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  1. Article: The Potential Predictors in Chemotherapy Sensitivity.

    Kim, Eun-Kyu / Shin, Hee-Chul

    Advances in experimental medicine and biology

    2021  Volume 1187, Page(s) 381–389

    Abstract: Monitoring of patient and tumor during chemotherapy is important to determine whether the chemotherapy is effective to the patient. Variants affect drug enzyme activities and altered enzyme activities can be potential predictors for chemotherapeutic ... ...

    Abstract Monitoring of patient and tumor during chemotherapy is important to determine whether the chemotherapy is effective to the patient. Variants affect drug enzyme activities and altered enzyme activities can be potential predictors for chemotherapeutic agents including cyclophosphamide and paclitaxel. Response to chemotherapy is primarily based on somatic mutations but germline variants may predict cancer cell sensitivity to chemotherapeutic agents. Furthermore, patient's genetic variation of immune system was reported to be associated with drug response and toxicity. Recently, the somaric and germilne genomic variation influences the pharmacokinetics of chemotherapy and these variation can be biomarkers for chemotherapy.
    MeSH term(s) Antineoplastic Agents/therapeutic use ; Antineoplastic Combined Chemotherapy Protocols ; Breast Neoplasms ; Chemotherapy, Adjuvant ; Cyclophosphamide/adverse effects ; Humans ; Paclitaxel
    Chemical Substances Antineoplastic Agents ; Cyclophosphamide (8N3DW7272P) ; Paclitaxel (P88XT4IS4D)
    Language English
    Publishing date 2021-05-13
    Publishing country United States
    Document type Journal Article
    ISSN 2214-8019 ; 0065-2598
    ISSN (online) 2214-8019
    ISSN 0065-2598
    DOI 10.1007/978-981-32-9620-6_19
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Structural phase transition and resistive switching properties of Cu

    Seo, Juwon / Kim, Taeyoung / Kim, Yoonsok / Jeong, Mun Seok / Kim, Eun Kyu

    Nanotechnology

    2024  Volume 35, Issue 18

    Abstract: We studied the phase change and resistive switching characteristics of copper oxide ( ... ...

    Abstract We studied the phase change and resistive switching characteristics of copper oxide (Cu
    Language English
    Publishing date 2024-02-12
    Publishing country England
    Document type Journal Article
    ZDB-ID 1362365-5
    ISSN 1361-6528 ; 0957-4484
    ISSN (online) 1361-6528
    ISSN 0957-4484
    DOI 10.1088/1361-6528/ad22b0
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Analysis of ZnS and MgF

    Oh, Gyujin / Kim, Eun Kyu

    Nanotechnology

    2020  Volume 31, Issue 24, Page(s) 245301

    Abstract: This study investigated the multilayer growth and properties of ZnS and ... ...

    Abstract This study investigated the multilayer growth and properties of ZnS and MgF
    Language English
    Publishing date 2020-03-05
    Publishing country England
    Document type Journal Article
    ZDB-ID 1362365-5
    ISSN 1361-6528 ; 0957-4484
    ISSN (online) 1361-6528
    ISSN 0957-4484
    DOI 10.1088/1361-6528/ab7ce9
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  4. Article: Evaluating the Efficacy of Machine Performance Checks as an Alternative to Winston-Lutz Quality Assurance Testing in the TrueBeam Linear Accelerator with HyperArc.

    Kim, Eun Kyu / Kim, Sung Yeop / Park, Jae Won / Park, Jaehyeon / Yea, Ji Woon / Jo, Yoon Young / Oh, Se An

    Diagnostics (Basel, Switzerland)

    2024  Volume 14, Issue 4

    Abstract: HyperArc is a preferred technique for treating brain metastases, employing a single isocenter for multiple lesions. Geometrical isocentricity in the TrueBeam linear accelerator with HyperArc is crucial. We evaluated machine performance checks (MPCs) as ... ...

