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  1. Article ; Online: Relationship between self-consciousness and empathy for cancer patients among nursing students: The moderating effects of clinical practice satisfaction.

    Lee, Ye Sol / Yun, Younghee / Kim, Eun Kyung / Kim, Hye Sook

    Nurse education today

    2023  Volume 121, Page(s) 105715

    Abstract: Background: Patients with cancer experience physical and mental difficulties that can be relieved with the support and empathy of healthcare professionals. Empathy can be affected by self-consciousness. The clinical performance and interpersonal ... ...

    Abstract Background: Patients with cancer experience physical and mental difficulties that can be relieved with the support and empathy of healthcare professionals. Empathy can be affected by self-consciousness. The clinical performance and interpersonal competence of nursing students are related to their satisfaction with clinical practice.
    Objective: This study explored the moderating effect of clinical practice satisfaction of nursing students on the relationship between self-consciousness and empathy for patients with cancer.
    Design: Cross-sectional descriptive study.
    Setting: Three colleges of nursing in South Korea.
    Participants: A total of 136 senior nursing students across three universities.
    Methods: The participants completed an online questionnaire on demographic and education-related characteristics, self-consciousness, and empathy competency. We used the Korean versions of the Self-Consciousness Scale and Empathy Construct Rating Scale. The overall response rate was 42.5 %. SPSS PROCESS macro was used to test the moderating role of satisfaction with clinical practice.
    Results: Private self-consciousness was significantly associated with clinical practice satisfaction and empathy. The relationship between practice satisfaction and empathy was significantly positive. In addition, the satisfaction of the nursing students with clinical practice moderated the association between private self-consciousness and empathy for patients with cancer. Empathy was more affected by private self-consciousness among senior nursing students who were less satisfied with clinical practice than among those who were more satisfied with clinical practice.
    Conclusion: To improve empathy for patients with cancer, educational strategies must be created to improve the private self-consciousness and satisfaction with the clinical practice of nursing students.
    MeSH term(s) Humans ; Empathy ; Students, Nursing ; Cross-Sectional Studies ; Consciousness ; Patient Satisfaction ; Education, Nursing, Baccalaureate ; Surveys and Questionnaires ; Personal Satisfaction ; Neoplasms
    Language English
    Publishing date 2023-01-11
    Publishing country Scotland
    Document type Journal Article
    ZDB-ID 1062570-7
    ISSN 1532-2793 ; 0260-6917
    ISSN (online) 1532-2793
    ISSN 0260-6917
    DOI 10.1016/j.nedt.2023.105715
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Prognostic Model for High-Grade Neuroendocrine Carcinoma of the Lung Incorporating Genomic Profiling and Poly (ADP-ribose) Polymerase-1 Expression.

    Kim, Hye Sook / Kim, Jong Kwang / Lee, Jeong Hyeon / Lee, Young Joo / Lee, Geon-Kuk / Han, Ji-Youn

    JCO precision oncology

    2024  Volume 8, Page(s) e2300495

    Abstract: Purpose: High-grade neuroendocrine carcinoma (HGNEC) of the lung is an aggressive cancer with a complex biology. We aimed to explore the prognostic value of genetic aberrations and poly(ADP-ribose) polymerase-1 (PARP1) expression in HGNEC and to ... ...

    Abstract Purpose: High-grade neuroendocrine carcinoma (HGNEC) of the lung is an aggressive cancer with a complex biology. We aimed to explore the prognostic value of genetic aberrations and poly(ADP-ribose) polymerase-1 (PARP1) expression in HGNEC and to establish a novel prognostic model.
    Materials and methods: We retrospectively enrolled 191 patients with histologically confirmed HGNEC of the lung. Tumor tissues were analyzed using PARP1 immunohistochemistry (IHC; N = 191) and comprehensive cancer panel sequencing (n = 102). Clinical and genetic data were used to develop an integrated Cox hazards model.
    Results: Strong PARP1 IHC expression (intensity 3) was observed in 153 of 191 (80.1%) patients, and the mean PARP1 H-score was 285 (range, 5-300). To develop an integrated Cox hazard model, our data set included information from 357 gene mutations and 19 clinical profiles. When the targeted mutation profiles were combined with clinical profiles, 12 genes (
    Conclusion: We introduced a new prognostic model for HGNEC that combines genetic and clinical data. The integrated Cox hazard model outperformed the baseline model in predicting the survival of patients with HGNEC.
    MeSH term(s) Humans ; Prognosis ; Poly (ADP-Ribose) Polymerase-1/genetics ; Lung Neoplasms/genetics ; Lung Neoplasms/pathology ; Retrospective Studies ; Carcinoma, Neuroendocrine/genetics ; Lung/metabolism ; Lung/pathology ; Genomics
    Chemical Substances Poly (ADP-Ribose) Polymerase-1 (EC 2.4.2.30)
    Language English
    Publishing date 2024-04-08
    Publishing country United States
    Document type Journal Article
    ISSN 2473-4284
    ISSN (online) 2473-4284
    DOI 10.1200/PO.23.00495
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Synthesis of 1,5-diaryl-2-fluoro-6,7-dioxabicyclo[3.2.2]nonanes with high antimalarial activity utilizing photoinduced electron-transfer oxygenation reactions

