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Article ; Online: Double-barreled IMA-M2 and STA-MCA bypass in severe stenosis of terminal internal carotid artery: three case reports.

Cho, Byung-Rae / Jang, Dong-Kyu / Kim, Dong-Sub / Han, Young-Min

2023 Volume 165, Issue 3, Page(s) 631–636

Abstract: EC-IC bypasses have been performed to treat complex aneurysms or moyamoya disease or atherosclerotic steno-occlusive disease. We report the three cases that underwent EC-IC revascularization of the IMA-M2 bypass using the radial artery graft concurrently ...

Abstract	EC-IC bypasses have been performed to treat complex aneurysms or moyamoya disease or atherosclerotic steno-occlusive disease. We report the three cases that underwent EC-IC revascularization of the IMA-M2 bypass using the radial artery graft concurrently after the STA-MCA anastomosis to prevent potential ischemic damage during the operation and augment more flow in terminal internal carotid artery stenosis. All patients experienced neither perioperative complications nor further events for a 3-month follow-up. The double-barreled IMA-M2 and STA-MCA bypass is a good option for substantial amount of EC-IC revascularization with minimizing ischemic injury and maximizing flow amount in patients with severe hemodynamic compromise.
MeSH term(s)	Humans ; Cerebral Revascularization ; Carotid Artery, Internal/surgery ; Constriction, Pathologic ; Moyamoya Disease/surgery ; Aneurysm ; Middle Cerebral Artery/surgery ; Temporal Arteries/surgery
Language	English
Publishing date	2023-01-16
Publishing country	Austria
Document type	Case Reports ; Journal Article
ZDB-ID	80010-7
ISSN	0942-0940 ; 0001-6268
ISSN (online)	0942-0940
ISSN	0001-6268
DOI	10.1007/s00701-023-05499-5
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Article ; Online: Feasibility and safety values of activated clotting time-guided systemic heparinization in coil embolization for unruptured intracranial aneurysms.

Jang, Hyuk / Cho, Byung-Rae / Jang, Dong-Kyu / Kim, Dong-Sub

Acta neurochirurgica

2023 Volume 165, Issue 12, Page(s) 3743–3757

Abstract: Objective: This study aimed to evaluate the feasibility and safety values of activated clotting time (ACT)-guided systemic heparinization in reducing periprocedural thrombosis and bleeding complications during coil embolization of unruptured ... ...

Abstract	Objective: This study aimed to evaluate the feasibility and safety values of activated clotting time (ACT)-guided systemic heparinization in reducing periprocedural thrombosis and bleeding complications during coil embolization of unruptured intracranial aneurysms. Methods: A total of 228 procedures performed on 213 patients between 2016 and 2021 were included in the retrospective analysis. The target ACT was set at 250 s. Logistic regression was performed to assess predictors for the occurrence of thrombosis and bleeding. Receiver operating characteristic (ROC) analyses were employed to determine the optimal cut-off values for ACT, heparinization, and procedure time. Results: Most (85.1%) of procedures were stent-assisted embolization. The mean baseline ACT was 128.8 ± 45.7 s. The mean ACT at 20 min after the initial intravenous heparin loading of 78.2 ± 18.8 IU/kg was 185 ± 46.4 s. The mean peak ACT was 255.6 ± 63.8 s with 51.3% (117 cases) achieving the target ACT level. Peak ACT was associated with symptomatic thrombosis (OR per second, 1.008; 95% CI, 1.000-1.016; P = 0.035) (cut-off value, 275 s; area under ROC (AUROC), 0.7624). Total administered heparin dose per body weight was negatively associated with symptomatic thrombosis (OR per IU/kg, 0.972; 95% CI, 0.949-0995; P = 0.018) (cut-off value, 294 IU/kg; AUROC, 0.7426) but positively associated with significant bleeding (OR, 1.008 per IU/kg; 95% CI, 1.005-1.012; P <0 .001) (cut-off value, 242 IU/kg; AUROC, 0.7391). Procedure time was significantly associated with symptomatic thrombosis (OR per minute, 1.05; 95% CI, 1.017-1.084; P value = 0.002) (cut-off value, 158 min; area under ROC, 0.8338). Conclusion: This study demonstrated that ACT-guided systemic heparinization was feasible to achieve the target ACT value and proposes probable safety thresholds to prevent periprocedural complications through reducing procedure time during coil embolization of unruptured intracranial aneurysms in the stent era.
MeSH term(s)	Humans ; Retrospective Studies ; Intracranial Aneurysm/therapy ; Feasibility Studies ; Heparin/therapeutic use ; Stents ; Thrombosis ; Embolization, Therapeutic/adverse effects ; Embolization, Therapeutic/methods ; Treatment Outcome
Chemical Substances	Heparin (9005-49-6)
Language	English
Publishing date	2023-11-20
Publishing country	Austria
Document type	Journal Article
ZDB-ID	80010-7
ISSN	0942-0940 ; 0001-6268
ISSN (online)	0942-0940
ISSN	0001-6268
DOI	10.1007/s00701-023-05869-z
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Article ; Online: Differences in the Clinical Significance of Antinuclear Antibodies According to Titers and Patterns in Children.

