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Article ; Online: Characteristics of a "rebound" in smoking after a tobacco price increase.

Jung, J W / Kim, J Y

The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease

2020 Volume 24, Issue 4, Page(s) 390–395

Abstract: SETTING: ...

Abstract	SETTING:
MeSH term(s)	Commerce ; Female ; Humans ; Male ; Nutrition Surveys ; Republic of Korea/epidemiology ; Smoking/epidemiology ; Smoking Cessation ; Nicotiana ; Tobacco Products
Language	English
Publishing date	2020-04-21
Publishing country	France
Document type	Journal Article
ZDB-ID	1385624-8
ISSN	1815-7920 ; 1027-3719
ISSN (online)	1815-7920
ISSN	1027-3719
DOI	10.5588/ijtld.19.0318
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Zs.A 4776: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MO 261: Show issues

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Article ; Online: Lung function decline in non-tuberculous mycobacterial pulmonary disease according to disease severity.

Park, H-J / Kim, J-Y / Kim, H-J / Yim, J-J / Kwak, N

The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease

2023 Volume 27, Issue 6, Page(s) 465–470

Abstract: BACKGROUND: ...

Abstract	BACKGROUND:
MeSH term(s)	Humans ; Lung ; Nontuberculous Mycobacteria ; Lung Diseases ; Forced Expiratory Volume ; Vital Capacity ; Patient Acuity ; Pulmonary Diffusing Capacity
Language	English
Publishing date	2023-05-26
Publishing country	France
Document type	Journal Article
ZDB-ID	1385624-8
ISSN	1815-7920 ; 1027-3719
ISSN (online)	1815-7920
ISSN	1027-3719
DOI	10.5588/ijtld.22.0616
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Zs.A 4776: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MO 261: Show issues

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Article ; Online: Detection of novel drug-adverse drug reaction signals in rheumatoid arthritis and ankylosing spondylitis: analysis of Korean real-world biologics registry data.

Kwon, M / Joung, C I / Shin, H / Lee, C C / Song, Y S / Lee, Y J / Kang, S / Kim, J Y / Lee, S

Scientific reports

2024 Volume 14, Issue 1, Page(s) 2660

Abstract: This study aimed to detect signals of adverse drug reactions (ADRs) associated with biological disease-modifying antirheumatic drugs (DMARDs) and targeted therapies in rheumatoid arthritis (RA) and ankylosing spondylitis (AS) patients. Utilizing the ... ...

Abstract	This study aimed to detect signals of adverse drug reactions (ADRs) associated with biological disease-modifying antirheumatic drugs (DMARDs) and targeted therapies in rheumatoid arthritis (RA) and ankylosing spondylitis (AS) patients. Utilizing the KOrean College of Rheumatology BIOlogics & Targeted Therapy Registry (KOBIO) data, we calculated relative risks, excluded previously reported drug-ADR pairs, and externally validated remaining pairs using US Food and Drug Administration (FDA) Adverse Event Reporting System (FAERS) and single centre's electronic health records (EHR) data. Analyzing data from 2279 RA and 1940 AS patients, we identified 35 significant drug-ADR pairs in RA and 26 in AS, previously unreported in drug labels. Among the novel drug-ADR pairs from KOBIO, 15 were also significant in the FAERS data. Additionally, 2 significant drug-laboratory abnormality pairs were found in RA using CDM MetaLAB analysis. Our findings contribute to the identification of 14 novel drug-ADR signals, expanding our understanding of potential adverse effects related to biological DMARDs and targeted therapies in RA and AS. These results emphasize the importance of ongoing pharmacovigilance for patient safety and optimal therapeutic interventions.
MeSH term(s)	Humans ; Spondylitis, Ankylosing/drug therapy ; Spondylitis, Ankylosing/chemically induced ; Pharmaceutical Preparations ; Routinely Collected Health Data ; Arthritis, Rheumatoid/drug therapy ; Arthritis, Rheumatoid/chemically induced ; Antirheumatic Agents/adverse effects ; Registries ; Drug-Related Side Effects and Adverse Reactions/epidemiology ; Biological Products/adverse effects ; Republic of Korea/epidemiology
Chemical Substances	Pharmaceutical Preparations ; Antirheumatic Agents ; Biological Products
Language	English
Publishing date	2024-02-01
Publishing country	England
Document type	Journal Article
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-024-52822-w
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Article ; Online: Ameliorating effect of 2'-Fucosyllactose and 6'-Sialyllactose on lipopolysaccharide-induced intestinal inflammation.

