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Article ; Online: Occurrence of Gastrointestinal Adverse Events Upon GLP-1 Receptor Agonist Initiation With Concomitant Metformin Use: A Post Hoc Analysis of LEADER, STEP 2, SUSTAIN-6, and PIONEER 6.

Klein, Klara R / Clemmensen, Kim K B / Fong, Edwin / Olsen, Søren / Abrahamsen, Trine / Lingvay, Ildiko

2023 Volume 47, Issue 2, Page(s) 280–284

Abstract: Objective: To assess the impact of concomitant metformin use on gastrointestinal adverse events during the initiation and titration of a glucagon-like peptide 1 receptor agonist (GLP-1RA).: Research design and methods: Using data from four clinical ... ...

Abstract	Objective: To assess the impact of concomitant metformin use on gastrointestinal adverse events during the initiation and titration of a glucagon-like peptide 1 receptor agonist (GLP-1RA). Research design and methods: Using data from four clinical trials of liraglutide and semaglutide (Liraglutide Effect and Action in Diabetes: Evaluation of Cardiovascular Outcome Results [LEADER], Semaglutide Treatment Effect in People with Obesity [STEP 2], Trial to Evaluate Cardiovascular and Other Long-Term Outcomes With Semaglutide in Subjects With Type 2 Diabetes [SUSTAIN-6], and Peptide Innovation for Early Diabetes Treatment [PIONEER] 6), we compared the incidence of gastrointestinal adverse events during GLP-1RA initiation and titration in participants with and without concomitant metformin use. Results: Of 16,996 participants, 12,928 (76%) were treated with metformin. Concomitant metformin use did not increase the percentage of participants who developed gastrointestinal adverse events or their severity during the observation window. Among participants experiencing gastrointestinal adverse events, metformin use did not increase study product discontinuation. Within treatment arms (GLP-1RA and placebo), a numerically higher percentage of metformin nonusers experienced gastrointestinal adverse events and discontinued the study product compared with metformin users. Conclusions: Concomitant metformin use does not increase occurrence of gastrointestinal symptoms during GLP-1RA initiation or impact GLP-1RA discontinuation.
MeSH term(s)	Humans ; Metformin/adverse effects ; Diabetes Mellitus, Type 2/complications ; Hypoglycemic Agents/adverse effects ; Glucagon-Like Peptide-1 Receptor Agonists ; Liraglutide/adverse effects ; Glucagon-Like Peptides/adverse effects ; Glucagon-Like Peptide-1 Receptor/agonists
Chemical Substances	Metformin (9100L32L2N) ; Hypoglycemic Agents ; Glucagon-Like Peptide-1 Receptor Agonists ; Liraglutide (839I73S42A) ; Glucagon-Like Peptides (62340-29-8) ; Glucagon-Like Peptide-1 Receptor
Language	English
Publishing date	2023-12-04
Publishing country	United States
Document type	Journal Article
ZDB-ID	441231-x
ISSN	1935-5548 ; 0149-5992
ISSN (online)	1935-5548
ISSN	0149-5992
DOI	10.2337/dc23-1791
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Zs.A 1434: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
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Article ; Online: Associations Between Physical Activity and Gastrointestinal Transit Times in People with Normal Weight, Overweight, and Obesity.

Jensen, Marie M / Pedersen, Hanne E / Clemmensen, Kim K B / Ekblond, Trine S / Ried-Larsen, Mathias / Færch, Kristine / Brock, Christina / Quist, Jonas S

The Journal of nutrition

2023 Volume 154, Issue 1, Page(s) 41–48

Abstract: Background: Rapid gastric emptying is associated with obesity and overeating, whereas delayed gastric emptying is associated with anorexia. Acute effects of exercise on gastric emptying have been investigated extensively, but the influence of habitual ... ...

