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Article ; Online: Predictors of Outcomes in Patients With Clinically Lymph Node Positive Prostate Cancer After Definitive Radiotherapy.

Kim, Tae Hyun / Kim, Dong-Yun / Kim, Jae-Sung

2023 Volume 37, Issue 5, Page(s) 2365–2370

Abstract: Background/aim: Studies have suggested that benefits of definitive radiotherapy might be limited to specific patients in clinically lymph node positive (cN1) prostate cancer (PC). However, the beneficial subgroup remains to be elucidated. This study ... ...

Abstract	Background/aim: Studies have suggested that benefits of definitive radiotherapy might be limited to specific patients in clinically lymph node positive (cN1) prostate cancer (PC). However, the beneficial subgroup remains to be elucidated. This study aimed to analyze survival outcomes and prognostic factors after definitive radiotherapy and androgen deprivation therapy (definitive RT+ADT) in these patients and to define subgroups of patients who would benefit from definitive RT+ADT the most. Patients and methods: A total of 60 patients with cN1 PC treated with definitive RT+ADT in a single tertiary hospital were accrued. Their clinicopathological variables were analyzed and a new subgroup was identified based on statistically significant variables. Results: At a median follow-up of 31 months, ADT duration ≥24 months (p=0.043, HR=0.26) and positive biopsy core ≥75% (p=0.044, HR=5.29) showed significant relationships with distant metastasis-free survival. Overall survival showed significant relationships with ADT duration ≥24 months (p=0.002, HR=0.06) and number of lymph node (LN) metastases ≥4 (p=0.019, HR=7.17). For prognostic subgroup analysis, patients were divided into three risk groups: low-risk group (LN metastases <4 and ADT ≥24 months), high-risk group (LN metastases ≥4 and ADT <24 months), and intermediate-risk group (all remaining cases). Three-year actuarial overall survival rates for the low-, intermediate-, and high-risk groups were 100%, 93.3%, and 45.7%. Conclusion: ADT duration and number of LN metastases were important prognostic factors in patients with cN1 PC receiving definitive RT+ADT, with low-risk cN1 PC patients showing better outcomes than others.
MeSH term(s)	Male ; Humans ; Prostatic Neoplasms/pathology ; Androgen Antagonists/therapeutic use ; Prognosis ; Risk Factors ; Lymphatic Metastasis/pathology ; Lymph Nodes/pathology ; Retrospective Studies
Chemical Substances	Androgen Antagonists
Language	English
Publishing date	2023-08-29
Publishing country	Greece
Document type	Journal Article
ZDB-ID	807031-3
ISSN	1791-7549 ; 0258-851X
ISSN (online)	1791-7549
ISSN	0258-851X
DOI	10.21873/invivo.13341
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Oocytes can repair DNA damage during meiosis via a microtubule-dependent recruitment of CIP2A-MDC1-TOPBP1 complex from spindle pole to chromosomes.

Leem, Jiyeon / Kim, Jae-Sung / Oh, Jeong Su

Nucleic acids research

2023 Volume 51, Issue 10, Page(s) 4899–4913

Abstract: Because DNA double-strand breaks (DSBs) greatly threaten genomic integrity, effective DNA damage sensing and repair are essential for cellular survival in all organisms. However, DSB repair mainly occurs during interphase and is repressed during mitosis. ...

