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Article ; Online: Systematic review of benefits and practical challenges for application of Mohs surgery for oral tumors.

Hussain, Aamir / Kim, Emily Y / Khachemoune, Amor

2023 Volume 315, Issue 9, Page(s) 2479–2484

Abstract: Mohs micrographic surgery (MMS) may be an effective treatment modality for oral cavity cancers (OCC) due to possibility of more effective visualization of tumor margins and greater preservation of benign tissue. The objective of this study is to review ... ...

Abstract	Mohs micrographic surgery (MMS) may be an effective treatment modality for oral cavity cancers (OCC) due to possibility of more effective visualization of tumor margins and greater preservation of benign tissue. The objective of this study is to review the existing literature on the use of MMS for the treatment of OCC and categorize its uses and limitations. A systematic review was performed in accordance with Assessing the Methodological Quality of Systematic Reviews (AMSTAR) guidelines. PubMed, Scopus, and Google Scholar from inception of databases to January 20, 2023 identified all published studies on the use of MMS for OCC. Nine studies met inclusion criteria. Seventy-seven patients were treated with MMS for OCC, 74 of which (96%) were treated for squamous cell carcinoma (SCC). The tongue was the most common site (n = 57). Six out of seven studies showed no recurrence of disease during the follow-up periods, which ranged from 8 to 42 months, and one study reported significantly lower loco-regional recurrence over a 2-years follow-up period (10.5% vs 25.7%). Mohs technique did not cause a statistically significant increase in operating time. Applicability of MMS is limited by operator comfort with surgical technique and pathological interpretation of specimens in the oral cavity. The main limitation was that various studies did not report specific patient characteristics. In conclusion, MMS may be an effective treatment for OCC, especially for squamous cell carcinomas, and tumors involving the tongue.
MeSH term(s)	Humans ; Carcinoma, Squamous Cell/surgery ; Carcinoma, Squamous Cell/pathology ; Mohs Surgery ; Mouth Neoplasms/surgery ; Neoplasm Recurrence, Local/pathology ; Retrospective Studies ; Skin Neoplasms/pathology ; Systematic Reviews as Topic
Language	English
Publishing date	2023-05-12
Publishing country	Germany
Document type	Journal Article ; Review ; Systematic Review
ZDB-ID	130131-7
ISSN	1432-069X ; 0340-3696
ISSN (online)	1432-069X
ISSN	0340-3696
DOI	10.1007/s00403-023-02632-3
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Article ; Online: Research Note: Impact of Eimeria on apparent retention of components and metabolizable energy in broiler chickens fed single or mixture of feed ingredients-based diets.

Kim, Emily / Lambert, William / Kiarie, Elijah G

Poultry science

2023 Volume 102, Issue 4, Page(s) 102526

Abstract: The effect of Eimeria on apparent retention (AR) of components and metabolizable energy corrected for nitrogen (AMEn) content in corn, wheat, soybean meal (SBM), and pork meal (PM) was investigated in broiler chickens. A total of 840 male d-old Ross 708 ... ...

Abstract	The effect of Eimeria on apparent retention (AR) of components and metabolizable energy corrected for nitrogen (AMEn) content in corn, wheat, soybean meal (SBM), and pork meal (PM) was investigated in broiler chickens. A total of 840 male d-old Ross 708 chicks were placed in 84 cages (10 birds/cage) and allocated either a nitrogen-free diet (NFD), or 1 of 6 test cornstarch-based semipurified diets: 1) corn, 2) wheat, 3) SBM, 4) PM, 5) corn, SBM, and PM (CSP) mixture, and 6) wheat, SBM, and PM (WSP) mixture (n = 12). Diets contained 0.3% titanium dioxide and nutrient digestibility was determined by difference method using NFD. On d 10, birds in half of replicates per diet were orally challenge with 1 mL of E. acervulina and E. maxima culture and the other half equal volume of saline. Excreta samples were collected from d 12 to 14. With exception of AR of Ca and P, there was no interaction (P > 0.05) between Eimeria and diet on AR of dry matter, crude fat (CF), crude protein and gross energy and AMEn of ingredients. Eimeria reduced AR of CF (P = 0.01) and had a tendency to reduce AR of DM (P = 0.09) and AMEn (P = 0.063) of ingredients. The data demonstrated exposure to Eimeria impacted nutrient retention and energy utilization irrespective to diet composition.
MeSH term(s)	Animals ; Male ; Chickens/metabolism ; Eimeria ; Animal Feed/analysis ; Animal Nutritional Physiological Phenomena ; Diet/veterinary ; Zea mays ; Glycine max ; Digestion ; Energy Metabolism
Chemical Substances	N-formyl-13-dihydrocarminomycin (76634-96-3)
Language	English
Publishing date	2023-01-26
Publishing country	England
Document type	Journal Article
ZDB-ID	242586-5
ISSN	1525-3171 ; 0032-5791
ISSN (online)	1525-3171
ISSN	0032-5791
DOI	10.1016/j.psj.2023.102526
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Article ; Online: Everolimus-induced Symmetrical Drug-related Intertriginous and Flexural Exanthema.

