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Article ; Online: Distinct subpopulations of ventral pallidal cholinergic projection neurons encode valence of olfactory stimuli.

Kim, Ronald / Ananth, Mala R / Desai, Niraj S / Role, Lorna W / Talmage, David A

2024 Volume 43, Issue 4, Page(s) 114009

Abstract: To better understand the function of cholinergic projection neurons in the ventral pallidum (VP), we examined behavioral responses to appetitive (APP) and aversive (AV) odors that elicited approach or avoidance, respectively. Exposure to each odor ... ...

Abstract	To better understand the function of cholinergic projection neurons in the ventral pallidum (VP), we examined behavioral responses to appetitive (APP) and aversive (AV) odors that elicited approach or avoidance, respectively. Exposure to each odor increased cFos expression and calcium signaling in VP cholinergic neurons. Activity and Cre-dependent viral vectors selectively labeled VP cholinergic neurons that were activated and reactivated in response to either APP or AV odors, but not both, identifying two non-overlapping populations of VP cholinergic neurons differentially activated by the valence of olfactory stimuli. These two subpopulations showed differences in electrophysiological properties, morphology, and projections to the basolateral amygdala. Although VP neurons are engaged in both approach and avoidance behavioral responses, cholinergic signaling is only required for approach behavior. Thus, two distinct subpopulations of VP cholinergic neurons differentially encode valence of olfactory stimuli and play distinct roles in approach and avoidance behaviors.
MeSH term(s)	Animals ; Cholinergic Neurons/physiology ; Basal Forebrain/physiology ; Odorants ; Mice ; Male ; Smell/physiology ; Mice, Inbred C57BL
Language	English
Publishing date	2024-03-26
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	2649101-1
ISSN	2211-1247 ; 2211-1247
ISSN (online)	2211-1247
ISSN	2211-1247
DOI	10.1016/j.celrep.2024.114009
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Basal forebrain cholinergic signalling: development, connectivity and roles in cognition.

Ananth, Mala R / Rajebhosale, Prithviraj / Kim, Ronald / Talmage, David A / Role, Lorna W

Nature reviews. Neuroscience

2023 Volume 24, Issue 4, Page(s) 233–251

Abstract: Acetylcholine plays an essential role in fundamental aspects of cognition. Studies that have mapped the activity and functional connectivity of cholinergic neurons have shown that the axons of basal forebrain cholinergic neurons innervate the pallium ... ...

Abstract	Acetylcholine plays an essential role in fundamental aspects of cognition. Studies that have mapped the activity and functional connectivity of cholinergic neurons have shown that the axons of basal forebrain cholinergic neurons innervate the pallium with far more topographical and functional organization than was historically appreciated. Together with the results of studies using new probes that allow release of acetylcholine to be detected with high spatial and temporal resolution, these findings have implicated cholinergic networks in 'binding' diverse behaviours that contribute to cognition. Here, we review recent findings on the developmental origins, connectivity and function of cholinergic neurons, and explore the participation of cholinergic signalling in the encoding of cognition-related behaviours.
MeSH term(s)	Humans ; Acetylcholine/physiology ; Basal Forebrain ; Cholinergic Agents/pharmacology ; Cognition ; Signal Transduction
Chemical Substances	Acetylcholine (N9YNS0M02X) ; Cholinergic Agents
Language	English
Publishing date	2023-02-23
Publishing country	England
Document type	Journal Article ; Review ; Research Support, N.I.H., Intramural
ZDB-ID	2034150-7
ISSN	1471-0048 ; 1471-0048 ; 1471-003X
ISSN (online)	1471-0048
ISSN	1471-0048 ; 1471-003X
DOI	10.1038/s41583-023-00677-x
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Zs.A 5473: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MG 47: Show issues

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Article: Distinct subpopulations of ventral pallidal cholinergic projection neurons encode valence of olfactory stimuli.

Kim, Ronald / Ananth, Mala / Desai, Niraj S / Role, Lorna W / Talmage, David A

bioRxiv : the preprint server for biology

2023

Abstract: The ventral pallidum (VP) mediates motivated behaviors largely via the action of VP GABA and glutamatergic neurons. In addition to these neuronal subtypes, there is a population of cholinergic projection neurons in the VP, whose functional significance ... ...

Abstract	The ventral pallidum (VP) mediates motivated behaviors largely via the action of VP GABA and glutamatergic neurons. In addition to these neuronal subtypes, there is a population of cholinergic projection neurons in the VP, whose functional significance remains unclear. To understand the functional role of VP cholinergic neurons, we first examined behavioral responses to an appetitive (APP) odor that elicited approach, and an aversive (AV) odor that led to avoidance. To examine how VP cholinergic neurons were engaged in APP vs. AV responses, we used an immediate early gene marker and in-vivo fiber photometry, examining the activation profile of VP cholinergic neurons in response to each odor. Exposure to each odor led to an increase in the number of cFos counts and increased calcium signaling of VP cholinergic neurons. Activity and cre-dependent viral vectors were designed to label engaged VP cholinergic neurons in two distinct contexts: (1) exposure to the APP odor, (2) followed by subsequent exposure to the AV odor, and vice versa. These studies revealed two distinct, non-overlapping subpopulations of VP cholinergic neurons: one activated in response to the APP odor, and a second distinct population activated in response to the AV odor. These two subpopulations of VP cholinergic neurons are spatially intermingled within the VP, but show differences in electrophysiological properties, neuronal morphology, and projections to the basolateral amygdala. Although VP cholinergic neurons are engaged in behavioral responses to each odor, VP cholinergic signaling is only required for approach behavior. Indeed, inhibition of VP cholinergic neurons not only blocks approach to the APP odor, but reverses the behavior, leading to active avoidance. Our results highlight the functional heterogeneity of cholinergic projection neurons within the VP. These two subpopulations of VP cholinergic neurons differentially encode valence of olfactory stimuli and play unique roles in approach and avoidance behaviors.
Language	English
Publishing date	2023-10-10
Publishing country	United States
Document type	Preprint
DOI	10.1101/2023.10.06.561261
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Article ; Online: High-Resolution Three-Dimensional Imaging of Individual Astrocytes Using Confocal Microscopy.