Abstract	Background: Rapid gastric emptying is associated with obesity and overeating, whereas delayed gastric emptying is associated with anorexia. Acute effects of exercise on gastric emptying have been investigated extensively, but the influence of habitual physical activity on gastric emptying and transit time in other regions of the gastrointestinal tract is poorly understood. Objective: The objective was to investigate associations between objectively measured habitual physical activity and gastrointestinal transit times in adults with varying degrees of adiposity. Methods: 50 adults (58% women) were included in this cross-sectional study. Physical activity was measured by an accelerometer placed on the lower back for 7 d. Gastric emptying time, small bowel transit time, colonic transit time, and whole gut transit time were simultaneously evaluated by a wireless motility capsule, which was ingested together with a standardized mixed meal. Linear regression models were applied to assess the associations of total activity counts and time spent at different intensities-sedentary activity (0-100 counts/min), low light activity (101-759 counts/min), high light activity (760-1951 counts/min); moderate and vigorous activity (≥1952 counts/min)) with gastrointestinal transit times. Results: Median [Q1; Q3] age was 56.5 [46.6-65.5] y, and body mass index (BMI) was 32.1 [28.5-35.1] kg/m Conclusions: More time spent on physical activity at high light intensity was associated with more rapid colonic and whole gut transit time, independent of age, sex, and body fat, whereas other intensities of physical activity and gastrointestinal transit times were not associated. Trial registration: Clinicaltrials.gov IDs (NCT03894670, NCT03854656).
MeSH term(s)	Adult ; Humans ; Female ; Male ; Gastrointestinal Transit ; Overweight ; Cross-Sectional Studies ; Obesity ; Exercise ; Gastric Emptying
Language	English
Publishing date	2023-06-12
Publishing country	United States
Document type	Journal Article
ZDB-ID	218373-0
ISSN	1541-6100 ; 0022-3166
ISSN (online)	1541-6100
ISSN	0022-3166
DOI	10.1016/j.tjnut.2023.06.005
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Article: Extraction of Histidine, Proline, and Methionine and Their Mixtures Using Systems Based on N-VinylFormamide

Mokshina, N. Ya / Pakhomova, O. A / Kim, K. B / Niftaliev, S. I

Journal of analytical chemistry. 2021 Jan., v. 76, no. 1

2021

Abstract: Methods are proposed for the extraction of amino acids histidine, methionine, and proline from aqueous media with water-soluble polymers for their subsequent determination by capillary electrophoresis. Regularities of the interphase distribution of ... ...

Abstract	Methods are proposed for the extraction of amino acids histidine, methionine, and proline from aqueous media with water-soluble polymers for their subsequent determination by capillary electrophoresis. Regularities of the interphase distribution of analytes in water–salt extraction systems based on poly-N-vinyl formamide and its copolymer with N-vinylimidazole are revealed and their efficiency is proved. The rate of formation of a two-phase system water-soluble polymer–aqueous salt solution of amino acid is substantially affected by the molecular weight and intrinsic viscosity of the extractant. The effect of the volume ratio of water and organic phases on the efficiency of extraction of histidine, methionine, and proline is studied, also on their simultaneous presence; quantitative characteristics of the process are calculated. Homo- and copolymers of N-vinylformamide are used for the efficient extraction and extraction separation of a histidine−methionine mixture. Partition coefficients and the recoveries of amino acids are specified in the systems containing poly-N-vinylformamide and its copolymer with N-vinylimidazole in the presence of an ammonium sulfate salting-out agent. The conditions for the electrophoretic determination of amino acids are optimized, i.e., the composition of the buffer solution and the type and concentration of the micelle-forming agent. The developed method for the electrophoretic separate determination of amino acids with the preliminary extraction of the target components with water-soluble polymers can be recommended for routine analyses in determining the safety of foodstuffs, energy drinks, and pharmaceuticals.
Keywords	ammonium sulfate ; analytical chemistry ; capillary electrophoresis ; chemical species ; composite polymers ; drugs ; energy ; histidine ; interphase ; methionine ; molecular weight ; proline ; viscosity ; water solubility
Language	English
Dates of publication	2021-01
Size	p. 57-63.
Publishing place	Pleiades Publishing
Document type	Article
Note	NAL-AP-2-clean
ZDB-ID	2057336-4
ISSN	1608-3199 ; 1061-9348
ISSN (online)	1608-3199
ISSN	1061-9348
DOI	10.1134/S106193482101007X
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Article ; Online: Predicting the HbA