Abstract	Because DNA double-strand breaks (DSBs) greatly threaten genomic integrity, effective DNA damage sensing and repair are essential for cellular survival in all organisms. However, DSB repair mainly occurs during interphase and is repressed during mitosis. Here, we show that, unlike mitotic cells, oocytes can repair DSBs during meiosis I through microtubule-dependent chromosomal recruitment of the CIP2A-MDC1-TOPBP1 complex from spindle poles. After DSB induction, we observed spindle shrinkage and stabilization, as well as BRCA1 and 53BP1 recruitment to chromosomes and subsequent DSB repair during meiosis I. Moreover, p-MDC1 and p-TOPBP1 were recruited from spindle poles to chromosomes in a CIP2A-dependent manner. This pole-to-chromosome relocation of the CIP2A-MDC1-TOPBP1 complex was impaired not only by depolymerizing microtubules but also by depleting CENP-A or HEC1, indicating that the kinetochore/centromere serves as a structural hub for microtubule-dependent transport of the CIP2A-MDC1-TOPBP1 complex. Mechanistically, DSB-induced CIP2A-MDC1-TOPBP1 relocation is regulated by PLK1 but not by ATM activity. Our data provide new insights into the critical crosstalk between chromosomes and spindle microtubules in response to DNA damage to maintain genomic stability during oocyte meiosis.
MeSH term(s)	Centromere ; DNA Damage ; Meiosis ; Microtubules ; Oocytes ; Spindle Apparatus/genetics ; Spindle Poles ; DNA Repair ; Animals ; Mice ; Multiprotein Complexes ; Chromosomes/metabolism
Chemical Substances	KIAA1524 protein, mouse ; MDC1 protein, mouse ; Topbp1 protein, mouse ; Multiprotein Complexes
Language	English
Publishing date	2023-03-28
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	186809-3
ISSN	1362-4962 ; 1362-4954 ; 0301-5610 ; 0305-1048
ISSN (online)	1362-4962 ; 1362-4954
ISSN	0301-5610 ; 0305-1048
DOI	10.1093/nar/gkad213
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Zs.A 1067: Show issues

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Article ; Online: Cytoprotection of rat hepatocytes by desipramine in a model of simulated ischemia/reperfusion.

Shin, Jun-Kyu / Kim, Jae-Sung

Biochemistry and biophysics reports

2021 Volume 27, Page(s) 101075

Abstract: We investigated the cytoprotective effect of desipramine (DMI) ... ...

Abstract	We investigated the cytoprotective effect of desipramine (DMI) during
Language	English
Publishing date	2021-07-15
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	2831046-9
ISSN	2405-5808 ; 2405-5808
ISSN (online)	2405-5808
ISSN	2405-5808
DOI	10.1016/j.bbrep.2021.101075
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Article: FARMs: A Geospatial Crop Modeling and Agricultural Water Management System

Kim, Jae Sung / Kisekka, Isaya

ISPRS international journal of geo-information. 2021 Aug. 17, v. 10, no. 8

2021

Abstract: To ensure agricultural sustainability and desirable environmental outcomes, stakeholders need systems-based model-driven decision support tools. The objective of this study was to develop a global scale web-based geospatial crop modeling application ... ...

Abstract	To ensure agricultural sustainability and desirable environmental outcomes, stakeholders need systems-based model-driven decision support tools. The objective of this study was to develop a global scale web-based geospatial crop modeling application called Food, Agriculture, and Resource Management system (FARMs), to simplify the application of the crop simulation model —Decision Support System for Agrotechnology Transfer (DSSAT) without requiring users to create input weather, climate, and soil files. FARMs was built based on open source Geographic Information System (GIS) technologies and DSSAT to allow for adaptive management through its ability to perform in-season yield predictions for alfalfa and maize, currently. Validation of FARMs against variety trial data in California was acceptable between measured and simulated yields for alfalfa. The work done in this study showed how a complex model like DSSAT can be translated into a useable web-based decision support tool for near-real-time simulation with the help of open-source GIS technologies.
Keywords	Internet ; adaptive management ; alfalfa ; climate ; corn ; decision support systems ; geographic information systems ; management systems ; resource management ; simulation models ; soil ; spatial data ; stakeholders ; sustainable agriculture ; water management ; weather ; California
Language	English
Dates of publication	2021-0817
Publishing place	Multidisciplinary Digital Publishing Institute
Document type	Article
ZDB-ID	2655790-3
ISSN	2220-9964
ISSN	2220-9964
DOI	10.3390/ijgi10080553
Database	NAL-Catalogue (AGRICOLA)

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Article: Effect of Laser Peening on Microstructural Changes in GTA-Welded 304L Stainless Steel.