    Kamata, Masaki / Maeda, Rie / Hayakawa, Jun / Kim, Hye-Sook

    Tetrahedron letters. 2022 Apr. 27, v. 96

    2022  

    Abstract: 1,5-Diaryl-2-fluoro-6,7-dioxabicyclo[3.2.2]nonanes were synthesized from corresponding 3-fluoro-2,6-diarylhepta-1,6-dienes utilizing 2,4,6-triphenylpyrylium salt (TPPX: X = BF₄, ClO₄)-sensitized photoinduced electron-transfer (PET) oxygenation reactions, ...

    Abstract 1,5-Diaryl-2-fluoro-6,7-dioxabicyclo[3.2.2]nonanes were synthesized from corresponding 3-fluoro-2,6-diarylhepta-1,6-dienes utilizing 2,4,6-triphenylpyrylium salt (TPPX: X = BF₄, ClO₄)-sensitized photoinduced electron-transfer (PET) oxygenation reactions, and their in-vitro antimalarial activity was evaluated. Results showed that these fluorinated bicyclic peroxides had higher antimalarial activity than their nonfluorinated parent bicyclic peroxides. In addition, it was shown that PET oxygenation reactions, particularly TPPX-biphenyl-cosensitized PET oxygenation reactions, are an efficient method for the construction of a COOC structure during the synthesis of fluorinated antimalarial bicyclic peroxides.
    Keywords antimalarials ; electron transfer ; methodology ; parenting ; parents ; peroxides ; salting ; salts
    Language English
    Dates of publication 2022-0427
    Publishing place Elsevier Ltd
    Document type Article
    ZDB-ID 204287-3
    ISSN 1873-3581 ; 0040-4039
    ISSN (online) 1873-3581
    ISSN 0040-4039
    DOI 10.1016/j.tetlet.2022.153752
    Database NAL-Catalogue (AGRICOLA)

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  4. Article ; Online: A Decision Tree Model for Breast Reconstruction of Women with Breast Cancer: A Mixed Method Approach.

    Park, Eun Young / Yi, Myungsun / Kim, Hye Sook / Kim, Haejin

    International journal of environmental research and public health

    2021  Volume 18, Issue 7

    Abstract: The number of breast reconstructions following mastectomy has increased significantly during the last decades, but women are experiencing a number of conflicts with breast reconstruction decisions. The aim of this study was to develop a decision tree ... ...

    Abstract The number of breast reconstructions following mastectomy has increased significantly during the last decades, but women are experiencing a number of conflicts with breast reconstruction decisions. The aim of this study was to develop a decision tree model of breast reconstruction and to examine its predictability. Mixed method design using ethnographic decision tree modeling was used. In the qualitative stage, data were collected using individual and focus group interviews and analyzed to construct a decision tree model. In the quantitative stage, the questionnaire was developed questions based on the criteria identified in the qualitative stage. A total of 61 women with breast cancer participated in 2017. Five major criteria: recovery of body image; impact on recurrence; recommendations from others; financial resources; and confirmation by physicians. The model also included nine predictive pathways. It turns out that the model predicted 90% of decisions concerning whether or not to have breast reconstruction. The findings indicate that the five criteria play a key role in decision-making about whether or not to have breast reconstruction. Thus, more comprehensive issues, including these five criteria, need to be integrated into an intervention for women with breast cancer to make their best decision on breast reconstruction.
    MeSH term(s) Breast Neoplasms/surgery ; Decision Making ; Decision Trees ; Female ; Humans ; Mammaplasty ; Mastectomy ; Neoplasm Recurrence, Local
    Language English
    Publishing date 2021-03-30
    Publishing country Switzerland
    Document type Journal Article
    ISSN 1660-4601
    ISSN (online) 1660-4601
    DOI 10.3390/ijerph18073579
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: Maternal and Fetal Effects of Gestational Vitamin D Concentration.

