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  1. AU="Kim, Dennis H"
  2. AU="Thai, Linh Duy"
  3. AU=Walker Scott C
  4. AU="Sheridan, Katherine"
  5. AU="Brown, Sharlie B"
  6. AU=Walker Kathleen
  7. AU="Miller, Donald G"
  8. AU="Sendino, O"
  9. AU="Rao, Arya"
  10. AU="Wong, Gary K W"

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  1. Artikel ; Online: Neuroendocrine gene expression coupling of interoceptive bacterial food cues to foraging behavior of

    Boor, Sonia A / Meisel, Joshua D / Kim, Dennis H

    eLife

    2024  Band 12

    Abstract: Animal internal state is modulated by nutrient intake, resulting in behavioral responses to changing food conditions. The neural mechanisms by which internal states are generated and maintained are not well understood. Here, we show that in the ... ...

    Abstract Animal internal state is modulated by nutrient intake, resulting in behavioral responses to changing food conditions. The neural mechanisms by which internal states are generated and maintained are not well understood. Here, we show that in the nematode
    Mesh-Begriff(e) Animals ; Caenorhabditis elegans/genetics ; Cues ; Bacteria ; Sensory Receptor Cells ; Gene Expression ; Mammals
    Sprache Englisch
    Erscheinungsdatum 2024-01-17
    Erscheinungsland England
    Dokumenttyp Journal Article
    ZDB-ID 2687154-3
    ISSN 2050-084X ; 2050-084X
    ISSN (online) 2050-084X
    ISSN 2050-084X
    DOI 10.7554/eLife.91120
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  2. Artikel: Bacteria Are a Major Determinant of Orsay Virus Transmission and Infection in

    Vassallo, Brian G / Scheidel, Noémie / Fischer, Sylvia E J / Kim, Dennis H

    bioRxiv : the preprint server for biology

    2024  

    Abstract: The microbiota is a key determinant of the physiology and immunity of animal hosts. The factors governing the transmissibility of viruses between susceptible hosts are incompletely understood. Bacteria serve as food ... ...

    Abstract The microbiota is a key determinant of the physiology and immunity of animal hosts. The factors governing the transmissibility of viruses between susceptible hosts are incompletely understood. Bacteria serve as food for
    Sprache Englisch
    Erscheinungsdatum 2024-03-18
    Erscheinungsland United States
    Dokumenttyp Preprint
    DOI 10.1101/2023.09.05.556377
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  3. Artikel: Neuroendocrine Gene Expression Coupling of Interoceptive Bacterial Food Cues to Foraging Behavior of

    Boor, Sonia A / Meisel, Joshua D / Kim, Dennis H

    bioRxiv : the preprint server for biology

    2023  

    Abstract: Animal internal state is modulated by nutrient intake, resulting in behavioral responses to changing food conditions. The neural mechanisms by which internal states are generated and maintained are not well understood. Here, we show that in the ... ...

    Abstract Animal internal state is modulated by nutrient intake, resulting in behavioral responses to changing food conditions. The neural mechanisms by which internal states are generated and maintained are not well understood. Here, we show that in the nematode
    Sprache Englisch
    Erscheinungsdatum 2023-11-13
    Erscheinungsland United States
    Dokumenttyp Preprint
    DOI 10.1101/2023.07.15.549072
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  4. Artikel ; Online: Bacterial Siderophores Promote Animal Host Iron Acquisition and Growth.

    Kim, Dennis H

    Cell

    2018  Band 175, Heft 2, Seite(n) 311–312

    Abstract: Siderophores are small molecules produced by bacteria that bind ferric iron in the surrounding environment with extraordinary affinity. A new study provides evidence that a simple animal host, Caenorhabditis elegans, co-opts siderophores to promote its ... ...

    Abstract Siderophores are small molecules produced by bacteria that bind ferric iron in the surrounding environment with extraordinary affinity. A new study provides evidence that a simple animal host, Caenorhabditis elegans, co-opts siderophores to promote its own iron acquisition and growth.
    Mesh-Begriff(e) Adenosine Triphosphate ; Animals ; Bacteria ; Enterobactin ; Iron ; Siderophores
    Chemische Substanzen Siderophores ; Enterobactin (28384-96-5) ; Adenosine Triphosphate (8L70Q75FXE) ; Iron (E1UOL152H7)
    Sprache Englisch
    Erscheinungsdatum 2018-10-05
    Erscheinungsland United States
    Dokumenttyp Journal Article ; Comment
    ZDB-ID 187009-9
    ISSN 1097-4172 ; 0092-8674
    ISSN (online) 1097-4172
    ISSN 0092-8674
    DOI 10.1016/j.cell.2018.09.020
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  5. Artikel: Germline mitotic quiescence and programmed cell death are induced in

    Bollen, Daniel P / Reddy, Kirthi C / Kim, Dennis H / Colaiácovo, Monica P

    bioRxiv : the preprint server for biology

    2023  

    Abstract: The impact of exposure to microbial pathogens on animal reproductive capacity and germline physiology is not well understood. The ... ...