Park, Min Ji / Jang, Hae Min / Kim, Dongsub / Won, Dong Il / Baek, Hee Sun / Cho, Min Hyun

Clinical pediatrics

2023 Volume 62, Issue 10, Page(s) 1254–1260

Abstract: This study aimed to evaluate the differences in the clinical significance of antinuclear antibody (ANA) according to their titers and patterns in the diagnosis of systemic autoimmune diseases (AiD) in pediatric patients. Of the 2442 children who had ... ...

Abstract	This study aimed to evaluate the differences in the clinical significance of antinuclear antibody (ANA) according to their titers and patterns in the diagnosis of systemic autoimmune diseases (AiD) in pediatric patients. Of the 2442 children who had undergone an ANA test, 473 (19.4%) were positive for ANA, of whom 33 (7.0%) were diagnosed with significant AiD. The positive predictive value (PPV) for significant AiD was considerably high on application of an ANA titer of ≥1:640, and the PPV of a dense fine speckled (DFS) pattern was significantly lower compared with those of speckled and homogenous patterns. The diagnostic value of ANA positivity for AiD is limited, and the clinical significance of the DFS pattern is relatively lower compared with that of other patterns, such as homogenous and speckled patterns, in children. It is necessary to approach the significance of ANA in children individually depending on titers and patterns.
MeSH term(s)	Humans ; Child ; Antibodies, Antinuclear ; Autoimmune Diseases/diagnosis ; Clinical Relevance ; Predictive Value of Tests
Chemical Substances	Antibodies, Antinuclear
Language	English
Publishing date	2023-02-24
Publishing country	United States
Document type	Journal Article
ZDB-ID	207678-0
ISSN	1938-2707 ; 0009-9228
ISSN (online)	1938-2707
ISSN	0009-9228
DOI	10.1177/00099228231154948
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Article ; Online: Microbiologic Epidemiology of Early-onset Sepsis in Neonates Born at ≥35 0/7 Weeks' Gestation in Korea During 2009-2018.

Yoon, Yoonsun / So, Hyejin / Lee, Joon Kee / Kim, Dongsub / Jo, Kyo Jin / Kim, Hyun Ho / Kim, Yoo-Jin / Lee, Jina / Jo, Dae Sun / Kim, Yun-Kyung / Park, Su Eun / Chang, Yun Sil / Kim, Yae-Jean

The Pediatric infectious disease journal

2023 Volume 42, Issue 8, Page(s) 705–710

Abstract: Background: Sepsis within the first 3 days of life remains a leading cause of neonatal mortality and morbidity. However, few studies have addressed the epidemiology of sepsis in late preterm and term neonates, particularly in Asia. We aimed to estimate ... ...