    Kwon, Ki-Wook / Lee, Young-Hyeon / Yeo, Min-Ho / Park, Sang-Hyun / Kim, Hye-Ran / Kim, Hye-Sook / Chang, Kyung-Soo

    Healthcare (Basel, Switzerland)

    2023  Volume 11, Issue 16

    Abstract: Most (90%) vitamin D synthesis occurs in the skin using sunlight (ultraviolet rays), and 10% is obtained through food. Vitamin D is an essential nutrient for skeletal growth and maintenance, cell proliferation and differentiation, and immune function. ... ...

    Abstract Most (90%) vitamin D synthesis occurs in the skin using sunlight (ultraviolet rays), and 10% is obtained through food. Vitamin D is an essential nutrient for skeletal growth and maintenance, cell proliferation and differentiation, and immune function. This study investigated whether maternal serum vitamin D concentrations induce maternofetal effects. Hematological analysis, serological changes, and precision fetal ultrasound findings were analyzed by maternal vitamin D concentration in gestational weeks 22-25 to ascertain direct effects on fetal growth. Bone density-vitamin D concentration correlation was analyzed. No hematologic or serological effect of maternal vitamin D concentration was detected; however, the sexually transmitted infection and cross-infection rates were inversely proportional to maternal vitamin D concentration. No significant correlation between vitamin D concentration and vertebral and femoral BMD was detected. For fetal growth, biparietal diameter, head circumference, abdominal circumference, femur length, and humerus length were analyzed. Humerus (
    Language English
    Publishing date 2023-08-17
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2721009-1
    ISSN 2227-9032
    ISSN 2227-9032
    DOI 10.3390/healthcare11162325
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Extracellular Leakage Protein Patterns in Two Types of Cancer Cell Death: Necrosis and Apoptosis.

    Sato, Akira / Shimotsuma, Akira / Miyoshi, Tetsuya / Takahashi, Yui / Funayama, Naoki / Ogino, Yoko / Hiramoto, Akiko / Wataya, Yusuke / Kim, Hye-Sook

    ACS omega

    2023  Volume 8, Issue 28, Page(s) 25059–25065

    Abstract: Dead cells release fragments of DNA, RNA, and proteins (including peptides) into the extracellular space. Two major forms of cell death during cancer development have been identified: necrosis and apoptosis. Our group investigated the mechanisms that ... ...

    Abstract Dead cells release fragments of DNA, RNA, and proteins (including peptides) into the extracellular space. Two major forms of cell death during cancer development have been identified: necrosis and apoptosis. Our group investigated the mechanisms that regulate cell death during the treatment of mouse tumor FM3A cells with the anticancer drug floxuridine (FUdR). In the original strain F28-7, FUdR induced necrosis, whereas in the variant F28-7-A, it induced apoptosis. Here, we report that the extracellular leakage proteome (
    Language English
    Publishing date 2023-07-07
    Publishing country United States
    Document type Journal Article
    ISSN 2470-1343
    ISSN (online) 2470-1343
    DOI 10.1021/acsomega.3c01691
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Evaluation of schistosomula lung antigen preparation and soluble egg antigen vaccines on experimental schistosomiasis mansoni.

    Aly, Nagwa S M / Kim, Hye-Sook / Eraky, Maysa A / Kholy, Asmaa A El / Ali, Basma T / Miyoshi, Shin-Ichi / Omar, Rabab E

    Parasites, hosts and diseases

    2023  Volume 61, Issue 3, Page(s) 251–262

    Abstract: Schistosomiasis causes significant morbidity and mortality worldwide. This study aimed to assess the effect of schistosomula lung antigen preparation (SLAP) and soluble egg antigen (SEA) on a murine schistosomiasis mansoni model. Ninety laboratory-bred ... ...

