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  1. AU="Kim, Kyu Won"
  2. AU="Wang, Qianlong"
  3. AU=Zare-Zardini Hadi
  4. AU="Boorman, James P"
  5. AU="Duan, Jiasong"
  6. AU="He, Ruiying"
  7. AU="Auricchio, Salvatore"
  8. AU="Farnesini, L"
  9. AU="Gerald Berger"
  10. AU="Lenning, Ole Bernt"
  11. AU="Voetsch, Barbara"
  12. AU="Jakielska, Ewelina"
  13. AU="Sholl, Lynette"
  14. AU="Izquierdo, Inmaculada"
  15. AU="Miller, Andrew S"
  16. AU="Vincent-Levy-Frebault, V"
  17. AU="Willis, Zachary I"
  18. AU="Kruger, Eric S"
  19. AU="Ge, Shiyu"
  20. AU="Srivastava, Rajat"
  21. AU="Nemanja Vuksanovic"

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Treffer 1 - 10 von insgesamt 296

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  1. Buch ; Online ; E-Book: Cancer drug discovery

    Kim, Kyu-wŏn / Roh, Jae Kyung / Wee, Hee-Jun / Kim, Chan

    science and history

    2016  

    Verfasserangabe Kyu-Won Kim, Jae Kyung Roh, Hee-Jun Wee, Chan Kim
    Schlagwörter Medicine ; Pharmacy ; Cancer research ; Medicine/History
    Thema/Rubrik (Code) 614.5999
    Sprache Englisch
    Umfang 1 Online-Ressource (xvii, 276 Seiten), Illustrationen
    Verlag Springer
    Erscheinungsort Dordrecht
    Erscheinungsland Niederlande
    Dokumenttyp Buch ; Online ; E-Book
    Bemerkung Zugriff für angemeldete ZB MED-Nutzerinnen und -Nutzer
    HBZ-ID HT019469324
    ISBN 978-94-024-0844-7 ; 9789402408423 ; 94-024-0844-4 ; 9402408428
    DOI 10.1007/978-94-024-0844-7
    Datenquelle ZB MED Katalog Medizin, Gesundheit, Ernährung, Umwelt, Agrar

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  2. Artikel ; Online: Free-Resolution Probability Distributions Map-Based Precise Vehicle Localization in Urban Areas.

    Kim, Kyu-Won / Jee, Gyu-In

    Sensors (Basel, Switzerland)

    2020  Band 20, Heft 4

    Abstract: We propose a free-resolution probability distributions map (FRPDM) and an FRPDM-based precise vehicle localization method using 3D light detection and ranging (LIDAR). An FRPDM is generated by Gaussian mixture modeling, based on road markings and ... ...

    Abstract We propose a free-resolution probability distributions map (FRPDM) and an FRPDM-based precise vehicle localization method using 3D light detection and ranging (LIDAR). An FRPDM is generated by Gaussian mixture modeling, based on road markings and vertical structure point cloud. Unlike single resolution or multi-resolution probability distribution maps, in the case of the FRPDM, the resolution is not fixed and the object can be represented by various sizes of probability distributions. Thus, the shape of the object can be represented efficiently. Therefore, the map size is very small (61 KB/km) because the object is effectively represented by a small number of probability distributions. Based on the generated FRPDM, point-to-probability distribution scan matching and feature-point matching were performed to obtain the measurements, and the position and heading of the vehicle were derived using an extended Kalman filter-based navigation filter. The experimental area is the Gangnam area of Seoul, South Korea, which has many buildings around the road. The root mean square (RMS) position errors for the lateral and longitudinal directions were 0.057 m and 0.178 m, respectively, and the RMS heading error was 0.281°.
    Sprache Englisch
    Erscheinungsdatum 2020-02-23
    Erscheinungsland Switzerland
    Dokumenttyp Journal Article
    ZDB-ID 2052857-7
    ISSN 1424-8220 ; 1424-8220
    ISSN (online) 1424-8220
    ISSN 1424-8220
    DOI 10.3390/s20041220
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  3. Artikel: Sustainable Landscapes in the Traditional Korean Residential Environment: Focus on the Joseon Dynasty

    Kim, Hyung-Suk / Kim, Kyu-Won

    Land. 2021 June 30, v. 10, no. 7

    2021  

    Abstract: This study examines the sustainable landscapes displayed in traditional Korean houses of the Joseon Dynasty (1392–1910) by investigating urban agricultural practices implemented in the palace, private houses, and an imaginary garden (Uiwon). Currently ... ...

