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Article ; Online: A Novel Time-Saving Synthesis Approach for Li-Argyrodite Superionic Conductor.

Hwang, Suk-Ho / Seo, Seung-Deok / Kim, Dong-Wan

Advanced science (Weinheim, Baden-Wurttemberg, Germany)

2023 Volume 10, Issue 22, Page(s) e2301707

Abstract: The wet-chemical synthetic approach for Li-argyrodite superionic conductors for all-solid-state batteries (ASSBs) is promising as it saves time, energy, and cost, while achieving scalable production. However, it faces certain commercialization issues ... ...

Abstract	The wet-chemical synthetic approach for Li-argyrodite superionic conductors for all-solid-state batteries (ASSBs) is promising as it saves time, energy, and cost, while achieving scalable production. However, it faces certain commercialization issues such as byproduct generation, nucleophilic attack of the solvent, and long processing times. In this study, a facile and time-saving microwave-assisted wet synthesis (MW-process) approach is proposed for Li
Language	English
Publishing date	2023-05-03
Publishing country	Germany
Document type	Journal Article
ZDB-ID	2808093-2
ISSN	2198-3844 ; 2198-3844
ISSN (online)	2198-3844
ISSN	2198-3844
DOI	10.1002/advs.202301707
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Molecular and Treatment Characteristics of SMARCB1 or SMARCA4-Deficient Undifferentiated Tumor: Retrospective Case Series.

Kang, Hyeon Gyu / Koh, Jiwon / Kim, Tae Min / Han, Doo Hee / Won, Tae-Bin / Kim, Dong-Wan / Kim, Dong-Young / Keam, Bhumsuk

Cancer research and treatment

2024

Abstract: SMARCB1 or SMARCA4-deficient sinonasal carcinoma or thoracic undifferentiated tumor has aggressive nature with a poor prognosis. Patients with this disease were diagnosed by immunohistochemistry (IHC) or next-generation sequencing (NGS). Those who were ... ...

Abstract	SMARCB1 or SMARCA4-deficient sinonasal carcinoma or thoracic undifferentiated tumor has aggressive nature with a poor prognosis. Patients with this disease were diagnosed by immunohistochemistry (IHC) or next-generation sequencing (NGS). Those who were able to receive a surgery tended to be cured, while the others treated with chemotherapy, radiation therapy, or immune checkpoint inhibitor were often insensitive to these therapies. However, one having CD274 (PD-L1) amplification showed the response to immune checkpoint inhibitor and a good prognosis. We believed that this report could provide promising information for determining the optimal treatment option.
Language	English
Publishing date	2024-02-13
Publishing country	Korea (South)
Document type	Journal Article
ZDB-ID	2133613-1
ISSN	2005-9256 ; 1598-2998
ISSN (online)	2005-9256
ISSN	1598-2998
DOI	10.4143/crt.2023.1308
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Article ; Online: Polymer Electrolyte/Sulfur Double-Shelled Anisotropic Reduced Graphene Oxide Lamellar Scaffold Enables Stable and High-Loading Cathode for Quasi-Solid-State Lithium-Sulfur Batteries.

Shin, Hyun Jung / Park, Sung-Woo / Park, Sangbaek / Kim, Dong-Wan

Advanced science (Weinheim, Baden-Wurttemberg, Germany)

2022 Volume 10, Issue 6, Page(s) e2205424

Abstract: Lithium-sulfur batteries (LSBs) can replace lithium-ion batteries by delivering a higher specific capacity. However, the areal capacity of current LSBs is low because the intrinsic limitations of sulfur make achieving a high sulfur loading difficult. ... ...