    Abstract Schistosomiasis causes significant morbidity and mortality worldwide. This study aimed to assess the effect of schistosomula lung antigen preparation (SLAP) and soluble egg antigen (SEA) on a murine schistosomiasis mansoni model. Ninety laboratory-bred male Swiss albino mice were divided into 6 groups. Two doses of the vaccine were given at 2-week intervals. All mice were subcutaneously infected with 80±10 Schistosoma mansoni cercariae 2 weeks after the last vaccination dose. They were sacrificed 7 weeks post-infection. Parasitological and histopathological studies were conducted to assess the effect of inoculated antigens (single or combined). The results showed that the combination of SLAP and SEA (combination group) led to a significant reduction in worm burden (65.56%), and liver and intestine egg count (59% and 60.59%, respectively). The oogram pattern revealed a reduction in immature and mature eggs (15±0.4 and 10±0.8, respectively) and an increased number of dead eggs in the combination group (P<0.001). In terms of histopathological changes, the combination group showed notably small compact fibrocellular egg granuloma and moderate fibrosis in the liver. A high percentage of destroyed ova was observed in the intestine of the combination group. This study demonstrates for the first time the prophylactic effect of combined SLAP and SEA vaccine. The vaccine induced a significant reduction in the parasitological and pathological impacts of schistosomiasis mansoni in hepatic and intestinal tissues, making it a promising vaccine candidate for controlling schistosomiasis.
    MeSH term(s) Male ; Animals ; Mice ; Schistosomiasis mansoni/prevention & control ; Vaccines ; Vaccination ; Liver ; Eggs
    Chemical Substances Vaccines
    Language English
    Publishing date 2023-08-21
    Publishing country Korea (South)
    Document type Journal Article
    ISSN 2982-6799
    ISSN (online) 2982-6799
    DOI 10.3347/PHD.22154
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Dynamics of disease progression during treatment with Osimertinib in patients with EGFR T790M-positive non-small cell lung cancer.

    Kim, Hye Sook / Lim, Kun Young / Lee, Soo-Hyun / Kim, Hyae Young / Lee, Youngjoo / Han, Ji-Youn

    Cancer medicine

    2023  Volume 12, Issue 11, Page(s) 12285–12298

    Abstract: Background: Patterns of treatment failure and subsequent treatment in non-small cell lung cancer (NSCLC) patients treated with osimertinib are scarcely known. We analyzed the disease progression during osimertinib treatment to identify potential ... ...

    Abstract Background: Patterns of treatment failure and subsequent treatment in non-small cell lung cancer (NSCLC) patients treated with osimertinib are scarcely known. We analyzed the disease progression during osimertinib treatment to identify potential treatment strategies.
    Methods: We identified advanced NSCLC patients who commenced osimertinib treatment after progression on previous epidermal growth factor receptor (EGFR)-tyrosine-kinase inhibitor (TKI) from June 2014 to November 2018 from electronic records. Patients' tumor characteristics, efficacy outcomes, affected organs from radiology studies, and treatment modalities before and after osimertinib were analyzed.
    Results: Eighty-four patients were included. At osimertinib initiation, bone (50.0%) and brain (41.9%) were the commonest single metastatic sites, whereas thoracic involvement (73.3%) was more frequent than bone (27.4%) or brain (20.2%) metastasis during disease progression on osimertinib. Oligo-progressive disease (PD) and central nervous system (CNS)-sanctuary PD were observed in 15 (17.9%) and 3 (3.6%) patients, respectively. Most patients without brain metastasis (BM) at osimertinib initiation remained BM-free (46/49, 93.9%), and 60% of patients (21/35) with pre-existing BM showed intracranial disease control despite extracranial PD. The resistance mechanisms to osimertinib were explored in 23 patients (27.4%), and T790M-loss was observed in 14 patients (60.9%) who had worse survival outcomes than those without T790M-loss (progression-free survival, 5.4 vs. 16.5 months, p = 0.02; overall survival, not reached, p = 0.03).
    Conclusion: PD during osimertinib treatment occurred preferentially in the thorax and pre-existing sites. Extracranial PD prevailed over intracranial PD regardless of baseline BM and prior brain radiation. These results support osimertinib's intracranial efficacy and may guide treatment strategies for EGFR-mutated NSCLC with BM.
    MeSH term(s) Humans ; Brain Neoplasms/drug therapy ; Brain Neoplasms/genetics ; Carcinoma, Non-Small-Cell Lung/drug therapy ; Carcinoma, Non-Small-Cell Lung/genetics ; Disease Progression ; ErbB Receptors/genetics ; Lung Neoplasms/drug therapy ; Lung Neoplasms/genetics ; Mutation ; Protein Kinase Inhibitors/therapeutic use
    Chemical Substances EGFR protein, human (EC 2.7.10.1) ; ErbB Receptors (EC 2.7.10.1) ; osimertinib (3C06JJ0Z2O) ; Protein Kinase Inhibitors
    Language English
    Publishing date 2023-04-25
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2659751-2
    ISSN 2045-7634 ; 2045-7634
    ISSN (online) 2045-7634
    ISSN 2045-7634
    DOI 10.1002/cam4.5926
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Extract of

