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  1. Article: Pharmacogenomic Biomarkers in US FDA-Approved Drug Labels (2000-2020).

    Kim, Jeeyun A / Ceccarelli, Rachel / Lu, Christine Y

    Journal of personalized medicine

    2021  Volume 11, Issue 3

    Abstract: Pharmacogenomics (PGx) is a key subset of precision medicine that relates genomic variation to individual response to pharmacotherapy. We assessed longitudinal trends in US FDA approval of new drugs labeled with PGx information. Drug labels containing ... ...

    Abstract Pharmacogenomics (PGx) is a key subset of precision medicine that relates genomic variation to individual response to pharmacotherapy. We assessed longitudinal trends in US FDA approval of new drugs labeled with PGx information. Drug labels containing PGx information were obtained from Drugs@FDA and guidelines from PharmGKB were used to compare the actionability of PGx information in drug labels across therapeutic areas. The annual proportion of new drug approvals with PGx labeling has increased by nearly threefold from 10.3% (
    Language English
    Publishing date 2021-03-04
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2662248-8
    ISSN 2075-4426
    ISSN 2075-4426
    DOI 10.3390/jpm11030179
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Risk Scoring System of Mortality and Prediction Model of Hospital Stay for Critically Ill Patients Receiving Parenteral Nutrition.

    Kim, Jee-Yun / Yee, Jeong / Park, Tae-Im / Shin, So-Youn / Ha, Man-Ho / Gwak, Hye-Sun

    Healthcare (Basel, Switzerland)

    2021  Volume 9, Issue 7

    Abstract: Predicting the clinical progression of intensive care unit (ICU) patients is crucial for survival and prognosis. Therefore, this retrospective study aimed to develop the risk scoring system of mortality and the prediction model of ICU length of stay (LOS) ...

    Abstract Predicting the clinical progression of intensive care unit (ICU) patients is crucial for survival and prognosis. Therefore, this retrospective study aimed to develop the risk scoring system of mortality and the prediction model of ICU length of stay (LOS) among patients admitted to the ICU. Data from ICU patients aged at least 18 years who received parenteral nutrition support for ≥50% of the daily calorie requirement from February 2014 to January 2018 were collected. In-hospital mortality and log-transformed LOS were analyzed by logistic regression and linear regression, respectively. For calculating risk scores, each coefficient was obtained based on regression model. Of 445 patients, 97 patients died in the ICU; the observed mortality rate was 21.8%. Using logistic regression analysis, APACHE II score (15-29: 1 point, 30 or higher: 2 points), qSOFA score ≥ 2 (2 points), serum albumin level < 3.4 g/dL (1 point), and infectious or respiratory disease (1 point) were incorporated into risk scoring system for mortality; patients with 0, 1, 2-4, and 5-6 points had approximately 10%, 20%, 40%, and 65% risk of death. For LOS, linear regression analysis showed the following prediction equation: log(LOS) = 0.01 × (APACHE II) + 0.04 × (total bilirubin) - 0.09 × (admission diagnosis of gastrointestinal disease or injury, poisoning, or other external cause) + 0.970. Our study provides the mortality risk score and LOS prediction equation. It could help clinicians to identify those at risk and optimize ICU management.
    Language English
    Publishing date 2021-07-06
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2721009-1
    ISSN 2227-9032
    ISSN 2227-9032
    DOI 10.3390/healthcare9070853
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: A Randomized Controlled Trial of the Korean Version of the Program for the Education and Enrichment of Relational Skills for Young Adults (PEERS®-YA-K) With Autism Spectrum Disorder: A Pilot Study.