Abstract	Lithium-sulfur batteries (LSBs) can replace lithium-ion batteries by delivering a higher specific capacity. However, the areal capacity of current LSBs is low because the intrinsic limitations of sulfur make achieving a high sulfur loading difficult. Herein, the authors report vertically aligned reduced graphene oxide (rGO) with sulfur and poly(ethylene oxide)-based polymer electrolyte double-shell layers (VRG@S@PPE) as a high-loading sulfur cathode. The addition of vapor-grown carbon fiber (VGCF) into rGO is the key to success, as it allows for gas evacuation from internal nano/micropores without structural collapse, enabling perfect double-shell layer contact. Owing to the anisotropic rGO lamellar structure that enables straightforward ion/electron transport and provides numerous active sites, sulfur-infiltrated rGO reinforced via VGCF (VRG@S) exhibits a high capacity of 998 mAh g
Language	English
Publishing date	2022-12-27
Publishing country	Germany
Document type	Journal Article
ZDB-ID	2808093-2
ISSN	2198-3844 ; 2198-3844
ISSN (online)	2198-3844
ISSN	2198-3844
DOI	10.1002/advs.202205424
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Article: Constitutive Activating Eel Luteinizing Hormone Receptors Induce Constitutively Signal Transduction and Inactivating Mutants Impair Biological Activity.

Byambaragchaa, Munkhzaya / Choi, Seung-Hee / Kim, Dong-Wan / Min, Kwan-Sik

Development & reproduction

2021 Volume 25, Issue 3, Page(s) 133–143

Abstract: In contrast to the human lutropin receptor (hLHR) and rat LHR (rLHR), very few naturally occurring mutants in other mammalian species have been identified. The present study aimed to delineate the mechanism of signal transduction by three constitutively ... ...

Abstract	In contrast to the human lutropin receptor (hLHR) and rat LHR (rLHR), very few naturally occurring mutants in other mammalian species have been identified. The present study aimed to delineate the mechanism of signal transduction by three constitutively activating mutants (designated M410T, L469R, and D590Y) and two inactivating mutants (D383N and Y546F) of the eel LHR, known to be naturally occurring in human LHR transmembrane domains. The mutants were constructed and measured cyclic adenosine monophosphate (cAMP) accumulation via homogeneous time-resolved fluorescence assays in Chinese hamster ovary (CHO)-K1 cells. The activating mutant cells expressing eel LHR-M410T, L469R, and D590Y exhibited a 4.0-, 19.1-, and 7.8-fold increase in basal cAMP response without agonist treatment, respectively. However, inactivating mutant cells expressing D417N and Y558F did not completely impaired signal transduction. Specifically, signal transduction in the cells expressing activating mutant L469R was not occurred with a further ligand stimulation, showing that the maximal response exhibited approximately 53% of those of wild type receptor. Our results suggested that the constitutively activating mutants of the eel LHR consistently occurred without agonist treatment. These results provide important information of LHR function in fish and regulation with regard to mutations of highly conserved amino acids in glycoprotein hormone receptors.
Language	English
Publishing date	2021-09-30
Publishing country	Korea (South)
Document type	Journal Article
ZDB-ID	3018107-0
ISSN	2465-9541 ; 2465-9525
ISSN (online)	2465-9541
ISSN	2465-9525
DOI	10.12717/DR.2021.25.3.133
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Article: Cell-Surface Loss of Constitutive Activating and Inactivating Mutants of Eel Luteinizing Hormone Receptors.

Byambaragchaa, Munkhzaya / Choi, Seung-Hee / Kim, Dong-Wan / Min, Kwan-Sik

Development & reproduction

2021 Volume 25, Issue 4, Page(s) 225–234

Abstract: The present study aimed to investigate the mechanism of cell surface receptor loss by two constitutively activating mutants (designated L469R, and D590Y) and two inactivating mutants (D417N and Y558F) of the luteinizing hormone receptor (LHR) in the ... ...

Abstract	The present study aimed to investigate the mechanism of cell surface receptor loss by two constitutively activating mutants (designated L469R, and D590Y) and two inactivating mutants (D417N and Y558F) of the luteinizing hormone receptor (LHR) in the Japanese eel
Language	English
Publishing date	2021-12-31
Publishing country	Korea (South)
Document type	Journal Article
ZDB-ID	3018107-0
ISSN	2465-9541 ; 2465-9525
ISSN (online)	2465-9541
ISSN	2465-9525
DOI	10.12717/DR.2021.25.4.225
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Article: High-power lithium-ion capacitor using orthorhombic Nb2O5 nanotubes enabled by cellulose-based electrospun scaffolds

Park, Jong Chel / Park, Sangbaek / Kim, Dong-Wan

Cellulose. 2020 Nov., v. 27, no. 17

2020

Abstract: Orthorhombic Nb₂O₅-based nanoarchitectures have shown promise as electrode materials for Li-ion capacitors because they improve lithium ion transport and conductivity of Nb₂O₅ with high theoretical capacity. However, despite the several advantages of ... ...