Bruhn, Lea / Vistisen, Dorte / Amadid, Hanan / Clemmensen, Kim K B / Karstoft, Kristian / Ried-Larsen, Mathias / Persson, Frederik / Jørgensen, Marit E / Møller, Cathrine Laustrup / Stallknecht, Bente / Færch, Kristine / Blond, Martin B

Endocrine

2023 Volume 81, Issue 1, Page(s) 67–76

Abstract: Purpose: To investigate whether the prediction of post-treatment HbA: Methods: We performed an exploratory analysis based on data from 112 individuals with prediabetes (HbA: Results: The prediction models explained 46-50% of the variation (R: ... ...

Abstract	Purpose: To investigate whether the prediction of post-treatment HbA Methods: We performed an exploratory analysis based on data from 112 individuals with prediabetes (HbA Results: The prediction models explained 46-50% of the variation (R Conclusion: Adding an additional biomarker of the glucose metabolism did not improve the prediction of post-treatment HbA
MeSH term(s)	Humans ; Prediabetic State/drug therapy ; Diabetes Mellitus, Type 2 ; Blood Glucose/metabolism ; Glucose ; Glycated Hemoglobin ; Biomarkers ; Insulins
Chemical Substances	Blood Glucose ; Glucose (IY9XDZ35W2) ; Glycated Hemoglobin ; Biomarkers ; Insulins
Language	English
Publishing date	2023-05-17
Publishing country	United States
Document type	Randomized Controlled Trial ; Journal Article
ZDB-ID	1194484-5
ISSN	1559-0100 ; 1355-008X ; 0969-711X
ISSN (online)	1559-0100
ISSN	1355-008X ; 0969-711X
DOI	10.1007/s12020-023-03384-w
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Zs.A 3884: Show issues

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Article ; Online: Hand eczema patients' knowledge of skin protection following a guided talk-A retrospective study with a follow-up questionnaire.

Topal, Yasemin / Agner, Tove / van der Heiden, Janique / Ebbehøj, Niels E / Clemmensen, Kim K B

Contact dermatitis

2019 Volume 81, Issue 2, Page(s) 117–123

Abstract: Background: Several studies have assessed the effect of patient education regarding hand eczema (HE) severity and quality of life. Few studies, however, have evaluated patients' knowledge.: Objectives: To examine knowledge of skin protection in HE ... ...

Abstract	Background: Several studies have assessed the effect of patient education regarding hand eczema (HE) severity and quality of life. Few studies, however, have evaluated patients' knowledge. Objectives: To examine knowledge of skin protection in HE patients following a guided talk, and to identify variables associated with knowledge. Methods: HE patients referred to the outpatient dermatological clinic, Bispebjerg Hospital, between January 2013 and July 2014 were offered a guided talk on HE prevention. HE severity and the Dermatology Life Quality Index (DLQI) score were assessed. A questionnaire comprising 10 questions about skin protection was sent 1 to 2.5 years later. Results: One hundred and twenty patients responded to the questionnaire (response 53.5%). The mean percentage of correct answers was 74.7%. Sixty per cent responded correctly to at least eight questions. Male sex, older age and education for >5 years were associated with a low level of knowledge. Education for 3 to 4 years (P = 0.045) was associated with a higher level of knowledge. No significant impact of previous/current atopic dermatitis, HE severity or previous information on skin protection was found with respect to level of knowledge. Conclusions: Females and patients with education for 3 to 4 years showed the highest level of knowledge, whereas males, older patients and patients with education for >5 years should be brought more into focus in skin protection programmes.
MeSH term(s)	Adolescent ; Adult ; Aged ; Aged, 80 and over ; Eczema/prevention & control ; Female ; Follow-Up Studies ; Hand Dermatoses/prevention & control ; Health Knowledge, Attitudes, Practice ; Humans ; Logistic Models ; Male ; Middle Aged ; Patient Education as Topic/methods ; Preventive Medicine/methods ; Quality of Life ; Retrospective Studies ; Severity of Illness Index ; Skin Care/methods ; Surveys and Questionnaires ; Treatment Outcome ; Young Adult
Language	English
Publishing date	2019-05-21
Publishing country	England
Document type	Journal Article
ZDB-ID	193121-0
ISSN	1600-0536 ; 0105-1873
ISSN (online)	1600-0536
ISSN	0105-1873
DOI	10.1111/cod.13264
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Zs.A 1116: Show issues

