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  1. Article ; Online: Molecular alterations of appendiceal serrated lesions.

    Choi, Eunice K / Kim, Dowhan / Divatia, Mukul / Takei, Hidehiro

    Human pathology

    2015  Volume 46, Issue 7, Page(s) 1062–1063

    MeSH term(s) Appendiceal Neoplasms/genetics ; Appendix/pathology ; Humans ; Proto-Oncogene Proteins/genetics ; Proto-Oncogene Proteins B-raf/genetics ; ras Proteins/genetics
    Chemical Substances Proto-Oncogene Proteins ; Proto-Oncogene Proteins B-raf (EC 2.7.11.1) ; ras Proteins (EC 3.6.5.2)
    Language English
    Publishing date 2015-07
    Publishing country United States
    Document type Comment ; Letter
    ZDB-ID 207657-3
    ISSN 1532-8392 ; 0046-8177
    ISSN (online) 1532-8392
    ISSN 0046-8177
    DOI 10.1016/j.humpath.2015.02.017
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 722: Show issues Location:
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  2. Article: Strategic use of delegation in almost strictly competitive games

    Kim, Dowhan

    Seoul journal of economics 9 ,1, S. 17-32

    1996  

    Author's details Dowhan Kim
    Keywords Spieltheorie ; Prinzipal-Agent-Theorie ; Theorie
    Language English
    Publisher Univ.
    Publishing place Seoul
    Document type Article
    ZDB-ID 1084412-0
    ISSN 1225-0279
    Database ECONomics Information System

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  3. Article ; Online: Validation of tumor markers in central nervous system germ cell tumors by real-time reverse transcriptase polymerase chain reaction using formalin-fixed paraffin-embedded tissues.

    Kim, Dowhan / Lee, Da Hye / Choi, Junjeong / Shim, Kyu Won / Kim, Se Hoon

    Molecular medicine reports

    2013  Volume 7, Issue 1, Page(s) 337–341

    Abstract: The therapeutic protocols for treatment of germinomas and non-germinomatous germ cell tumors (NGGCTs) are completely different, so it is important to distinguish pure germinomas from NGGCTs. As it can be difficult to diagnose by morphology alone, ... ...

    Abstract The therapeutic protocols for treatment of germinomas and non-germinomatous germ cell tumors (NGGCTs) are completely different, so it is important to distinguish pure germinomas from NGGCTs. As it can be difficult to diagnose by morphology alone, immunohisto-chemistry (IHC) has been widely used as an ancillary test to improve diagnostic accuracy. However, IHC has limitations due to the misinterpretation of results or the aberrant loss of immunoreactivity. However, real-time RT-PCR has certain advantages over IHC, including its quantitative nature. The aim of our study was to evaluate the usefulness of real-time RT-PCR on formalin-fixed paraffin-embedded (FFPE) tissue blocks for the diagnosis of germ cell tumors of the central nervous system. We selected eight markers of germ cell tumors using a literature search, and validated them using real-time RT-PCR. Among them, POU5F1, NANOG and TGFB2 were statistically significant (P=0.05) in multiple comparisons (MANOVA) of three groups (pure germinomas, mature teratomas and malignant germ cell tumors). Two-group (pure germinomas and NGGCTs) discriminant analysis achieved a 70.0% success rate in cross-validation. We concluded that real-time RT-PCR using FFPE tissue has adequate validating power comparable to IHC in the diagnosis of central nervous system germ cell tumors; therefore, when IHC is not available, not conclusive or not informative, RT-PCR is a potential alternative to a repeat biopsy.
    MeSH term(s) Biomarkers, Tumor/genetics ; Biomarkers, Tumor/metabolism ; Central Nervous System Neoplasms/diagnosis ; Central Nervous System Neoplasms/genetics ; Central Nervous System Neoplasms/metabolism ; Humans ; Immunohistochemistry ; Neoplasms, Germ Cell and Embryonal/diagnosis ; Neoplasms, Germ Cell and Embryonal/genetics ; Neoplasms, Germ Cell and Embryonal/metabolism ; Real-Time Polymerase Chain Reaction ; Reproducibility of Results
    Chemical Substances Biomarkers, Tumor
    Language English
    Publishing date 2013-01
    Publishing country Greece
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ISSN 1791-3004
    ISSN (online) 1791-3004
    DOI 10.3892/mmr.2012.1144
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Sinonasal carcinoma associated with inverted papilloma: a report of 16 cases.