    Abstract HyperArc is a preferred technique for treating brain metastases, employing a single isocenter for multiple lesions. Geometrical isocentricity in the TrueBeam linear accelerator with HyperArc is crucial. We evaluated machine performance checks (MPCs) as an alternative to the Winston-Lutz (WL) test to verify the treatment isocenter. Between January and July 2023, we assessed 53 data points using MPC and Winston-Lutz tests. The isocenter size obtained from the MPC and its sum, including the rotation-induced couch shift, were compared with the maximum total delta value from the Winston-Lutz test. The maximum total delta was 0.68 ± 0.10 mm, while the isocenter size was 0.28 ± 0.02 mm. The sum of the isocenter size and rotation-induced couch shift measured by MPC was 0.61 ± 0.03 mm. During the Winston-Lutz test (without couch rotation), the maximum total delta value was 0.56 ± 0.13 mm. A
    Language English
    Publishing date 2024-02-13
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2662336-5
    ISSN 2075-4418
    ISSN 2075-4418
    DOI 10.3390/diagnostics14040410
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  5. Article: Comparative profiling by data-independent acquisition mass spectrometry reveals featured plasma proteins in breast cancer: a pilot study.

    Yoon, Kyung-Hwak / Chu, Hyosub / Kim, Hyeonji / Huh, Sunghyun / Kim, Eun-Kyu / Kang, Un-Beom / Shin, Hee-Chul

    Annals of surgical treatment and research

    2024  Volume 106, Issue 4, Page(s) 195–202

    Abstract: Purpose: Breast cancer is known to be influenced by genetic and environmental factors, and several susceptibility genes have been discovered. Still, the majority of genetic contributors remain unknown. We aimed to analyze the plasma proteome of breast ... ...

    Abstract Purpose: Breast cancer is known to be influenced by genetic and environmental factors, and several susceptibility genes have been discovered. Still, the majority of genetic contributors remain unknown. We aimed to analyze the plasma proteome of breast cancer patients in comparison to healthy individuals to identify differences in protein expression profiles and discover novel biomarkers.
    Methods: This pilot study was conducted using bioresources from Seoul National University Bundang Hospital's Human Bioresource Center. Serum samples from 10 breast cancer patients and 10 healthy controls were obtained. Liquid chromatography-mass spectrometry analysis was performed to identify differentially expressed proteins.
    Results: We identified 891 proteins; 805 were expressed in the breast cancer group and 882 in the control group. Gene set enrichment and differential expression analysis identified 30 upregulated and 100 downregulated proteins in breast cancer. Among these, 10 proteins were selected as potential biomarkers. Three proteins were upregulated in breast cancer patients, including cluster of differentiation 44, eukaryotic translation initiation factor 2-α kinase 3, and fibronectin 1. Seven proteins downregulated in breast cancer patients were also selected: glyceraldehyde-3-phosphate dehydrogenase, α-enolase, heat shock protein member 8, integrin-linked kinase, tissue inhibitor of metalloproteinases-1, vasodilator-stimulated phosphoprotein, and 14-3-3 protein gamma. All proteins had been previously reported to be related to tumor development and progression.
    Conclusion: The findings suggest that plasma proteome profiling can reveal potential diagnostic biomarkers for breast cancer and may contribute to early detection and personalized treatment strategies. A further validation study with a larger sample cohort of breast cancer patients is planned.
    Language English
    Publishing date 2024-03-29
    Publishing country Korea (South)
    Document type Journal Article
    ZDB-ID 3012234-X
    ISSN 2288-6796 ; 2288-6575
    ISSN (online) 2288-6796
    ISSN 2288-6575
    DOI 10.4174/astr.2024.106.4.195
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  6. Article ; Online: Investigating charge traps in MoTe

    Kim, Giheon / Dang, Dang Xuan / Gul, Hamza Zad / Ji, Hyunjin / Kim, Eun Kyu / Lim, Seong Chu

    Nanotechnology

    2023  Volume 35, Issue 3

    Abstract: Two-dimensional material-based field-effect transistors are promising for future use in electronic and optoelectronic applications. However, trap states existing in the transistors are known to hinder device performance. They capture/release carriers in ... ...