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Article ; Online: Role of Weekday Variation on Glucose, Insulin, and Triglyceride: A Cross-Sectional Analysis From the Maastricht Study.

Clemmensen, Kim K B / Koster, Annemarie / Nielen, Yannick T H / Dagnelie, Pieter C / Stehouwer, Coen D A / Bosma, Hans / Wesselius, Anke / Færch, Kristine / Eussen, Simone J P M

The Journal of clinical endocrinology and metabolism

2022 Volume 107, Issue 8, Page(s) e3145–e3151

Abstract: Context: The timing of sleep, physical activity, and dietary intake show variation over the week, with different timings in the weekend compared to the weekdays, which may potentially lead to impaired glucose and lipid regulation on Mondays compared to ... ...

Abstract	Context: The timing of sleep, physical activity, and dietary intake show variation over the week, with different timings in the weekend compared to the weekdays, which may potentially lead to impaired glucose and lipid regulation on Mondays compared to other weekdays. Objective: The aim of the study was to investigate differences in glucose metabolism and fasting triglyceride concentrations on Mondays compared to the rest of the week. Design, setting and participants: This cross-sectional study is based on data from the Maastricht Study, including 6067 participants without known diabetes and 1568 previously diagnosed with type 2 diabetes. Main outcome measures: Confounder-adjusted linear regression analysis was applied to study the associations of day of the week of examination with glucose and insulin responses to an oral glucose tolerance test and fasting triglyceride concentrations. Results: In fully confounder-adjusted models, mean (95% CI) concentrations of fasting glucose, insulin, and triglycerides were slightly higher on Mondays compared with the other weekdays [glucose: 1% (0-2); insulin: 9% (1-18); triglycerides: 5% (2-8)]. Interaction analyses revealed that the association of weekday with insulin was only pronounced in men [18% (3-35)], but not in women [1% (-8-10)], whereas the associations with glucose and triglycerides were only apparent for individuals with known type 2 diabetes [glucose: 4% (0-7); triglycerides: 14% (6-23)] compared to the background population [glucose: 0% (0-1); triglycerides: 3% (0-6)]. Discussion: Being examined on a Monday was associated with higher fasting insulin concentrations among men but not women.
MeSH term(s)	Blood Glucose/metabolism ; Cross-Sectional Studies ; Diabetes Mellitus, Type 2/epidemiology ; Fasting ; Glucose ; Humans ; Hyperinsulinism ; Insulin ; Male ; Triglycerides
Chemical Substances	Blood Glucose ; Insulin ; Triglycerides ; Glucose (IY9XDZ35W2)
Language	English
Publishing date	2022-05-16
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	3029-6
ISSN	1945-7197 ; 0021-972X
ISSN (online)	1945-7197
ISSN	0021-972X
DOI	10.1210/clinem/dgac286
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Article ; Online: Incidence, survival, and risk of cardiovascular events in adult inflammatory myopathies in South Korea: a nationwide population-based study.

