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Article: Regulation of Med1 protein by overexpression of BAP1 in breast cancer cells.

Kim, Hyunju

Molecular & cellular oncology

2024 Volume 11, Issue 1, Page(s) 2347827

Abstract: Med1 binds to a nuclear receptor and regulates transcription. Elevated Med1 protein expression promotes cancer growth in hormone-dependent breast and prostate cancers. Med1 protein expression was investigated by deubiquitinating enzymes (DUBs) ... ...

Abstract	Med1 binds to a nuclear receptor and regulates transcription. Elevated Med1 protein expression promotes cancer growth in hormone-dependent breast and prostate cancers. Med1 protein expression was investigated by deubiquitinating enzymes (DUBs) overexpression in breast cancer cell lines. Various DNA constructs of SRT-DUBs were overexpressed in the MCF7 cell line, and Med1 protein expression was investigated by western blotting. The cell growth and in vitro invasion assay were performed in BRCA1-associated protein 1 (BAP1) wild type and mutant (C91A) overexpressed cells. Ubiquitination of the Med1 protein was observed, and Med1 protein expression and transcriptional activity were verified by various DUBs overexpressed. Although Med1 protein expression increased upon the overexpression of BAP1, it was not affected by the overexpression of BAP1 mutant (C91A). BAP1 was increased by the E2 treatment, which has an important effect on the breast cancer growth, and cell growth was decreased by BAP1 C91A overexpression. However, metastatic capacities were decreased by BAP1. In addition, the binding between the Med1 and the BAP1 protein was observed. These data suggested that BAP1 regulated Med1 protein expression in breast cancer cells and involved in cancer cell growth and metastasis by binding to Med1 protein.
Language	English
Publishing date	2024-05-02
Publishing country	United States
Document type	Journal Article
ISSN	2372-3556
ISSN	2372-3556
DOI	10.1080/23723556.2024.2347827
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Article ; Online: Visualization of maternal IL-17a across the placental membrane.

Kim, Hyunju

Science progress

2023 Volume 106, Issue 3, Page(s) 368504231195500

Abstract: IL-17a is a pro-inflammatory cytokine produced primarily by T helper-17 cells. Several studies have shown that maternal IL-17a, associated with maternal immune activation (MIA), affects the developing brain. However, the mechanisms underlying maternal IL- ...

Abstract	IL-17a is a pro-inflammatory cytokine produced primarily by T helper-17 cells. Several studies have shown that maternal IL-17a, associated with maternal immune activation (MIA), affects the developing brain. However, the mechanisms underlying maternal IL-17a signaling remain partially unknown. This study detected trans-placental IL-17a passage using luminescent activity studies and an
MeSH term(s)	Female ; Pregnancy ; Animals ; Mice ; Placenta ; Signal Transduction ; Cell Line ; Brain ; RNA, Messenger/genetics
Chemical Substances	RNA, Messenger
Language	English
Publishing date	2023-08-27
Publishing country	England
Document type	Journal Article
ZDB-ID	128412-5
ISSN	2047-7163 ; 0036-8504 ; 0302-1785
ISSN (online)	2047-7163
ISSN	0036-8504 ; 0302-1785
DOI	10.1177/00368504231195500
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Article ; Online: Alleviative Effect of Geniposide on Lipopolysaccharide-Stimulated Macrophages via Calcium Pathway.

Kim, Hyun-Ju / Park, Wansu

International journal of molecular sciences

2024 Volume 25, Issue 3

Abstract: In this study, we investigated how geniposide (a bioactive ingredient of gardenia fruit) acts on lipopolysaccharide (LPS)-stimulated macrophages. Griess reagent assay, Fluo-4 calcium assay, dihydrorhodamine 123 assay, multiplex cytokine assay, ... ...