Yoo, Young-Ran / Kim, Jae-Sung / Kim, Young-Sik

Materials (Basel, Switzerland)

2022 Volume 15, Issue 11

Abstract: The introduction of tensile residual stress has led to the induction of damage such as fatigue, corrosion fatigue, and stress corrosion cracking (SCC) in stainless steel in association with the influence of environments, components, surface defects, and ... ...

Abstract	The introduction of tensile residual stress has led to the induction of damage such as fatigue, corrosion fatigue, and stress corrosion cracking (SCC) in stainless steel in association with the influence of environments, components, surface defects, and corrosive factors during its use. Compressive residual stress can be achieved through various techniques. Among several methods, laser peening can be more attractive as it creates regularity on the surface with a high-quality surface finish. However, there is very little research on heavily peened surface and cross-section of stainless steel with very deep compressive residual stress. This work focused on welding and laser peening and the influence of Al coating on the microstructural changes in 304L stainless steel. The specimen obtained by laser peening had a very deep compressive residual stress of over 1 mm and was evaluated based on microstructural and hardness analysis. Therefore, a model for microstructural change by laser peening on welded 304L stainless steel was proposed.
Language	English
Publishing date	2022-06-01
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2487261-1
ISSN	1996-1944
ISSN	1996-1944
DOI	10.3390/ma15113947
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Article ; Online: Cytotoxicity of 9,10-Phenanthrenequinone Impairs Mitotic Progression and Spindle Assembly Independent of ROS Production in HeLa Cells.

Kim, Seul / Leem, Jiyeon / Oh, Jeong Su / Kim, Jae-Sung

Toxics

2022 Volume 10, Issue 6

Abstract: The polycyclic aromatic hydrocarbon quinone derivative 9,10-phenanthrenequinone (9,10-PQ) is one of the most abundant and toxic components found in diesel exhaust particles (DEPs). These DEPs are created during diesel fuel combustion and are considered ... ...

Abstract	The polycyclic aromatic hydrocarbon quinone derivative 9,10-phenanthrenequinone (9,10-PQ) is one of the most abundant and toxic components found in diesel exhaust particles (DEPs). These DEPs are created during diesel fuel combustion and are considered the main source of urban air pollution. As 9,10-PQ can produce excessive reactive oxygen species (ROS) through redox cycling, it has been shown to exert potent cytotoxic effects against various cell types. However, the mechanisms underlying this cytotoxicity remain unclear. In this study, we showed that 9,10-PQ exerts cytotoxicity by impairing mitotic progression and spindle assembly in HeLa cells. Exposure to 9,10-PQ impaired spindle assembly and chromosome alignment, resulting in delayed mitotic entry and progression in HeLa cells. Furthermore, 9,10-PQ exposure decreased the CEP192 and p-Aurora A levels at the spindle poles. Notably, these mitotic defects induced by 9,10-PQ were not rescued by scavenging ROS, implying the ROS-independent activity of 9,10-PQ. Therefore, our results provide the first evidence that 9,10-PQ exerts its cytotoxicity through specific inhibition of mitotic progression and spindle assembly, independent of ROS.
Language	English
Publishing date	2022-06-16
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2733883-6
ISSN	2305-6304 ; 2305-6304
ISSN (online)	2305-6304
ISSN	2305-6304
DOI	10.3390/toxics10060327
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Article ; Online: Pathogen-derived peptides in drug targeting and its therapeutic approach.

Mun, Seok-Jun / Cho, Euni / Kim, Jae-Sung / Yang, Chul-Su

Journal of controlled release : official journal of the Controlled Release Society

2022 Volume 350, Page(s) 716–733

Abstract: Peptides, short stretches of amino acids or small proteins that occupy a strategic position between proteins and amino acids, are readily accessible by chemical and biological methods. With ideal properties for forming high-affinity and specific ... ...

