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  1. Article ; Online: 2-

    Kim, Kang Sub / Choi, Yea Jung / Jang, Dae Sik / Lee, Sullim

    International journal of molecular sciences

    2022  Volume 23, Issue 23

    Abstract: Human skin is composed of three layers, of which the dermis is composed of an extracellular matrix (ECM) comprising collagen, elastin, and other proteins. These proteins are reduced due to skin aging caused by intrinsic and extrinsic factors. Among ... ...

    Abstract Human skin is composed of three layers, of which the dermis is composed of an extracellular matrix (ECM) comprising collagen, elastin, and other proteins. These proteins are reduced due to skin aging caused by intrinsic and extrinsic factors. Among various internal and external factors related to aging, ultraviolet (UV) radiation is the main cause of photoaging of the skin. UV radiation stimulates DNA damage, reactive oxygen species (ROS) generation, and pro-inflammatory cytokine production such as tumor necrosis factor-alpha (TNF-α), and promotes ECM degradation. Stimulation with ROS and TNF-α upregulates mitogen-activated protein kinases (MAPKs), nuclear factor kappa B (NF-κB), and activator protein 1 (AP-1) transcription factors that induce the expression of the collagenase matrix metalloproteinase-1 (MMP-1). Moreover, TNF-α induces intracellular ROS production and several molecular pathways. Skin aging progresses through various processes and can be prevented through ROS generation and TNF-α inhibition. In our previous study, 2-
    Language English
    Publishing date 2022-11-26
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms232314802
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Integrative Approach to Identifying System-Level Mechanisms of Chung-Sang-Bo-Ha-Hwan's Influence on Respiratory Tract Diseases: A Network Pharmacological Analysis with Experimental Validation.

    Park, Sa-Yoon / Kim, Kang-Sub / Lee, Won-Yung / Kim, Chang-Eop / Lee, Sullim

    Plants (Basel, Switzerland)

    2023  Volume 12, Issue 17

    Abstract: Chung-Sang-Bo-Ha-Hwan (CSBHH) is an herbal prescription widely used to treat various chronic respiratory diseases. To investigate the system-level treatment mechanisms of CSBHH in respiratory tract diseases, we identified 56 active ingredients of CSBHH ... ...

    Abstract Chung-Sang-Bo-Ha-Hwan (CSBHH) is an herbal prescription widely used to treat various chronic respiratory diseases. To investigate the system-level treatment mechanisms of CSBHH in respiratory tract diseases, we identified 56 active ingredients of CSBHH and evaluated the degree of overlap between their targets and respiratory tract disease-associated proteins. We then investigated the respiratory tract disease-related signaling pathways associated with CSBHH targets. Enrichment analysis showed that the CSBHH targets were significantly associated with various signaling pathways related to inflammation, alveolar structure, and tissue fibrosis. Experimental validation was conducted using phorbol-12-myristate-13-acetate (PMA)-stimulated NCI-H292 cells by analyzing the mRNA expression levels of biomarkers (IL-1β and TNF-α for inflammation; GSTP1, GSTM1, and PTEN for apoptosis) derived from network pharmacological analysis, in addition to the mucin genes MUC5AC and MUC2, to investigate the phlegm-expelling effect of CSBHH. The mRNA expression levels of these genes were consistent with network pharmacological predictions in a concentration-dependent manner. These results suggest that the therapeutic mechanisms of CSBHH in respiratory tract diseases could be attributed to the simultaneous action of multiple active ingredients in the herbal prescription.
    Language English
    Publishing date 2023-08-22
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2704341-1
    ISSN 2223-7747
    ISSN 2223-7747
    DOI 10.3390/plants12173024
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Rosarugosides A and D from

    Kim, Kang Sub / Son, So-Ri / Choi, Yea Jung / Kim, Yejin / Ahn, Si-Young / Jang, Dae Sik / Lee, Sullim

    Plants (Basel, Switzerland)

    2024  Volume 13, Issue 9

    Abstract: This present study investigated the anti-skin-aging properties ... ...

    Abstract This present study investigated the anti-skin-aging properties of
    Language English
    Publishing date 2024-05-02
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2704341-1
    ISSN 2223-7747
    ISSN 2223-7747
    DOI 10.3390/plants13091266
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: Oddioside A, a New Phenolic Glycoside Isolated from the Fruits of

    Kim, Kang Sub / Kim, Ranhee / Son, So-Ri / Kang, Ki Sung / Jang, Dae Sik / Lee, Sullim

    Antioxidants (Basel, Switzerland)

    2022  Volume 11, Issue 10

    Abstract: In our preliminary study, a hot water extract from the fruits ... ...

    Abstract In our preliminary study, a hot water extract from the fruits of
    Language English
    Publishing date 2022-09-24
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2704216-9
    ISSN 2076-3921
    ISSN 2076-3921
    DOI 10.3390/antiox11101894
    Database MEDical Literature Analysis and Retrieval System OnLINE

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