Abstract	Background: Sepsis within the first 3 days of life remains a leading cause of neonatal mortality and morbidity. However, few studies have addressed the epidemiology of sepsis in late preterm and term neonates, particularly in Asia. We aimed to estimate the epidemiology of early-onset sepsis (EOS) in neonates born at ≥35 0/7 weeks' gestation in Korea. Methods: A retrospective study was conducted in neonates with proven EOS born at ≥35 0/7 weeks' gestation from 2009 to 2018 at seven university hospitals. EOS was defined as identifying bacteria from a blood culture within 72 hours after birth. Results: A total of 51 neonates (0.36/1,000 live births) with EOS were identified. The median duration from birth to the first positive blood culture collection was 17 hours (range, 0.2-63.9). Among the 51 neonates, 32 (63%) patients were born by vaginal delivery. The median Apgar score was 8 (range, 2-9) at 1 minute and 9 (range, 4-10) at 5 minutes. The most common pathogen was group B Streptococcus (n = 21; 41.2%), followed by coagulase-negative staphylococci (n = 7; 13.7%) and Staphylococcus aureus (n = 5, 9.8%). Forty-six (90.2%) neonates were treated with antibiotics on the first day of symptom onset, and 34 (73.9%) neonates received susceptible antibiotics. The overall 14-day case-fatality rate was 11.8%. Conclusion: This is the first multicenter study on the epidemiology of proven EOS in neonates born at ≥35 0/7 weeks' gestation and found that group B Streptococcus was the most common pathogen in Korea.
MeSH term(s)	Infant, Newborn ; Pregnancy ; Female ; Humans ; Infant, Premature ; Retrospective Studies ; Sepsis/microbiology ; Anti-Bacterial Agents/therapeutic use ; Republic of Korea/epidemiology ; Neonatal Sepsis/drug therapy
Chemical Substances	Anti-Bacterial Agents
Language	English
Publishing date	2023-06-15
Publishing country	United States
Document type	Multicenter Study ; Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	392481-6
ISSN	1532-0987 ; 0891-3668
ISSN (online)	1532-0987
ISSN	0891-3668
DOI	10.1097/INF.0000000000003931
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Article: Genome-wide association study and fine-mapping on Korean biobank to discover renal trait-associated variants.

Lee, Dong-Jin / Moon, Jong-Seok / Song, Dae Kwon / Lee, Yong Seok / Kim, Dong-Sub / Cho, Nam-Jun / Gil, Hyo-Wook / Lee, Eun Young / Park, Samel

Kidney research and clinical practice

2023

Abstract: Background: Chronic kidney disease is a significant health burden worldwide, with increasing incidence. Although several genome-wide association studies (GWAS) have investigated single nucleotide polymorphisms (SNP) associated with kidney trait, most ... ...

Abstract	Background: Chronic kidney disease is a significant health burden worldwide, with increasing incidence. Although several genome-wide association studies (GWAS) have investigated single nucleotide polymorphisms (SNP) associated with kidney trait, most studies were focused on European ancestry. Methods: We utilized clinical and genetic information collected from the Korean Genome and Epidemiology Study (KoGES). Results: More than five million SNPs from 58,406 participants were analyzed. After meta-GWAS, 1,360 loci associated with estimated glomerular filtration rate (eGFR) at a genome-wide significant level (p = 5 × 10-8) were identified. Among them, 399 loci were validated with at least one other biomarker (blood urea nitrogen [BUN] or eGFRcysC) and 149 loci were validated using both markers. Among them, 18 SNPs (nine known ones and nine novel ones) with 20 putative genes were found. The aggregated effect of genes estimated by MAGMA gene analysis showed that these significant genes were enriched in kidney-associated pathways, with the kidney and liver being the most enriched tissues. Conclusion: In this study, we conducted GWAS for more than 50,000 Korean individuals and identified several variants associated with kidney traits, including eGFR, BUN, and eGFRcysC. We also investigated functions of relevant genes using computational methods to define putative causal variants.
Language	English
Publishing date	2023-11-03
Publishing country	Korea (South)
Document type	Journal Article
ZDB-ID	2656420-8
ISSN	2211-9132
ISSN	2211-9132
DOI	10.23876/j.krcp.23.079
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Article ; Online: Anti-Atopic Activities of

Woo, Ga-Eun / Hwang, Hye-Ji / Park, A-Yeoung / Sim, Ji-Yoon / Woo, Seon-Young / Kim, Min-Ji / Jeong, So-Mi / Sung, Nak-Yun / Kim, Dong-Sub / Ahn, Dong-Hyun

Journal of microbiology and biotechnology

2023 Volume 33, Issue 3, Page(s) 363–370

Abstract: Atopic dermatitis (AD) is a chronic inflammation associated with skin hypersensitivity caused by environmental factors. The objent of this study was to assess the hot water extracts ... ...