Jung, K H / Kim, H J / Park, W / Lim, M J / Kang, T / Kang, M J / Kim, K-B / Ahn, H S

Scandinavian journal of rheumatology

2020 Volume 49, Issue 4, Page(s) 323–331

Abstract: Objective: Epidemiological studies on inflammatory myopathies (IMs) show widely variable results, and studies on Asians are lacking. Despite emerging interest in the cardiovascular disease (CVD) risk associated with IMs, the prevalence of CVD in IM ... ...

Abstract	Objective: Epidemiological studies on inflammatory myopathies (IMs) show widely variable results, and studies on Asians are lacking. Despite emerging interest in the cardiovascular disease (CVD) risk associated with IMs, the prevalence of CVD in IM patients and its impact on mortality remain unclear. We conducted a nationwide, population-based study on the incidence, mortality, and associated major CVD events of IMs in the Republic of Korea over 11 years. Method: Using the nationwide, population-based National Health Insurance claims database and the Rare Intractable Disease registration programme, we estimated incidence, mortality, and CVD occurrence. Survival was examined using the Kaplan-Meier method. Mortality rate in IMs with CVD was analysed by Cox proportional hazards regression. Results: There were 3014 incident cases, 640 of whom died during the study period. The mean annual incidence was 7.16/10 Conclusion: We found persistently low incidence, poor survival, and high major CVD incidence in IMs, and increased mortality in IMs with CVD.
MeSH term(s)	Adult ; Aged ; Aged, 80 and over ; Cardiovascular Diseases/etiology ; Cardiovascular Diseases/mortality ; Female ; Humans ; Incidence ; Male ; Middle Aged ; Myositis/complications ; Registries ; Republic of Korea/epidemiology ; Young Adult
Language	English
Publishing date	2020-04-14
Publishing country	England
Document type	Journal Article
ZDB-ID	121265-5
ISSN	1502-7732 ; 0300-9742
ISSN (online)	1502-7732
ISSN	0300-9742
DOI	10.1080/03009742.2019.1707281
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Zs.A 832: Show issues

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Article ; Online: Hyperkeratotic hand eczema compared to other subgroups of hand eczema - a retrospective study with a follow-up questionnaire.

van der Heiden, Janique / Agner, Tove / Rustemeyer, Thomas / Clemmensen, Kim K B

Contact dermatitis

2018 Volume 78, Issue 3, Page(s) 216–222

Abstract: Background: Only a few clinical trials on hand eczema have included further classification into subtypes, and there is a need for studies evaluating the present classifications.: Objectives: To examine differences in demographic factors, lifestyle ... ...

Abstract	Background: Only a few clinical trials on hand eczema have included further classification into subtypes, and there is a need for studies evaluating the present classifications. Objectives: To examine differences in demographic factors, lifestyle factors and severity between subgroups of hand eczema patients, with a focus on hyperkeratotic hand eczema. Methods: This was a retrospective study including hand eczema patients referred to the outpatient dermatological clinic, Bispebjerg Hospital, between January 2013 and July 2014. The study comprises information on subdiagnoses, treatment and foot eczema from patient files, as well as a follow-up questionnaire. Results: A total of 120 patients were included, 10 of whom were diagnosed with hyperkeratotic hand eczema. A significantly higher proportion of the patients with hyperkeratotic hand eczema were male (p = 0.002) and received systemic or ultraviolet (UV) treatment (p = 0.026). The frequency of tobacco smoking was significantly higher in patients with hyperkeratotic hand eczema (p = 0.016), as well as in the other subgroups combined (p = 0.049), than in the background population. Conclusions: Studies evaluating the subdiagnoses of hand eczema are needed, to further validate the classification system, and to provide more detailed information about demographic factors, severity and possible risk factors for different subgroups of hand eczema.
MeSH term(s)	Adolescent ; Adult ; Aged ; Denmark/epidemiology ; Eczema/complications ; Eczema/epidemiology ; Eczema/therapy ; Female ; Foot Dermatoses/epidemiology ; Hand Dermatoses/epidemiology ; Hand Dermatoses/therapy ; Humans ; Keratosis/complications ; Keratosis/epidemiology ; Keratosis/therapy ; Life Style ; Male ; Middle Aged ; Retrospective Studies ; Severity of Illness Index ; Sex Factors ; Surveys and Questionnaires ; Tobacco Smoking ; Young Adult
Language	English
Publishing date	2018-01-04
Publishing country	England
Document type	Comparative Study ; Journal Article
ZDB-ID	193121-0
ISSN	1600-0536 ; 0105-1873
ISSN (online)	1600-0536
ISSN	0105-1873
DOI	10.1111/cod.12945
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Article ; Online: A comparison of the health and related quality of life between middle-aged Korean and Chinese women.