Abstract	Orthorhombic Nb₂O₅-based nanoarchitectures have shown promise as electrode materials for Li-ion capacitors because they improve lithium ion transport and conductivity of Nb₂O₅ with high theoretical capacity. However, despite the several advantages of nanotubes, the facile synthesis of Nb₂O₅ nanotubes remains challenging. Herein, we present Nb₂O₅ nanotubes as an efficient ion- and electron-conducting electrode using environmentally friendly cellulose as sacrificial templates. The rational synthetic design based on sol–gel interactions with hydroxyl groups on the cellulosic surface enables uniformly covering the electrospun-cellulose one-dimensional templates with Nb₂O₅, resulting in unusual nanotubular Nb₂O₅ crystals featuring crystallographic iso-orientation owing to a controlled two-step calcination. Such crystallographically oriented nanotubes are favorable to fast Li⁺ intercalation kinetics for pseudocapacitive behavior with efficient lithium ion channels. The orthorhombic Nb₂O₅ nanotubes provide electrodes with a high initial capacity (163 mAh g⁻¹), excellent rate capability (95 mAh g⁻¹ at 5 A g⁻¹), and stable cycle performance (81.8% retention after 1000 cycles at 5 A g⁻¹) without any carbon composite and are thus superior to previously reported Nb₂O₅ electrodes. This simple strategy can open a new avenue for fabricating nanotubes of various transition metal oxides.
Keywords	capacitors ; carbon ; cellulose ; electrodes ; lithium ; nanotubes
Language	English
Dates of publication	2020-11
Size	p. 9991-10006.
Publishing place	Springer Netherlands
Document type	Article
Note	NAL-AP-2-clean
ZDB-ID	1496831-9
ISSN	1572-882X ; 0969-0239
ISSN (online)	1572-882X
ISSN	0969-0239
DOI	10.1007/s10570-020-03468-0
Database	NAL-Catalogue (AGRICOLA)

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Article: A synergistic engineering layer with a versatile H₂Ti₃O₇ electrocatalyst for a suppressed shuttle effect and enhanced catalytic conversion in lithium–sulfur batteries

Choi, Changhoon / Park, Jung Been / Kim, Dong-Wan

Journal of materials chemistry A. 2020 Dec. 15, v. 8, no. 47

2020

Abstract: Lithium–sulfur batteries (Li–S batteries) are considered a promising technology for advanced energy storage devices, owing to their exceptionally high theoretical energy density and cost-effectiveness. However, the detrimental polysulfide shuttle effect ... ...