Abstract	In this study, we investigated how geniposide (a bioactive ingredient of gardenia fruit) acts on lipopolysaccharide (LPS)-stimulated macrophages. Griess reagent assay, Fluo-4 calcium assay, dihydrorhodamine 123 assay, multiplex cytokine assay, quantitative RT-PCR, and flow cytometry assay were used for this study. Data showed that geniposide at concentrations of 10, 25, and 50 μM reduced significantly the levels of nitric oxide, intracellular Ca
MeSH term(s)	Humans ; Lipopolysaccharides/pharmacology ; Lipopolysaccharides/metabolism ; Calcium/metabolism ; Macrophages/metabolism ; Cytokines/metabolism ; Nitric Oxide/metabolism ; NF-kappa B/metabolism ; Inflammation/metabolism ; Iridoids
Chemical Substances	Lipopolysaccharides ; Calcium (SY7Q814VUP) ; geniposide (145295QLXY) ; Cytokines ; Nitric Oxide (31C4KY9ESH) ; NF-kappa B ; Iridoids
Language	English
Publishing date	2024-01-31
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2019364-6
ISSN	1422-0067 ; 1422-0067 ; 1661-6596
ISSN (online)	1422-0067
ISSN	1422-0067 ; 1661-6596
DOI	10.3390/ijms25031728
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Article ; Online: Enhancing Safety in Tumescent Liposuction: Managing Sedation-Related Respiratory Issues and Serious Complications Under Deep Sedation with the Propofol-Ketamine Protocol.

Kim, Eun Ju / Kim, Hyunju / Park, Younchan

Aesthetic plastic surgery

2024

Abstract: Background: Over the past 4 years, aesthetic surgery, notably liposuction, has substantially increased. Tumescent liposuction, a popular technique, has two variants-true tumescent liposuction (TTL) and semi-tumescent liposuction. While TTL reduces risks, ...

Abstract	Background: Over the past 4 years, aesthetic surgery, notably liposuction, has substantially increased. Tumescent liposuction, a popular technique, has two variants-true tumescent liposuction (TTL) and semi-tumescent liposuction. While TTL reduces risks, it has limitations. There is no literature reported on semi-tumescent liposuction under deep sedation using the propofol-ketamine protocol, which is proposed as a potentially safe alternative. Methods: The retrospective analysis covered 8 years and included 3094 patients performed for tumescent liposuction under deep sedation, utilizing the propofol-ketamine protocol. The evaluation of patient safety involved an examination of potential adverse events with a specific focus on respiratory issues related to sedation, including instances of mask ventilation. Results: Among the 3094 cases, no fatalities were recorded. Noteworthy events included 43 mask ventilation instances, primarily occurring in the initial 10 min. Twelve cases experienced surgery cancellation due to various factors, including respiratory issues. Three patients were transferred to upper-level hospitals, while another three required blood transfusions. Vigilant management prevented significant complications, and other adverse events like venous thromboembolism (VTE), fat embolism, severe lidocaine toxicity, and so on were not observed. Conclusions: The analysis of 3094 tumescent liposuction cases highlighted the overall safety profile of the propofol-ketamine protocol under deep sedation. The scarcity of severe complications underscores its viability. The study emphasizes the significance of thorough preoperative assessments, careful patient selection, and awareness of potential complications. Prompt interventions, particularly in addressing sedation-related respiratory issues, further contribute to positive outcomes for patients. Level of evidence iv: This journal requires that authors assign a level of evidence to each article. For a full description of these Evidence-Based Medicine ratings, please refer to the Table of Contents or the online Instructions to Authors www.springer.com/00266 .
Language	English
Publishing date	2024-03-27
Publishing country	United States
Document type	Journal Article
ZDB-ID	532791-x
ISSN	1432-5241 ; 0364-216X
ISSN (online)	1432-5241
ISSN	0364-216X
DOI	10.1007/s00266-024-03963-w
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Article ; Online: Multimodal neural correlates of dispositional resilience among healthy individuals.