    Abstract The impact of exposure to microbial pathogens on animal reproductive capacity and germline physiology is not well understood. The nematode
    Sprache Englisch
    Erscheinungsdatum 2023-08-11
    Erscheinungsland United States
    Dokumenttyp Preprint
    DOI 10.1101/2023.08.08.552522
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  6. Artikel ; Online: Host-microbe interactions and the behavior of

    Kim, Dennis H / Flavell, Steven W

    Journal of neurogenetics

    2020  Band 34, Heft 3-4, Seite(n) 500–509

    Abstract: Microbes are ubiquitous in the natural environment ... ...

    Abstract Microbes are ubiquitous in the natural environment of
    Mesh-Begriff(e) Animals ; Avoidance Learning/physiology ; Bacteria/metabolism ; Caenorhabditis elegans/genetics ; Caenorhabditis elegans/microbiology ; Caenorhabditis elegans/physiology ; Caenorhabditis elegans Proteins/genetics ; Caenorhabditis elegans Proteins/physiology ; Carbon Dioxide/metabolism ; Cues ; Escherichia coli ; Feeding Behavior/physiology ; Host Microbial Interactions/physiology ; Neural Pathways/physiology ; Oxygen/metabolism ; Pseudomonas aeruginosa/pathogenicity ; Serotonin/physiology
    Chemische Substanzen Caenorhabditis elegans Proteins ; Carbon Dioxide (142M471B3J) ; Serotonin (333DO1RDJY) ; Oxygen (S88TT14065)
    Sprache Englisch
    Erscheinungsdatum 2020-08-12
    Erscheinungsland England
    Dokumenttyp Journal Article ; Research Support, N.I.H., Extramural ; Review
    ZDB-ID 605543-6
    ISSN 1563-5260 ; 0167-7063
    ISSN (online) 1563-5260
    ISSN 0167-7063
    DOI 10.1080/01677063.2020.1802724
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  7. Artikel ; Online: IRE1 Sulfenylation by Reactive Oxygen Species Coordinates Cellular Stress Signaling.

    Kim, Dennis H

    Molecular cell

    2016  Band 63, Heft 4, Seite(n) 541–542

    Abstract: In this issue of Molecular Cell, Hourihan et al. (2016) show that sulfenylation of IRE1 by reactive oxygen species inhibits the role of IRE1 in the Unfolded Protein Response and activates a SKN-1/Nrf2-dependent response to oxidative stress. ...

    Abstract In this issue of Molecular Cell, Hourihan et al. (2016) show that sulfenylation of IRE1 by reactive oxygen species inhibits the role of IRE1 in the Unfolded Protein Response and activates a SKN-1/Nrf2-dependent response to oxidative stress.
    Mesh-Begriff(e) Oxidative Stress ; Protein-Serine-Threonine Kinases/genetics ; Reactive Oxygen Species ; Signal Transduction ; Unfolded Protein Response
    Chemische Substanzen Reactive Oxygen Species ; Protein-Serine-Threonine Kinases (EC 2.7.11.1)
    Sprache Englisch
    Erscheinungsdatum 2016-08-18
    Erscheinungsland United States
    Dokumenttyp Journal Article
    ZDB-ID 1415236-8
    ISSN 1097-4164 ; 1097-2765
    ISSN (online) 1097-4164
    ISSN 1097-2765
    DOI 10.1016/j.molcel.2016.08.003
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  8. Artikel ; Online: Germline mitotic quiescence and cell death are induced in Caenorhabditis elegans by exposure to pathogenic Pseudomonas aeruginosa.

    Bollen, Daniel P / Reddy, Kirthi C / Lascarez-Lagunas, Laura I / Kim, Dennis H / Colaiácovo, Monica P

    Genetics

    2023  Band 226, Heft 1

    Abstract: The impact of exposure to microbial pathogens on animal reproductive capacity and germline physiology is not well understood. The nematode Caenorhabditis elegans is a bacterivore that encounters pathogenic microbes in its natural environment. How ... ...

