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Article ; Online: Cytosolic zinc mediates the cytotoxicity of thiol-reactive electrophiles in rat vascular smooth muscle cells.

Park, Jung-Min / Park, Suin / Seo, Yoon-Seok / Kim, Jae-Hyeong / Lee, Moo-Yeol

Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association

2024 Volume 185, Page(s) 114446

Abstract: The aberrant increase or dysregulation of cytosolic ... ...

Abstract	The aberrant increase or dysregulation of cytosolic Zn
MeSH term(s)	Rats ; Animals ; Sulfhydryl Compounds/metabolism ; Zinc/metabolism ; Muscle, Smooth, Vascular/metabolism ; Cytosol ; Acids/metabolism ; Ethylenediamines
Chemical Substances	N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine (R9PTU1U29I) ; Sulfhydryl Compounds ; Zinc (J41CSQ7QDS) ; Acids ; Ethylenediamines
Language	English
Publishing date	2024-01-18
Publishing country	England
Document type	Journal Article
ZDB-ID	782617-5
ISSN	1873-6351 ; 0278-6915
ISSN (online)	1873-6351
ISSN	0278-6915
DOI	10.1016/j.fct.2024.114446
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Zs.A 529: Show issues

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Article: Cigarette Smoke-Induced Reactive Oxygen Species Formation: A Concise Review.

Seo, Yoon-Seok / Park, Jung-Min / Kim, Jae-Hyeong / Lee, Moo-Yeol

Antioxidants (Basel, Switzerland)

2023 Volume 12, Issue 9

Abstract: Smoking is recognized as a significant risk factor for numerous disorders, including cardiovascular diseases, respiratory conditions, and various forms of cancer. While the exact pathogenic mechanisms continue to be explored, the induction of oxidative ... ...

Abstract	Smoking is recognized as a significant risk factor for numerous disorders, including cardiovascular diseases, respiratory conditions, and various forms of cancer. While the exact pathogenic mechanisms continue to be explored, the induction of oxidative stress via the production of excess reactive oxygen species (ROS) is widely accepted as a primary molecular event that predisposes individuals to these smoking-related ailments. This review focused on how cigarette smoke (CS) promotes ROS formation rather than the pathophysiological repercussions of ROS and oxidative stress. A comprehensive analysis of existing studies revealed the following key ways through which CS imposes ROS burden on biological systems: (1) ROS, as well as radicals, are intrinsically present in CS, (2) CS constituents generate ROS through chemical reactions with biomolecules, (3) CS stimulates cellular ROS sources to enhance production, and (4) CS disrupts the antioxidant system, aggravating the ROS generation and its functions. While the evidence supporting these mechanisms is chiefly based on in vitro and animal studies, the direct clinical relevance remains to be fully elucidated. Nevertheless, this understanding is fundamental for deciphering molecular events leading to oxidative stress and for developing intervention strategies to counter CS-induced oxidative stress.
Language	English
Publishing date	2023-09-07
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2704216-9
ISSN	2076-3921
ISSN	2076-3921
DOI	10.3390/antiox12091732
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Article ; Online: NCAPH Stabilizes GEN1 in Chromatin to Resolve Ultra-Fine DNA Bridges and Maintain Chromosome Stability.

Kim, Jae Hyeong / Youn, Yuna / Hwang, Jin-Hyeok

Molecules and cells

2022 Volume 45, Issue 11, Page(s) 792–805

Abstract: Repairing damaged DNA and removing all physical connections between sister chromosomes is important to ensure proper chromosomal segregation by contributing to chromosomal stability. Here, we show that the depletion of non-SMC condensin I complex subunit ...

