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Article ; Online: Physical Properties of Poly(ether-thiourea)-Based Elastomer Formed by Zigzag Hydrogen Bonding and Slidable Cross-Linking.

Seo, Sojung / Park, Jin-Woo / Kim, Dong-Gyun / Seo, Ji-Hun

ACS macro letters

2023 Volume 12, Issue 11, Page(s) 1558–1563

Abstract: In this study, the effects of zigzag hydrogen bonding and slidable cross-linking on the design of stretchable elastomers were explored. Poly(ether-thiourea) (TU), capable of generating strong zigzag hydrogen bonds without crystallization, was introduced ... ...

Abstract	In this study, the effects of zigzag hydrogen bonding and slidable cross-linking on the design of stretchable elastomers were explored. Poly(ether-thiourea) (TU), capable of generating strong zigzag hydrogen bonds without crystallization, was introduced as the main chain in the non-cross-linked region of the developed elastomer. Consequently, the toughness of the TU-based elastomer was 14 times higher than that of elastomers formed using linear poly(ethylene glycol), despite the relatively low molecular weight of TU (∼3k). When a slidable polyrotaxane cross-linker was introduced into the TU-based elastomer, its flexibility became twice as high as that of the rigid polymer cross-linker. Moreover, the mechanical properties of the elastomer were prevented from deterioration against repeated deformation under the limited strain condition of 150%.
Language	English
Publishing date	2023-11-03
Publishing country	United States
Document type	Journal Article
ISSN	2161-1653
ISSN (online)	2161-1653
DOI	10.1021/acsmacrolett.3c00526
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Article ; Online: Metabolic syndrome-related factors as possible targets for lower urinary tract symptoms in Korean males.

Heo, Ji Eun / Kim, Dong Gyun / Yoo, Jeong Woo / Lee, Kwang Suk

The aging male : the official journal of the International Society for the Study of the Aging Male

2023 Volume 26, Issue 1, Page(s) 6–12

Abstract: Introduction: A positive association between benign prostate hyperplasia (BPH)/lower urinary tract symptoms (LUTS) and metabolic syndrome (MetS) was reported in several studies, but studies from Asia often showed conflicting results.: Materials and ... ...

Abstract	Introduction: A positive association between benign prostate hyperplasia (BPH)/lower urinary tract symptoms (LUTS) and metabolic syndrome (MetS) was reported in several studies, but studies from Asia often showed conflicting results. Materials and methods: Medical records were obtained from a health promotion center database between 2021 and 2022. Men without a history of treatment for LUTS were evaluated using the International Prostate Symptom Score (IPSS), Overactive Bladder Symptom Score (OABSS), transrectal ultrasonography. Results: Of 1345 individuals, 603 (44.8%) had MetS. Older age, higher IPSS values, higher prevalence rates of BPH and overactive bladder, higher triiodothyronine, and lower testosterone and sex-hormone binding globulin were observed in individuals with MetS than in individuals without MetS. The severity of LUTS significantly increased in the individuals with MetS ( Conclusions: We confirmed the positive correlation between MetS and BPH/LUTS in Korean. Factors including TSH and atherosclerosis affected LUTS in individuals with MetS. These findings suggested a potential role of thyroid hormones and atherosclerosis in the etiology and treatment of BPH/LUTS in patients with MetS.
MeSH term(s)	Humans ; Male ; Cardiovascular Diseases/epidemiology ; Glycated Hemoglobin/analysis ; Lower Urinary Tract Symptoms/epidemiology ; Metabolic Syndrome/epidemiology ; Prostatic Hyperplasia/epidemiology ; Republic of Korea/epidemiology ; Urinary Bladder, Overactive/epidemiology
Chemical Substances	Glycated Hemoglobin
Language	English
Publishing date	2023-01-12
Publishing country	England
Document type	Journal Article
ZDB-ID	2108146-3
ISSN	1473-0790 ; 1368-5538
ISSN (online)	1473-0790
ISSN	1368-5538
DOI	10.1080/13685538.2023.2166920
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Thesis ; Online: Exploring the relationship between zooplankton diel vertical migration and a tertiary nitrite peak in the mesopelagic oxygen minimum zone (OMZ)

Kim, Dong-gyun

2019

Abstract: Oxygen Minimum Zone (OMZ) is the intense oxygen depletion area located in three main regions, the Eastern South Pacific, Eastern Tropical North Pacific, and the Arabian Sea. The OMZ occurs due to the intense upwelling event supplying the nutrients from ... ...

