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Article ; Online: Reevaluation of the earlobe types in Koreans.

Kim, K E / Song, W J / Kim, D K

Homo : internationale Zeitschrift fur die vergleichende Forschung am Menschen

2018 Volume 69, Issue 6, Page(s) 377–380

Abstract: The shape of the earlobes has a variety of genetic significance. This study analyzed the frequencies of the earlobe shapes in the Korean population. Data were collected on randomly selected 500 males and 500 females in Daegu Metropolitan City, with all ... ...

Abstract	The shape of the earlobes has a variety of genetic significance. This study analyzed the frequencies of the earlobe shapes in the Korean population. Data were collected on randomly selected 500 males and 500 females in Daegu Metropolitan City, with all participant ages being in their twenties. Obtuse angled earlobes accounted for 41.2% of the earlobes observed, while acute angled earlobes prevalence was calculated at 38.8% and right angled earlobe was 20.0% of the total (sexes combined). In men, the acute angled earlobe was the most frequent type (43.0%), while the obtuse angled earlobe was the most frequent type in females (45.2%). These differences were statistically significant (p = 0.015). Overall, attached type earlobe (61.2%) was more frequent than free type earlobe. The attached type earlobe was more common in both sex groups (57.0% in male and 65.4% in female), and the proportion was significantly higher for females (p = 0.006). In conclusion, the findings in this study suggest that the attached earlobe type is the most common among Koreans, and the proportion of earlobe types among males and females is significantly different. Further studies are needed to understand the genetic background of earlobe types among Koreans.
MeSH term(s)	Adult ; Asian Continental Ancestry Group/statistics & numerical data ; Cross-Sectional Studies ; Ear Auricle/anatomy & histology ; Female ; Humans ; Male ; Republic of Korea/epidemiology ; Sex Characteristics ; Young Adult
Language	English
Publishing date	2018-10-29
Publishing country	Germany
Document type	Journal Article
ZDB-ID	2466-1
ISSN	1618-1301 ; 0018-442X
ISSN (online)	1618-1301
ISSN	0018-442X
DOI	10.1016/j.jchb.2018.10.003
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Article: Ranking surface soil pollution potential of chemicals from accidental release by using two indicators calculated with a multimedia model (SoilPCA)

Kim, K.-E. / Jung, J. E. / Lee, Y. / Lee, D. S.

Ecological indicators

2018 Volume 85, Issue -, Page(s) 664

Language	English
Document type	Article
ZDB-ID	2036774-0
ISSN	1470-160x
Database	Current Contents Nutrition, Environment, Agriculture

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Article: The role of vitamin D in normal and pathologic processes in the colon.

Kim, K E / Brasitus, T A

Current opinion in gastroenterology

2006 Volume 17, Issue 1, Page(s) 72–77

Abstract: Vitamin D(3) metabolites and analogues have recently been shown to play an important role in the regulation of a number of important cellular processes, including proliferation, differentiation, and apoptosis, in addition to their established roles in ... ...

Abstract	Vitamin D(3) metabolites and analogues have recently been shown to play an important role in the regulation of a number of important cellular processes, including proliferation, differentiation, and apoptosis, in addition to their established roles in mineral homeostasis. The actions of these secosteroids involve both rapid, nongenomic effects and genomic effects; the latter mediated via the vitamin D receptor and other transcription factors. Their effects have been described in a variety of cell types, including normal and malignant colonocytes. This article summarizes the rapid and genomic actions of vitamin D(3) metabolites and analogues on normal and pathologic processes in the colon, with particular emphasis on the potential of these secosteroids to prevent colon cancer.
Language	English
Publishing date	2006-09-28
Publishing country	United States
Document type	Journal Article
ZDB-ID	632571-3
ISSN	1531-7056 ; 0267-1379
ISSN (online)	1531-7056
ISSN	0267-1379
DOI	10.1097/00001574-200101000-00014
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Article ; Online: IgE cross-reactivity of peanut with walnut and soybean in children with food allergy.