Abstract	Lithium–sulfur batteries (Li–S batteries) are considered a promising technology for advanced energy storage devices, owing to their exceptionally high theoretical energy density and cost-effectiveness. However, the detrimental polysulfide shuttle effect and the sluggish redox kinetics of Li–S batteries are the major obstacles to the development of high-performance Li–S batteries. In this study, a synergistic engineering layer comprising a versatile H₂Ti₃O₇ electrocatalyst and conductive supporting materials (HTO–sCNT–G) was developed for advanced Li–S batteries. In the ingenious three-dimensional internal hierarchical percolating microstructure of HTO–sCNT–G, the polar H₂Ti₃O₇ nanowires acted as an effective mediator of polysulfide (PS) conversion and suppressed the shuttle effect due to their strong chemical interaction with PSs, while the carbon components (CNTs and graphene) provided a three-dimensional conductive network that increased the electronic conductivity of H₂Ti₃O₇. Furthermore, the hierarchical porous structure without graphene overstacking increased the accessible surface area for rapid Li⁺ diffusion, thereby improving the ionic conductivity, and HTO–sCNT–G acted as an auxiliary sulfur host, providing an additional conductive network to reutilize the trapped PSs. Owing to the synergistic effect of HTO–sCNT–G, the resultant Li–S batteries exhibited an excellent electrochemical performance with a significantly high reversibility (1001 mA h g⁻¹ after 100 cycles at 0.2C and 794 mA h g⁻¹ after 500 cycles at 1C with an ultralow capacity decay of 0.057% per cycle) and improved rate capabilities at different current rates (792.1, 631.7, and 509.5 mA h g⁻¹ at 1, 2, and 3C). Thus, this study provides new insight for the development of synergistic engineering interlayers/modified separators for advanced Li–S batteries without elaborate electrocatalyst–conductive agent hybrid synthesis.
Keywords	cost effectiveness ; electrochemistry ; energy ; energy density ; graphene ; microstructure ; nanowires ; sulfur ; surface area ; synergism
Language	English
Dates of publication	2020-1215
Size	p. 25411-25424.
Publishing place	The Royal Society of Chemistry
Document type	Article
Note	NAL-AP-2-clean
ZDB-ID	2702232-8
ISSN	2050-7496 ; 2050-7488
ISSN (online)	2050-7496
ISSN	2050-7488
DOI	10.1039/d0ta08589h
Database	NAL-Catalogue (AGRICOLA)

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Article: Anti-SARS-CoV-2 Neutralizing Antibody Responses after Two Doses of ChAdOx1 nCoV-19 vaccine (AZD1222) in Healthcare Workers.

Lim, Sera / Lee, Yuil / Kim, Dong Wan / Park, Won Sang / Yoon, Jung Hwan / Lee, Jung Young

Infection & chemotherapy

2022 Volume 54, Issue 1, Page(s) 140–152

Abstract: Background: The kinetics of neutralizing antibodies against severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) play an important role in evaluating vaccine efficacy and durability, herd immunity, additional vaccination, and prediction models ... ...

Abstract	Background: The kinetics of neutralizing antibodies against severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) play an important role in evaluating vaccine efficacy and durability, herd immunity, additional vaccination, and prediction models of immune protection against coronavirus disease 2019. Materials and methods: Serum collection times were 4 and 8 weeks after 1st inoculation of AZD1222 (AstraZeneca, Cambridge, UK), and 2 and 16 weeks after 2nd inoculation with 12-week dosing intervals. Neutralizing antibody (Nab) titers were measured indirectly using commercially available R-FIND SARS-CoV-2 Neutralizing Antibody ELISA Kit (SG Medical Inc., Seoul, Korea). Possible influences of gender, age, and adverse events on neutralizing antibody titer were also investigated. Results: Nab titers (median inhibition %) started to decrease shortly after reaching peaks. This decrease was more pronounced in the elderly group (≥56 years) than in the young group (≤39 years) at 8 weeks (49.5% Conclusion: Nab induced by AZD1222 (AstraZeneca, UK) vaccination started to degrade shortly after the production period. Nab titers were lower in the elderly than in younger group during the degradation period. This seems to be because the degradation process of Nab is more pronounced in the elderly. This may explain why the frequency of breakthrough infections, disease severity, and mortality were higher in the elderly and may require revaccination to ensure robust immunity.
Language	English
Publishing date	2022-04-05
Publishing country	Korea (South)
Document type	Journal Article
ZDB-ID	2573798-3
ISSN	2093-2340
ISSN	2093-2340
DOI	10.3947/ic.2022.0009
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Article ; Online: Effectiveness and Safety of Regdanvimab in Patients With Mild-To-Moderate COVID-19: A Retrospective Cohort Study.

Park, Susin / Je, Nam Kyung / Kim, Dong Wan / Park, Miran / Heo, Jeonghun

Journal of Korean medical science

2022 Volume 37, Issue 13, Page(s) e102

Abstract: Background: Regdanvimab has decreased the time to clinical recovery from coronavirus disease 2019 (COVID-19) and lowered the rate of oxygen therapy according to the results from phase 2/3 randomized controlled trial. More information is needed about the ...