    Abstract This study examines the sustainable landscapes displayed in traditional Korean houses of the Joseon Dynasty (1392–1910) by investigating urban agricultural practices implemented in the palace, private houses, and an imaginary garden (Uiwon). Currently popular productive gardening applications, such as urban agriculture, productive landscapes, and edible landscapes, also formed the backbone of the traditional Korean housing environment in the Joseon Dynasty, which has had substantial implications for today’s landscaping practices. Landscapes that are productive rather than decorative are important for environmentally sound and sustainable development not only for South Korea but also for modern housing design worldwide. This research provides concrete discussions of the definition and range of urban agriculture, agricultural methods, and principal agents of gardening-related businesses. This information advances the cultural conversation as well as the understanding and application of gardening in the modern context. Through a comparison of traditional and modern South Korean housing environments, this study contributes to developing the research on the role of gardens in sustainable landscapes.
    Schlagwörter gardens ; land ; sustainable development ; urban agriculture ; South Korea
    Sprache Englisch
    Erscheinungsverlauf 2021-0630
    Erscheinungsort Multidisciplinary Digital Publishing Institute
    Dokumenttyp Artikel
    ZDB-ID 2682955-1
    ISSN 2073-445X
    ISSN 2073-445X
    DOI 10.3390/land10070690
    Datenquelle NAL Katalog (AGRICOLA)

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  4. Artikel: Claudin-5a knockdown attenuates blood-neural barrier in zebrafish.

    Ahn, Jong-Chan / Hwang, Su Jung / Lee, Hyo-Jong / Kim, Kyu-Won

    Comparative biochemistry and physiology. Toxicology & pharmacology : CBP

    2021  Band 250, Seite(n) 109176

    Abstract: Mammalian claudin-5 (cldn5), a zebrafish cldn5a homolog, is essential to blood-brain barrier (BBB) integrity. Previously, the existence of an endothelial tight junction-based BBB with cldn5a expression in the cerebral microvessels was reported in ... ...

    Abstract Mammalian claudin-5 (cldn5), a zebrafish cldn5a homolog, is essential to blood-brain barrier (BBB) integrity. Previously, the existence of an endothelial tight junction-based BBB with cldn5a expression in the cerebral microvessels was reported in zebrafish. However, the role of cldn5a in the cerebral microvessels of developing zebrafish has not been elucidated. Here, we further investigated the functional integrity of cldn5a in developing zebrafish by injecting cldn5a morpholinos. At 7 days post-fertilization, cldn5a immunoreactivity was detected on the brain surface, ventricular ependyma, and cerebral mircovessels but disappeared following cldna5a knockdown. Cldn5a morphants showed size-selective leakage of tracers through the BBB and downregulated expression of glucose transporter 1 (glut1) in the cerebral microvessels. In addition, leakiness in the blood-cerebrospinal fluid barrier was observed, implying the overall abnormal development of blood-neural barriers. The results of our study suggest that cldn5a is required for building and maintaining the blood-neural barrier during zebrafish development.
    Mesh-Begriff(e) Animals ; Biological Transport ; Blood-Brain Barrier/metabolism ; Blood-Brain Barrier/pathology ; Brain/metabolism ; Brain/pathology ; Cerebral Ventricles/metabolism ; Cerebral Ventricles/pathology ; Claudin-5/antagonists & inhibitors ; Claudin-5/genetics ; Claudin-5/metabolism ; Morpholinos/pharmacology ; Tight Junctions/metabolism ; Tight Junctions/pathology ; Zebrafish/embryology ; Zebrafish/genetics ; Zebrafish/physiology ; Zebrafish Proteins/antagonists & inhibitors ; Zebrafish Proteins/genetics ; Zebrafish Proteins/metabolism
    Chemische Substanzen Claudin-5 ; Morpholinos ; Zebrafish Proteins ; cldn5a protein, zebrafish
    Sprache Englisch
    Erscheinungsdatum 2021-09-06
    Erscheinungsland United States
    Dokumenttyp Journal Article
    ZDB-ID 189285-x
    ISSN 1532-0456 ; 0306-4492 ; 0742-8413
    ISSN 1532-0456 ; 0306-4492 ; 0742-8413
    DOI 10.1016/j.cbpc.2021.109176
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  5. Artikel: Development of an inclusive 580K SNP array and its application for genomic selection and genome-wide association studies in rice.