Abstract	Repairing damaged DNA and removing all physical connections between sister chromosomes is important to ensure proper chromosomal segregation by contributing to chromosomal stability. Here, we show that the depletion of non-SMC condensin I complex subunit H (NCAPH) exacerbates chromosome segregation errors and cytokinesis failure owing to sister-chromatid intertwinement, which is distinct from the ultra-fine DNA bridges induced by DNA inter-strand crosslinks (DNA-ICLs). Importantly, we identified an interaction between NCAPH and GEN1 in the chromatin involving binding at the N-terminus of NCAPH. DNA-ICL activation, using ICL-inducing agents, increased the expression and interaction between NCAPH and GEN1 in the soluble nuclear and chromatin, indicating that the NCAPH-GEN1 interaction participates in repairing DNA damage. Moreover, NCAPH stabilizes GEN1 within chromatin at the G2/M-phase and is associated with DNA-ICL-induced damage repair. Therefore, NCAPH resolves DNA-ICL-induced ultra-fine DNA bridges by stabilizing GEN1 and ensures proper chromosome separation and chromosome structural stability.
MeSH term(s)	Humans ; Cell Cycle Proteins/metabolism ; Chromatin/genetics ; Chromosomal Instability ; Chromosomes ; DNA ; Nuclear Proteins/metabolism
Chemical Substances	Cell Cycle Proteins ; Chromatin ; DNA (9007-49-2) ; NCAPH protein, human ; Nuclear Proteins ; GEN1 protein, human (EC 3.1.21.-)
Language	English
Publishing date	2022-11-03
Publishing country	United States
Document type	Journal Article
ZDB-ID	1148964-9
ISSN	0219-1032 ; 1016-8478
ISSN (online)	0219-1032
ISSN	1016-8478
DOI	10.14348/molcells.2022.0048
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Zs.A 4713: Show issues

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Article ; Online: Downregulation of ASF1B inhibits tumor progression and enhances efficacy of cisplatin in pancreatic cancer.

Kim, Jae Hyeong / Youn, Yuna / Lee, Jong-Chan / Kim, Jaihwan / Ryu, Ji Kon / Hwang, Jin-Hyeok

Cancer biomarkers : section A of Disease markers

2022 Volume 34, Issue 4, Page(s) 647–659

Abstract: Pancreatic cancer is an aggressive and lethal cancer with the highest mortality rate. Hence, the development of new targeting and innovative treatment strategies is needed. Recent studies reported that the histone chaperone anti-silencing function 1B ( ... ...

Abstract	Pancreatic cancer is an aggressive and lethal cancer with the highest mortality rate. Hence, the development of new targeting and innovative treatment strategies is needed. Recent studies reported that the histone chaperone anti-silencing function 1B (ASF1B) can be used as a diagnosis and prognosis cancer biomarker. However, functional studies of ASF1B in pancreatic cancer have not been performed. This study compared expression levels of ASF1B in pancreatic cancer specimens with those of normal tissues using publicly available online databases. We found that ASF1B was commonly overexpressed in pancreatic cancer specimens, which is associated with poor prognosis. ASF1B downregulation in pancreatic cancer cells reduced their colony formation, proliferation, migration, and invasion abilities, and inhibited MMP9 activity. Furthermore, ASF1B expression downregulation increased cell cycle S-phase arrest and DNA damage though activation of the checkpoint kinases Chk1 and Chk2 pathways. Additionally, increased caspase (caspases-3 and -9) activation and PARP cleavage led to enhanced caspase-dependent apoptosis and improved cisplatin sensitivity. Collectively, our results indicate that ASF1B may serve as a potential biomarker of pancreatic cancer and a novel therapeutic target.
MeSH term(s)	Apoptosis/genetics ; Cell Cycle ; Cell Cycle Proteins/genetics ; Cell Line, Tumor ; Cell Proliferation ; Cisplatin/pharmacology ; Down-Regulation ; Humans ; Pancreatic Neoplasms/drug therapy ; Pancreatic Neoplasms/genetics
Chemical Substances	ASF1B protein, human ; Cell Cycle Proteins ; Cisplatin (Q20Q21Q62J)
Language	English
Publishing date	2022-06-02
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	2203517-5
ISSN	1875-8592 ; 1574-0153 ; 1875-8592
ISSN (online)	1875-8592 ; 1574-0153
ISSN	1875-8592
DOI	10.3233/CBM-210490
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Zs.A 6127: Show issues

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Article ; Online: Antiviral activity of adenoviral vector expressing human interferon lambda-4 against influenza virus.

Kim, Dong-Hwi / Kim, Jae-Hyeong / Lim, Kyu-Beom / Lee, Joong-Bok / Park, Seung-Yong / Song, Chang-Seon / Lee, Sang-Won / Lee, Dong-Hun / Choi, In-Soo

Journal of medical virology

2024 Volume 96, Issue 4, Page(s) e29605

Abstract: Interferon lambda (IFNλ), classified as a type III IFN, is a representative cytokine that plays an important role in innate immunity along with type I IFN. IFNλ can elicit antiviral states by inducing peculiar sets of IFN-stimulated genes (ISGs). In this ...