Kim, M N / Lee, K E / Hong, J Y / Kim, K W / Kim, K-E / Sohn, M H / Park, J W

Allergologia et immunopathologia

2016 Volume 44, Issue 6, Page(s) 524–530

Abstract: Background: Peanut allergies are common and can be life-threating for sensitised individuals. Peanut allergens share significant amino acid homology with those of other legumes and tree nuts, but their cross-reactivity still remains unclear.: ... ...

Abstract	Background: Peanut allergies are common and can be life-threating for sensitised individuals. Peanut allergens share significant amino acid homology with those of other legumes and tree nuts, but their cross-reactivity still remains unclear. Objective: We sought to determine the clinical significance of the cross-reactivity of peanut allergens with those of walnut and soybean. Methods: Pooled sera from eight subjects with both peanut and walnut specific IgE were investigated in an inhibition test. After the sera were incubated with either peanut or walnut protein extracts, the quantity of IgE antibodies against the peanut and walnut was measured using an immunoCAP test. Likewise, pooled sera from 18 subjects with both peanut and soybean specific IgE antibodies were incubated with either peanut or soybean protein extracts and evaluated with a peanut and soybean immunoCAP test. SDS-PAGE and immunoblotting were also performed with peanut, walnut and soybean protein extracts and relevant sera. Results: Peanut specific IgE was inhibited up to 20% and 26% by walnut and soybean protein extracts, respectively. In reverse, walnut and soybean specific IgE were inhibited up to 21% and 23% by peanut protein extracts, respectively. In the immunoblot analysis, pooled serum from the subjects with peanut specific IgE antibodies reacted with walnut protein extracts significantly. Conclusion: Although the clinical significance of the cross-reactivity of peanut specific IgE with walnut and soybean protein extracts has not been established, we believe that individuals who are allergic to peanuts need to be cautious about consuming walnuts and soybeans.
MeSH term(s)	Antigens, Plant/immunology ; Arachis/immunology ; Binding, Competitive ; Child ; Child, Preschool ; Cross Reactions ; Female ; Humans ; Immunoglobulin E/blood ; Infant ; Infant, Newborn ; Juglans/immunology ; Male ; Nut Hypersensitivity/immunology ; Glycine max/immunology
Chemical Substances	Antigens, Plant ; Immunoglobulin E (37341-29-0)
Language	English
Publishing date	2016-10-07
Publishing country	Singapore
Document type	Journal Article
ZDB-ID	193144-1
ISSN	1578-1267 ; 0301-0546
ISSN (online)	1578-1267
ISSN	0301-0546
DOI	10.1016/j.aller.2016.04.012
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Article: Comparative clinical pharmacology of calcium channel blockers.

Kim, K E

American family physician

1991 Volume 43, Issue 2, Page(s) 583–588

Abstract: Calcium channel blockers are effective antihypertensive agents, both as initial monotherapy and in combination with other antihypertensive agents. These drugs are also effective in the treatment of chronic, stable angina, variant angina and ... ...

Abstract	Calcium channel blockers are effective antihypertensive agents, both as initial monotherapy and in combination with other antihypertensive agents. These drugs are also effective in the treatment of chronic, stable angina, variant angina and supraventricular arrhythmias. Drugs in this class have different affinities for calcium channels in vascular smooth muscle, cardiac muscle, cardiac sinus and atrioventricular node. They are all useful in hypertension and angina, but only verapamil and diltiazem are also useful in the control of heart rate and supraventricular arrhythmias. Nimodipine may control vascular spasm following subarachnoid hemorrhage. Calcium channel blockers have also been used in the treatment of migraine headache and Raynaud's phenomenon.
MeSH term(s)	Calcium Channel Blockers/pharmacology ; Calcium Channel Blockers/therapeutic use ; Cardiovascular Diseases/drug therapy ; Humans ; Hypertension/drug therapy
Chemical Substances	Calcium Channel Blockers
Language	English
Publishing date	1991-02
Publishing country	United States
Document type	Comparative Study ; Journal Article ; Review
ZDB-ID	412694-4
ISSN	0002-838X ; 0572-3612
ISSN	0002-838X ; 0572-3612
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Article ; Online: Increased sputum levels of thymus and activation-regulated chemokine in children with asthma not eosinophilic bronchitis.