Kim, Emily Y / Awh, Katherine C / Larocca, Cecilia A

Acta dermato-venereologica

2023 Volume 103, Page(s) adv12197

MeSH term(s)	Humans ; Everolimus/adverse effects ; Drug Eruptions/diagnosis ; Drug Eruptions/etiology ; Exanthema/chemically induced ; Exanthema/diagnosis
Chemical Substances	Everolimus (9HW64Q8G6G)
Language	English
Publishing date	2023-12-19
Publishing country	Sweden
Document type	Journal Article
ZDB-ID	80007-7
ISSN	1651-2057 ; 0001-5555
ISSN (online)	1651-2057
ISSN	0001-5555
DOI	10.2340/actadv.v103.12197
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Article ; Online: Research Note: Impact of Eimeria on apparent retention of components and metabolizable energy in broiler chickens fed single or mixture of feed ingredients-based diets

Kim, Emily / Lambert, William / Kiarie, Elijah G.

Poultry Science 2023 Apr., v. 102, no. 4, p. 102526

2023 , Page(s) 102526

Abstract: The effect of Eimeria on apparent retention (AR) of components and metabolizable energy corrected for nitrogen (AMEn) content in corn, wheat, soybean meal (SBM) and pork meal (PM) was investigated in broiler chickens. A total of 840 male d-old Ross 708 ... ...

Abstract	The effect of Eimeria on apparent retention (AR) of components and metabolizable energy corrected for nitrogen (AMEn) content in corn, wheat, soybean meal (SBM) and pork meal (PM) was investigated in broiler chickens. A total of 840 male d-old Ross 708 chicks were placed in 84 cages (10 birds/cage) and allocated either a nitrogen-free diet (NFD), or one of six test cornstarch based semi-purified diets: 1) corn, 2) wheat, 3) SBM, 4) PM, 5) corn, SBM, and PM (CSP) mixture, and 6) wheat, SBM, and PM (WSP) mixture (n=12). Diets contained 0.3% titanium dioxide and nutrient digestibility was determined by difference method using NFD. On d 10, birds in half of replicates per diet were orally challenge with 1 mL of E. acervulina and E. maxima culture and the other half equal volume of saline. Excreta samples were collected from d 12 to 14. With exception of AR of Ca and P, there was no interaction (P>0.05) between Eimeria and diet on AR of dry matter, crude fat (CF), crude protein and gross energy and AMEn of ingredients. Eimeria reduced AR of CF (P=0.01) and had a tendency to reduce AR of DM (P=0.09) and AMEn (P=0.063) of ingredients. The data demonstrated exposure to Eimeria impacted nutrient retention and energy utilization irrespective to diet composition.
Keywords	Eimeria ; cages ; corn ; corn starch ; crude fat ; crude protein ; diet ; digestibility ; energy ; excreta ; males ; metabolizable energy ; nitrogen ; nutrient retention ; pork ; poultry science ; soybean meal ; titanium dioxide ; wheat ; broiler chickens ; digestibility, Eimeria
Language	English
Dates of publication	2023-0126
Size	p. 102526
Publishing place	Poultry Science Association, etc.
Document type	Article ; Online
Note	Pre-press version ; Resource is Open Access ; Consyn License Information ; Use and reproduction
ZDB-ID	242586-5
ISSN	1525-3171 ; 0032-5791
ISSN (online)	1525-3171
ISSN	0032-5791
DOI	10.1016/j.psj.2023.102526
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Article ; Online: The impact of household pets on children's daily lives: Differences in parent-child conversations and implications for children's emotional development.

Reider, Lori B / Kim, Emily / Mahaffey, Elise / LoBue, Vanessa

Developmental psychology

2023 Volume 59, Issue 11, Page(s) 2148–2161

Abstract: Living with a pet is related to a host of socioemotional health benefits for children, yet few studies have examined the mechanisms that drive the relations between pet ownership and positive socioemotional outcomes. The current study examined one of the ...

