, ASA use associated with improved 5-year DFS (p = .01, 87.0% vs 79.6%, adjusted HR = 0.48) and improved 5-year DMFS (p = .04, 92.8% vs 89.2%, adjusted HR = 0.57). In the ypN + patients, ASA use associated with improved 5-year DMFS (p = .008, 85.7% vs 70.7%, adjusted HR = 0.43) and DFS (p = .02, 86.8% vs 74.3%, adjusted HR = 0.48). Conclusion: For non-responders, particularly ypN + patients, ASA use associated with improved outcome. These hypotheses-generating results suggest for development of prospective clinical trials of augmented ASA use in selected very high-risk BC patients.
MeSH term(s)	Humans ; Female ; Breast Neoplasms/pathology ; Neoadjuvant Therapy/methods ; Prospective Studies ; Chemotherapy, Adjuvant/methods ; Disease-Free Survival ; Antineoplastic Combined Chemotherapy Protocols/therapeutic use ; Receptor, ErbB-2 ; Prognosis
Chemical Substances	Receptor, ErbB-2 (EC 2.7.10.1)
Language	English
Publishing date	2023-03-30
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	604563-7
ISSN	1573-7217 ; 0167-6806
ISSN (online)	1573-7217
ISSN	0167-6806
DOI	10.1007/s10549-023-06920-4
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Article ; Online: Usefulness of Vessel Wall MR Imaging for Follow-Up after Stent-Assisted Coil Embolization of Intracranial Aneurysms.

Kim, S / Kang, M / Kim, D W / Choi, J-H

AJNR. American journal of neuroradiology

2018 Volume 39, Issue 11, Page(s) 2088–2094

Abstract: Background and purpose: Follow-up with MRA for intracranial aneurysms after stent-assisted coiling is complicated by imaging artifacts. We evaluated the usefulness of an alternative method: vessel wall MR imaging.: Materials and methods: We conducted ...

Abstract	Background and purpose: Follow-up with MRA for intracranial aneurysms after stent-assisted coiling is complicated by imaging artifacts. We evaluated the usefulness of an alternative method: vessel wall MR imaging. Materials and methods: We conducted a single-center, retrospective review of medical records of 47 patients who underwent 3D TOF-MRA, vessel wall MRI, and DSA after stent-assisted coiling between March 2016 and January 2018. We evaluated the mean value of the signal intensity in the stented artery and the contralateral normal artery on vessel wall MRI. The quality of visualization was further compared between TOF-MRA and vessel wall MRI. Furthermore, we evaluated the diagnostic accuracy and concordance rate of TOF-MRA and vessel wall MRI for assessing the patency of the stented parent artery. DSA was used as a reference test. Results: The mean signal intensities of the stented and normal arteries on vessel wall MRI were not significantly different ( Conclusions: Vessel wall MRI may be useful in evaluating the patency of stented arteries after stent-assisted coil embolization for intracranial aneurysms.
MeSH term(s)	Adult ; Aged ; Angiography, Digital Subtraction/methods ; Arteries/diagnostic imaging ; Blood Vessel Prosthesis ; Embolization, Therapeutic/methods ; Female ; Follow-Up Studies ; Humans ; Intracranial Aneurysm/diagnostic imaging ; Intracranial Aneurysm/therapy ; Magnetic Resonance Imaging/methods ; Male ; Middle Aged ; Retrospective Studies ; Stents
Keywords	covid19
Language	English
Publishing date	2018-09-27
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	603808-6
ISSN	1936-959X ; 0195-6108
ISSN (online)	1936-959X
ISSN	0195-6108
DOI	10.3174/ajnr.A5824
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