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  1. Article ; Online: Potential Effects of Global Warming on Heart Failure Decompensation.

    Smith, Alexander T / Kim, Eun Ji

    Journal of general internal medicine

    2023  Volume 38, Issue 10, Page(s) 2234–2235

    MeSH term(s) Humans ; Global Warming ; Heart Failure/epidemiology ; Heart Failure/therapy
    Language English
    Publishing date 2023-05-03
    Publishing country United States
    Document type Editorial ; Comment
    ZDB-ID 639008-0
    ISSN 1525-1497 ; 0884-8734
    ISSN (online) 1525-1497
    ISSN 0884-8734
    DOI 10.1007/s11606-023-08211-6
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2205: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  2. Article ; Online: Health Disparities in People with Criminal Legal Involvement: a Call for Prison Health Reform.

    Hon, John / Conigliaro, Joseph / Kim, Eun Ji

    Journal of general internal medicine

    2024  Volume 39, Issue 1, Page(s) 3–4

    MeSH term(s) Humans ; Prisons ; Criminals ; Health Care Reform ; Prisoners ; Health Inequities
    Language English
    Publishing date 2024-02-20
    Publishing country United States
    Document type Editorial
    ZDB-ID 639008-0
    ISSN 1525-1497 ; 0884-8734
    ISSN (online) 1525-1497
    ISSN 0884-8734
    DOI 10.1007/s11606-023-08448-1
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2205: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  3. Article: Global citizenship education through curriculum-as-relations.

    Kim, Eun-Ji Amy

    Prospects

    2021  Volume 51, Issue 1-3, Page(s) 129–141

    Abstract: The Covid-19 pandemic was a reminder of the importance of increasing connectivity amidst the accelerated rate of changes and disruptive events of our era. The need and the rationale for global citizenship education (GCED) were ever more emphasized by ... ...

    Abstract The Covid-19 pandemic was a reminder of the importance of increasing connectivity amidst the accelerated rate of changes and disruptive events of our era. The need and the rationale for global citizenship education (GCED) were ever more emphasized by many educational organizations, including UNESCO. This article reviews the GCED discourses conceptualizing global competence as instrumental action and a binary view of global-local relations. In turn, the article proposes the idea of curriculum-as-relations for GCED. Curriculum-as-relations conceptualizes competence as situated praxis and focuses on providing
    Language English
    Publishing date 2021-05-15
    Publishing country France
    Document type Journal Article
    ZDB-ID 2088432-1
    ISSN 1573-9090 ; 0033-1538
    ISSN (online) 1573-9090
    ISSN 0033-1538
    DOI 10.1007/s11125-021-09554-w
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  4. Article ; Online: Investigating raised creatine kinase.

    Kim, Eun Ji / Wierzbicki, Anthony S

    BMJ (Clinical research ed.)

    2021  Volume 373, Page(s) n1486

    MeSH term(s) Aged ; Biomarkers/blood ; Creatine Kinase/blood ; Humans ; Hydroxymethylglutaryl-CoA Reductase Inhibitors/adverse effects ; Hydroxymethylglutaryl-CoA Reductase Inhibitors/pharmacology ; Hypercholesterolemia/complications ; Male ; Muscle Weakness/blood ; Muscle Weakness/chemically induced ; Myalgia/blood
    Chemical Substances Biomarkers ; Hydroxymethylglutaryl-CoA Reductase Inhibitors ; Creatine Kinase (EC 2.7.3.2)
    Language English
    Publishing date 2021-06-23
    Publishing country England
    Document type Case Reports ; Journal Article ; Review
    ZDB-ID 1362901-3
    ISSN 1756-1833 ; 0959-8154 ; 0959-8146 ; 0959-8138 ; 0959-535X ; 1759-2151
    ISSN (online) 1756-1833
    ISSN 0959-8154 ; 0959-8146 ; 0959-8138 ; 0959-535X ; 1759-2151
    DOI 10.1136/bmj.n1486
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    In stock of ZB MED Cologne/Königswinter

    Ua VI Zs.10: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  5. Article: Comparison of the Prognosis of Upper-Third Gastric Cancer With That of Middle and Lower-Third Gastric Cancer.

    Park, Ji Yeon / Kim, Eun Ji / Yang, Jae Yeong / Park, Ki Bum / Kwon, Oh Kyoung

    Journal of gastric cancer

    2024  Volume 24, Issue 2, Page(s) 159–171

    Abstract: Purpose: Gastric cancer is one of the most common cancers in Korea, and the proportion of upper-third gastric cancers has been steadily increasing over the last two decades. This study aimed to evaluate the effect of tumor location on gastric cancer ... ...