Kim, J-Y / Lee, S / Kim, G / Shin, H J / Lee, E J / Lee, C S / Yoon, S / Lee, E / Lim, A / Kim, S H

Journal of dairy science

2024

Abstract: Human milk oligosaccharides (HMO) affect gut microbiota during neonatal development, particularly with respect to the immune system. Bovine milk-based infant formulas have low oligosaccharide contents. Thus, efforts to fortify infant formulas with HMO ... ...

Abstract	Human milk oligosaccharides (HMO) affect gut microbiota during neonatal development, particularly with respect to the immune system. Bovine milk-based infant formulas have low oligosaccharide contents. Thus, efforts to fortify infant formulas with HMO are being undertaken. Two major HMO, 2'-fucosyllactose (2'-FL) and 6'-sialyllactose (6'-SL), exert anti-inflammatory effects; however, the associations between anti-inflammatory effects induced by 2'-FL and 6'-SL co-treatment and gut microbiota composition and metabolite modulation remain unclear. Therefore, in this study, we evaluated the effects of a mixture of these HMO. To determine the optimal HMO ratio for anti-inflammatory effects and elucidate its mode of action, LPS-induced inflammatory HT-29 epithelial cells and intestinal inflamed suckling mice were treated with various mixtures of 2'-FL and 6'-SL. 2'-FL:6'-SL ratio of 5:1 was identified as the most effective pre-treatment HMO mixture in vitro; thus, this ratio was selected and used for low, middle, and high-dose treatments for subsequent in vivo studies. In vivo, high-dose HMO treatment restored LPS-induced inflammation symptoms, such as body weight loss, colon length reduction, histological structural damage, and intestinal gene expression related to inflammatory responses. High-dose HMO was the only treatment that modulated the major phyla Bacteroidetes and Firmicutes and the genera Ihubacter, Mageeibacillus, and Saccharofermentans. These changes in microbial composition were correlated with intestinal inflammation-related gene expression and short-chain fatty acid production. To our knowledge, our study is the first to report the effects of Ihubacter, Mageeibacillus, and Saccharofermentans on short chain fatty acid levels, which can subsequently affect inflammatory cytokine and tight junction protein levels. Conclusively, the HMO mixture exerted anti-inflammatory effects through changes in microbiota and metabolite production. These findings suggested that supplementation of infant formula with HMO may benefit formula-fed infants by forming unique microbiota contributing to neonatal development.
Language	English
Publishing date	2024-03-13
Publishing country	United States
Document type	Journal Article
ZDB-ID	242499-x
ISSN	1525-3198 ; 0022-0302
ISSN (online)	1525-3198
ISSN	0022-0302
DOI	10.3168/jds.2024-24325
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Zs.B 810: Show issues

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Article: Generation of Transgenic Napier Grass (Cenchrus purpureus Schum.) Plants by Biolistic Gene Transfer of a Minimal Expression Cassette

Faleiro, F. G. / Kim, J. Y. / Parikh, A. / Altpeter, F.

Tropical plant biology. 2021 Dec., v. 14, no. 4

2021

Abstract: Napier grass (Cenchrus purpureus Schum.) is one of the highest yielding tropical C4 forage grasses and a promising candidate feedstock for the production of biofuel. Genetic engineering and genome editing have tremendous potential for crop improvement ... ...

Abstract	Napier grass (Cenchrus purpureus Schum.) is one of the highest yielding tropical C4 forage grasses and a promising candidate feedstock for the production of biofuel. Genetic engineering and genome editing have tremendous potential for crop improvement and require the establishment of a transformation protocol. In this study, transgenic Napier grass was generated by introducing a minimal cassette (MC) encoding the antibiotic resistance gene nptII with biolistic gene transfer into embryogenic callus. Paromomycin was superior to geneticin as a selective agent in the selection of transgenic calli. Two high-biomass producing Napier grass accessions were successfully transformed. Southern blot analysis revealed simple transgene integration patterns with 33% of the regenerated transgenic lines having a single insert of the minimal transgene expression cassette. NPTII-ELISA confirmed transgene expression in all transgenic lines. The results of this study will enable the acceleration of Napier grass improvement by genetic transformation or genome editing.
Keywords	Cenchrus purpureus ; Southern blotting ; antibiotic resistance genes ; biofuels ; biolistics ; callus ; feedstocks ; gene expression ; genetic transformation ; genetically modified organisms ; geneticin ; transgenes ; tropical plants
Language	English
Dates of publication	2021-12
Size	p. 371-380.
Publishing place	Springer US
Document type	Article
ZDB-ID	2455624-5
ISSN	1935-9764 ; 1935-9756
ISSN (online)	1935-9764
ISSN	1935-9756
DOI	10.1007/s12042-021-09298-z
Database	NAL-Catalogue (AGRICOLA)

