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  1. Article ; Online: Cera-Glow, ferment lysates of Lacticaseibacillus rhamnosus IDCC 3201, improves skin barrier function in clinical study.

    Lee, Minjee / Kim, Myun Soo / Jang, Sung Hee / Kim, Hayoung / Kim, Gwang Seob / Lee, Hyerin / Park, Hyun Min / Yang, Jungwoo

    Journal of cosmetic dermatology

    2023  Volume 22, Issue 6, Page(s) 1879–1886

    Abstract: Background: Ceramides are essential lipids in stratum corneum for skin permeability barrier function in that they retain the skin moisture and protect from the invasion of foreign pathogens. Previously, we demonstrated that ferment lysates of ... ...

    Abstract Background: Ceramides are essential lipids in stratum corneum for skin permeability barrier function in that they retain the skin moisture and protect from the invasion of foreign pathogens. Previously, we demonstrated that ferment lysates of Lacticaseibacillus rhamnosus IDCC 3201 enhanced ceramide production in human epidermal keratinocytes. Furthermore, for comprehensive knowledge of this effect, in vitro experiments and multi-omics analysis were conducted to explore the underlying mechanisms.
    Aims: This study was designed to identify whether a cosmetic sample (i.e., Cera-Glow) containing the lysates improves the skin barrier function in clinical trials.
    Patients/methods: Twenty-four female participants (45.46 ± 9.78 years) had been enrolled in the transepidermal water loss (TEWL) measurement for 5 days and 21 female participants (50.33 ± 5.74 years) had undergone a skin hydration evaluation for 4 weeks. TEWL and skin hydration were evaluated using a Tewameter and the Epsilon Permittivity Imaging System, respectively. After applying the Cera-Glow sample, all participants recorded a satisfaction survey questionnaire (e.g., satisfaction, efficacy, and adverse reactions).
    Results: Application of Cera-Glow significantly improved transepidermal water loss induced by 1% (w/v) sodium lauryl sulfate (p < 0.05-0.01) and increased skin hydration (p < 0.01). Metabolic analysis suggested that Cera-Glow should contain beneficial gradients for skin barrier function. According to the questionnaire, most of participants were satisfied with the skin hydration improvement and efficacy of Cera-Glow.
    Conclusions: Cera-Glow, ferment lysates of Lacticaseibacillus rhamnosus IDCC 3201, can significantly improve skin barrier function.
    MeSH term(s) Humans ; Female ; Lacticaseibacillus ; Lacticaseibacillus rhamnosus ; Skin ; Epidermis ; Dermatologic Agents/pharmacology ; Water/metabolism
    Chemical Substances Dermatologic Agents ; Water (059QF0KO0R)
    Language English
    Publishing date 2023-01-31
    Publishing country England
    Document type Journal Article
    ZDB-ID 2280551-5
    ISSN 1473-2165 ; 1473-2130
    ISSN (online) 1473-2165
    ISSN 1473-2130
    DOI 10.1111/jocd.15642
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 6539: Show issues Location:
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    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  2. Article: Enhanced ceramides production by Lactobacillus rhamnosus IDCC 3201 and its proposed mechanism

    Kim, Myun Soo / Lee, Minjee / Oh, Hanna / Seo, Wonsang / Kim, Gwang-Seob / Ban, O-Hyun / Shin, Minhye / Jung, Young Hoon / Yang, Jungwoo

    Applied biological chemistry. 2021 Dec., v. 64, no. 1

    2021  

    Abstract: The use of probiotics has been applied for a variety of fields (e.g., immune system, mental health, and heart). In this study, the feasibility of lysates from L. rhamnosus IDCC 3201 for cosmetic ingredients was evaluated. More specifically, enhanced ... ...

    Abstract The use of probiotics has been applied for a variety of fields (e.g., immune system, mental health, and heart). In this study, the feasibility of lysates from L. rhamnosus IDCC 3201 for cosmetic ingredients was evaluated. More specifically, enhanced ceramides production in human epidermal keratinocytes by the lysates and its proposed machanism were investigated through in vitro and genome analysis. In results, enhanced spingomyelinase activity and thereby increased ceramides production by the lysates from L. rhamnosus IDCC 3201 was observed. Furthermore, it was found that the existence of glucosylceramdase in L. rhamonsus IDCC 3201 was attributed to enhanced ceramides production. Finally, it was verified that the lysates from L. rhamonsus IDCC 3201 was regarded as safe for its use as cosmetic materials. Thus, these findings have significant implications that might lead to the development of functional and safe cosmetic products from probiotics.
    Keywords Lactobacillus rhamnosus ; ceramides ; heart ; humans ; immune system ; keratinocytes ; mental health ; probiotics ; sequence analysis
    Language English
    Dates of publication 2021-12
    Size p. 50.
    Publishing place Springer Singapore
    Document type Article
    ZDB-ID 2846955-0
    ISSN 2468-0842 ; 2468-0834
    ISSN (online) 2468-0842
    ISSN 2468-0834
    DOI 10.1186/s13765-021-00620-7
    Database NAL-Catalogue (AGRICOLA)

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  3. Article ; Online: Double-Chambered Ferritin Platform: Dual-Function Payloads of Cytotoxic Peptides and Fluorescent Protein.