Kim, Hyun-Ju / Bang, Minji / Pae, Chongwon / Lee, Sang-Hyuk

Scientific reports

2024 Volume 14, Issue 1, Page(s) 9875

Abstract: Resilient individuals are less likely to develop psychiatric disorders despite extreme psychological distress. This study investigated the multimodal structural neural correlates of dispositional resilience among healthy individuals. Participants ... ...

Abstract	Resilient individuals are less likely to develop psychiatric disorders despite extreme psychological distress. This study investigated the multimodal structural neural correlates of dispositional resilience among healthy individuals. Participants included 92 healthy individuals. The Korean version of the Connor-Davidson Resilience Scale and other psychological measures were used. Gray matter volumes (GMVs), cortical thickness, local gyrification index (LGI), and white matter (WM) microstructures were analyzed using voxel-based morphometry, FreeSurfer, and tract-based spatial statistics, respectively. Higher resilient individuals showed significantly higher GMVs in the inferior frontal gyrus (IFG), increased LGI in the insula, and lower fractional anisotropy values in the superior longitudinal fasciculus II (SLF II). These resilience's neural correlates were associated with good quality of life in physical functioning or general health and low levels of depression. Therefore, the GMVs in the IFG, LGI in the insula, and WM microstructures in the SLF II can be associated with resilience that contributes to emotional regulation, empathy, and social cognition.
MeSH term(s)	Humans ; Male ; Female ; Resilience, Psychological ; Adult ; Gray Matter/diagnostic imaging ; Gray Matter/physiology ; Gray Matter/anatomy & histology ; White Matter/diagnostic imaging ; White Matter/physiology ; Young Adult ; Magnetic Resonance Imaging ; Healthy Volunteers ; Brain/physiology ; Brain/diagnostic imaging ; Quality of Life
Language	English
Publishing date	2024-04-30
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-024-60619-0
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Article ; Online: Algae development in rivers with artificially constructed weirs: Dominant influence of discharge over temperature.

Kim, Hyunju / Lee, Gyesik / Lee, Chang-Gu / Park, Seong-Jik

Journal of environmental management

2024 Volume 355, Page(s) 120551

Abstract: Algal blooms contribute to water quality degradation, unpleasant odors, taste issues, and the presence of harmful substances in artificially constructed weirs. Mitigating these adverse effects through effective algal bloom management requires identifying ...

Abstract	Algal blooms contribute to water quality degradation, unpleasant odors, taste issues, and the presence of harmful substances in artificially constructed weirs. Mitigating these adverse effects through effective algal bloom management requires identifying the contributing factors and predicting algal concentrations. This study focused on the upstream region of the Seungchon Weir in Korea, which is characterized by elevated levels of total nitrogen and phosphorus due to a significant influx of water from a sewage treatment plant. We employed four distinct machine learning models to predict chlorophyll-a (Chl-a) concentrations and identified the influential variables linked to local algal bloom events. The gradient boosting model enabled an in-depth exploration of the intricate relationships between algal occurrence and water quality parameters, enabling accurate identification of the causal factors. The models identified the discharge flow rate (D-Flow) and water temperature as the primary determinants of Chl-a levels, with feature importance values of 0.236 and 0.212, respectively. Enhanced model precision was achieved by utilizing daily average D-Flow values, with model accuracy and significance of the D-Flow amplifying as the temporal span of daily averaging increased. Elevated Chl-a concentrations correlated with diminished D-Flow and temperature, highlighting the pivotal role of D-Flow in regulating Chl-a concentration. This trend can be attributed to the constrained discharge of the Seungchon Weir during winter. Calculating the requisite D-Flow to maintain a desirable Chl-a concentration of up to 20 mg/m
MeSH term(s)	Rivers ; Temperature ; Environmental Monitoring ; Chlorophyll A ; Chlorophyll/analysis ; Water Quality ; Eutrophication ; Nitrogen/analysis ; Phosphorus/analysis ; China
Chemical Substances	Chlorophyll A (YF5Q9EJC8Y) ; Chlorophyll (1406-65-1) ; Nitrogen (N762921K75) ; Phosphorus (27YLU75U4W)
Language	English
Publishing date	2024-03-09
Publishing country	England
Document type	Journal Article
ZDB-ID	184882-3
ISSN	1095-8630 ; 0301-4797
ISSN (online)	1095-8630
ISSN	0301-4797
DOI	10.1016/j.jenvman.2024.120551
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Article ; Online: Moutan Cortex Extract Modulates Macrophage Activation via Lipopolysaccharide-Induced Calcium Signaling and ER Stress-CHOP Pathway.