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Article: Air jet attrition measurements at hot conditions of oxygen carriers for chemical looping combustion

Mendiara, T. / García-Labiano, F. / Abad, A. / Knittler, D. / Kim, J.Y. / Ellis, N.

Powder technology. 2021 Nov., v. 392

2021

Abstract: The attrition behaviour of several promising oxygen carriers tested in Chemical Looping Combustion (CLC) units has been evaluated using an air-jet apparatus based on ASTM D5757 at 20 and 800 °C. Results were evaluated to determine a general testing ... ...

Abstract	The attrition behaviour of several promising oxygen carriers tested in Chemical Looping Combustion (CLC) units has been evaluated using an air-jet apparatus based on ASTM D5757 at 20 and 800 °C. Results were evaluated to determine a general testing procedure that allows estimating the adequacy at working temperature of a potential oxygen carrier. For both fresh and used oxygen carriers, attrition was lower when the temperature of the Air Jet attrition Index (AJI) test was increased. Thus, tests with potential oxygen carriers must be performed close to the temperature they are planned to be used to obtain reliable information. Results indicated that used oxygen carriers with AJI value at hot conditions between 1 and 2% showed long lifetimes under continuous CLC operation.
Keywords	air ; air temperature ; combustion ; oxygen ; technology
Language	English
Dates of publication	2021-11
Size	p. 661-671.
Publishing place	Elsevier B.V.
Document type	Article
ISSN	0032-5910
DOI	10.1016/j.powtec.2021.07.038
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Vertical height augmentation genioplasty using autogenous bone harvested from proximal segments after vertical ramus osteotomy.

Kim, J-Y / Kim, J-K / Park, J H / Jung, Y-S

The British journal of oral & maxillofacial surgery

2020 Volume 58, Issue 9, Page(s) e124–e126

MeSH term(s)	Alveolar Ridge Augmentation ; Genioplasty ; Mandible/surgery ; Osteotomy, Sagittal Split Ramus
Language	English
Publishing date	2020-07-04
Publishing country	Scotland
Document type	Journal Article
ZDB-ID	605685-4
ISSN	1532-1940 ; 0266-4356
ISSN (online)	1532-1940
ISSN	0266-4356
DOI	10.1016/j.bjoms.2020.06.026
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Uk I Zs.238: Show issues

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Article ; Online: Comparison of Dynamic Contrast-Enhancement Parameters between Gadobutrol and Gadoterate Meglumine in Posttreatment Glioma: A Prospective Intraindividual Study.

Park, J E / Kim, J Y / Kim, H S / Shim, W H

AJNR. American journal of neuroradiology

2020 Volume 41, Issue 11, Page(s) 2041–2048

Abstract: Background and purpose: Differences in molecular properties between one-molar and half-molar gadolinium-based contrast agents are thought to affect parameters obtained from dynamic contrast-enhanced imaging. The aim of our study was to investigate ... ...