Abstract	Oxygen Minimum Zone (OMZ) is the intense oxygen depletion area located in three main regions, the Eastern South Pacific, Eastern Tropical North Pacific, and the Arabian Sea. The OMZ occurs due to the intense upwelling event supplying the nutrients from bottom to surface. The oxygen concentration is one of the important factors that affect the Dial Vertical Migrating (DVM) zooplanktons behavior. During the day time, DVM zooplankton stays in the core of OMZ to escape their visual oriented predators, and move to the surface during the night time to do the feeding activity. Further, It is believed that this vertically migrating behavior affects the mid water depth nutrients content as DVM zooplankton actively transport the organic matter from surface to mid water depth. But, it is not clear how the DVM zooplankton affects the nutrients content in mid water depth. This study aims to figure out whether the DVM zooplankton affects to the nitrite content in two intense OMZ regions, Eastern South Pacific (ETSP) and the Arabian Sea. Through the ADCP backscatter signal, the abundance of DVM zooplankton and their migrating depth during the day time is calculated. The oxygen and nitrite concentration is collected from several CTD, Niskin bottle, and pump CTD data, and the particle data is collected from UVP5. By using these data, we estimated the relationship between them. In addition to the secondary nitrite maximum, we found another nitrite maximum, which has can be distinguishable from secondary nitrite maximum. We named this nitrite maximum as ’tertiary nitrite maximum’. In both ETSP and the Arabian Sea, the tertiary nitrite maximum occurred in very intense oxygen regions. Especially, the tertiary nitrite maximum occurs if; 1) the oxygen concentration is less than 1 �mol kg-1, 2) DVM zooplankton goes deeper than the depth at which secondary nitrite maximum occurred. The regression analysis between the abundance of DVM zooplankton (calculated from ADCP backscatter signal) and tertiary nitrite concentration in midwater ...
Keywords	Course of study: MSc Biological Oceanography
Subject code	551
Language	English
Publishing date	2019-11-28
Publishing country	de
Document type	Thesis ; Online
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Article ; Online: Meat Quality Changes in Aged Pork Loin using Jeju Volcanic Scoria Earthenware.

Kim, DongGyun / Lee, SangHoon / Kim, GwangHeun / Ko, KyoungBo / Ryu, YounChul

Food science of animal resources

2023 Volume 43, Issue 5, Page(s) 901–913

Abstract: This study aimed to investigate changes in the quality of meat aged using Jeju scoria earthenware. Water-holding properties, pH, color, tenderization, fatty acid composition, and free amino acid characteristics of aged pork loin were evaluated to ... ...

Abstract	This study aimed to investigate changes in the quality of meat aged using Jeju scoria earthenware. Water-holding properties, pH, color, tenderization, fatty acid composition, and free amino acid characteristics of aged pork loin were evaluated to determine the effects of wet and dry (normal and Jeju Scoria) aging methods and aging time (0, 10, 20, 30, and 40 days) on meat quality. The aging methods altered pH and CIE L* after 10 days of aging. However, the aging method did not alter the pH and CIE L* of the aged pork loin after 10 days of aging. The shear force was significantly lower in the Scoria aging method than in the wet aging method after 10 and 20 days of aging. Both the normal and Scoria aging methods increased aging loss compared to the wet aging method, which could be attributed to longer air exposure times of the two non-packaged aging methods than in the packaged aging method. The scoria aging method had significantly higher contents and ratios of saturated (SFA) to mono-unsaturated fatty acids but lower ratios of poly-unsaturated fatty acids to SFA than the wet aging method. The content of most free amino acids significantly increased with aging time, especially those related to the sweet, and umami categories. In summary, this study suggests that the Scoria aging method provides positive aspects of eating quality, such as improvement of meat tenderness and taste, including umami, with minimum changes in the overall meat quality.
Language	English
Publishing date	2023-09-01
Publishing country	Korea (South)
Document type	Journal Article
ZDB-ID	3016289-0
ISSN	2636-0780 ; 2636-0772
ISSN (online)	2636-0780
ISSN	2636-0772
DOI	10.5851/kosfa.2023.e46
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Article ; Online: Changes in the Gut Microbiota Composition of Juvenile Olive Flounder (Paralichthys olivaceus) Caused by Pathogenic Bacterial Infection

Kim, Dong-Gyun / Lee, Su-Jeong / Lee, Jong Min / Lee, Eun-Woo / Jang, Won Je

Fishes. 2023 June 01, v. 8, no. 6

2023

Abstract: The fish gut microbiota plays an important role in overall health. However, few reports have described the changes in the composition of gut microbiota following infection with pathogenic bacteria in olive flounder (Paralichthys olivaceus). Here, we ... ...