    Kim, Kyubo / Kim, Dowhan / Koo, Yongcheol / Kim, Chang-Hoon / Choi, Eun Chang / Lee, Jeung-Gweon / Yoon, Joo-Heon

    Journal of cranio-maxillo-facial surgery : official publication of the European Association for Cranio-Maxillo-Facial Surgery

    2012  Volume 40, Issue 4, Page(s) e125–9

    Abstract: Objectives: To analyse the characteristics and outcome of patients with carcinoma associated with inverted papilloma, and find predictors of associated malignancy.: Methods: The medical records of 228 patients who were diagnosed with IP between ... ...

    Abstract Objectives: To analyse the characteristics and outcome of patients with carcinoma associated with inverted papilloma, and find predictors of associated malignancy.
    Methods: The medical records of 228 patients who were diagnosed with IP between January 1990 and December 2010 were retrospectively reviewed. Out of 228 patients, 16 were also diagnosed with carcinoma. We evaluated their clinical characteristics, treatment modalities, and survival outcomes.
    Results: The incidence of carcinoma associated with IP was 7.0%. Fourteen were synchronous carcinomas and two were metachronous. Tumours arising inside the frontal sinus or the frontoethmoidal recess were more likely to be associated with carcinoma. Patients who had a stage of T2 or less had a much better outcome than those who had a stage of T3 or greater (disease-free period, 84.8 months vs. 5.7 months, p<0.001).
    Conclusion: Tumours originating in the frontal sinus or frontoethmoidal recess have a tendency to be associated with carcinoma. As most (87.5%) of the carcinomas were diagnosed at the same time as the inverted papilloma, complete histological examination of the whole excised tumour is warranted because early diagnosis and treatment is essential as T2 and lower stage carcinomas had a strikingly better prognosis than T3 and higher stage carcinomas.
    MeSH term(s) Adolescent ; Adult ; Aged ; Aged, 80 and over ; Carcinoma/pathology ; Carcinoma, Squamous Cell/pathology ; Carcinoma, Transitional Cell/pathology ; Cause of Death ; Disease-Free Survival ; Ethmoid Sinus/pathology ; Female ; Follow-Up Studies ; Frontal Sinus/pathology ; Humans ; Male ; Maxillary Sinus Neoplasms/pathology ; Middle Aged ; Neoplasm Recurrence, Local/pathology ; Neoplasm Staging ; Neoplasms, Multiple Primary/pathology ; Neoplasms, Second Primary/pathology ; Nose Neoplasms/pathology ; Papilloma, Inverted/pathology ; Paranasal Sinus Neoplasms/pathology ; Prognosis ; Retrospective Studies ; Survival Rate ; Treatment Outcome ; Young Adult
    Language English
    Publishing date 2012-06
    Publishing country Scotland
    Document type Comparative Study ; Journal Article
    ZDB-ID 91267-0
    ISSN 1878-4119 ; 1010-5182 ; 0301-0503
    ISSN (online) 1878-4119
    ISSN 1010-5182 ; 0301-0503
    DOI 10.1016/j.jcms.2011.07.007
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 882: Show issues Location:
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  5. Article ; Online: Added value of subtraction imaging in detecting arterial enhancement in small (<3 cm) hepatic nodules on dynamic contrast-enhanced MRI in patients at high risk of hepatocellular carcinoma.

    An, Chansik / Park, Mi-Suk / Kim, Dowhan / Kim, Yeo-Eun / Chung, Woo-Suk / Rhee, Hyungjin / Kim, Myeong-Jin / Kim, Ki Whang

    European radiology

    2012  Volume 23, Issue 4, Page(s) 924–930

    Abstract: Objectives: To determine the importance of arterial enhancement in diagnosing small (<3 cm) hepatocellular carcinomas (HCCs) and to evaluate the added value of dynamic subtraction magnetic resonance imaging (MRI) in detecting arterial enhancement in ... ...

