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  1. Article ; Online: Which Is the Best Laser for Lithotripsy? Holmium Laser.

    Kim, Hyung Joon / Ghani, Khurshid R

    European urology open science

    2022  Volume 44, Page(s) 27–29

    Language English
    Publishing date 2022-08-19
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 3040546-4
    ISSN 2666-1683 ; 2058-4881
    ISSN (online) 2666-1683
    ISSN 2058-4881
    DOI 10.1016/j.euros.2022.05.017
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  2. Article ; Online: Re: Øyvind Ulvik, Mathias Sørstrand Æsøy, Patrick Juliebø-Jones, Peder Gjengstø, Christian Beisland. Thulium Fibre Laser versus Holmium:YAG for Ureteroscopic Lithotripsy: Outcomes from a Prospective Randomised Clinical Trial. Eur Urol. 2022;82:73-9.

    Kim, Hyung Joon / Ghani, Khurshid R

    European urology

    2022  Volume 82, Issue 2, Page(s) e39–e40

    MeSH term(s) Holmium ; Humans ; Lasers ; Lasers, Solid-State/therapeutic use ; Lithotripsy ; Lithotripsy, Laser ; Prospective Studies ; Thulium ; Ureteroscopy
    Chemical Substances Thulium (8RKC5ATI4P) ; Holmium (W1XX32SQN1)
    Language English
    Publishing date 2022-05-21
    Publishing country Switzerland
    Document type Letter ; Randomized Controlled Trial ; Comment
    ZDB-ID 193790-x
    ISSN 1873-7560 ; 1421-993X ; 0302-2838
    ISSN (online) 1873-7560 ; 1421-993X
    ISSN 0302-2838
    DOI 10.1016/j.eururo.2022.04.027
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    Zs.A 1247: Show issues Location:
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    Zs.MO 294: Show issues

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  3. Article ; Online: Virulence factors released from

    Heo, Soon Chul / Kim, Ye Seul / Kim, Yu Na / Kim, Jae Ho / Kim, Hyung Joon

    Journal of dental sciences

    2022  Volume 17, Issue 4, Page(s) 1559–1565

    Abstract: Background/purpose: Periodontal disease development correlates with the occurrence of systemic diseases. The present study investigated the association between periodontal disease and the development of cardiac arrhythmia.: Materials and methods: ... ...

    Abstract Background/purpose: Periodontal disease development correlates with the occurrence of systemic diseases. The present study investigated the association between periodontal disease and the development of cardiac arrhythmia.
    Materials and methods: Human embryonic stem cell-derived cardiomyocytes (hESC-CMs) were treated with
    Results: Treatment with Pg broth significantly decreased the beat period, field potential duration, spike amplitude, and conduction velocity without affecting the viability of hESC-CMs. In addition, the mRNA expression of
    Conclusion: These findings indicate that Pg may induce cardiac arrhythmia mediated by virulence factors.
    Language English
    Publishing date 2022-04-26
    Publishing country Netherlands
    Document type Journal Article
    ISSN 2213-8862
    ISSN (online) 2213-8862
    DOI 10.1016/j.jds.2022.04.013
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  4. Article ; Online: The natural course of incidental ureteral polyp during ureteroscopic surgery: KSER research.

    Cho, Sung Yong / Oh, Kyung-Jin / Jung, Wonho / Kim, Hyung Joon / Lee, Sang Hyub / Lee, Joo Yong / Lee, Dong Sup

    BMC urology

    2023  Volume 23, Issue 1, Page(s) 101

    Abstract: Background: The natural course of polypoid lesions in the ureter during ureteroscopic stone surgery was not yet clarified.: Methods: Patient data were collected prospectively from six teaching hospitals between 2019 and 2021. Patients with polypoid ... ...