    Oh, Miae / Laugeson, Elizabeth / Kim, Joo-Hyun / Lee, Kyungah / Kim, Jeeyun / Lee, SeungHa / Lim, Bora / Cha, Seyoung / Bong, Guiyoung / Yoon, Nan-He / Bahn, Geon Ho / Yoo, Hee Jeong

    Frontiers in psychiatry

    2021  Volume 12, Page(s) 730448

    Abstract: Evidence-based social skills interventions for young adults are limited, despite social difficulties in autism spectrum disorder (ASD) persisting after transition to adulthood. The Program for the Education and Enrichment of Relational Skills for Young ... ...

    Abstract Evidence-based social skills interventions for young adults are limited, despite social difficulties in autism spectrum disorder (ASD) persisting after transition to adulthood. The Program for the Education and Enrichment of Relational Skills for Young Adults (PEERS®-YA) is an evidence-based intervention found to be effective in improving relational skills in young adults with ASD. To translate the original American version of the PEERS®-YA treatment manual into Korean, intensive interviews were performed. Based on results from interviews, several rules of dating etiquette and social activities were modified to be culturally sensitive and linguistically appropriate. Next, young adults diagnosed with ASD (18-35 years of age; IQ > 70) and their social coaches were recruited for the randomized controlled trial (RCT). Participants were randomly assigned either to a treatment group (TG;
    Language English
    Publishing date 2021-10-06
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2564218-2
    ISSN 1664-0640
    ISSN 1664-0640
    DOI 10.3389/fpsyt.2021.730448
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Association between reduction in copayment and gastric cancer patient concentration to the capital area in South Korea: NHI cohort 2003-2013.

    Han, Kyu-Tae / Kim, Jeeyun / Nam, Chung Mo / Moon, Ki Tae / Lee, Sang Gyu / Kim, Seung Ju / Ju, Yeong Jun / Kwon, Jeoung A / Kim, Sun Jung / Kim, Woorim / Park, Eun-Cheol

    Health policy (Amsterdam, Netherlands)

    2016  Volume 120, Issue 6, Page(s) 580–589

    Abstract: Since 2004, the South Korean government has introduced a policy that decreases copayment for cancer patients by strengthening public coverage in the National Health Insurance (NHI) system (first phase=copayment for outpatient care from 30% to 20%; second ...

    Abstract Since 2004, the South Korean government has introduced a policy that decreases copayment for cancer patients by strengthening public coverage in the National Health Insurance (NHI) system (first phase=copayment for outpatient care from 30% to 20%; second phase=copayment for total medical expenditures from 20% to 10%; third phase=copayment for total medical expenditures from 10% to 5%). We aimed to investigate the relationship between the policy introduction and patient visits to hospitals in the capital area. We used data from the NHI Cohort 2003-2013, which included all medical claims (7193 cases) filed for 2124 patients who visited the hospital due to stomach cancer, and performed a segmented Poisson regression analysis. Of all hospital visits, 40.6% of patients were from the capital area. After the introduction of the second phase of the policy, there was an increase in patient concentration in the capital area, although there were no significant effects on patient concentration during the first and third phases of the policy. In conclusion, our findings suggest that the introduction of a policy that reduces copayment for cancer patients had a substantial impact on patient concentration in the capital area. Therefore, health policymakers should consider effective alternatives including efficient allocation of medical resources or support for the more vulnerable population as flexible benefit plans to aid healthcare utilization by cancer patients.
    MeSH term(s) Adult ; Aged ; Costs and Cost Analysis/economics ; Female ; Health Expenditures ; Health Policy/economics ; Hospitalization/economics ; Humans ; Insurance, Health/economics ; Male ; Middle Aged ; National Health Programs/economics ; Patient Acceptance of Health Care ; Republic of Korea ; Social Class ; Stomach Neoplasms/economics
    Language English
    Publishing date 2016-06
    Publishing country Ireland
    Document type Journal Article
    ZDB-ID 605805-x
    ISSN 1872-6054 ; 0168-8510
    ISSN (online) 1872-6054
    ISSN 0168-8510
    DOI 10.1016/j.healthpol.2016.05.006
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Fluctuation of peripheral blood T, B, and NK cells during a menstrual cycle of normal healthy women.