    Abstract Purpose: Gastric cancer is one of the most common cancers in Korea, and the proportion of upper-third gastric cancers has been steadily increasing over the last two decades. This study aimed to evaluate the effect of tumor location on gastric cancer prognosis.
    Materials and methods: We retrospectively reviewed 2,466 patients who underwent gastrectomy for pathologically proven gastric cancer between January 2011 and December 2016. The patients were divided into an upper-third group (U group; n=419, 17.0%) and a middle- and lower-third group (ML group; n=2,047, 83.0%). Clinicopathological characteristics, overall survival (OS), and recurrence-free survival (RFS) after surgery were compared.
    Results: The U group had more advanced disease than the ML group and a higher incidence of N3b disease for T3 (12.0% vs. 4.9%, p=0.023) and T4 tumors (33.3% vs. 17.5%, p=0.001). The 5-year RFS rate for stage III disease was marginally lower in the U group than that in the ML group (47.1% vs. 56.7%, p=0.082). The upper third location was an independent prognostic factor for both OS (hazard ratio [HR], 1.350; 95% confidence interval [CI], 1.065-1.711) and RFS (HR, 1.430; 95% CI, 1.080-1.823).
    Conclusions: Upper-third gastric cancer shows extensive node metastasis compared to those located more distally in ≥T3 tumors. The upper third location is an independent prognostic factor for both OS and RFS and may have an adverse impact on RFS, particularly in patients with stage III gastric cancer.
    Language English
    Publishing date 2024-04-04
    Publishing country Korea (South)
    Document type Journal Article
    ZDB-ID 2637180-7
    ISSN 2093-5641 ; 2093-582X
    ISSN (online) 2093-5641
    ISSN 2093-582X
    DOI 10.5230/jgc.2024.24.e3
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  6. Article ; Online: Evaluating the Anti-Osteoarthritis Potential of Standardized

    Choi, Yean-Jung / Jung, Jae In / Bae, Jaewoo / Lee, Jae Kyoung / Kim, Eun Ji

    International journal of molecular sciences

    2024  Volume 25, Issue 6

    Abstract: Osteoarthritis is a widespread chronic degenerative disease marked by the deterioration of articular cartilage, modifications in subchondral bone, and a spectrum of symptoms, including pain, stiffness, and disability. Ultimately, this condition impairs ... ...

    Abstract Osteoarthritis is a widespread chronic degenerative disease marked by the deterioration of articular cartilage, modifications in subchondral bone, and a spectrum of symptoms, including pain, stiffness, and disability. Ultimately, this condition impairs the patient's quality of life. This study aimed to evaluate the therapeutic efficacy of standardized
    MeSH term(s) Rats ; Humans ; Animals ; Boswellia/metabolism ; Aggrecans/metabolism ; Quality of Life ; Disease Models, Animal ; Osteoarthritis/metabolism ; Inflammation/metabolism ; Knee Joint/pathology ; Iodoacetic Acid/adverse effects ; Tumor Necrosis Factor-alpha/metabolism ; Interleukin-6/metabolism ; RNA, Messenger/metabolism ; Cartilage, Articular/metabolism
    Chemical Substances Aggrecans ; Iodoacetic Acid (WF5188V710) ; Tumor Necrosis Factor-alpha ; Interleukin-6 ; RNA, Messenger
    Language English
    Publishing date 2024-03-12
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms25063218
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  7. Article ; Online: Shaping brassinosteroid signaling through scaffold proteins.

    Guo, Boyu / Kim, Eun-Ji / Zhu, Yuxian / Wang, Kun / Russinova, Eugenia

    Plant & cell physiology

    2024  

    Abstract: Cellular responses to internal and external stimuli are orchestrated by intricate intracellular signaling pathways. To ensure an efficient and specific information flow, cells employ scaffold proteins as critical signaling organizers. With the ability to ...

    Abstract Cellular responses to internal and external stimuli are orchestrated by intricate intracellular signaling pathways. To ensure an efficient and specific information flow, cells employ scaffold proteins as critical signaling organizers. With the ability to bind multiple signaling molecules, scaffold proteins can sequester signaling components within specific subcellular domains or modulate the efficiency of signal transduction. Scaffolds can also tune the output of signaling pathways by serving as regulatory targets. This review focuses on scaffold proteins associated with the plant GLYCOGEN SYNTHASE KINASE3-like kinase, BRASSINOSTEROID-INSENSITIVE2 (BIN2) that serve as a key negative regulator of brassinosteroid (BR) signaling. Here we summarize the current understanding of how scaffold proteins actively shape BR signaling outputs and crosstalk in plant cells via interactions with BIN2.
    Language English
    Publishing date 2024-04-08
    Publishing country Japan
    Document type Journal Article
    ZDB-ID 208907-5
    ISSN 1471-9053 ; 0032-0781
    ISSN (online) 1471-9053
    ISSN 0032-0781
    DOI 10.1093/pcp/pcae040
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    In stock of ZB MED Bonn / Germany

    Z 79/710: Show issues

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  8. Article: Peanut sprout tea extract inhibits lung metastasis of 4T1 murine mammary carcinoma cells by suppressing the crosstalk between cancer cells and macrophages in BALB/c mice.

    Jung, Jae In / Lee, Hyun Sook / Lee, Jaehak / Kim, Eun Ji

    Nutrition research and practice

    2023  Volume 17, Issue 5, Page(s) 917–933

    Abstract: Background/objectives: As peanuts germinate, the content of the components beneficial to health, such as resveratrol, increases within the peanut sprout. This study examined whether the ethanol extract of peanut sprout tea (PSTE) inhibits breast cancer ... ...

