Article ; Online: Association Between Clinicopathological Parameters and S100A8/A9 Expression According to Smoking History in Patients With Non-small Cell Lung Cancer.
2023 Volume 38, Issue 1, Page(s) 474–481
Abstract: Background/aim: Lung cancer is a major cause of cancer-related deaths worldwide, and chronic inflammation caused by cigarette smoke plays a crucial role in the development and progression of this disease. S100A8/9 and RAGE are associated with chronic ... ...
| Abstract | Background/aim: Lung cancer is a major cause of cancer-related deaths worldwide, and chronic inflammation caused by cigarette smoke plays a crucial role in the development and progression of this disease. S100A8/9 and RAGE are associated with chronic inflammatory diseases and cancer. This study aimed to investigate the expression of S100A8/9, HMBG1, and other related pro-inflammatory molecules and clinical characteristics in patients with non-small cell lung cancer (NSCLC). Patients and methods: We obtained serum and bronchoalveolar lavage (BAL) fluid samples from 107 patients and categorized them as never or ever-smokers. We measured the levels of S100A8/9, RAGE, and HMGB1 in the collected samples using enzyme-linked immunosorbent kits. Immunohistochemical staining was also performed to assess the expression of S100A8/9, CD11b, and CD8 in lung cancer tissues. The correlation between the expression of these proteins and the clinical characteristics of patients with NSCLC was also explored. Results: The expression of S100A8/A9, RAGE, and HMGB was significantly correlated with smoking status and was higher in people with a history of smoking or who were currently smoking. There was a positive correlation between serum and BAL fluid S100A8/9 levels. The expression of S100A8/A9 and CD8 in lung tumor tissues was significantly correlated with smoking history in patients with NSCLC. Ever-smokers, non-adenocarcinoma histology, and high PD-L1 expression were significant factors predicting high serum S100A8/9 levels in multivariate analysis. Conclusion: The S100A8/9-RAGE pathway and CD8 expression were increased in smoking-related NSCLC patients. The S100A8/9-RAGE pathway could be a promising biomarker for chronic airway inflammation and carcinogenesis in smoking-related lung diseases. |
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| MeSH term(s) | Humans ; Calgranulin A/genetics ; Calgranulin A/metabolism ; Calgranulin B/genetics ; Calgranulin B/metabolism ; Carcinoma, Non-Small-Cell Lung/genetics ; Inflammation ; Lung Neoplasms/etiology ; Lung Neoplasms/genetics ; Receptor for Advanced Glycation End Products/genetics ; Receptor for Advanced Glycation End Products/metabolism ; Smoking/adverse effects |
| Chemical Substances | Calgranulin A ; Calgranulin B ; Receptor for Advanced Glycation End Products |
| Language | English |
| Publishing date | 2023-12-26 |
| Publishing country | Greece |
| Document type | Journal Article |
| ZDB-ID | 807031-3 |
| ISSN | 1791-7549 ; 0258-851X |
| ISSN (online) | 1791-7549 |
| ISSN | 0258-851X |
| DOI | 10.21873/invivo.13462 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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