    Lee, Sungki / Kim, Jeeyun / Jang, Byungwoo / Hur, Sungeun / Jung, Unsuk / Kil, Kihyun / Na, Baegju / Lee, Millina / Choi, Youngmin / Fukui, Atsushi / Gilman-Sachs, Alice / Kwak-Kim, Joanne Y

    Journal of immunology (Baltimore, Md. : 1950)

    2010  Volume 185, Issue 1, Page(s) 756–762

    Abstract: Cyclical hormonal changes during an ovarian cycle may affect immune responses, which is crucial for the embryonic implantation. We aim to investigate whether the levels and activity of T, B, and NK cells change during a menstrual cycle. Twenty-two ... ...

    Abstract Cyclical hormonal changes during an ovarian cycle may affect immune responses, which is crucial for the embryonic implantation. We aim to investigate whether the levels and activity of T, B, and NK cells change during a menstrual cycle. Twenty-two normally cycling women were enrolled and peripheral blood was drawn serially during a menstrual cycle. Intracellular cytokine expression of CD3(+)CD4(+) and CD3(+)CD8(+) cells, and Th1/Th2 cytokine-producing T cell ratios were determined using flow cytometric analysis. NK cell cytotoxicity was measured by flow cytometric analysis at E:T ratios of 50:1, 25:1, and 12.5:1 and also using LU at 20%. Proportions (percentage) of CD3(+) (p = 0.046) and CD3(+)CD4(+) (p = 0.002) T cells were increased in the follicular phase compared with the luteal phase. The levels of CD3(-)CD56(+) (p = 0.010) and CD3(-)CD56(dim) (p = 0.012) NK cells and NK cytotoxicity at E:T ratio of 50:1, 25:1, and 12.5:1 and LU at 20% were significantly increased in the luteal phase compared with the follicular phase. Even though IL-10-producing CD3(+)CD4(+) T cells were significantly lower in the midluteal phase as compared with the early follicular phase, proportions of CD19(+) B cells, CD3(+)CD56(+) NKT cells, Th1 cytokine-producing T cell subsets, and ratios of Th1/Th2 cytokine-producing T cells were not significantly changed during a menstrual cycle. We conclude that peripheral blood NK and T cell levels as well as NK cytotoxicity are changed during a menstrual cycle. Neuroendocrine regulation on immune responses is suggested during an ovarian cycle, which may be critical for embryonic implantation and pregnancy.
    MeSH term(s) Adult ; B-Lymphocyte Subsets/cytology ; B-Lymphocyte Subsets/immunology ; B-Lymphocyte Subsets/metabolism ; Cross-Sectional Studies ; Cytokines/biosynthesis ; Cytokines/blood ; Cytotoxicity Tests, Immunologic ; Female ; Humans ; Immunophenotyping ; Killer Cells, Natural/cytology ; Killer Cells, Natural/immunology ; Lymphocyte Count ; Menstrual Cycle/immunology ; Prospective Studies ; T-Lymphocyte Subsets/cytology ; T-Lymphocyte Subsets/immunology ; T-Lymphocyte Subsets/metabolism ; Th1 Cells/cytology ; Th1 Cells/immunology ; Th1 Cells/metabolism ; Th2 Cells/cytology ; Th2 Cells/immunology ; Th2 Cells/metabolism ; Women's Health ; Young Adult
    Chemical Substances Cytokines
    Language English
    Publishing date 2010-07-01
    Publishing country United States
    Document type Comparative Study ; Journal Article
    ZDB-ID 3056-9
    ISSN 1550-6606 ; 0022-1767 ; 1048-3233 ; 1047-7381
    ISSN (online) 1550-6606
    ISSN 0022-1767 ; 1048-3233 ; 1047-7381
    DOI 10.4049/jimmunol.0904192
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Ud II Zs.37: Show issues Location:
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