Abstract	Interferon lambda (IFNλ), classified as a type III IFN, is a representative cytokine that plays an important role in innate immunity along with type I IFN. IFNλ can elicit antiviral states by inducing peculiar sets of IFN-stimulated genes (ISGs). In this study, an adenoviral vector expression system with a tetracycline operator system was used to express human IFNλ4 in cells and mice. The formation of recombinant adenovirus (rAd-huIFNλ4) was confirmed using immunohistochemistry assays and transmission electron microscopy. Its purity was verified by quantifying host cell DNA and host cell proteins, as well as by confirming the absence of the replication-competent adenovirus. The transduction of rAd-huIFNλ4 induced ISGs and inhibited four subtypes of the influenza virus in both mouse-derived (LA-4) and human-derived cells (A549). The antiviral state was confirmed in BALB/c mice following intranasal inoculation with 10
MeSH term(s)	Animals ; Humans ; Mice ; Antiviral Agents/pharmacology ; Immunity, Innate ; Influenza, Human/immunology ; Influenza, Human/prevention & control ; Interferon Lambda/metabolism ; Interferon Lambda/pharmacology ; Interferon Type I/genetics ; Interferons/metabolism ; Orthomyxoviridae ; Orthomyxoviridae Infections/immunology ; Orthomyxoviridae Infections/prevention & control ; Genetic Vectors
Chemical Substances	Antiviral Agents ; IFNL4 protein, human ; Interferon Lambda ; Interferon Type I ; Interferons (9008-11-1)
Language	English
Publishing date	2024-04-18
Publishing country	United States
Document type	Journal Article
ZDB-ID	752392-0
ISSN	1096-9071 ; 0146-6615
ISSN (online)	1096-9071
ISSN	0146-6615
DOI	10.1002/jmv.29605
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Zs.A 1320: Show issues

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ab Jg. 2022: Lesesaal (EG)

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Article ; Online: Pharmacoethnicity of FOLFIRINOX versus gemcitabine plus nab-paclitaxel in metastatic pancreatic cancer: a systematic review and meta-analysis.

Lee, Yoon Suk / Lee, Jong-Chan / Kim, Jae-Hyeong / Kim, Jaihwan / Hwang, Jin-Hyeok

Scientific reports

2021 Volume 11, Issue 1, Page(s) 20152

Abstract: Treatment outcomes between FOLFIRINOX (5-fluorouracil, leucovorin, irinotecan, and oxaliplatin) and GNP (gemcitabine with albumin-bound paclitaxel) as first-line chemotherapy regimens for metastatic pancreatic cancer (PC) were assessed according to ... ...

Abstract	Treatment outcomes between FOLFIRINOX (5-fluorouracil, leucovorin, irinotecan, and oxaliplatin) and GNP (gemcitabine with albumin-bound paclitaxel) as first-line chemotherapy regimens for metastatic pancreatic cancer (PC) were assessed according to ethnic groups categorized as Western or Asian subgroups. PubMed, EMBASE, and Cochrane library were searched. Thirteen studies were eligible in this meta-analysis. Overall survival was not significantly different between FOLFIRINOX and GNP (HR 1.00, 95% CI 0.83-1.20, P = 0.990). However, the Western subgroup showed a higher survival benefit for FOLFIRINOX over GNP (HR 0.84, 95% CI 0.74-0.95, P = 0.006) whereas the Asian subgroup showed the survival benefit for GNP over FOLFIRINOX (HR 1.29, 95% CI 1.03-1.60, P = 0.030). Progression free survival was not significantly different between the two regimens in the Western subgroup (HR 1.01, 95% CI 0.84-1.20, P = 0.950) and the Asian subgroup (HR 1.13, 95% CI 0.97-1.33, P = 0.110). Occurrence of febrile neutropenia was significantly higher in FOLFIRINOX at both ethnic subgroups; however, that of peripheral neuropathy was significantly higher only in GNP of the Asian subgroup. Therefore, pharmacoethnicity might be a factor worth considering when deciding on a frontline chemotherapeutic regimen although the overall survival was not significantly different between FOLFIRINOX and GNP for metastatic PCs.
MeSH term(s)	Albumins/administration & dosage ; Antineoplastic Combined Chemotherapy Protocols/therapeutic use ; Deoxycytidine/administration & dosage ; Deoxycytidine/analogs & derivatives ; Ethnicity/statistics & numerical data ; Fluorouracil/administration & dosage ; Humans ; Irinotecan/administration & dosage ; Leucovorin/administration & dosage ; Neoplasm Metastasis ; Oxaliplatin/administration & dosage ; Paclitaxel/administration & dosage ; Pancreatic Neoplasms/drug therapy ; Pancreatic Neoplasms/ethnology ; Pancreatic Neoplasms/pathology ; Treatment Outcome
Chemical Substances	130-nm albumin-bound paclitaxel ; Albumins ; Oxaliplatin (04ZR38536J) ; Deoxycytidine (0W860991D6) ; Irinotecan (7673326042) ; gemcitabine (B76N6SBZ8R) ; Paclitaxel (P88XT4IS4D) ; Leucovorin (Q573I9DVLP) ; Fluorouracil (U3P01618RT)
Language	English
Publishing date	2021-10-11
Publishing country	England
Document type	Journal Article ; Meta-Analysis ; Systematic Review
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-021-99647-5
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Cdc6 disruption leads to centrosome abnormalities and chromosome instability in pancreatic cancer cells.