    Abstract Two-dimensional material-based field-effect transistors are promising for future use in electronic and optoelectronic applications. However, trap states existing in the transistors are known to hinder device performance. They capture/release carriers in the channel and lead to hysteresis in the transfer characteristics. In this work, we fabricated MoTe
    Language English
    Publishing date 2023-10-31
    Publishing country England
    Document type Journal Article
    ZDB-ID 1362365-5
    ISSN 1361-6528 ; 0957-4484
    ISSN (online) 1361-6528
    ISSN 0957-4484
    DOI 10.1088/1361-6528/ad0126
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  7. Article ; Online: Nipple Projection Change in Immediate Breast Reconstruction and Use of an Acellular Dermal Matrix Strut for Maintaining Nipple Projection.

    Kim, Jong-Ho / Kang, Jiwon / Najmiddinov, Bakhtiyor / Kim, Eun-Kyu / Myung, Yujin / Heo, Chan Yeong

    Plastic and reconstructive surgery

    2023  Volume 152, Issue 5, Page(s) 949–957

    Abstract: Background: Nipple-sparing mastectomy (NSM) has gained popularity as more studies have supported its oncologic safety. Although there have been some studies reporting complications including mastectomy flap and nipple necrosis, there have been few ... ...

    Abstract Background: Nipple-sparing mastectomy (NSM) has gained popularity as more studies have supported its oncologic safety. Although there have been some studies reporting complications including mastectomy flap and nipple necrosis, there have been few reports discussing the change in nipple projection following NSM. This study aimed to analyze the change in nipple projection after NSM and identify risk factors for nipple depression. In addition, the authors present a new method for maintaining nipple projection.
    Methods: Patients who underwent NSM between March of 2017 and December of 2020 at the authors' institute were included in this study. The authors measured the preoperative and postoperative nipple projection height and used a nipple projection ratio (NPR) to compare the change in height. Univariate and multivariate analyses were performed to examine the correlation of variables with the NPR.
    Results: A total of 307 patients and 330 breasts were included in this study. There were 13 cases of nipple necrosis. The postoperative nipple height was decreased by 32.8%, which was statistically significant. In multiple linear regression analysis, the use of an acellular dermal matrix strut was positively correlated with the NPR and implant-based reconstruction and postmastectomy radiation therapy were negatively correlated with the NPR.
    Conclusions: The results of this study demonstrated that the reduction in nipple height after NSM was statistically significant. Surgeons need to be aware of these changes following NSM and explain this possibility to patients who have risk factors. The application of an acellular dermal matrix strut should be considered for the prevention of nipple reduction.
    Clinical question/level of evidence: Therapeutic, III.
    MeSH term(s) Humans ; Female ; Nipples/surgery ; Mastectomy/adverse effects ; Mastectomy/methods ; Breast Neoplasms/surgery ; Breast Neoplasms/etiology ; Acellular Dermis ; Mammaplasty/methods ; Necrosis/etiology ; Retrospective Studies
    Language English
    Publishing date 2023-03-07
    Publishing country United States
    Document type Journal Article
    ZDB-ID 208012-6
    ISSN 1529-4242 ; 0032-1052 ; 0096-8501
    ISSN (online) 1529-4242
    ISSN 0032-1052 ; 0096-8501
    DOI 10.1097/PRS.0000000000010355
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Uk I Zs.142: Show issues Location:
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    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)
    Zs.MO 293: Show issues

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  8. Article ; Online: Recurrence is Not Associated with Margin Status in Phyllodes Tumor.

    Yoon, Kyung-Hwak / Kang, Eunyoung / Kim, Eun-Kyu / Park, So Yeon / Shin, Hee-Chul

    Annals of surgical oncology

    2023  Volume 30, Issue 4, Page(s) 2154–2161

    Abstract: Background: Phyllodes tumor (PT) is a rare fibroepithelial neoplasm of the breast. The proper extent of resection is still under debate. This study aimed to investigate the optimal surgical margin to prevent recurrence after surgery for PT and to ... ...