Kim, K-B / Sok, S R

International nursing review

2010 Volume 57, Issue 4, Page(s) 463–469

Abstract: Background: The proportion of middle-aged people in one's total life cycle has increased. Health providers are required to promote and manage their health, and improve the quality of their life, especially middle-aged women. As international ... ...

Abstract	Background: The proportion of middle-aged people in one's total life cycle has increased. Health providers are required to promote and manage their health, and improve the quality of their life, especially middle-aged women. As international interchanges in nursing are growing between Korea and China, understanding of the level related to health and quality of life between middle-aged Korean and Chinese women is critical to improve their health and quality of life. Aim: To compare and examine the health perception, anger expression, self-esteem and quality of life between middle-aged Korean and Chinese women. Methods: A cross-sectional survey was conducted. The participants were comprised of a total 430 middle-aged Korean (n=220) and Chinese (n=210) women aged 40-64 years. The survey included a set of four questionnaires. All measures were self-administered. Data were analysed using the statistical package, SPSS/WIN Ver16.0 (SPSS, Inc., Chicago, IL, USA). Results: Middle-aged Chinese women had higher health perception than middle-aged Korean women. Anger expression, self-esteem and quality of life of middle-aged Korean women were higher than in middle-aged Chinese women. Also, there were the differences in the health perception, anger expression and self-esteem according to the general characteristics in all middle-aged Korean and Chinese women. Conclusions: Various nursing intervention strategies should be developed and adjusted to improve the self-esteem and quality of life for all middle-aged Korean and Chinese women, especially middle-aged Chinese women. Additionally, the individual characteristics and national culture of the middle-aged women should be considered as a basis for the nursing intervention.
MeSH term(s)	Adult ; China ; Cross-Sectional Studies ; Female ; Health Status ; Humans ; Middle Aged ; Quality of Life ; Republic of Korea ; Self Concept ; Surveys and Questionnaires
Language	English
Publishing date	2010-12
Publishing country	England
Document type	Comparative Study ; Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	80342-x
ISSN	1466-7657 ; 0020-8132
ISSN (online)	1466-7657
ISSN	0020-8132
DOI	10.1111/j.1466-7657.2010.00816.x
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Article ; Conference proceedings: Clinical analysis of sporadic nonampullary duodenal adenomas: multi-center retrospective study

Kim, K. B. / Moon, H. S. / Sung, J. K. / Kang, S. H. / Lee, S. W. / Cho, Y. S. / Kim, S. H. / Song, K. H. / Bang, K. B. / Kim, S. M.

Endoscopy

2023 Volume 55, Issue S 02

Event/congress	ESGE Days 2023, Dublin, Ireland, 2023-04-20
Language	English
Publishing date	2023-04-01
Publisher	Georg Thieme Verlag KG
Publishing place	Stuttgart ; New York
Document type	Article ; Conference proceedings
ZDB-ID	80120-3
ISSN	1438-8812 ; 0013-726X
ISSN (online)	1438-8812
ISSN	0013-726X
DOI	10.1055/s-0043-1765809
Database	Thieme publisher's database

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