    Abstract Background/objectives: As peanuts germinate, the content of the components beneficial to health, such as resveratrol, increases within the peanut sprout. This study examined whether the ethanol extract of peanut sprout tea (PSTE) inhibits breast cancer growth and metastasis.
    Materials/methods: After orthotopically injecting 4T1 cells into BALB/c mice to induce breast cancer, 0, 30, or 60 mg/kg body weight/day of PSTE was administered orally. Angiogenesis-related protein expression in the tumors and the degree of metastasis were analyzed. 4T1 and RAW 264.7 cells were co-cultured, and reverse transcription polymerase chain reaction was performed to measure the crosstalk between breast cancer cells and macrophages.
    Results: PSTE reduced tumor growth and lung metastasis. In particular, PSTE decreased matrix metalloproteinase-9, platelet endothelial cell adhesion molecule-1, vascular endothelial growth factor-A, F4/80, CD11c, macrophage mannose receptor, macrophage colony-stimulating factor, and monocyte chemoattractant protein 1 expression in the tumors. Moreover, PSTE prevented 4T1 cell migration, invasion, and macrophage activity in RAW 264.7 cells. PSTE inhibited the crosstalk between 4T1 cells and RAW 264.7 cells and promoted the macrophage M1 subtype while inhibiting the M2 subtype.
    Conclusions: These results suggest that PSTE blocks breast cancer growth and metastasis to the lungs. This may be because the PSTE treatment inhibits the crosstalk between mammary cancer cells and macrophages and inhibits the differentiation of macrophages into the M2 subtype.
    Language English
    Publishing date 2023-06-23
    Publishing country Korea (South)
    Document type Journal Article
    ZDB-ID 2387946-4
    ISSN 2005-6168 ; 1976-1457
    ISSN (online) 2005-6168
    ISSN 1976-1457
    DOI 10.4162/nrp.2023.17.5.917
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    In stock of ZB MED Bonn / Germany

    Z 7762: Show issues

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  9. Article ; Online: A fluorescent molecular rotor for the

    Choi, Na-Eun / Kim, Eun-Ji / Lee, Jiyoun

    RSC advances

    2022  Volume 12, Issue 51, Page(s) 33180–33186

    Abstract: Efficient techniques for developing latent fingerprints are invaluable resources to solve crimes. In this work, we developed a fluorescent molecular rotor probe that responds to hydrophobic and viscous environments and visualizes latent fingerprints with ...

    Abstract Efficient techniques for developing latent fingerprints are invaluable resources to solve crimes. In this work, we developed a fluorescent molecular rotor probe that responds to hydrophobic and viscous environments and visualizes latent fingerprints with level 3 details. We believe that the simple and convenient features of LFP-1 will benefit forensic practice.
    Language English
    Publishing date 2022-11-22
    Publishing country England
    Document type Journal Article
    ISSN 2046-2069
    ISSN (online) 2046-2069
    DOI 10.1039/d2ra06728e
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  10. Article: The history of proprotein convertase subtilisin kexin-9 inhibitors and their role in the treatment of cardiovascular disease.

    Kim, Eun Ji / Wierzbicki, Anthony S

    Therapeutic advances in chronic disease

    2020  Volume 11, Page(s) 2040622320924569

    Abstract: A consensus has formed based on epidemiological studies and clinical trials that intervention to reduce low density lipoprotein cholesterol (LDL-C) will reduce cardiovascular disease (CVD) events. This has progressively reduced the thresholds for ... ...

    Abstract A consensus has formed based on epidemiological studies and clinical trials that intervention to reduce low density lipoprotein cholesterol (LDL-C) will reduce cardiovascular disease (CVD) events. This has progressively reduced the thresholds for intervention and targets for treatment. Whist statins are sufficient for many people in primary prevention, they only partially achieve the newer targets of secondary prevention for established CVD. Increasing use of statins has highlighted that 1-2% cannot tolerate these drugs. Other cholesterol-lowering drugs such as ezetimibe add to the benefits of statins but have limited efficacy. The discovery of activating mutations in proprotein convertase subtilisin kexin-9 (PCSK9) as a cause of familial hypercholesterolaemia while inactivating mutations lower LDL-C led to the idea to develop PCSK9 inhibitors as drugs. This article reviews the history of lipid-lowering therapies, the discovery of PCSK9 and the development of PCSK9 inhibitors. It reviews the key trials of the current antibody-based drugs and how these have influenced new guidelines. It also reviews the controversy caused by their cost and the increasing application of health economics to determine the optimum strategy for implementation of novel therapeutic pathways and surveys other options for targeting PCSK9 as well as other LDL-C lowering compounds in late development.
    Language English
    Publishing date 2020-05-30
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 2554816-5
    ISSN 2040-6231 ; 2040-6223
    ISSN (online) 2040-6231
    ISSN 2040-6223
    DOI 10.1177/2040622320924569
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