Youn, Yuna / Lee, Jong-Chan / Kim, Jaihwan / Kim, Jae Hyeong / Hwang, Jin-Hyeok

Scientific reports

2020 Volume 10, Issue 1, Page(s) 16518

Abstract: Cell division cycle 6 (Cdc6) plays key roles in regulating DNA replication, and activation and maintenance of cell cycle check points. In addition, Cdc6 exerts oncogenic properties via genomic instability associated with incomplete DNA replication. This ... ...

Abstract	Cell division cycle 6 (Cdc6) plays key roles in regulating DNA replication, and activation and maintenance of cell cycle check points. In addition, Cdc6 exerts oncogenic properties via genomic instability associated with incomplete DNA replication. This study aimed to examine the effects of Cdc6 on pancreatic cancer (PC) cells. Our results showed that Cdc6 expression was higher in clinical PC specimens (based on analysis of the GEPIA database) and cell lines, and the high Cdc6 expression was associated with poorer survival in The Cancer Genome Atlas-PC cohort. In addition, Cdc6-depleted PC cells significantly inhibited cell proliferation and colony formation, delayed G
MeSH term(s)	Cell Cycle ; Cell Cycle Proteins/metabolism ; Cell Cycle Proteins/physiology ; Cell Line, Tumor ; Centrosome/metabolism ; Centrosome/physiology ; Chromosomal Instability/genetics ; Chromosomal Instability/physiology ; Cyclin A2/genetics ; DNA Replication ; Databases, Genetic ; Genomic Instability/genetics ; Histones/metabolism ; Humans ; Microtubules/metabolism ; Mitosis ; Nuclear Proteins/metabolism ; Nuclear Proteins/physiology ; Oncogenes/genetics ; Oncogenes/physiology ; Pancreatic Neoplasms/genetics ; Pancreatic Neoplasms/metabolism
Chemical Substances	CDC6 protein, human ; Cell Cycle Proteins ; Cyclin A2 ; Histones ; Nuclear Proteins
Language	English
Publishing date	2020-10-05
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-020-73474-6
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Article: Involvement of the NF-κB signaling pathway in proliferation and invasion inhibited by Zwint-1 deficiency in Pancreatic Cancer Cells.

Kim, Jae Hyeong / Youn, Yuna / Lee, Jong-Chan / Kim, Jaihwan / Hwang, Jin-Hyeok

Journal of Cancer

2020 Volume 11, Issue 19, Page(s) 5601–5611

Abstract: Pancreatic cancer (PC) is an intractable cancer that is difficult to diagnose early and has a 5-year survival rate of less than 8%. ZW10-interacting kinetochore protein ( ...

Abstract	Pancreatic cancer (PC) is an intractable cancer that is difficult to diagnose early and has a 5-year survival rate of less than 8%. ZW10-interacting kinetochore protein (
Language	English
Publishing date	2020-07-25
Publishing country	Australia
Document type	Journal Article
ZDB-ID	2573318-7
ISSN	1837-9664
ISSN	1837-9664
DOI	10.7150/jca.46173
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Article ; Online: Non-SMC condensin I complex subunit H mediates mature chromosome condensation and DNA damage in pancreatic cancer cells.