Abstract	Atopic dermatitis (AD) is a chronic inflammation associated with skin hypersensitivity caused by environmental factors. The objent of this study was to assess the hot water extracts of
MeSH term(s)	Animals ; Mice ; Sargassum ; Plant Extracts/pharmacology ; Skin ; Dermatitis, Atopic/chemically induced ; Cytokines ; Water ; Immunoglobulin E ; Mice, Inbred BALB C
Chemical Substances	Plant Extracts ; Cytokines ; Water (059QF0KO0R) ; Immunoglobulin E (37341-29-0)
Language	English
Publishing date	2023-01-13
Publishing country	Korea (South)
Document type	Journal Article
ZDB-ID	2412195-2
ISSN	1738-8872 ; 1738-8872
ISSN (online)	1738-8872
ISSN	1738-8872
DOI	10.4014/jmb.2211.11007
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Article: Rubus fruticosus

Sung, Nak Song / Uhm, Sun Ho / Kang, Hyun Bae / Lee, Nam Seob / Jeong, Young-Gil / Kim, Do Kyung / Sung, Nak-Yun / Kim, Dong-Sub / Yoo, Young Choon / Han, Seung Yun

Anatomy & cell biology

2023 Volume 56, Issue 4, Page(s) 494–507

Abstract: Vascular dementia (VaD) is characterized by progressive memory impairment, which is associated with microglia-mediated neuroinflammation. Polyphenol-rich natural plants, which possess anti-inflammatory activities, have attracted scientific interest ... ...

Abstract	Vascular dementia (VaD) is characterized by progressive memory impairment, which is associated with microglia-mediated neuroinflammation. Polyphenol-rich natural plants, which possess anti-inflammatory activities, have attracted scientific interest worldwide. This study investigated whether
Language	English
Publishing date	2023-09-25
Publishing country	Korea (South)
Document type	Journal Article
ZDB-ID	2590173-4
ISSN	2093-3673 ; 2093-3665
ISSN (online)	2093-3673
ISSN	2093-3665
DOI	10.5115/acb.23.195
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Article ; Online: The Multifaceted Clinical Characteristics of Congenital Cytomegalovirus Infection: From Pregnancy to Long-Term Outcomes.

Kim, Yejin / Kim, Yoo-Min / Kim, Doo Ri / Kim, Han Gyeol / Sung, Ji-Hee / Choi, Suk-Joo / Oh, Soo-Young / Kim, Yae-Jean / Chang, Yun Sil / Kim, Dongsub / Kim, Jung-Sun / Moon, Il Joon / Roh, Cheong-Rae

Journal of Korean medical science

2023 Volume 38, Issue 32, Page(s) e249

Abstract: Background: The aim of this study was to capture multifaceted clinical characteristics of congenital cytomegalovirus (CMV) infection from diagnosis to treatment using a multidisciplinary approach including obstetrics, pediatrics, pathology, and ... ...