    Jeong, Mi Jin / Kang, Shin Ae / Yu, Sun Nyoung / Ahn, Soon Cheol / Miyoshi, Shin-Ichi / Kim, Hye-Sook / Yu, Hak Sun

    Journal of medicinal food

    2023  Volume 26, Issue 9, Page(s) 624–630

    Abstract: Benzimidazole derivatives can effectively treat nematode parasitic infections; however, some derivatives demand distinct administrative strategies depending on plasma concentration and patient conditions. Numerous studies have examined the potential of ... ...

    Abstract Benzimidazole derivatives can effectively treat nematode parasitic infections; however, some derivatives demand distinct administrative strategies depending on plasma concentration and patient conditions. Numerous studies have examined the potential of natural extracts to exert parasiticidal activity with minimal side effects. Herein, we examined the potential parasiticidal effects of
    MeSH term(s) Humans ; Mice ; Animals ; Trichinella spiralis ; Parasites ; Antiparasitic Agents/pharmacology ; Antiparasitic Agents/therapeutic use ; Trichinellosis/drug therapy ; Trichinellosis/diagnosis ; Trichinellosis/parasitology ; Muscles ; Larva
    Chemical Substances Antiparasitic Agents
    Language English
    Publishing date 2023-08-28
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1427365-2
    ISSN 1557-7600 ; 1096-620X
    ISSN (online) 1557-7600
    ISSN 1096-620X
    DOI 10.1089/jmf.2022.K.0112
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Anticancer Strategy Targeting Cell Death Regulators: Switching the Mechanism of Anticancer Floxuridine-Induced Cell Death from Necrosis to Apoptosis.

    Sato, Akira / Hiramoto, Akiko / Kim, Hye-Sook / Wataya, Yusuke

    International journal of molecular sciences

    2020  Volume 21, Issue 16

    Abstract: Cell death can be broadly characterized as either necrosis or apoptosis, depending on the morphological and biochemical features of the cell itself. We have previously reported that the treatment of mouse mammary carcinoma FM3A cells with the anticancer ... ...

    Abstract Cell death can be broadly characterized as either necrosis or apoptosis, depending on the morphological and biochemical features of the cell itself. We have previously reported that the treatment of mouse mammary carcinoma FM3A cells with the anticancer drug floxuridine (FUdR) induces necrosis in the original clone F28-7 but apoptosis in the variant F28-7-A. We have identified regulators, including heat shock protein 90, lamin-B1, cytokeratin-19, and activating transcription factor 3, of cell death mechanisms by using comprehensive gene and protein expression analyses and a phenotype-screening approach. We also observed that the individual inhibition or knockdown of the identified regulators in F28-7 results in a shift from necrotic to apoptotic morphology. Furthermore, we investigated microRNA (miRNA, miR) expression profiles in sister cell strains F28-7 and F28-7-A using miRNA microarray analyses. We found that several unique miRNAs, miR-351-5p and miR-743a-3p, were expressed at higher levels in F28-7-A than in F28-7. Higher expression of these miRNAs in F28-7 induced by transfecting miR mimics resulted in a switch in the mode of cell death from necrosis to apoptosis. Our findings suggest that the identified cell death regulators may play key roles in the decision of cell death mechanism: necrosis or apoptosis.
    MeSH term(s) Animals ; Antimetabolites, Antineoplastic/pharmacology ; Antimetabolites, Antineoplastic/therapeutic use ; Apoptosis/drug effects ; Floxuridine/pharmacology ; Floxuridine/therapeutic use ; Gene Expression Regulation, Neoplastic/drug effects ; Humans ; MicroRNAs/genetics ; MicroRNAs/metabolism ; Neoplasms/drug therapy ; Neoplasms/genetics ; Neoplasms/metabolism
    Chemical Substances Antimetabolites, Antineoplastic ; MicroRNAs ; Floxuridine (039LU44I5M)
    Language English
    Publishing date 2020-08-16
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms21165876
    Database MEDical Literature Analysis and Retrieval System OnLINE

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