Abstract	The fish gut microbiota plays an important role in overall health. However, few reports have described the changes in the composition of gut microbiota following infection with pathogenic bacteria in olive flounder (Paralichthys olivaceus). Here, we reported the changes in the gut microbiota composition of flounder after treatment with each of the three pathogenic bacteria (Edwardsiella tarda, Streptococcus iniae, and Vibrio harveyi). Edwardsiella tarda infection decreased the relative abundance of Verrucomicrobia and increased Proteobacteria abundance at the phylum level of the gut microbiota over time. Similarly, Streptococcus iniae infection reduced the relative abundance of Verrucomicrobia. Vibrio harveyi infection caused a decrease in the relative abundance of Firmicutes and Verrucomicrobia and increased Proteobacteria. At the genus level, infection with all three pathogens increased the relative abundance of Ralstonia and Sphingomonas species. Conversely, this infection decreased the relative abundances of Rubritalea, Saccharimonas, and Bacillus species. Therefore, reducing the abundance of Ralstonia and Sphingomonas and increasing the abundance of Rubritalea, Saccharimonas, and Bacillus in the gut microbiota composition of flounder might help maintain a healthy gut microbiota balance. This research might be useful for future studies on improving the health of flounder through gut microbiota regulation.
Keywords	Edwardsiella tarda ; Paralichthys olivaceus ; Ralstonia ; Sphingomonas ; Streptococcus iniae ; Verrucomicrobia ; Vibrio harveyi ; bacterial infections ; flounder ; intestinal microorganisms ; juveniles
Language	English
Dates of publication	2023-0601
Publishing place	Multidisciplinary Digital Publishing Institute
Document type	Article ; Online
ISSN	2410-3888
DOI	10.3390/fishes8060294
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Usefulness of grayscale values of hypoechoic lesions matched with target lesions observed on magnetic resonance imaging for the prediction of clinically significant prostate cancer.

Kim, Dong Gyun / Yoo, Jeong Woo / Koo, Kyo Chul / Chung, Byung Ha / Lee, Kwang Suk

BMC urology

2022 Volume 22, Issue 1, Page(s) 164

Abstract: Background: To analyze grayscale values for hypoechoic lesions matched with target lesions evaluated using prebiopsy magnetic resonance imaging (MRI) according to the Prostate Imaging-Reporting and Data System (PI-RADS).: Methods: We collected data ... ...

Abstract	Background: To analyze grayscale values for hypoechoic lesions matched with target lesions evaluated using prebiopsy magnetic resonance imaging (MRI) according to the Prostate Imaging-Reporting and Data System (PI-RADS). Methods: We collected data on 420 target lesions in patients who underwent MRI/transrectal ultrasound fusion-targeted biopsies between January 2017 and September 2020. Images of hypoechoic lesions that matched the target lesions on MRI were stored in a picture archiving and communication system, and their grayscale values were estimated using the red/green/blue scoring method through an embedded function. We analyzed imaging data using grayscale values. Results: Of the 420 lesions, 261 (62.1%) were prostate cancer lesions. There was no difference in the median grayscale values between benign and prostate cancer lesions. However, grayscale ranges (41.8-98.5 and 42.6-91.8) were significant predictors of prostate cancer and clinically significant prostate cancer (csPC) in multivariable logistic regression analyses. Area under the curve for detecting csPC using grayscale values along with conventional variables (age, prostate-specific antigen levels, prostate volume, previous prostate biopsy results, and PI-RADS scores) was 0.839, which was significantly higher than that for detecting csPC using only conventional variables (0.828; P = 0.036). Subgroup analysis revealed a significant difference for PI-RADS 3 lesions between grayscale values for benign and cancerous lesions (74.5 vs. 58.8, P = 0.008). Grayscale values were the only significant predictive factor (odds ratio = 4.46, P = 0.005) for csPC. Conclusions: Distribution of grayscale values according to PI-RAD 3 scores was potentially useful, and the grayscale range (42.6-91.8) was a potential predictor for csPC diagnosis.
MeSH term(s)	Male ; Humans ; Prostatic Neoplasms/pathology ; Magnetic Resonance Imaging/methods ; Neoplasm Grading ; Retrospective Studies ; Image-Guided Biopsy/methods
Language	English
Publishing date	2022-10-29
Publishing country	England
Document type	Journal Article
ZDB-ID	2059857-9
ISSN	1471-2490 ; 1471-2490
ISSN (online)	1471-2490
ISSN	1471-2490
DOI	10.1186/s12894-022-01111-7
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Article ; Online: Phylogenetic diversity and spatiotemporal dynamics of bacterial and microeukaryotic plankton communities in Gwangyang Bay of the Korean Peninsula.