Kim, Hyun-Ju / Kim, Do-Hoon / Park, Wansu

International journal of molecular sciences

2023 Volume 24, Issue 3

Abstract: Moutan Cortex, ...

Abstract	Moutan Cortex,
MeSH term(s)	Animals ; Mice ; Calcium/metabolism ; Calcium Signaling ; Cytokines/metabolism ; Hydrogen Peroxide/metabolism ; Lipopolysaccharides/pharmacology ; Lipopolysaccharides/metabolism ; Macrophage Activation ; Macrophages/metabolism ; NF-kappa B/metabolism ; Nitric Oxide/metabolism ; Paeonia/metabolism ; RAW 264.7 Cells ; Endoplasmic Reticulum Stress
Chemical Substances	Calcium (SY7Q814VUP) ; Cytokines ; Hydrogen Peroxide (BBX060AN9V) ; Lipopolysaccharides ; moutan cortex ; NF-kappa B ; Nitric Oxide (31C4KY9ESH)
Language	English
Publishing date	2023-01-20
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2019364-6
ISSN	1422-0067 ; 1422-0067 ; 1661-6596
ISSN (online)	1422-0067
ISSN	1422-0067 ; 1661-6596
DOI	10.3390/ijms24032062
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Article: Functional Role of Phospholipase D in Bone Metabolism.

Kim, Hyun-Ju / Lee, Dong-Kyo / Choi, Je-Yong

Journal of bone metabolism

2023 Volume 30, Issue 2, Page(s) 117–125

Abstract: Phospholipase D (PLD) proteins are major enzymes that regulate various cellular functions, such as cell growth, cell migration, membrane trafficking, and cytoskeletal dynamics. As they are responsible for such important biological functions, PLD proteins ...

Abstract	Phospholipase D (PLD) proteins are major enzymes that regulate various cellular functions, such as cell growth, cell migration, membrane trafficking, and cytoskeletal dynamics. As they are responsible for such important biological functions, PLD proteins have been considered promising therapeutic targets for various diseases, including cancer and vascular and neurological diseases. Intriguingly, emerging evidence indicates that PLD1 and PLD2, 2 major mammalian PLD isoenzymes, are the key regulators of bone remodeling; this suggests that these isozymes could be used as potential therapeutic targets for bone diseases, such as osteoporosis and rheumatoid arthritis. PLD1 or PLD2 deficiency in mice can lead to decreased bone mass and dysregulated bone homeostasis. Although both mutant mice exhibit similar skeletal phenotypes, PLD1 and PLD2 play distinct and nonredundant roles in bone cell function. This review summarizes the physiological roles of PLD1 and PLD2 in bone metabolism, focusing on recent findings of the biological functions and action mechanisms of PLD1 and PLD2 in bone cells.
Language	English
Publishing date	2023-05-31
Publishing country	Korea (South)
Document type	Journal Article
ZDB-ID	2765291-9
ISSN	2287-7029 ; 2287-6375
ISSN (online)	2287-7029
ISSN	2287-6375
DOI	10.11005/jbm.2023.30.2.117
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Article ; Online: Experiences Pertaining to Successful Aging in Middle-Aged Women in South Korea.