Abstract	Background and purpose: Differences in molecular properties between one-molar and half-molar gadolinium-based contrast agents are thought to affect parameters obtained from dynamic contrast-enhanced imaging. The aim of our study was to investigate differences in dynamic contrast-enhanced parameters between one-molar nonionic gadobutrol and half-molar ionic gadoterate meglumine in patients with posttreatment glioma. Materials and methods: This prospective study enrolled 32 patients who underwent 2 20-minute dynamic contrast-enhanced examinations, one with gadobutrol and one with gadoterate meglumine. The model-free parameter of area under the signal intensity curve from 30 to 1100 seconds and the Tofts model-based pharmacokinetic parameters were calculated and compared intraindividually using paired Results: Gadobutrol and gadoterate meglumine did not show any significant differences in the area under the signal intensity curve or pharmacokinetic parameters of Conclusions: Model-free and pharmacokinetic parameters did not show any significant differences between the 2 gadolinium-based contrast agents, except for a higher wash-in rate with gadobutrol and a higher washout rate with gadoterate meglumine, supporting the interchangeable use of gadolinium-based contrast agents for dynamic contrast-enhanced imaging in patients with posttreatment glioma.
MeSH term(s)	Adult ; Aged ; Contrast Media/pharmacokinetics ; Female ; Glioma/diagnostic imaging ; Humans ; Image Interpretation, Computer-Assisted/methods ; Magnetic Resonance Imaging/methods ; Male ; Meglumine/pharmacokinetics ; Middle Aged ; Organometallic Compounds/pharmacokinetics ; Prospective Studies ; Reproducibility of Results ; Young Adult
Chemical Substances	Contrast Media ; Organometallic Compounds ; gadobutrol (1BJ477IO2L) ; Meglumine (6HG8UB2MUY) ; gadoterate meglumine (L0ND3981AG)
Language	English
Publishing date	2020-10-15
Publishing country	United States
Document type	Comparative Study ; Journal Article ; Randomized Controlled Trial ; Research Support, Non-U.S. Gov't
ZDB-ID	603808-6
ISSN	1936-959X ; 0195-6108
ISSN (online)	1936-959X
ISSN	0195-6108
DOI	10.3174/ajnr.A6792
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Zs.A 1580: Show issues

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Article ; Online: Blood high mobility group box 1 levels are not a suitable biomarker for disease activity or severity in nonsegmental vitiligo.

Park, S / Lee, E J / Kim, J Y / Bae, Y J / Oh, S H

Clinical and experimental dermatology

2021 Volume 46, Issue 8, Page(s) 1597–1599

MeSH term(s)	Adult ; Biomarkers/blood ; Female ; HMGB1 Protein/blood ; Humans ; Male ; Middle Aged ; Severity of Illness Index ; Vitiligo/blood ; Vitiligo/classification
Chemical Substances	Biomarkers ; HMGB1 Protein ; HMGB1 protein, human
Language	English
Publishing date	2021-07-17
Publishing country	England
Document type	Letter
ZDB-ID	195504-4
ISSN	1365-2230 ; 0307-6938
ISSN (online)	1365-2230
ISSN	0307-6938
DOI	10.1111/ced.14782
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Article: Clinical effectiveness of house dust mite immunotherapy in mono- versus poly-sensitised patients with allergic rhinitis: a systematic review and meta-analysis.

Kim, J Y / Hwang, D / Jang, M / Rhee, C S / Han, D H

Rhinology

2021 Volume 59, Issue 4, Page(s) 352–359

Abstract: Selecting an appropriate allergen-specific immunotherapy (AIT) regimen for polysensitised allergic rhinitis (AR) patients is challenging for clinicians. Although previous studies showed comparable effectiveness of single-allergen AIT with house dust mite ...

Abstract	Selecting an appropriate allergen-specific immunotherapy (AIT) regimen for polysensitised allergic rhinitis (AR) patients is challenging for clinicians. Although previous studies showed comparable effectiveness of single-allergen AIT with house dust mite (HDM) extract between monosensitised and polysensitised AR patients, there is no systematic review and meta-analysis demonstrating the comparable effectiveness of HDM AIT. In this meta-analysis, we analysed nine studies to compare the clinical effectiveness of HDM AIT. The primary outcome was nasal symptom score and secondary outcomes were medication and quality of life scores. The changes in nasal symptom score after HDM AIT did not significantly differ between monosensitised and polysensitised patients. The clinical effectiveness of HDM AIT regarding medication and quality of life score was not significantly different between monosensitised and polysensitised patients). In conclusion, single-allergen AIT with HDM extract showed comparable clinical effectiveness between polysensitised and monosensitised patients with AR.
MeSH term(s)	Animals ; Desensitization, Immunologic ; Humans ; Pyroglyphidae ; Quality of Life ; Rhinitis, Allergic/therapy ; Sublingual Immunotherapy ; Treatment Outcome
Language	English
Publishing date	2021-06-27
Publishing country	Netherlands
Document type	Journal Article ; Meta-Analysis ; Systematic Review
ZDB-ID	80336-4
ISSN	0300-0729
ISSN	0300-0729
DOI	10.4193/Rhin20.588
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