Abstract	Living with a pet is related to a host of socioemotional health benefits for children, yet few studies have examined the mechanisms that drive the relations between pet ownership and positive socioemotional outcomes. The current study examined one of the ways that pets may change the environment through which children learn and whether childhood pet ownership might promote empathy and prosocial behavior through parent-child conversations about emotions and mental states in the presence of a pet dog. Participants included 123 parent (118 mothers, four fathers) and child (65 female, 58 male,
MeSH term(s)	Humans ; Male ; Female ; United States ; Animals ; Dogs ; Child ; Child, Preschool ; Emotions ; Mothers/psychology ; Empathy ; Parents/psychology ; Parent-Child Relations
Language	English
Publishing date	2023-10-12
Publishing country	United States
Document type	Journal Article
ZDB-ID	2066223-3
ISSN	1939-0599 ; 0012-1649
ISSN (online)	1939-0599
ISSN	0012-1649
DOI	10.1037/dev0001595
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Article ; Online: Evidence-based management of cutaneous scarring in dermatology part 2: atrophic acne scarring.

Kim, Emily Y / Wong, Jasmine H / Hussain, Aamir / Khachemoune, Amor

Archives of dermatological research

2023 Volume 316, Issue 1, Page(s) 19

Abstract: Atrophic acne scars are the most common type of acne scars and are classified into three main types: icepick, boxcar, and rolling scars. Various procedures and techniques for atrophic acne scarring are discussed in detail, with stronger evidence-based ... ...

Abstract	Atrophic acne scars are the most common type of acne scars and are classified into three main types: icepick, boxcar, and rolling scars. Various procedures and techniques for atrophic acne scarring are discussed in detail, with stronger evidence-based support for lasers (non-fractional, fractional, ablative, and non-ablative), platelet-rich plasma as adjunctive treatment, chemical peels (glycolic acid, trichloroacetic acid, and Jessner's solution), dermal fillers such as hyaluronic acid, and microneedling, and lesser quality evidence for microdermabrasion, subcision, and lipoaspirate grafting. Further research is needed to optimize treatment protocols, assess the efficacy of monotherapies, and establish standardized guidelines for clinicians. This paper will provide a comprehensive review of the evidence-based management of atrophic acne scars, including currently commonly utilized therapies as well as more innovative treatment options.
MeSH term(s)	Humans ; Cicatrix/etiology ; Cicatrix/therapy ; Cicatrix/pathology ; Dermatology ; Acne Vulgaris/complications ; Acne Vulgaris/therapy ; Chemexfoliation/methods ; Combined Modality Therapy ; Atrophy/therapy ; Treatment Outcome
Language	English
Publishing date	2023-12-07
Publishing country	Germany
Document type	Journal Article ; Review
ZDB-ID	130131-7
ISSN	1432-069X ; 0340-3696
ISSN (online)	1432-069X
ISSN	0340-3696
DOI	10.1007/s00403-023-02737-9
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Article ; Online: Evidence-based management of keloids and hypertrophic scars in dermatology.

Kim, Emily Y / Hussain, Aamir / Khachemoune, Amor

Archives of dermatological research

2022 Volume 315, Issue 6, Page(s) 1487–1495

Abstract: While normal, controlled wound-healing results in scars that are nearly imperceptible, hypertrophic scars (HTS) and keloids are the result of an abnormal wound-healing process that can leave unsightly, difficult-to-treat lesions. While such scars are ... ...

Abstract	While normal, controlled wound-healing results in scars that are nearly imperceptible, hypertrophic scars (HTS) and keloids are the result of an abnormal wound-healing process that can leave unsightly, difficult-to-treat lesions. While such scars are classically associated with surgical incisions, they may also result from burns or accidental trauma to the skin. Several different measures can be taken to prevent the formation of scars or treat those that have already formed. Prevention focuses on reducing inflammation during the wound-healing process, and minimizing tension in the lesion when appropriate. Treatments range from non-invasive modalities such as pressure therapy, topicals, and symptom management, to invasive methods such as injections, lasers, and even surgery. While some treatments, such as corticosteroid injections, have been used in the treatment of HTS and keloids for decades, other newer therapies have only been described in case reports or are still in early phases of clinical trials. Because optimal scar management will not be the same for every patient, further investigation of newer agents and methods is warranted and may benefit a great number of patients. This paper will review the evidence-based management of scars, including current widely used treatment options and promising newly emerging therapies.
MeSH term(s)	Humans ; Keloid/pathology ; Cicatrix, Hypertrophic/pathology ; Dermatology ; Skin/pathology ; Wound Healing
Language	English
Publishing date	2022-12-11
Publishing country	Germany
Document type	Journal Article ; Review
ZDB-ID	130131-7
ISSN	1432-069X ; 0340-3696
ISSN (online)	1432-069X
ISSN	0340-3696
DOI	10.1007/s00403-022-02509-x
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Article: Phylotranscriptomics Illuminates the Placement of Whole Genome Duplications and Gene Retention in Ferns.