Lee, Do-Young / Kim, Hyun-Ju / Jo, A-Young

International journal of environmental research and public health

2023 Volume 20, Issue 19

Abstract: This study aimed to analyze and gain an in-depth understanding of the experiences pertaining to successful aging in middle-aged women in South Korea. A sample of 12 middle-aged women, capable of sharing their lived experiences, was divided into three age- ...

Abstract	This study aimed to analyze and gain an in-depth understanding of the experiences pertaining to successful aging in middle-aged women in South Korea. A sample of 12 middle-aged women, capable of sharing their lived experiences, was divided into three age-based groups: those in their 40s, those in their 50s, and those aged 60-65 years. The collected data were analyzed using Colaizzi's phenomenological method. Five theme clusters and ten themes emerged. The experiences of successful aging among middle-aged women were categorized as: "Coping with changes in the mind and body", "Financially stable life", "Undergoing the aging process with a healthy family", "Preparations for dying well", and "Pursuing a meaningful, harmonious life". These findings highlight the need for programs that prepare middle-aged women to positively accept and enjoy older adulthood by identifying and addressing the factors essential for successful aging and reducing any negative emotions attached to aging and older adulthood.
MeSH term(s)	Middle Aged ; Humans ; Female ; Aged ; Aging/psychology ; Republic of Korea ; Adaptation, Psychological ; Data Collection ; Qualitative Research
Language	English
Publishing date	2023-10-04
Publishing country	Switzerland
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2175195-X
ISSN	1660-4601 ; 1661-7827
ISSN (online)	1660-4601
ISSN	1661-7827
DOI	10.3390/ijerph20196882
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Article ; Online: Hypoxia enhances the hair growth-promoting effects of embryonic stem cell-derived mesenchymal stem cells via NADPH oxidase 4.

Jeon, Seng-Ho / Kim, Hyunju / Sung, Jong-Hyuk

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie

2023 Volume 159, Page(s) 114303

Abstract: Human embryonic stem cell (hES)-derived mesenchymal stem cells (-MSCs) are an unlimited source of MSCs. The hair growth-promoting effects of diverse MSCs have been reported, but not that of hES-MSCs. In the present study, we investigated the hair growth- ... ...

Abstract	Human embryonic stem cell (hES)-derived mesenchymal stem cells (-MSCs) are an unlimited source of MSCs. The hair growth-promoting effects of diverse MSCs have been reported, but not that of hES-MSCs. In the present study, we investigated the hair growth-promoting effects of hES-MSCs and their underlying mechanisms. hES-MSCs or conditioned medium of hES-MSCs exhibited hair-growth effects, which increased the length of mouse vibrissae and human hair follicles. hES-MSCs accelerated the telogen-to-anagen transition in C3H mice and were more effective than adipose-derived stem cells. We further examined whether hypoxia could enhance the hair-growth promoting effects of hES-MSCs. The injection of hES-MSCs or conditioned medium (Hyp-CM) cultured under hypoxia (2% O
MeSH term(s)	Humans ; Animals ; Mice ; NADPH Oxidase 4/metabolism ; Reactive Oxygen Species/metabolism ; Culture Media, Conditioned/pharmacology ; Culture Media, Conditioned/metabolism ; Mice, Inbred C3H ; Cell Proliferation ; Hair Follicle/metabolism ; Mesenchymal Stem Cells/metabolism ; Embryonic Stem Cells/metabolism ; Intercellular Signaling Peptides and Proteins/metabolism ; Hypoxia/metabolism ; Cells, Cultured
Chemical Substances	NADPH Oxidase 4 (EC 1.6.3.-) ; Reactive Oxygen Species ; Culture Media, Conditioned ; Intercellular Signaling Peptides and Proteins
Language	English
Publishing date	2023-01-25
Publishing country	France
Document type	Journal Article
ZDB-ID	392415-4
ISSN	1950-6007 ; 0753-3322 ; 0300-0893
ISSN (online)	1950-6007
ISSN	0753-3322 ; 0300-0893
DOI	10.1016/j.biopha.2023.114303
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