    Abstract Background: The natural course of polypoid lesions in the ureter during ureteroscopic stone surgery was not yet clarified.
    Methods: Patient data were collected prospectively from six teaching hospitals between 2019 and 2021. Patients with polypoid lesions in the ureter distal to ureteral stones were included during ureteroscopy. Computed tomography was performed on all enrolled patients three months after the procedure. Follow-up ureteroscopy was performed only if the patient consented, due to the need for general anesthesia and ethical considerations.
    Results: Among the 35 patients who were followed up, 14 had fibroepithelial polyps and 21 had inflammatory polyps. Twenty of the followed-up patients underwent ureteroscopy, and nine of them had fibroepithelial polyps. Although fibroepithelial polyps did not disappear in the follow-up ureteroscopy (p = 0.002), the rate of postoperative hydronephrosis was not higher in the fibroepithelial group than in the inflammatory group. Postoperative ureteral stricture and moderate-to-severe hydronephrosis were found to be closely related to the number of resected polyps, regardless of the type of polyp (p = 0.014 and 0.006, respectively).
    Conclusion: Fibroepithelial polyps in the ureter may persist after treatment of adjacent ureter stones. However, conservative management may be preferable to active removal of ureteral polyps because fibroepithelial polyps may not contribute to clinically significant hydronephrosis after surgery, and inflammatory polyps disappear spontaneously. Hasty resections of polyps may increase the risk of ureteral stricture.
    MeSH term(s) Humans ; Ureteroscopy ; Constriction, Pathologic ; Ureteral Neoplasms/surgery ; Ureter/diagnostic imaging ; Ureter/surgery ; Polyps/surgery ; Hydronephrosis/etiology ; Hydronephrosis/surgery ; Kidney Neoplasms
    Language English
    Publishing date 2023-06-03
    Publishing country England
    Document type Journal Article
    ZDB-ID 2059857-9
    ISSN 1471-2490 ; 1471-2490
    ISSN (online) 1471-2490
    ISSN 1471-2490
    DOI 10.1186/s12894-023-01249-y
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  5. Article ; Online: Quantification of outflow resistance for ureteral drainage devices used during ureteroscopy.

    Kim, Hyung Joon / Louters, Marne M / Dau, Julie J / Hall, Timothy L / Ghani, Khurshid R / Roberts, William W

    World journal of urology

    2023  Volume 41, Issue 3, Page(s) 873–878

    Abstract: Purpose: Since renal pelvis pressure is directly related to irrigation flowrate and outflow resistance, knowledge of outflow resistance associated with commonly used drainage devices could help guide the selection of the type and size of ureteral access ...

    Abstract Purpose: Since renal pelvis pressure is directly related to irrigation flowrate and outflow resistance, knowledge of outflow resistance associated with commonly used drainage devices could help guide the selection of the type and size of ureteral access sheath or catheter for individual ureteroscopic cases. This study aims to quantitatively measure outflow resistance for different drainage devices utilized during ureteroscopy.
    Methods: With measured irrigation flowrate and renal pelvis pressure, outflow resistance was calculated using a hydrodynamic formula. After placement of a drainage device into a silicone kidney-ureter model, a disposable ureteroscope with a 9.5-Fr outer diameter was inserted with its tip positioned at the renal pelvis. Irrigation was delivered through the ureteroscope from varying heights above the renal pelvis. Renal pelvis pressure was measured directly from the port of the kidney model using a pressure sensor (Opsens, Canada). Outflow resistance was determined by plotting flowrate versus renal pelvis pressure. All trials were performed in triplicate for each drainage device inserted.
    Results: Flowrate was linearly dependent on renal pelvis pressure for all drainage devices tested. Outflow resistance values were 0.2, 1.1, 1.4, 3.9, and 6.5 cmH
    Conclusions: In this study, outflow resistance of different ureteral drainage devices was quantitatively measured. This knowledge can be useful when selecting which type and size of drainage device to insert to maintain safe renal pelvis pressure during ureteroscopy.
    MeSH term(s) Humans ; Ureter/surgery ; Ureteroscopy ; Pressure ; Kidney Pelvis/surgery ; Ureteroscopes ; Drainage
    Language English
    Publishing date 2023-02-07
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 380333-8
    ISSN 1433-8726 ; 0724-4983
    ISSN (online) 1433-8726
    ISSN 0724-4983
    DOI 10.1007/s00345-023-04299-x
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    Zs.A 1832: Show issues Location:
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  6. Article ; Online: Effect of outflow resistance on intrarenal pressure at different irrigation rates during ureteroscopy: in vivo evaluation.

    Marom, Ron / Dau, Julie J / Hall, Timothy L / Ghani, Khurshid R / Louters, Marne M / Kim, Hyung Joon / Khajeh, Nikta Rezakahn / Roberts, William W

    Urolithiasis

    2023  Volume 51, Issue 1, Page(s) 98

    Abstract: To maintain visualization and control temperature elevation during ureteroscopy, higher irrigation rates are necessary, but this can increase intrarenal pressure (IRP) and lead to adverse effects like sepsis. The IRP is also dependent on outflow ... ...