Pelosi, Jessie A / Kim, Emily H / Barbazuk, W Brad / Sessa, Emily B

Frontiers in plant science

2022 Volume 13, Page(s) 882441

Abstract: Ferns are the second largest clade of vascular plants with over 10,000 species, yet the generation of genomic resources for the group has lagged behind other major clades of plants. Transcriptomic data have proven to be a powerful tool to assess ... ...

Abstract	Ferns are the second largest clade of vascular plants with over 10,000 species, yet the generation of genomic resources for the group has lagged behind other major clades of plants. Transcriptomic data have proven to be a powerful tool to assess phylogenetic relationships, using thousands of markers that are largely conserved across the genome, and without the need to sequence entire genomes. We assembled the largest nuclear phylogenetic dataset for ferns to date, including 2884 single-copy nuclear loci from 247 transcriptomes (242 ferns, five outgroups), and investigated phylogenetic relationships across the fern tree, the placement of whole genome duplications (WGDs), and gene retention patterns following WGDs. We generated a well-supported phylogeny of ferns and identified several regions of the fern phylogeny that demonstrate high levels of gene tree-species tree conflict, which largely correspond to areas of the phylogeny that have been difficult to resolve. Using a combination of approaches, we identified 27 WGDs across the phylogeny, including 18 large-scale events (involving more than one sampled taxon) and nine small-scale events (involving only one sampled taxon). Most inferred WGDs occur within single lineages (e.g., orders, families) rather than on the backbone of the phylogeny, although two inferred events are shared by leptosporangiate ferns (excluding Osmundales) and Polypodiales (excluding Lindsaeineae and Saccolomatineae), clades which correspond to the majority of fern diversity. We further examined how retained duplicates following WGDs compared across independent events and found that functions of retained genes were largely convergent, with processes involved in binding, responses to stimuli, and certain organelles over-represented in paralogs while processes involved in transport, organelles derived from endosymbiotic events, and signaling were under-represented. To date, our study is the most comprehensive investigation of the nuclear fern phylogeny, though several avenues for future research remain unexplored.
Language	English
Publishing date	2022-07-14
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2613694-6
ISSN	1664-462X
ISSN	1664-462X
DOI	10.3389/fpls.2022.882441
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Article ; Online: Standardized ileal digestibility of amino acids in broiler chickens fed single or mixture of feed ingredients-based diets with or without Eimeria challenge.

Kim, Emily / Barta, John R / Lambert, William / Kiarie, Elijah G

Poultry science

2022 Volume 101, Issue 6, Page(s) 101839

Abstract: The effect of Eimeria challenge on standardized ileal digestibility (SID) of amino acids (AA) in major poultry feed ingredients fed to broiler chickens was determined. A total of 840 male 9-day-old Ross 708 chicks were placed in 84 cages (10 birds/cage) ... ...