    Kim, Kyu-Won / Nawade, Bhagwat / Nam, Jungrye / Chu, Sang-Ho / Ha, Jungmin / Park, Yong-Jin

    Frontiers in plant science

    2022  Band 13, Seite(n) 1036177

    Abstract: Rice is a globally cultivated crop and is primarily a staple food source for more than half of the world's population. Various single-nucleotide polymorphism (SNP) arrays have been developed and utilized as standard genotyping methods for rice breeding ... ...

    Abstract Rice is a globally cultivated crop and is primarily a staple food source for more than half of the world's population. Various single-nucleotide polymorphism (SNP) arrays have been developed and utilized as standard genotyping methods for rice breeding research. Considering the importance of SNP arrays with more inclusive genetic information for GWAS and genomic selection, we integrated SNPs from eight different data resources: resequencing data from the Korean World Rice Collection (KRICE) of 475 accessions, 3,000 rice genome project (3 K-RGP) data, 700 K high-density rice array, Affymetrix 44 K SNP array, QTARO, Reactome, and plastid and GMO information. The collected SNPs were filtered and selected based on the breeder's interest, covering all key traits or research areas to develop an integrated array system representing inclusive genomic polymorphisms. A total of 581,006 high-quality SNPs were synthesized with an average distance of 200 bp between adjacent SNPs, generating a 580 K Axiom Rice Genotyping Chip (580 K _ KNU chip). Further validation of this array on 4,720 genotypes revealed robust and highly efficient genotyping. This has also been demonstrated in genome-wide association studies (GWAS) and genomic selection (GS) of three traits: clum length, heading date, and panicle length. Several SNPs significantly associated with cut-off, -log
    Sprache Englisch
    Erscheinungsdatum 2022-10-24
    Erscheinungsland Switzerland
    Dokumenttyp Journal Article
    ZDB-ID 2613694-6
    ISSN 1664-462X
    ISSN 1664-462X
    DOI 10.3389/fpls.2022.1036177
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  6. Artikel ; Online: NRF2 activation by 2-methoxycinnamaldehyde attenuates inflammatory responses in macrophages via enhancing autophagy flux.

    Kim, Bo-Sung / Shin, Minwook / Kim, Kyu-Won / Ha, Ki-Tae / Bae, Sung-Jin

    BMB reports

    2022  Band 55, Heft 8, Seite(n) 407–412

    Abstract: A well-controlled inflammatory response is crucial for the recovery from injury and maintenance of tissue homeostasis. The anti-inflammatory response of 2-methoxycinnamaldehyde (2-MCA), a natural compound derived from cinnamon, has been studied; however, ...

    Abstract A well-controlled inflammatory response is crucial for the recovery from injury and maintenance of tissue homeostasis. The anti-inflammatory response of 2-methoxycinnamaldehyde (2-MCA), a natural compound derived from cinnamon, has been studied; however, the underlying mechanism on macrophage has not been fully elucidated. In this study, LPS-stimulated production of TNF-α and NO was reduced by 2-MCA in macrophages. 2-MCA significantly activated the NRF2 pathway, and expression levels of autophagy-associated proteins in macrophages, including LC3 and P62, were enhanced via NRF2 activation regardless of LPS treatment, suggesting the occurrence of 2-MCA-mediated autophagy. Moreover, evaluation of autophagy flux using luciferase-conjugated LC3 revealed that incremental LC3 and P62 levels are coupled to enhanced autophagy flux. Finally, reduced expression levels of TNF-α and NOS2 by 2-MCA were reversed by autophagy inhibitors, such as bafilomycin A1 and NH4Cl, in LPS-stimulated macrophages. In conclusion, 2-MCA enhances autophagy flux in macrophages via NRF2 activation and consequently reduces LPS-induced inflammation. [BMB Reports 2022; 55(8): 407-412].
    Mesh-Begriff(e) Acrolein/analogs & derivatives ; Autophagy ; Lipopolysaccharides/metabolism ; Lipopolysaccharides/toxicity ; Macrophages/metabolism ; NF-E2-Related Factor 2/metabolism ; Tumor Necrosis Factor-alpha/metabolism
    Chemische Substanzen Lipopolysaccharides ; NF-E2-Related Factor 2 ; Tumor Necrosis Factor-alpha ; 2-methoxycinnamaldehyde (4940G3R6HE) ; Acrolein (7864XYD3JJ)
    Sprache Englisch
    Erscheinungsdatum 2022-06-17
    Erscheinungsland Korea (South)
    Dokumenttyp News
    ZDB-ID 2410389-5
    ISSN 1976-670X ; 1976-6696
    ISSN (online) 1976-670X
    ISSN 1976-6696
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  7. Artikel: Thunbergia laurifolia Leaf Extract Inhibits Glutamate-Induced Neurotoxicity and Cell Death through Mitophagy Signaling