Abstract	Peptides, short stretches of amino acids or small proteins that occupy a strategic position between proteins and amino acids, are readily accessible by chemical and biological methods. With ideal properties for forming high-affinity and specific interactions with host target proteins, they have established an important niche in the drug development spectrum complementing small molecule and biological therapeutics. Among the most successful biomedicines in use today, peptide-based drugs show great promise. This, coupled with recent advances in synthetic and nanochemical biology, has led to the creation of tailor-made peptide therapeutics for improved biocompatibility. This review presents an overview of the latest research on pathogen-derived, host-cell-interacting peptides. It also highlights strategies for using peptide-based therapeutics that address cellular transport challenges through the introduction of nanoparticles that serve as platforms to facilitate the delivery of peptide biologics and therapeutics for treating various inflammatory diseases. Finally, this paper describes future perspectives, specific pathogen-based peptides that can enhance specificity, efficiency, and capacity in functional peptide-based therapeutics, which are in the spotlight as new treatment alternatives for various diseases, and also presents verified sequences and targets that can increase chemical and pharmacological value.
MeSH term(s)	Amino Acids ; Biological Products ; Drug Delivery Systems ; Peptides/chemistry ; Proteins
Chemical Substances	Amino Acids ; Biological Products ; Peptides ; Proteins
Language	English
Publishing date	2022-09-07
Publishing country	Netherlands
Document type	Journal Article ; Review ; Research Support, Non-U.S. Gov't
ZDB-ID	632533-6
ISSN	1873-4995 ; 0168-3659
ISSN (online)	1873-4995
ISSN	0168-3659
DOI	10.1016/j.jconrel.2022.08.041
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Zs.A 2055: Show issues

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Article ; Online: Centrosome de-clustering of cancer cells induces cGAS-STING-mediated innate immunity of tumor-associated tumor cells in response to irradiation.

Kim, Seul / Choe, Min Ho / Oh, Jeong Su / Kim, Jae-Sung

Biochemical and biophysical research communications

2022 Volume 636, Issue Pt 2, Page(s) 24–30

Abstract: Although radiotherapy (RT) increases the extra centrosomes of cancer cells compared to normal cells, centrosome clustering of cancer cells with amplified centrosomes ensures bipolar mitosis for cell proliferation in response to RT. Recent evidence ... ...

Abstract	Although radiotherapy (RT) increases the extra centrosomes of cancer cells compared to normal cells, centrosome clustering of cancer cells with amplified centrosomes ensures bipolar mitosis for cell proliferation in response to RT. Recent evidence suggests that centrosome clustering is a tumor-selective target for improving RT in breast cancer cells. However, whether centrosome de-clustering is involved in the activation of innate immunity in response to RT remains unknown. In this study, we showed that centrosome de-clustering of irradiated cancer cells modulates cyclic GMP-AMP synthase (cGAS)-stimulator of interferon genes (STING)-mediated innate immunity in monocytes and macrophages after co-culture. Centrosome de-clustering intensifies mitotic abnormalities and cytosolic dsDNA in breast cancer cells in response to irradiation. Unexpectedly, centrosome de-clustering did not modulate the cGAS-STING signaling pathway in irradiated breast cancer cells. Importantly, centrosome de-clustering activated the cGAS-STING signaling pathway in human monocytes and mouse macrophages after co-culture with irradiated breast cancer cells. Thus, our data provide the first evidence that centrosome de-clustering of irradiated breast cancer cells induces innate immunity in tumor-associated immune cells.
MeSH term(s)	Animals ; Female ; Humans ; Mice ; Breast Neoplasms/radiotherapy ; Centrosome/metabolism ; Immunity, Innate ; Membrane Proteins/metabolism ; Nucleotidyltransferases/metabolism
Chemical Substances	Membrane Proteins ; Nucleotidyltransferases (EC 2.7.7.-) ; STING1 protein, human ; cGAS protein, human (EC 2.7.7.-)
Language	English
Publishing date	2022-10-31
Publishing country	United States
Document type	Journal Article
ZDB-ID	205723-2
ISSN	1090-2104 ; 0006-291X ; 0006-291X
ISSN (online)	1090-2104 ; 0006-291X
ISSN	0006-291X
DOI	10.1016/j.bbrc.2022.10.092
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Article ; Online: ROS-independent cytotoxicity of 9,10-phenanthrenequinone inhibits cell cycle progression and spindle assembly during meiotic maturation in mouse oocytes.