    Abstract Objectives: To determine the importance of arterial enhancement in diagnosing small (<3 cm) hepatocellular carcinomas (HCCs) and to evaluate the added value of dynamic subtraction magnetic resonance imaging (MRI) in detecting arterial enhancement in small (<3 cm) hepatic nodules in high-risk patients.
    Methods: Eighty-six patients with 135 pathologically confirmed small (<3 cm) hepatic nodules (104 HCCs, 31 benign nodules) underwent MRI before curative surgery. Arterial enhancement was determined by three methods: (1) visual assessment of the arterial phase alone, (2) visual comparison of the arterial phase with the unenhanced phase and (3) additional review of subtraction images. The diagnostic performance of each method was calculated and compared using generalised estimating equations analysis.
    Results: Arterial enhancement demonstrated high positive predictive value (PPV) (96.5-98.9 %) and specificity (90.3-96.8 %), but low negative predictive value (NPV) (54.6-62.5 %) and intermediate sensitivity (76-79.8 %) for diagnosing small HCCs. Diagnostic performance was highest for subtraction imaging. There were significant differences among the three methods in sensitivity (P = 0.04), accuracy (P = 0.044), PPV (P < 0.001) and NPV (P = 0.024), but not in specificity (P = 0.167).
    Conclusion: The accurate detection of arterial enhancement in small hepatic nodules is important for diagnosing HCC and may be enhanced by subtraction imaging.
    MeSH term(s) Adult ; Aged ; Carcinoma, Hepatocellular/pathology ; Contrast Media ; Female ; Gadolinium DTPA ; Hepatic Artery/pathology ; Humans ; Image Enhancement/methods ; Liver Neoplasms/pathology ; Magnetic Resonance Imaging/methods ; Male ; Middle Aged ; Reproducibility of Results ; Sensitivity and Specificity ; Subtraction Technique
    Chemical Substances Contrast Media ; gadolinium ethoxybenzyl DTPA ; Gadolinium DTPA (K2I13DR72L)
    Language English
    Publishing date 2012-11-09
    Publishing country Germany
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1085366-2
    ISSN 1432-1084 ; 0938-7994 ; 1613-3749
    ISSN (online) 1432-1084
    ISSN 0938-7994 ; 1613-3749
    DOI 10.1007/s00330-012-2685-x
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Use of Endoscopic Ultrasound to Evaluate Large Gastric Folds: Features Predictive of Malignancy.

    Lim, Hyun / Lee, Gin Hyug / Na, Hee Kyong / Ahn, Ji Yong / Lee, Jeong Hoon / Choi, Kwi-Sook / Kim, Do Hoon / Choi, Kee Don / Song, Ho June / Jung, Hwoon-Yong / Kim, Jin-Ho / Kim, Dowhan / Park, Young Soo

    Ultrasound in medicine & biology

    2015  Volume 41, Issue 10, Page(s) 2614–2620

    Abstract: The aim of this study was to investigate with endoscopic ultrasound (EUS) the features of the gastric wall that can be used to predict malignant disease in patients with large gastric folds. We retrospectively reviewed the EUS findings of 65 patients (26 ...

    Abstract The aim of this study was to investigate with endoscopic ultrasound (EUS) the features of the gastric wall that can be used to predict malignant disease in patients with large gastric folds. We retrospectively reviewed the EUS findings of 65 patients (26 with benign and 39 with malignant disease) with large gastric folds on endoscopy and EUS and analyzed the predictors of malignant disease (e.g., gastric wall thickness, preservation of five-layered structure, thickened layers). Gastric wall thickness (≥9.8 mm), thickened deep layer, thickened muscularis propria and non-preserved wall layer structures were significantly more prevalent in patients with malignant disease on EUS. Among them, gastric wall thickness (≥9.8 mm) (odds ratio = 6.72, 95% confidence interval = 1.23-36.73, p = 0.028) and thickened muscularis propria (odds ratio = 37.14, 95% confidence interval = 7.02-196.49, p < 0.001) were significantly associated with malignant disease. Our data indicate that EUS is a useful tool for assessing large gastric folds and that gastric wall thickness (≥9.8 mm) and thickened muscularis propria are significant features predictive of malignant disease on EUS.
    MeSH term(s) Adolescent ; Adult ; Aged ; Endosonography/methods ; Female ; Humans ; Image Enhancement/methods ; Image Interpretation, Computer-Assisted/methods ; Male ; Middle Aged ; Observer Variation ; Reproducibility of Results ; Sensitivity and Specificity ; Stomach/diagnostic imaging ; Stomach Neoplasms/diagnostic imaging ; Young Adult
    Language English
    Publishing date 2015
    Publishing country England
    Document type Journal Article
    ZDB-ID 186150-5
    ISSN 1879-291X ; 0301-5629
    ISSN (online) 1879-291X
    ISSN 0301-5629
    DOI 10.1016/j.ultrasmedbio.2015.05.017
    Database MEDical Literature Analysis and Retrieval System OnLINE

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