Abstract	Background: The aim of this study was to capture multifaceted clinical characteristics of congenital cytomegalovirus (CMV) infection from diagnosis to treatment using a multidisciplinary approach including obstetrics, pediatrics, pathology, and otorhinolaryngology-head and neck surgery. Methods: This is a retrospective study including 30 consecutive cases of congenital CMV infection that were diagnosed at a single tertiary hospital located in Seoul, Korea from January 2009 to December 2020. Congenital CMV infection was defined as a positive result by polymerase chain reaction from urine, saliva or cerebrospinal fluid or positive CMV IgM from neonatal blood sampled within 3 weeks after birth. All cases were analyzed with respect to whole clinical characteristics from diagnosis to treatment of congenital CMV by a multidisciplinary approach including prenatal sonographic findings, maternal immune status regarding CMV infection, detailed placental pathology, neonatal clinical manifestation, auditory brainstem response test, and antiviral treatment (ganciclovir or valganciclovir). Long-term outcomes including developmental delay and hearing loss were also investigated. Results: The total number of births during the study period in our institution was 19,385, with the prevalence of congenital infection estimated to be 0.15%. Among 30 cases of congenital CMV, the median gestational age at delivery was 32.2 weeks [range, 22.6-40.0] and 66.7% of these infants were delivered preterm at less than 37 weeks. Suspected fetal growth restriction was the most common prenatal ultrasound finding (50%) followed by ventriculomegaly (17.9%) and abnormal placenta (17.9%), defined as thick placenta with calcification. No abnormal findings on ultrasound examination were observed in one-third of births. Maternal CMV serology tests were conducted in only 8 cases, and one case each of positive and equivocal IgM were found. The most common placental pathologic findings were chronic villitis (66.7%) and calcification (63.0%), whereas viral inclusions were identified in only 22.2%. The most common neonatal manifestations were jaundice (58.6%) followed by elevation of aspartate aminotransferase (55.2%) and thrombocytopenia (51.7%). After excluding cases for which long-term outcomes were unavailable due to death (n = 4) or subsequent follow up loss (n = 3), developmental delay was confirmed in 43.5% of infants (10/23), and hearing loss was confirmed in 42.9% (9/21) during the follow-up period. In our cohort, 56.7% (17/30) of neonates were treated for congenital CMV with ganciclovir or valganciclovir. Conclusion: Our data show that prenatal findings including maternal serologic tests and ultrasound have limited ability to detect congenital CMV in Korea. Given that CMV is associated with high rates of developmental delay and hearing loss in infants, there is an urgent need to develop specific strategies for the definite diagnosis of congenital CMV infection during the perinatal period by a multidisciplinary approach to decrease the risks of neurologic impairment and hearing loss through early antiviral treatment.
MeSH term(s)	Infant ; Infant, Newborn ; Pregnancy ; Female ; Humans ; Child ; Valganciclovir/therapeutic use ; Retrospective Studies ; Placenta ; Cytomegalovirus Infections/diagnosis ; Cytomegalovirus Infections/drug therapy ; Cytomegalovirus Infections/complications ; Ganciclovir/therapeutic use ; Antiviral Agents/therapeutic use ; Hearing Loss ; Fetal Growth Retardation ; Parturition ; Immunoglobulin M
Chemical Substances	Valganciclovir (GCU97FKN3R) ; Ganciclovir (P9G3CKZ4P5) ; Antiviral Agents ; Immunoglobulin M
Language	English
Publishing date	2023-08-14
Publishing country	Korea (South)
Document type	Journal Article
ZDB-ID	639262-3
ISSN	1598-6357 ; 1011-8934
ISSN (online)	1598-6357
ISSN	1011-8934
DOI	10.3346/jkms.2023.38.e249
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Article ; Online: Antidiabetic Effect of Fermented

Kim, Hye-Lin / Jung, Yunu / Kim, Hyo In / Sung, Nak-Yun / Kim, Min-Jee / Han, In-Jun / Kim, Geon / Nho, Eun Yeong / Park, Sang-Yun / Han, Yohan / Jung, Ji Hoon / Kim, Dong-Sub / Park, Jinbong

Current issues in molecular biology

2023 Volume 45, Issue 8, Page(s) 6415–6431

Abstract: Type 2 diabetes (T2D) is a serious health issue with increasing incidences worldwide. However, current medications have limitations due to side effects such as decreased appetite, stomach pain, diarrhea, and extreme tiredness. Here, we report the effect ... ...

Abstract	Type 2 diabetes (T2D) is a serious health issue with increasing incidences worldwide. However, current medications have limitations due to side effects such as decreased appetite, stomach pain, diarrhea, and extreme tiredness. Here, we report the effect of fermented ice plant (FMC) in the T2M mouse model of
Language	English
Publishing date	2023-08-03
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2000024-8
ISSN	1467-3045 ; 1467-3037
ISSN (online)	1467-3045
ISSN	1467-3037
DOI	10.3390/cimb45080405
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Article ; Online: Neuroprotective Effects of Water Extract from Brown Algae

Eom, Sun Ho / Hong, Geum-Lan / Kang, Hyun Bae / Lee, Nam-Seob / Kim, Do Kyung / Jeong, Young Gil / Kim, Chun-Sung / Yoo, Yung Choon / Lee, Bong Ho / Jung, Ju-Young / Kim, Dong-Sub / Han, Seung Yun

Current issues in molecular biology

2023 Volume 45, Issue 10, Page(s) 8427–8443

Abstract: Focal cerebral ischemia (fCI) can result in brain injury and sensorimotor deficits. Brown algae are currently garnering scientific attention as potential therapeutic candidates for fCI. This study investigated the therapeutic effects of the hot water ... ...

Abstract	Focal cerebral ischemia (fCI) can result in brain injury and sensorimotor deficits. Brown algae are currently garnering scientific attention as potential therapeutic candidates for fCI. This study investigated the therapeutic effects of the hot water extract of
Language	English
Publishing date	2023-10-17
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2000024-8
ISSN	1467-3045 ; 1467-3037
ISSN (online)	1467-3045
ISSN	1467-3037
DOI	10.3390/cimb45100531
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