    Abstract Background: Phyllodes tumor (PT) is a rare fibroepithelial neoplasm of the breast. The proper extent of resection is still under debate. This study aimed to investigate the optimal surgical margin to prevent recurrence after surgery for PT and to evaluate risk factors for local recurrence (LR).
    Methods: Retrospective analysis of a prospective cohort database was performed. Patients who underwent curative surgery for PT at Seoul National University Bundang Hospital between July 2003 and February 2022 were reviewed.
    Results: Of the 439 patients included, 285 were benign, 129 were borderline, and 25 were malignant. There was no statistically significant difference in 5-year disease-free survival (DFS) between margin-negative and margin-involved patients (87.3% vs. 85.1%, p = 0.081). When patients were classified into groups, according to margin status, as conventional (≥ 1 cm from tumor), close (< 1 cm from tumor), or involved, 5-year DFS rates were also similar (100% vs. 86.9% vs. 85.1%, p = 0.170). In subgroup analysis for different histologic grades, 5-year DFS was not affected by margin involvement. In univariate analysis, large tumor size (> 5 cm; hazard ratio [HR] 2.857, p = 0.028) and infiltrative tumor border (HR 3.096, p = 0.012) were independent risk factors for LR. Further multivariate analysis found both factors to be prognostic.
    Conclusions: Recurrence was not significantly influenced by margin status in all histological grades. In benign and borderline tumors, local excision without wide surgical margins could be sufficient, and watchful waiting could be an option for patients with positive margins after initial surgery.
    MeSH term(s) Humans ; Female ; Phyllodes Tumor/pathology ; Retrospective Studies ; Prospective Studies ; Neoplasm Recurrence, Local/pathology ; Margins of Excision ; Breast Neoplasms/surgery ; Breast Neoplasms/complications
    Language English
    Publishing date 2023-01-03
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1200469-8
    ISSN 1534-4681 ; 1068-9265
    ISSN (online) 1534-4681
    ISSN 1068-9265
    DOI 10.1245/s10434-022-12997-w
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4042: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  9. Article ; Online: Photoelectric Characteristics of a Large-Area n-MoS

    Kim, Yoonsok / Kim, Taeyoung / Kim, Eun Kyu

    Sensors (Basel, Switzerland)

    2020  Volume 20, Issue 24

    Abstract: Two-dimensional (2D) materials, such as molybdenum disulfide ( ... ...

    Abstract Two-dimensional (2D) materials, such as molybdenum disulfide (MoS
    Language English
    Publishing date 2020-12-21
    Publishing country Switzerland
    Document type Letter
    ZDB-ID 2052857-7
    ISSN 1424-8220 ; 1424-8220
    ISSN (online) 1424-8220
    ISSN 1424-8220
    DOI 10.3390/s20247340
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  10. Article: Clinicopathological characteristics of BRCA-associated breast cancer in Asian patients.

    Kim, Eun-Kyu / Park, So Yeon / Kim, Sung-Won

    Journal of pathology and translational medicine

    2020  Volume 54, Issue 4, Page(s) 265–275

    Abstract: BRCA1/2 germline mutations account for the majority of hereditary breast cancers. Since the identification of the BRCA genes, several attempts have been made to define the clinicopathological characteristics of BRCA-associated breast cancer in comparison ...

    Abstract BRCA1/2 germline mutations account for the majority of hereditary breast cancers. Since the identification of the BRCA genes, several attempts have been made to define the clinicopathological characteristics of BRCA-associated breast cancer in comparison with sporadic breast cancer. Asians constitute 60% of the world population, and although the incidence of breast cancer in Asia remains low compared to the West, breast cancer is the most prevalent female cancer in the region. The epidemiological aspects of breast cancer are different between Asians and Caucasians. Asian patients present with breast cancer at a younger age than Western patients. The contributions of BRCA1/2 mutations to breast cancer incidence are expected to differ between Asians and Caucasians, and the different genetic backgrounds among races are likely to influence the breast cancer phenotypes. However, most large-scale studies on the clinicopathological characteristics of BRCA-associated breast cancer have been on Western patients, while studies on Asian populations were small and sporadic. In this review, we provide an overview of the clinical and pathological characteristics of BRCA-associated breast cancer, incorporating findings on Asian patients.
    Language English
    Publishing date 2020-05-14
    Publishing country Korea (South)
    Document type Journal Article ; Review
    ZDB-ID 3022395-7
    ISSN 2383-7845 ; 2383-7837
    ISSN (online) 2383-7845
    ISSN 2383-7837
    DOI 10.4132/jptm.2020.04.07
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