Han, Dukki / Shin, Hanseob / Lee, Ji-Hoon / Kang, Chang-Keun / Kim, Dong-Gyun / Hur, Hor-Gil

Scientific reports

2022 Volume 12, Issue 1, Page(s) 2980

Abstract: Nutrient dynamics function globally, flowing from rivers to the ocean (estuarine-coastal zone), and are vulnerable to climate change. Microbial habitats can be affected by marine nutrient dynamics and may provide a clue to predict microbial responses to ... ...

Abstract	Nutrient dynamics function globally, flowing from rivers to the ocean (estuarine-coastal zone), and are vulnerable to climate change. Microbial habitats can be affected by marine nutrient dynamics and may provide a clue to predict microbial responses to environmental heterogeneity in estuarine-coastal zones. We surveyed surface seawater in Gwangyang Bay, a semi-enclosed estuary in Korea, from 2016 to 2018 using a metabarcoding approach with prokaryotic 16S and eukaryotic 18S rRNA genes. Bacterial and microeukaryotic communities in these waters showed distinct local communities in response to environmental heterogeneity and community transition at spatiotemporal scales in the estuarine-coastal zone. The relative abundance of prokaryotic and eukaryotic operational taxonomic units suggested a microbial trophic interaction in the Gwangyang Bay waters. We found that the community assembly process in prokaryotic communities was primarily influenced by biological interaction (immigration-emigration), whereas that in eukaryotic communities was more affected by environmental stress (habitat specificity) rather than by biotic factors. Our findings in the Gwangyang Bay waters may provide information on underlying (biotic or abiotic) factors of the assembly process in microbial communities in the estuarine-coastal zone.
MeSH term(s)	Bacteria/classification ; Bacteria/genetics ; Bacteria/growth & development ; Bays/microbiology ; Biodiversity ; Eukaryota/classification ; Eukaryota/genetics ; Eukaryota/growth & development ; Phylogeny ; Plankton/classification ; Plankton/genetics ; Plankton/growth & development ; RNA, Ribosomal, 16S/genetics ; RNA, Ribosomal, 18S/genetics ; Republic of Korea ; Seawater/microbiology
Chemical Substances	RNA, Ribosomal, 16S ; RNA, Ribosomal, 18S
Language	English
Publishing date	2022-02-22
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-022-06624-7
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Article ; Online: Enterovibrio paralichthyis

Kim, Young-Ok / Park, In-Suk / Kim, Dong-Gyun / Park, Sooyeon / Han, Sung Hoon / Yoon, Jung-Hoon

International journal of systematic and evolutionary microbiology

2023 Volume 72, Issue 12

Abstract: A Gram-stain-negative, facultatively anaerobic, flagellated and coccoid, ovoid or rod-shaped bacterial strain, NIFS-20- ... ...

Abstract	A Gram-stain-negative, facultatively anaerobic, flagellated and coccoid, ovoid or rod-shaped bacterial strain, NIFS-20-8
MeSH term(s)	Animals ; Fatty Acids/chemistry ; Flounder/genetics ; Seawater/microbiology ; Phylogeny ; RNA, Ribosomal, 16S/genetics ; Sequence Analysis, DNA ; DNA, Bacterial/genetics ; Base Composition ; Bacterial Typing Techniques ; Republic of Korea
Chemical Substances	Fatty Acids ; RNA, Ribosomal, 16S ; DNA, Bacterial
Language	English
Publishing date	2023-02-07
Publishing country	England
Document type	Journal Article
ZDB-ID	2002336-4
ISSN	1466-5034 ; 1466-5026
ISSN (online)	1466-5034
ISSN	1466-5026
DOI	10.1099/ijsem.0.005593
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Article ; Online: [Acute Acalculous Cholecystitis Associated with Sunitinib Treatment for Renal Cell Carcinoma].

Choi, Se Woong / Lee, Jeong Min / Kim, Dong Gyun / Noh, Myung Hwan

The Korean journal of gastroenterology = Taehan Sohwagi Hakhoe chi

2020 Volume 75, Issue 2, Page(s) 103–107

Abstract: A 64-year-old man was treated with sunitinib as a first-line therapy for metastatic renal cell carcinoma. He was given oral sunitinib in cycles of 50 mg once daily for 2 weeks followed by a week off. During the 5th week of treatment right upper quadrant ... ...