    Abstract To maintain visualization and control temperature elevation during ureteroscopy, higher irrigation rates are necessary, but this can increase intrarenal pressure (IRP) and lead to adverse effects like sepsis. The IRP is also dependent on outflow resistance but this has not been quantitatively evaluated in a biological system. In this study, we sought to characterize the IRP as a function of irrigation rate in an in vivo porcine model at different outflow resistances. Ureteroscopy was performed in a porcine model with a 9.5 Fr prototype ureteroscope containing a pressure sensor. A modified ureteral access sheath (UAS) (11/13 Fr, 36 cm) was configured to adjust outflow resistance. IRP-irrigation rate curves were generated at four different outlet resistances representing different outflow scenarios. At lower irrigation rates, the pressure change in response to increased irrigation was gradual and non-linear, likely reflecting a "compliant" phase of the renal collecting system. Once IRP reached the range of 35-50 cm H
    MeSH term(s) Swine ; Animals ; Ureteroscopy/adverse effects ; Ureter ; Ureteroscopes/adverse effects ; Pressure ; Fever ; Therapeutic Irrigation/adverse effects
    Language English
    Publishing date 2023-07-29
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 2703553-0
    ISSN 2194-7236 ; 2194-7228
    ISSN (online) 2194-7236
    ISSN 2194-7228
    DOI 10.1007/s00240-023-01470-2
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    Zs.A 928: Show issues Location:
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  7. Article ; Online: Three-directional engineering of IsPETase with enhanced protein yield, activity, and durability.

    Lee, Seul Hoo / Seo, Hogyun / Hong, Hwaseok / Park, Jiyoung / Ki, Dongwoo / Kim, Mijeong / Kim, Hyung-Joon / Kim, Kyung-Jin

    Journal of hazardous materials

    2023  Volume 459, Page(s) 132297

    Abstract: The mesophilic PETase from Ideonella sakaiensis (IsPETase) has been shown to exhibit high PET hydrolysis activity, but its low stability limits its industrial applications. Here, we developed a variant, Z1-PETase, with enhanced soluble protein yield and ... ...

    Abstract The mesophilic PETase from Ideonella sakaiensis (IsPETase) has been shown to exhibit high PET hydrolysis activity, but its low stability limits its industrial applications. Here, we developed a variant, Z1-PETase, with enhanced soluble protein yield and durability while maintaining or improving activity at lower temperatures. The selected Z1-PETase not only exhibited a 20-fold improvement in soluble protein yield compared to the previously engineered IsPETase
    MeSH term(s) Bioreactors ; Hydrolases ; Hydrolysis ; Polymers ; Powders
    Chemical Substances Hydrolases (EC 3.-) ; Polymers ; Powders
    Language English
    Publishing date 2023-08-15
    Publishing country Netherlands
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1491302-1
    ISSN 1873-3336 ; 0304-3894
    ISSN (online) 1873-3336
    ISSN 0304-3894
    DOI 10.1016/j.jhazmat.2023.132297
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  8. Article ; Online: Thermal Safety Boundaries for Laser Power and Irrigation Rate During Ureteroscopy: In Vivo Porcine Assessment With a Ho:YAG Laser.

    Marom, Ron / Dau, Julie J / Hall, Timothy L / Ghani, Khurshid R / Louters, Marne M / Kim, Hyung Joon / Khajeh, Nikta Rezakahn / Roberts, William W

    Urology

    2023  Volume 180, Page(s) 81–85

    Abstract: Objective: To map thermal safety boundaries during ureteroscopy (URS) with laser activation in two in vivo porcine subjects to better understand the interplay between laser power, irrigation rate, and fluid temperature in the collecting system.: ... ...