Kim, Jae Hyeong / Youn, Yuna / Kim, Kyung-Tae / Jang, Gyubeom / Hwang, Jin-Hyeok

Scientific reports

2019 Volume 9, Issue 1, Page(s) 17889

Abstract: Non-SMC condensin I complex subunit H (NCAPH) is a vital gene associated with chromosome stability and is required for proper chromosome condensation and segregation. However, the mechanisms through which NCAPH affects pancreatic cancer (PC) and its ... ...

Abstract	Non-SMC condensin I complex subunit H (NCAPH) is a vital gene associated with chromosome stability and is required for proper chromosome condensation and segregation. However, the mechanisms through which NCAPH affects pancreatic cancer (PC) and its molecular function remain unclear. In this study, we examined the role of NCAPH in PC cells. Our results showed that NCAPH was overexpressed in clinical PC specimens (GEPIA) and cell lines. In addition, in NCAPH-knockdown cells, colony formation and proliferation were inhibited, and the cell cycle was arrested at the S and G
MeSH term(s)	Apoptosis ; Caspase 3/metabolism ; Cell Cycle Checkpoints/drug effects ; Cell Cycle Proteins/antagonists & inhibitors ; Cell Cycle Proteins/genetics ; Cell Cycle Proteins/metabolism ; Cell Line, Tumor ; Checkpoint Kinase 1/metabolism ; Checkpoint Kinase 2/metabolism ; Chromosome Aberrations ; DNA Damage ; Humans ; Kaplan-Meier Estimate ; Nuclear Proteins/antagonists & inhibitors ; Nuclear Proteins/genetics ; Nuclear Proteins/metabolism ; Pancreatic Neoplasms/metabolism ; Pancreatic Neoplasms/mortality ; Pancreatic Neoplasms/pathology ; RNA Interference ; RNA, Small Interfering/metabolism
Chemical Substances	Cell Cycle Proteins ; NCAPH protein, human ; Nuclear Proteins ; RNA, Small Interfering ; Checkpoint Kinase 2 (EC 2.7.1.11) ; Checkpoint Kinase 1 (EC 2.7.11.1) ; Caspase 3 (EC 3.4.22.-)
Language	English
Publishing date	2019-11-29
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-019-54478-3
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Genetic Analysis of Torque Teno Canis Virus Identified in Republic of Korea.

Kim, Da-Yoon / Ahn, Hee-Seop / Han, Sang-Hoon / Go, Hyeon-Jeong / Kim, Dong-Hwi / Kim, Jae-Hyeong / Lee, Joong-Bok / Park, Seung-Yong / Song, Chang-Seon / Lee, Sang-Won / Choi, In-Soo

Veterinary sciences

2022 Volume 9, Issue 12

Abstract: Torque teno canis virus (TTCaV) is an approximately 2.8 kb circular single-stranded DNA virus known to cause infections in dogs. However, its incidence in Republic of Korea remains unknown. In this study, 135 dog fecal samples were collected to determine ...

Abstract	Torque teno canis virus (TTCaV) is an approximately 2.8 kb circular single-stranded DNA virus known to cause infections in dogs. However, its incidence in Republic of Korea remains unknown. In this study, 135 dog fecal samples were collected to determine TTCaV infection status in Republic of Korea. Based on polymerase chain reaction (PCR) analysis, 13 of 135 (9.6%) dogs tested positive for TTCaV. Three full-length genome sequences (GenBank IDs: MZ503910, MZ503911, and MZ503912) were obtained from the positive specimens. Phylogenetic tree construction and sequence identity, similarity plot, and recombination analyses were performed using these three full-length genomic sequences. Among the three full-length genomes, MZ503912 was determined to be a recombinant virus based on analysis with the reference TTCaV strains. This novel virus strain might have been generated by recombination between TTCaV strain KX827768 discovered in China and MZ503910 discovered in Republic of Korea. This is the first report to determine the incidence, genetic variation, and recombination of TTCaV in dogs in Republic of Korea. Further studies are needed to elucidate TTCaV pathogenesis in dogs.
Language	English
Publishing date	2022-12-13
Publishing country	Switzerland
Document type	Case Reports
ZDB-ID	2768971-2
ISSN	2306-7381 ; 2306-7381
ISSN (online)	2306-7381
ISSN	2306-7381
DOI	10.3390/vetsci9120693
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