    Kim, Soyoun / Kim, Gwang Seob / Seo, Junyoung / Gowri Rangaswamy, Gunassekaran / So, In-Seop / Park, Rang-Woon / Lee, Byung-Heon / Kim, In-San

    Biomacromolecules

    2016  Volume 17, Issue 1, Page(s) 12–19

    Abstract: Ferritin cage nanoparticles are promising platforms for targeted delivery of imaging and therapeutic agents. One of the main advantages of cage nanoparticles is the ability to display multiple functionalities through genetic modification so as to achieve ...

    Abstract Ferritin cage nanoparticles are promising platforms for targeted delivery of imaging and therapeutic agents. One of the main advantages of cage nanoparticles is the ability to display multiple functionalities through genetic modification so as to achieve desired therapeutic or diagnostic functions. Ferritin complexes formed from short ferritin (sFt) lacking the fifth helix can accommodate dual peptide and protein functionalities on N- and C-terminal sites in sFt monomers. The resulting double-chambered NanoCage (DCNC) offers the potential of dual activities; these activities are augmented by the avidity of the ligands, which do not impede each other's function. Here we demonstrated proof-of-concept of DCNCs, loading the tumor-targeting proapoptotic peptide CGKRK(KLAKLAK)2 onto the N-terminal chamber and green fluorescent protein (GFP) onto the C-terminal chamber. The resulting KLAK-sFt-GFP DCNCs were internalized into the human breast adenocarcinoma cell line MDA-MB-231 and induced apoptosis. These findings suggest that DCNCs containing various combinations of peptides and proteins could be applied as therapeutics in different diseases.
    MeSH term(s) Animals ; Cell Line, Tumor ; Drug Delivery Systems/methods ; Female ; Ferritins/chemistry ; Green Fluorescent Proteins/chemistry ; Humans ; Ligands ; Mice ; Mice, Inbred BALB C ; Mice, Nude ; Nanoparticles/chemistry ; Nanotechnology/methods ; Peptides/chemistry
    Chemical Substances Ligands ; Peptides ; Green Fluorescent Proteins (147336-22-9) ; Ferritins (9007-73-2)
    Language English
    Publishing date 2016-01-11
    Publishing country United States
    Document type Journal Article
    ISSN 1526-4602
    ISSN (online) 1526-4602
    DOI 10.1021/acs.biomac.5b01134
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: Double-Chambered Ferritin Platform: Dual-Function Payloads of Cytotoxic Peptides and Fluorescent Protein

    Kim, Soyoun / Kim Gwang Seob / Seo Junyoung / Gowri Rangaswamy Gunassekaran / So In-Seop / Park Rang-Woon / Lee Byung-Heon / Kim In-San

    Biomacromolecules. 2016 Jan. 11, v. 17, no. 1

    2016  

    Abstract: Ferritin cage nanoparticles are promising platforms for targeted delivery of imaging and therapeutic agents. One of the main advantages of cage nanoparticles is the ability to display multiple functionalities through genetic modification so as to achieve ...

    Abstract Ferritin cage nanoparticles are promising platforms for targeted delivery of imaging and therapeutic agents. One of the main advantages of cage nanoparticles is the ability to display multiple functionalities through genetic modification so as to achieve desired therapeutic or diagnostic functions. Ferritin complexes formed from short ferritin (sFt) lacking the fifth helix can accommodate dual peptide and protein functionalities on N- and C-terminal sites in sFt monomers. The resulting double-chambered NanoCage (DCNC) offers the potential of dual activities; these activities are augmented by the avidity of the ligands, which do not impede each other’s function. Here we demonstrated proof-of-concept of DCNCs, loading the tumor-targeting proapoptotic peptide CGKRK(KLAKLAK)₂ onto the N-terminal chamber and green fluorescent protein (GFP) onto the C-terminal chamber. The resulting KLAK-sFt-GFP DCNCs were internalized into the human breast adenocarcinoma cell line MDA-MB-231 and induced apoptosis. These findings suggest that DCNCs containing various combinations of peptides and proteins could be applied as therapeutics in different diseases.
    Keywords adenocarcinoma ; apoptosis ; breast neoplasms ; cytotoxicity ; ferritin ; genetic engineering ; green fluorescent protein ; humans ; image analysis ; ligands ; nanoparticles ; neoplasm cells ; peptides ; therapeutics
    Language English
    Dates of publication 2016-0111
    Size p. 12-19.
    Publishing place American Chemical Society
    Document type Article
    ISSN 1526-4602
    DOI 10.1021%2Facs.biomac.5b01134
    Database NAL-Catalogue (AGRICOLA)

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