Kim, M J / Lee, H S / Sol, I S / Kim, M N / Hong, J Y / Lee, K E / Kim, Y H / Kim, K W / Sohn, M H / Kim, K-E

Allergologia et immunopathologia

2017 Volume 45, Issue 3, Page(s) 220–226

Abstract: Background: Thymus and activation-regulated chemokine (TARC), a member of the CC chemokine family, plays a crucial role in Th2-specific inflammation. We aimed to determine the concentration of sputum TARC in children with asthma and eosinophilic ... ...

Abstract	Background: Thymus and activation-regulated chemokine (TARC), a member of the CC chemokine family, plays a crucial role in Th2-specific inflammation. We aimed to determine the concentration of sputum TARC in children with asthma and eosinophilic bronchitis (EB) and its relation with eosinophilic inflammation, pulmonary function, and bronchial hyper-responsiveness. Methods: In total, 90 children with asthma, 38 with EB, and 45 control subjects were enrolled. TARC levels were measured in sputum supernatants using an ELISA. We performed pulmonary function tests and measured exhaled fractional nitric oxide, eosinophil counts in blood, and sputum and serum levels of total IgE in all children. Results: Sputum TARC levels were significantly higher in children with asthma than in either children with EB (p=0.004) or the control subjects (p=0.014). Among patients with asthma, sputum TARC concentration was higher in children with sputum eosinophilia than in those without sputum eosinophilia (p=0.035). Sputum TARC levels positively correlated with eosinophil counts in sputum, serum total IgE levels, exhaled fractional nitric, and the bronchodilator response. Negative significant correlations were found between sputum TARC and FEV1/FVC (the ratio of forced expiratory volume in one second and forced expiratory vital capacity) or PC Conclusion: Elevated TARC levels in sputum were detected in children with asthma but not in children with EB. Sputum TARC could be a supportive marker for discrimination of asthma from EB in children showing characteristics of eosinophilic airway inflammation.
MeSH term(s)	Asthma/diagnosis ; Asthma/immunology ; Asthma/metabolism ; Biomarkers/analysis ; Bronchitis/diagnosis ; Bronchitis/immunology ; Bronchitis/metabolism ; Chemokine CCL17/biosynthesis ; Child ; Female ; Humans ; Male ; Pulmonary Eosinophilia/diagnosis ; Pulmonary Eosinophilia/immunology ; Pulmonary Eosinophilia/metabolism ; Sputum/chemistry
Chemical Substances	Biomarkers ; CCL17 protein, human ; Chemokine CCL17
Language	English
Publishing date	2017-02-21
Publishing country	Spain
Document type	Journal Article
ZDB-ID	193144-1
ISSN	1578-1267 ; 0301-0546
ISSN (online)	1578-1267
ISSN	0301-0546
DOI	10.1016/j.aller.2016.12.004
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Article: Hemodynamics and pathophysiology of hypertension in different stages of chronic renal parenchymal disease.

Kim, K E

Yonsei medical journal

1986 Volume 27, Issue 3, Page(s) 178–199

MeSH term(s)	Adolescent ; Adult ; Female ; Hemodynamics ; Humans ; Hypertension/etiology ; Hypertension/physiopathology ; Kidney Failure, Chronic/physiopathology ; Kidney Failure, Chronic/surgery ; Kidney Transplantation ; Male ; Middle Aged ; Nephrectomy
Language	English
Publishing date	1986
Publishing country	Korea (South)
Document type	Comparative Study ; Journal Article
ZDB-ID	303740-x
ISSN	1976-2437 ; 0513-5796
ISSN (online)	1976-2437
ISSN	0513-5796
DOI	10.3349/ymj.1986.27.3.178
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Article ; Online: Increased serum B cell-activating factor level in children with atopic dermatitis.

Jee, H M / Kim, K W / Hong, J Y / Sohn, M H / Kim, K E

Clinical and experimental dermatology

2010 Volume 35, Issue 6, Page(s) 593–598

Abstract: Background: B cell-activating factor (BAFF) is a tumour necrosis factor superfamily member best known for its role in the survival and maturation of B cells. BAFF activity is seen in naïve and effector/memory T cells.: Aim: To investigate the level ... ...