    Abstract Objective: To map thermal safety boundaries during ureteroscopy (URS) with laser activation in two in vivo porcine subjects to better understand the interplay between laser power, irrigation rate, and fluid temperature in the collecting system.
    Methods: URS was performed in two in vivo porcine subjects with a prototype ureteroscope containing a thermocouple at its tip. Up to 6 trials of 60 seconds laser activation were carried out at each selected power setting and irrigation rate. Thermal dose was calculated for each trial, and laser power-irrigation rate parameter pairs were categorized based on number of trials that exceeded a thermal dose of 120 equivalent minutes.
    Results: The collecting fluid temperature was increased with greater laser power and slower irrigation rate. In the first porcine subject, 25 W of laser power could safely be applied if irrigation was at least 15 mL/min, and 48 W with at least 30 mL/min. Intermediate values followed a linear curve between these bounds. For the second subject, where the calyx appeared larger, 15 W laser power required 9 mL/min irrigation, 48 W required 24 mL/min, and intermediate points also followed a near-linear curve.
    Conclusion: This study validates previous bench research and provides a conceptual framework for selection of safe laser lithotripsy settings and irrigation rates during URS with laser lithotripsy. Additionally, it provides insight and guidance for future development of thermal mitigation strategies and devices.
    Language English
    Publishing date 2023-07-22
    Publishing country United States
    Document type Journal Article
    ZDB-ID 192062-5
    ISSN 1527-9995 ; 0090-4295
    ISSN (online) 1527-9995
    ISSN 0090-4295
    DOI 10.1016/j.urology.2023.07.014
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    Zs.A 1142: Show issues Location:
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    Zs.MO 275: Show issues

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  9. Article ; Online: Mer tyrosine kinase regulates bone metabolism, and its deficiency partially ameliorates periodontitis- and ovariectomy-induced bone loss in mice.

    Ryu, Ka-Young / Pokhrel, Nitin Kumar / Jung, Hye-Jin / Kim, Hyo Jeong / Seok, Jiwon / Kim, Tae-Young / Kim, Hyung Joon / Lee, Ji Hye / Kim, Jae-Young / Kim, Yong-Gun / Lee, Youngkyun

    JBMR plus

    2024  Volume 8, Issue 2, Page(s) ziad014

    Abstract: Bone homeostasis is maintained by tightly coordinated activities of bone-forming osteoblasts and bone-resorbing osteoclasts. In the present report, the role of Mer tyrosine kinase (MerTK) in bone metabolism was investigated. The expression of MerTK ... ...

    Abstract Bone homeostasis is maintained by tightly coordinated activities of bone-forming osteoblasts and bone-resorbing osteoclasts. In the present report, the role of Mer tyrosine kinase (MerTK) in bone metabolism was investigated. The expression of MerTK decreased upon BMP2 stimulation of osteoblast precursors. The femurs of
    Language English
    Publishing date 2024-01-04
    Publishing country England
    Document type Journal Article
    ISSN 2473-4039
    ISSN (online) 2473-4039
    DOI 10.1093/jbmrpl/ziad014
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  10. Article ; Online: Physicochemical properties and cytocompatibility of newly developed calcium silicate-based sealers.

    Park, Min-Gyu / Kim, In-Ryoung / Kim, Hyung Joon / Kwak, Sang Won / Kim, Hyeon-Cheol

    Australian endodontic journal : the journal of the Australian Society of Endodontology Inc

    2021  Volume 47, Issue 3, Page(s) 512–519

    Abstract: The purpose of this study was to compare the physical properties and cytocompatibility of contemporary calcium silicate-based sealers. Four calcium silicate-based sealers (BrightEndo MTA sealer, CeraSeal, EndoSeal TCS and One-Fil) were compared to an ... ...

    Abstract The purpose of this study was to compare the physical properties and cytocompatibility of contemporary calcium silicate-based sealers. Four calcium silicate-based sealers (BrightEndo MTA sealer, CeraSeal, EndoSeal TCS and One-Fil) were compared to an epoxy resin-based sealer (AH Plus). Flow, setting time, radiopacity and dimensional change were evaluated according to ISO 6876 standards. Cytotoxicity on human periodontal ligament fibroblast (hPDLF) cells was compared for biological properties using MTT assay. The surface of the sealer was analysed using scanning electron microscopy to evaluate cell attachment. Flow and radiopacity of all sealers met ISO standards, while setting time and dimensional stability did not meet the ISO standards. Calcium silicate-based sealers showed favourable cytocompatibility, and hPDLF cells were well attached to the calcium silicate-based sealers. Calcium silicate-based sealers have clinically acceptable flow and radiopacity, and cytocompatibility. However, these sealers had longer setting time and higher dimensional change than those required by ISO 6876.
    MeSH term(s) Calcium Compounds ; Humans ; Research Design ; Silicates
    Chemical Substances Calcium Compounds ; Silicates ; calcium silicate (S4255P4G5M)
    Language English
    Publishing date 2021-04-24
    Publishing country Australia
    Document type Journal Article
    ZDB-ID 2146484-4
    ISSN 1747-4477 ; 1329-1947
    ISSN (online) 1747-4477
    ISSN 1329-1947
    DOI 10.1111/aej.12515
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    Zs.A 5877: Show issues Location:
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