Abstract	Background: Regdanvimab has decreased the time to clinical recovery from coronavirus disease 2019 (COVID-19) and lowered the rate of oxygen therapy according to the results from phase 2/3 randomized controlled trial. More information is needed about the effects and safety of regdanvimab. Methods: We analyzed data for patients with high-risk mild or moderate COVID-19 being admitted to Busan Medical Center between December 1, 2020 and April 16, 2021. A propensity score (PS) matched analysis was conducted to compare patients treated with and without regdanvimab. The primary outcome was in-hospital death or disease aggravation which means the need for oxygen therapy (low- or high-flow oxygen therapy and mechanical ventilation) and secondary outcomes comprised the length of hospital stay and adverse reactions. Results: Among 1,617 selected patients, 970 (60.0%) were indicated for regdanvimab. Of these, 377 (38.9%) were administered with regdanvimab. Among a 1:1 PS-matched cohort of 377 patients each treated with and without regdanvimab, 19 (5%) and 81 (21.5%) reached the composite outcome of death, or disease aggravation, respectively (absolute risk difference, -16.4%; 95% confidence interval [CI], -21.1, -11.7; relative risk difference, 76.5%; Conclusion: Regdanvimab was associated with a significantly lower risk of disease aggravation without increasing adverse reactions.
MeSH term(s)	Antibodies, Monoclonal, Humanized/adverse effects ; Antibodies, Neutralizing/adverse effects ; COVID-19/drug therapy ; Hospital Mortality ; Humans ; Immunoglobulin G/adverse effects ; Retrospective Studies ; Severity of Illness Index ; Treatment Outcome
Chemical Substances	Antibodies, Monoclonal, Humanized ; Antibodies, Neutralizing ; Immunoglobulin G ; regdanvimab (I0BGE6P6I6)
Language	English
Publishing date	2022-04-04
Publishing country	Korea (South)
Document type	Journal Article
ZDB-ID	639262-3
ISSN	1598-6357 ; 1011-8934
ISSN (online)	1598-6357
ISSN	1011-8934
DOI	10.3346/jkms.2022.37.e102
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Article: Immunogenicity and Protection against Foot-and-Mouth Disease Virus in Swine Intradermally Vaccinated with a Bivalent Vaccine of Foot-and-Mouth Disease Virus Type O and A.

Kim, Dong-Wan / Cho, Giyoun / Kim, Hyejin / Lee, Gyeongmin / Lim, Tae-Gwan / Kwak, Ho-Young / Park, Jong-Hyeon / Park, Sung-Han

Vaccines

2023 Volume 11, Issue 4

Abstract: Following the worst outbreak of foot-and-mouth disease (FMD), a highly contagious disease in cloven-hoofed animals caused by the FMD virus, from November 2010-April 2011, the Korean government enforced a mandatory vaccination policy. A bivalent (FMD type ...

Abstract	Following the worst outbreak of foot-and-mouth disease (FMD), a highly contagious disease in cloven-hoofed animals caused by the FMD virus, from November 2010-April 2011, the Korean government enforced a mandatory vaccination policy. A bivalent (FMD type O and A; O + A) vaccine has been recently implemented. Although the FMD outbreak was suppressed by vaccination, the intramuscular (IM) injection presents side effects. Therefore, improving FMD vaccine quality is necessary. Here, we investigated the side effects and immune efficacy of the O + A bivalent vaccine using two different routes of administration: intradermal (ID) and IM. To compare the immune efficacy of the two inoculation routes, virus neutralization titers and structural protein (antigen) levels were measured. The protective efficacy of ID vaccines was confirmed using two viruses (FMDV O/AS/SKR/2019 and A/GP/SKR/2018) isolated in the Republic of Korea. Serological analysis revealed that both animals administered by ID and IM injections exhibited equal immune efficacy. A virus challenge test in the target animal (swine) revealed no (or extremely low) clinical symptoms. Swine in the ID injected group exhibited no side effects. In conclusion, we suggest that the ID route of vaccination is an effective alternative to the existing IM route, which is associated with more frequent side effects.
Language	English
Publishing date	2023-04-07
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2703319-3
ISSN	2076-393X
ISSN	2076-393X
DOI	10.3390/vaccines11040815
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