Abstract	Background: B cell-activating factor (BAFF) is a tumour necrosis factor superfamily member best known for its role in the survival and maturation of B cells. BAFF activity is seen in naïve and effector/memory T cells. Aim: To investigate the level and role of BAFF in serum of patients with atopic dermatitis (AD). Methods: Levels of serum BAFF, a proliferation-inducing ligand (APRIL) and total serum IgE level, and total eosinophil count were measured in 245 children. Results: Patients were characterized as having atopic eczema (AE) (n = 90) or non-AE (n = 77); the remainder were healthy control subjects (n = 78). Serum BAFF level in children with AE (1625.04 +/- 708.32 pg/mL) was significantly higher than in non-AE children (1194.69 +/- 448.44 pg/mL, P < 0.0001) or healthy controls (1062.89 +/- 444.74 pg/mL, P < 0.0001). Serum APRIL level was not different between the three groups. Serum BAFF level significantly correlated with total serum IgE level (gamma = 0.42, P < 0.0001) and total eosinophil count. It was also positively correlated with serum BAFF and egg-specific IgE level (gamma = 0.252, P = 0.045) in AE. Conclusions: Serum BAFF level is high in AE and might be a useful marker for AE.
MeSH term(s)	Adolescent ; Analysis of Variance ; B-Cell Activating Factor/blood ; Biomarkers/blood ; Case-Control Studies ; Child ; Child, Preschool ; Dermatitis, Atopic/blood ; Female ; Humans ; Infant ; Male ; Severity of Illness Index
Chemical Substances	B-Cell Activating Factor ; Biomarkers
Language	English
Publishing date	2010-08
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	195504-4
ISSN	1365-2230 ; 0307-6938
ISSN (online)	1365-2230
ISSN	0307-6938
DOI	10.1111/j.1365-2230.2009.03635.x
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Article ; Online: Chitinase induce the release of IL-8 in human airway epithelial cells, via Ca2+-dependent PKC and ERK pathways.

Hong, J Y / Lee, K E / Kim, K W / Sohn, M H / Kim, K-E

Scandinavian journal of immunology

2010 Volume 72, Issue 1, Page(s) 15–21

Abstract: Chitinases are produced in significant quantities by hosts defending against infections with chitin-containing organisms. However, little is known about the immune response of exogenous chitinase in human epithelial cells. IL-8 has been suggested to have ...