    Vongthip, Wudtipong / Sillapachaiyaporn, Chanin / Kim, Kyu-Won / Sukprasansap, Monruedee / Tencomnao, Tewin

    Antioxidants. 2021 Oct. 25, v. 10, no. 11

    2021  

    Abstract: Oxidative stress plays a crucial role in neurodegeneration. Therefore, reducing oxidative stress in the brain is an important strategy to prevent neurodegenerative disorders. Thunbergia laurifolia (Rang-jued) is well known as an herbal tea in Thailand. ... ...

    Abstract Oxidative stress plays a crucial role in neurodegeneration. Therefore, reducing oxidative stress in the brain is an important strategy to prevent neurodegenerative disorders. Thunbergia laurifolia (Rang-jued) is well known as an herbal tea in Thailand. Here, we aimed to determine the protective effects of T. laurifolia leaf extract (TLE) on glutamate-induced oxidative stress toxicity and mitophagy-mediated cell death in mouse hippocampal cells (HT-22). Our results reveal that TLE possesses a high level of bioactive antioxidants by LC–MS technique. We found that the pre-treatment of cells with TLE prevented glutamate-induced neuronal death in a concentration-dependent manner. TLE reduced the intracellular ROS and maintained the mitochondrial membrane potential caused by glutamate. Moreover, TLE upregulated the gene expression of antioxidant enzymes (SOD1, SOD2, CAT, and GPx). Interestingly, glutamate also induced the activation of the mitophagy process. However, TLE could reverse this activity by inhibiting autophagic protein (LC3B-II/LC3B-I) activation and increasing a specific mitochondrial protein (TOM20). Our results suggest that excessive glutamate can cause neuronal death through mitophagy-mediated cell death signaling in HT-22 cells. Our findings indicate that TLE protects cells from neuronal death by stimulating the endogenous antioxidant enzymes and inhibiting glutamate-induced oxidative toxicity via the mitophagy–autophagy pathway. TLE might have potential as an alternative or therapeutic approach in neurodegenerative diseases.
    Schlagwörter Thunbergia laurifolia ; brain ; death ; gene expression ; glutamic acid ; herbal tea ; leaf extracts ; membrane potential ; mice ; mitochondrial membrane ; mitochondrial proteins ; mitophagy ; neurodegenerative diseases ; neurons ; neurotoxicity ; oxidative stress ; oxidative toxicity ; therapeutics ; Thailand
    Sprache Englisch
    Erscheinungsverlauf 2021-1025
    Erscheinungsort Multidisciplinary Digital Publishing Institute
    Dokumenttyp Artikel
    ZDB-ID 2704216-9
    ISSN 2076-3921
    ISSN 2076-3921
    DOI 10.3390/antiox10111678
    Datenquelle NAL Katalog (AGRICOLA)

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  8. Buch ; Online: Prompting for Discovery

    Almeda, Shm Garanganao / Zamfirescu-Pereira, J. D. / Kim, Kyu Won / Rathnam, Pradeep Mani / Hartmann, Bjoern

    Flexible Sense-Making for AI Art-Making with Dreamsheets

    2023  

    Abstract: Design space exploration (DSE) for Text-to-Image (TTI) models entails navigating a vast, opaque space of possible image outputs, through a commensurately vast input space of hyperparameters and prompt text. Minor adjustments to prompt input can surface ... ...