Abstract	The effect of Eimeria challenge on standardized ileal digestibility (SID) of amino acids (AA) in major poultry feed ingredients fed to broiler chickens was determined. A total of 840 male 9-day-old Ross 708 chicks were placed in 84 cages (10 birds/cage) and allocated to either a nitrogen-free diet (NFD) or one of the 6 test diets based on a single or mixture of feed ingredients as the sole source of AA (n = 12). Test diets were: 1) corn, 2) wheat, 3) soybean meal (SBM), 4) pork meal (PM), 5) corn, SBM, and PM (CSP), and 6) wheat, SBM, and PM (WSP). On d 10, birds in 6 cages/diet were orally gavaged with 1 mL of E. acervulina and E. maxima mixture and the other 6 cages with sham. On d 15, birds were bled for plasma AA and necropsied for intestinal lesion scores and ileal digesta samples. Challenge decreased (P < 0.05) plasma concentration of Arg, His, Thr, Asp, Gln, and Tyr and increased concentration of Lys, Ile, Leu, and Val. There was a diet by challenge interaction (P < 0.05) on intestinal lesion scores with birds fed mixed diets exhibiting more severe lesions than birds fed single ingredient diets. Diet by challenge interacted (P < 0.05) on ileal total endogenous flow (ITEF) of AA except for Arg, Met, Ala, Asp, and Cys, such that challenged birds fed the mixed, particularly WSP, had higher ITEF of AA compared to single ingredients birds. Diet and challenge interaction (P < 0.05) was observed for SID of Arg, Thr, Val, Glu, and Gly. Challenge decreased (P < 0.05) SID of most AA except for Met, Asp, and Cys with the largest impact seen on Lys, His, Ser, and Thr. With exception of Arg, Thr, Asp, and Cys, birds fed mixed diets had higher (P < 0.05) SID values compared to birds fed single ingredients. In conclusion, Eimeria reduced plasma availability and ileal digestibility of most AA. However, challenge interaction with diet composition on SID of some AA warrants further investigations.
MeSH term(s)	Animals ; Male ; Amino Acids/metabolism ; Animal Feed/analysis ; Animal Nutritional Physiological Phenomena ; Chickens/metabolism ; Diet/veterinary ; Digestion ; Eimeria ; Ileum/metabolism ; Glycine max/chemistry
Chemical Substances	Amino Acids
Language	English
Publishing date	2022-03-10
Publishing country	England
Document type	Journal Article
ZDB-ID	242586-5
ISSN	1525-3171 ; 0032-5791
ISSN (online)	1525-3171
ISSN	0032-5791
DOI	10.1016/j.psj.2022.101839
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Article ; Online: Lymphatic Abnormalities on Magnetic Resonance Imaging in Single-Ventricle Congenital Heart Defects Before Glenn Operation.

Kristensen, Rasmus / Kelly, Benjamin / Kim, Emily / Dori, Yoav / Hjortdal, Vibeke E

Journal of the American Heart Association

2023 Volume 12, Issue 12, Page(s) e029376

Abstract: Background In the palliative pathway of single-ventricle physiology, lymphatic abnormalities on T2-weighted magnetic resonance imaging have been shown after the Glenn operation. It is believed that postsurgical hemodynamic changes contribute to the ... ...

Abstract	Background In the palliative pathway of single-ventricle physiology, lymphatic abnormalities on T2-weighted magnetic resonance imaging have been shown after the Glenn operation. It is believed that postsurgical hemodynamic changes contribute to the lymphatic changes.However, little is known about how early these abnormalities occur. Our purpose was to determine if lymphatic abnormalities occur as early as before the Glenn operation. Methods and Results We retrospectively reviewed patients with single-ventricle physiology and a T2-weighted magnetic resonance imaging scan before their Glenn operation (superior cavopulmonary connection) at The Children's Hospital of Philadelphia from 2012 to 2022. Lymphatic perfusion patterns on T2-magnetic resonance imaging were categorized from type 1 (no supraclavicular T2-signal) to type 4 (supraclavicular, mediastinal, lung parenchymal T2-signal). Types 1 and 2 were considered normal variants. Distribution of lymphatic abnormalities were tabulated, as well as secondary outcomes including chylothorax and mortality. Comparison was done using analysis of variance, Kruskal-Wallis test, and Fisher's exact test. Seventy-one children were included: 30 with hypoplastic left heart syndrome and 41 with nonhypoplastic left heart syndrome. Lymphatic abnormalities were present before Glenn operation in 21% (type 3) and 20% (type 4), and normal lymphatic perfusion patterns (type 1-2) were seen in 59% of patients. Chylothorax was present in 17% (only types 3 and 4). Pre-Glenn mortality and mortality at any time was significantly increased when having a type 4 lymphatic abnormality compared with types 1 and 2 (
MeSH term(s)	Child ; Humans ; Infant ; Retrospective Studies ; Chylothorax ; Treatment Outcome ; Heart Defects, Congenital/diagnostic imaging ; Heart Defects, Congenital/surgery ; Fontan Procedure ; Univentricular Heart ; Lymphatic Abnormalities/diagnostic imaging ; Lymphatic Abnormalities/surgery ; Magnetic Resonance Imaging ; Heart Ventricles/diagnostic imaging ; Heart Ventricles/surgery ; Heart Ventricles/abnormalities
Language	English
Publishing date	2023-06-15
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2653953-6
ISSN	2047-9980 ; 2047-9980
ISSN (online)	2047-9980
ISSN	2047-9980
DOI	10.1161/JAHA.123.029376
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