Abstract	Chitinases are produced in significant quantities by hosts defending against infections with chitin-containing organisms. However, little is known about the immune response of exogenous chitinase in human epithelial cells. IL-8 has been suggested to have a role in the pathogenesis of the allergenic inflammation of bronchial asthma. We examined whether Streptomyces griseus (S. griseus) chitinase-induced IL-8 on airway epithelium and identified the involvement of intracellular signalling pathways. H292 cells were treated with S. griseus chitinase with different concentrations and times. The IL-8 levels were determined by specific human IL-8 enzyme-linked immunosorbent assay (ELISA) and reverse transcriptase polymerase chain reaction. Using a series of pharmacological inhibitors, we examined the upstream signalling pathway responsible for IL-8 expression in response to S. griseus chitinase. Cells exposed to S. griseus chitinase showed higher level of IL-8 protein production and mRNA expression. Cells stimulated by S. griseus chitinase resulted in the activation of protein kinase C (PKC), extracellular signal-regulated kinase (ERK) and nuclear factor kappa-B (NF-kB) pathways. Inhibitors of Ca(2+)-dependent PKC (Ro-31-8220, calphostin C and Go6976) significantly abolished chitinase-induced expression of IL-8. However, Ca(2+)-independent PKC inhibitor (rottlerin) did not inhibit IL-8 expression. Through ERK inhibitor (U0126) and NF-kB inhibitor (caffeine acid phenethyl ester) treatment, it was proven that ERK and NF-kB regulated chitinase-induced IL-8 expression. We concluded that S. griseus chitinase-induced IL-8 expression was regulated by the activation of Ca(2+/-)-dependent PKC, ERK and NF-kB in human airway epithelial cells.
MeSH term(s)	Blotting, Western ; Butadienes/pharmacology ; Caffeic Acids/pharmacology ; Carbazoles/pharmacology ; Cell Line, Tumor ; Chitinases/immunology ; Enzyme-Linked Immunosorbent Assay ; Epithelial Cells ; Extracellular Signal-Regulated MAP Kinases/antagonists & inhibitors ; Extracellular Signal-Regulated MAP Kinases/immunology ; Humans ; Indoles/pharmacology ; Interleukin-8/genetics ; Interleukin-8/immunology ; NF-kappa B/antagonists & inhibitors ; NF-kappa B/immunology ; Naphthalenes/pharmacology ; Nitriles/pharmacology ; Phenylethyl Alcohol/analogs & derivatives ; Phenylethyl Alcohol/pharmacology ; Protein Kinase C/antagonists & inhibitors ; Protein Kinase C/immunology ; Protein Kinase Inhibitors/pharmacology ; RNA, Messenger/chemistry ; RNA, Messenger/genetics ; Respiratory Mucosa/enzymology ; Respiratory Mucosa/immunology ; Reverse Transcriptase Polymerase Chain Reaction ; Signal Transduction
Chemical Substances	Butadienes ; Caffeic Acids ; Carbazoles ; Indoles ; Interleukin-8 ; NF-kappa B ; Naphthalenes ; Nitriles ; Protein Kinase Inhibitors ; RNA, Messenger ; U 0126 ; Go 6976 (136194-77-9) ; Protein Kinase C (EC 2.7.11.13) ; Extracellular Signal-Regulated MAP Kinases (EC 2.7.11.24) ; Chitinases (EC 3.2.1.14) ; caffeic acid phenethyl ester (G960R9S5SK) ; calphostin C (I271P23G24) ; Phenylethyl Alcohol (ML9LGA7468) ; Ro 31-8220 (W9A0B5E78O)
Language	English
Publishing date	2010-07
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	120476-2
ISSN	1365-3083 ; 0300-9475
ISSN (online)	1365-3083
ISSN	0300-9475
DOI	10.1111/j.1365-3083.2010.02404.x
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Article: Prediction of buckwheat allergy using specific IgE concentrations in children.

Sohn, M H / Lee, S Y / Kim, K-E

Allergy

2003 Volume 58, Issue 12, Page(s) 1308–1310

Abstract: Introduction: Buckwheat (BW) is considered to be one of the most important food allergens, and positive skin tests are found in about 5% of Koreans. We investigated the positive and negative predictive values of BW-specific IgE in subjects with a BW ... ...

Abstract	Introduction: Buckwheat (BW) is considered to be one of the most important food allergens, and positive skin tests are found in about 5% of Koreans. We investigated the positive and negative predictive values of BW-specific IgE in subjects with a BW allergy in order to reduce the need for buckwheat challenge, which can be more riskier than other causes of food allergies. Methods: Twenty-eight BW allergic subjects with symptoms after BW Open food challenge and 16 asymptomatic control subjects with positive skin test to BW were recruited. Serum samples from all patients were analyzed for BW-specific IgE antibodies using the Pharmacia CAP System. Results: According to the receiver operator characteristic (ROC) analysis, the optimal cutoff level of BW-specific IgE, as the definitions of serum BW-specific IgE positive, was 1.26 kUA/l. With this selected cutoff level, the sensitivity, specificity, positive and negative predictive values were 93.10, 93.33, 79.75 and 97.96%, respectively. Conclusion: The use of the optimal cutoff level, 1.26 kUA/l, that simultaneously maximizes sensitivity and specificity, would be helpful for avoiding unnecessary risky challenge in children with a strong clinical history and skin test responses.
MeSH term(s)	Adolescent ; Child ; Child, Preschool ; Fagopyrum/adverse effects ; Fagopyrum/immunology ; Female ; Food Hypersensitivity/immunology ; Humans ; Immunoglobulin E/immunology ; Korea ; Male ; Predictive Value of Tests ; Skin Tests/methods
Chemical Substances	Immunoglobulin E (37341-29-0)
Language	English
Publishing date	2003-09-29
Publishing country	Denmark
Document type	Journal Article
ZDB-ID	391933-x
ISSN	1398-9995 ; 0105-4538
ISSN (online)	1398-9995
ISSN	0105-4538
DOI	10.1046/j.1398-9995.2003.00339.x
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