    Abstract Design space exploration (DSE) for Text-to-Image (TTI) models entails navigating a vast, opaque space of possible image outputs, through a commensurately vast input space of hyperparameters and prompt text. Minor adjustments to prompt input can surface unexpectedly disparate images. How can interfaces support end-users in reliably steering prompt-space explorations towards interesting results? Our design probe, DreamSheets, supports exploration strategies with LLM-based functions for assisted prompt construction and simultaneous display of generated results, hosted in a spreadsheet interface. The flexible layout and novel generative functions enable experimentation with user-defined workflows. Two studies, a preliminary lab study and a longitudinal study with five expert artists, revealed a set of strategies participants use to tackle the challenges of TTI design space exploration, and the interface features required to support them - like using text-generation to define local "axes" of exploration. We distill these insights into a UI mockup to guide future interfaces.

    Comment: 13 pages, 14 figures, currently under review
    Schlagwörter Computer Science - Human-Computer Interaction
    Thema/Rubrik (Code) 004
    Erscheinungsdatum 2023-10-15
    Erscheinungsland us
    Dokumenttyp Buch ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  9. Artikel ; Konferenzbeitrag: HPLC Analysis on Ginseng Root in Normal and Root Rot model

    Choi, Minsik / Park, Geonha / Ku, Sejin / Kim, Kyu Won / Jang, Young Pyo

    Planta Medica

    2023  Band 89, Heft 14

    Veranstaltung/Kongress 71st International Congress and Annual Meeting of the Society for Medicinal Plant and Natural Product Research (GA), Trinity College Dublin Ireland, 2023-07-02
    Sprache Englisch
    Erscheinungsdatum 2023-11-01
    Verlag Georg Thieme Verlag KG
    Erscheinungsort Stuttgart ; New York
    Dokumenttyp Artikel ; Konferenzbeitrag
    ZDB-ID 123545-x
    ISSN 1439-0221 ; 0032-0943
    ISSN (online) 1439-0221
    ISSN 0032-0943
    DOI 10.1055/s-0043-1774216
    Datenquelle Thieme Verlag

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  10. Artikel: Claudin-5a knockdown attenuates blood-neural barrier in zebrafish

    Ahn, Jong-Chan / Hwang, Su Jung / Lee, Hyo-Jong / Kim, Kyu-Won

    Comparative biochemistry and physiology. 2021 Dec., v. 250

    2021  

    Abstract: Mammalian claudin-5 (cldn5), a zebrafish cldn5a homolog, is essential to blood-brain barrier (BBB) integrity. Previously, the existence of an endothelial tight junction-based BBB with cldn5a expression in the cerebral microvessels was reported in ... ...

    Abstract Mammalian claudin-5 (cldn5), a zebrafish cldn5a homolog, is essential to blood-brain barrier (BBB) integrity. Previously, the existence of an endothelial tight junction-based BBB with cldn5a expression in the cerebral microvessels was reported in zebrafish. However, the role of cldn5a in the cerebral microvessels of developing zebrafish has not been elucidated. Here, we further investigated the functional integrity of cldn5a in developing zebrafish by injecting cldn5a morpholinos. At 7 days post-fertilization, cldn5a immunoreactivity was detected on the brain surface, ventricular ependyma, and cerebral mircovessels but disappeared following cldna5a knockdown. Cldn5a morphants showed size-selective leakage of tracers through the BBB and downregulated expression of glucose transporter 1 (glut1) in the cerebral microvessels. In addition, leakiness in the blood-cerebrospinal fluid barrier was observed, implying the overall abnormal development of blood-neural barriers. The results of our study suggest that cldn5a is required for building and maintaining the blood-neural barrier during zebrafish development.
    Schlagwörter Danio rerio ; abnormal development ; blood-brain barrier ; ependyma ; glucose transporters ; immune response ; mammals ; microvessels
    Sprache Englisch
    Erscheinungsverlauf 2021-12
    Erscheinungsort Elsevier Inc.
    Dokumenttyp Artikel
    ZDB-ID 189285-x
    ISSN 0306-4492 ; 0742-8413 ; 1532-0456
    ISSN 0306-4492 ; 0742-8413 ; 1532-0456
    DOI 10.1016/j.cbpc.2021.109176
    Datenquelle NAL Katalog (AGRICOLA)

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