Leem, Jiyeon / Kim, Seul / Kim, Jae-Sung / Oh, Jeong Su

Journal of hazardous materials

2022 Volume 436, Page(s) 129248

Abstract: Diesel exhaust particles (DEPs) are major components of ambient particulate matter and are associated with various adverse health effects. Typically, DEPs contain a vast number of organic compounds, among which 9,10-phenanthrenequinone (9,10-PQ), the ... ...

Abstract	Diesel exhaust particles (DEPs) are major components of ambient particulate matter and are associated with various adverse health effects. Typically, DEPs contain a vast number of organic compounds, among which 9,10-phenanthrenequinone (9,10-PQ), the quinone derivative of the polycyclic aromatic hydrocarbon phenanthrene, is one of the most abundant and toxic. 9,10-PQ can produce excessive reactive oxygen species (ROS) via redox cycling and exhibit cytotoxicity in various cells. However, the underlying mechanisms involved in cytotoxicity of 9,10-PQ remain elusive. In this study, we investigated the effects of exposure to 9,10-PQ using mouse oocytes as a model system. We found that 9,10-PQ compromised meiotic maturation by impairing acentriolar microtubule organizing center (MTOC) assembly and subsequent spindle formation during meiotic maturation. Moreover, 9,10-PQ exposure prevented cell cycle progression by inhibiting Cdk1 activation via disturbance of cyclin B1 accumulation. Importantly, meiotic defects induced by 9,10-PQ exposure were not rescued by decreasing ROS levels, revealing that 9,10-PQ has ROS-independent activity that regulates cell cycle progression and spindle assembly. Therefore, our findings reveal that 9,10-PQ has novel activity that regulates cell-cycle progression and spindle formation in an ROS-independent manner during meiotic maturation in mouse oocytes.
MeSH term(s)	Animals ; Meiosis ; Mice ; Microtubule-Organizing Center/metabolism ; Oocytes ; Phenanthrenes ; Reactive Oxygen Species/metabolism
Chemical Substances	Phenanthrenes ; Reactive Oxygen Species ; 9,10-phenanthrenequinone (42L7BZ8H74)
Language	English
Publishing date	2022-05-30
Publishing country	Netherlands
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1491302-1
ISSN	1873-3336 ; 0304-3894
ISSN (online)	1873-3336
ISSN	0304-3894
DOI	10.1016/j.jhazmat.2022.129248
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Modulation of CD8

Jeon, Seung Hyuck / Song, Changhoon / Eom, Keun-Yong / Kim, In Ah / Kim, Jae-Sung

International journal of molecular sciences

2023 Volume 24, Issue 23

Abstract: Radiotherapy for cancer has been known to affect the responses of immune cells, especially those of ... ...

Abstract	Radiotherapy for cancer has been known to affect the responses of immune cells, especially those of CD8
MeSH term(s)	Humans ; Immune Checkpoint Inhibitors/pharmacology ; Immune Checkpoint Inhibitors/therapeutic use ; CD8-Positive T-Lymphocytes ; Combined Modality Therapy ; Neoplasms/drug therapy ; Neoplasms/radiotherapy ; Radiation Oncology ; Tumor Microenvironment
Chemical Substances	Immune Checkpoint Inhibitors
Language	English
Publishing date	2023-11-24
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2019364-6
ISSN	1422-0067 ; 1422-0067 ; 1661-6596
ISSN (online)	1422-0067
ISSN	1422-0067 ; 1661-6596
DOI	10.3390/ijms242316691
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