    Abstract The impact of exposure to microbial pathogens on animal reproductive capacity and germline physiology is not well understood. The nematode Caenorhabditis elegans is a bacterivore that encounters pathogenic microbes in its natural environment. How pathogenic bacteria affect host reproductive capacity of C. elegans is not well understood. Here, we show that exposure of C. elegans hermaphrodites to the Gram-negative pathogen Pseudomonas aeruginosa causes a marked reduction in brood size with concomitant reduction in the number of nuclei in the germline and gonad size. We define 2 processes that are induced that contribute to the decrease in the number of germ cell nuclei. First, we observe that infection with P. aeruginosa leads to the induction of germ cell apoptosis. Second, we observe that this exposure induces mitotic quiescence in the proliferative zone of the C. elegans gonad. Importantly, these processes appear to be reversible; when animals are removed from the presence of P. aeruginosa, germ cell apoptosis is abated, germ cell nuclei numbers increase, and brood sizes recover. The reversible germline dynamics during exposure to P. aeruginosa may represent an adaptive response to improve survival of progeny and may serve to facilitate resource allocation that promotes survival during pathogen infection.
    Mesh-Begriff(e) Animals ; Caenorhabditis elegans ; Pseudomonas aeruginosa/metabolism ; Cell Division ; Caenorhabditis elegans Proteins/genetics ; Germ Cells/metabolism ; Apoptosis
    Chemische Substanzen Caenorhabditis elegans Proteins
    Sprache Englisch
    Erscheinungsdatum 2023-11-03
    Erscheinungsland United States
    Dokumenttyp Journal Article
    ZDB-ID 2167-2
    ISSN 1943-2631 ; 0016-6731
    ISSN (online) 1943-2631
    ISSN 0016-6731
    DOI 10.1093/genetics/iyad197
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  9. Artikel ; Online: Signal Transduction: A Different Kind of Toll Is in the BAG.

    Kim, Dennis H

    Current biology : CB

    2015  Band 25, Heft 17, Seite(n) R767–9

    Abstract: A recent study identifies a role for a Toll pathway with likely non-canonical features in the developmental specification of BAG neurons in Caenorhabditis elegans. These neurons function to sense carbon dioxide, which is shown to facilitate avoidance of ... ...

    Abstract A recent study identifies a role for a Toll pathway with likely non-canonical features in the developmental specification of BAG neurons in Caenorhabditis elegans. These neurons function to sense carbon dioxide, which is shown to facilitate avoidance of pathogenic bacteria.
    Mesh-Begriff(e) Animals ; Caenorhabditis elegans/genetics ; Gene Expression ; Serratia marcescens/physiology ; Signal Transduction
    Sprache Englisch
    Erscheinungsdatum 2015-08-31
    Erscheinungsland England
    Dokumenttyp Comment ; Journal Article
    ZDB-ID 1071731-6
    ISSN 1879-0445 ; 0960-9822
    ISSN (online) 1879-0445
    ISSN 0960-9822
    DOI 10.1016/j.cub.2015.06.057
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  10. Artikel ; Online: Signaling in the innate immune response.

    Kim, Dennis H / Ewbank, Jonathan J

    WormBook : the online review of C. elegans biology

    2018  Band 2018, Seite(n) 1–35

    Abstract: The nematode Caenorhabditis elegans relies on its innate immune defenses to counter infection. In this review, we focus on its response to infection by bacterial and fungal pathogens. We describe the different families of effector proteins that ... ...

    Abstract The nematode Caenorhabditis elegans relies on its innate immune defenses to counter infection. In this review, we focus on its response to infection by bacterial and fungal pathogens. We describe the different families of effector proteins that contribute to host defense, as well as the signal transduction pathways that regulate their expression. We discuss what is known of the activation of innate immunity in C. elegans, via pathogen recognition or sensing the damage provoked by infection. Damage causes a stress response; we review the role of stress signaling in host defense to infection. We examine examples of inter-tissue communication in innate immunity and end with a survey of post-transcriptional regulation of innate immune responses.
    Mesh-Begriff(e) Animals ; Bacteria/immunology ; Caenorhabditis elegans/immunology ; Caenorhabditis elegans/metabolism ; Caenorhabditis elegans/microbiology ; Fungi/immunology ; Immunity, Innate/genetics ; Signal Transduction
    Sprache Englisch
    Erscheinungsdatum 2018-08-14
    Erscheinungsland United States
    Dokumenttyp Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Review
    ISSN 1551-8507
    ISSN (online) 1551-8507
    DOI 10.1895/wormbook.1.83.2
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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