Abstract	A 64-year-old man was treated with sunitinib as a first-line therapy for metastatic renal cell carcinoma. He was given oral sunitinib in cycles of 50 mg once daily for 2 weeks followed by a week off. During the 5th week of treatment right upper quadrant pain developed, but this resolved spontaneously during the 6th week (off treatment). However, on the 8th week of treatment, he was admitted to hospital because the acute right upper quadrant pain recurred with nausea, vomiting, and fever. Acute acalculous cholecystitis was then diagnosed by ultrasonography and CT. In addition, his laboratory findings indicated disseminated intravascular coagulation. Accordingly, sunitinib therapy was discontinued and broad-spectrum antibiotics initiated. He subsequently recovered after emergent percutaneous cholecystostomy. His Naranjo Adverse Drug Reaction Probability Scale score was 7, indicaing a probable association of the event with sunitinib. Suspicion of sunitinib-related acute cholecystitis is required, because, although uncommon, it can be life-threatening.
MeSH term(s)	Carcinoma, Renal Cell/drug therapy ; Cholecystitis, Acute/diagnosis ; Cholecystitis, Acute/etiology ; Cholecystitis, Acute/surgery ; Cholecystostomy ; Gallbladder/diagnostic imaging ; Humans ; Kidney Neoplasms/drug therapy ; Male ; Middle Aged ; Nausea/etiology ; Sunitinib/adverse effects ; Sunitinib/therapeutic use ; Tomography, X-Ray Computed ; Ultrasonography
Chemical Substances	Sunitinib (V99T50803M)
Language	Korean
Publishing date	2020-02-24
Publishing country	Korea (South)
Document type	Case Reports
ZDB-ID	2611091-X
ISSN	2233-6869 ; 1598-9992
ISSN (online)	2233-6869
ISSN	1598-9992
DOI	10.4166/kjg.2020.75.2.103
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Article: Crystal structure of the YoeBSa1-YefMSa1 complex from Staphylococcus aureus

Eun, Hyun-Jong / Lee, Ki-Young / Kim, Dong-Gyun / Im, Daseul / Lee, Bong-Jin

Biochemical and biophysical research communications. 2020 June 18, v. 527, no. 1

2020

Abstract: Toxin-antitoxin (TA) systems are ubiquitously found in bacteria and are related to cell maintenance and survival under environmental stresses such as heat shock, nutrient starvation, and antibiotic treatment. Here, we report for the first time the ... ...

Abstract	Toxin-antitoxin (TA) systems are ubiquitously found in bacteria and are related to cell maintenance and survival under environmental stresses such as heat shock, nutrient starvation, and antibiotic treatment. Here, we report for the first time the crystal structure of the Staphylococcus aureus TA complex YoeBSₐ₁-YefMSₐ₁ at a resolution of 1.7 Å. This structure reveals a heterotetramer with a 2:2 stoichiometry between YoeBSₐ₁ and YefMSₐ₁. The N-terminal regions of the YefMSₐ₁ antitoxin form a homodimer characteristic of a hydrophobic core, and the C-terminal extended region of each YefMSₐ₁ protomer makes contact with each YoeBSₐ₁ monomer. The binding stoichiometry of YoeBSₐ₁ and YefMSₐ₁ is different from that of YoeB and YefM of E. coli (YoeBEc and YefMEc), which is the only structural homologue among YoeB-YefM families; however, the structures of individual YoeBSₐ₁ and YefMSₐ₁ subunits in the complex are highly similar to the corresponding structures in E. coli. In addition, docking simulation with a minimal RNA substrate provides structural insight into the guanosine specificity of YoeBSₐ₁ for cleavage in the active site, which is distinct from the specificity of YoeBEc for adenosine rather than guanosine. Given the previous finding that YoeBSₐ₁ exhibits fatal toxicity without inducing persister cells, the structure of the YoeBSₐ₁-YefMSₐ₁ complex will contribute to the design of a new category of anti-staphylococcal agents that disrupt the YoeBSₐ₁-YefMSₐ₁ complex and increase YoeBSₐ₁ toxicity.
Keywords	Escherichia coli ; RNA ; Staphylococcus aureus ; active sites ; adenosine ; antibiotics ; antitoxins ; crystal structure ; guanosine ; heat stress ; hydrophobicity ; protein subunits ; research ; starvation ; stoichiometry ; toxicity
Language	English
Dates of publication	2020-0618
Size	p. 264-269.
Publishing place	Elsevier Inc.
Document type	Article
Note	NAL-AP-2-clean
ZDB-ID	205723-2
ISSN	0006-291X ; 0006-291X
ISSN (online)	0006-291X
ISSN	0006-291X
DOI	10.1016/j.bbrc.2020.04.089
Database	NAL-Catalogue (AGRICOLA)

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