Testen, Anze / Kim, Ronald / Reissner, Kathryn J

Current protocols in neuroscience

2020 Volume 91, Issue 1, Page(s) e92

Abstract: Astrocytes play numerous vital roles in the central nervous system. Accordingly, it is of merit to identify structural and functional properties of astrocytes in both health and disease. The majority of studies examining the morphology of astrocytes have ...

Abstract	Astrocytes play numerous vital roles in the central nervous system. Accordingly, it is of merit to identify structural and functional properties of astrocytes in both health and disease. The majority of studies examining the morphology of astrocytes have employed immunoassays for markers such as glial fibrillary acidic protein, which are insufficient to encapsulate the considerable structural complexity of these cells. Herein, we describe a method utilizing a commercially available and validated, genetically encoded membrane-associated fluorescent marker of astrocytes, AAV5-GfaABC1D-Lck-GFP. This tool and approach allow for visualization of a single isolated astrocyte in its entirety, including fine peripheral processes. Astrocytes are imaged using confocal microscopy and reconstructed in three dimensions to obtain detailed morphometric data. We further provide an immunohistochemistry procedure to assess colocalization of isolated astrocytes with synaptic markers throughout the z-plane. This technique, which can be utilized via a standard laboratory confocal microscope and Imaris software, allows for detailed analysis of the morphology and synaptic colocalization of astrocytes in fixed tissue. © 2020 by John Wiley & Sons, Inc. Basic Protocol 1: Microinjection of AAV5-GfaABC1D-Lck-GFP into the nucleus accumbens of rats Basic Protocol 2: Tissue processing and immunohistochemistry for post-synaptic density-95 Basic Protocol 3: Single-cell image acquisition Basic Protocol 4: Three-dimensional reconstruction of single cells Basic Protocol 5: Three-dimensional colocalization analysis.
MeSH term(s)	Animals ; Astrocytes/ultrastructure ; Dependovirus/genetics ; Genes, Reporter ; Genetic Vectors/administration & dosage ; Image Processing, Computer-Assisted ; Imaging, Three-Dimensional/methods ; Microinjections ; Microscopy, Confocal/methods ; Microscopy, Fluorescence/methods ; Nucleus Accumbens/cytology ; Rats ; Single-Cell Analysis/methods
Language	English
Publishing date	2020-03-09
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural
ZDB-ID	2179072-3
ISSN	1934-8576 ; 1934-8584
ISSN (online)	1934-8576
ISSN	1934-8584
DOI	10.1002/cpns.92
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Article ; Online: Arteriolar neuropathology in cerebral microvascular disease.

Fang, Chuo / Magaki, Shino D / Kim, Ronald C / Kalaria, Raj N / Vinters, Harry V / Fisher, Mark

Neuropathology and applied neurobiology

2022 Volume 49, Issue 1, Page(s) e12875

Abstract: Cerebral microvascular disease (MVD) is an important cause of vascular cognitive impairment. MVD is heterogeneous in aetiology, ranging from universal ageing to the sporadic (hypertension, sporadic cerebral amyloid angiopathy [CAA] and chronic kidney ... ...

Abstract	Cerebral microvascular disease (MVD) is an important cause of vascular cognitive impairment. MVD is heterogeneous in aetiology, ranging from universal ageing to the sporadic (hypertension, sporadic cerebral amyloid angiopathy [CAA] and chronic kidney disease) and the genetic (e.g., familial CAA, cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy [CADASIL] and cerebral autosomal recessive arteriopathy with subcortical infarcts and leukoencephalopathy [CARASIL]). The brain parenchymal consequences of MVD predominantly consist of lacunar infarcts (lacunes), microinfarcts, white matter disease of ageing and microhaemorrhages. MVD is characterised by substantial arteriolar neuropathology involving ubiquitous vascular smooth muscle cell (SMC) abnormalities. Cerebral MVD is characterised by a wide variety of arteriolar injuries but only a limited number of parenchymal manifestations. We reason that the cerebral arteriole plays a dominant role in the pathogenesis of each type of MVD. Perturbations in signalling and function (i.e., changes in proliferation, apoptosis, phenotypic switch and migration of SMC) are prominent in the pathogenesis of cerebral MVD, making 'cerebral angiomyopathy' an appropriate term to describe the spectrum of pathologic abnormalities. The evidence suggests that the cerebral arteriole acts as both source and mediator of parenchymal injury in MVD.
MeSH term(s)	Humans ; Arterioles/metabolism ; Arterioles/pathology ; Cerebral Infarction/genetics ; Cerebral Infarction/pathology ; CADASIL/pathology ; Brain/pathology ; Cerebral Amyloid Angiopathy/pathology ; Neuromuscular Diseases/pathology
Language	English
Publishing date	2022-10-19
Publishing country	England
Document type	Journal Article ; Review ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	80371-6
ISSN	1365-2990 ; 0305-1846
ISSN (online)	1365-2990
ISSN	0305-1846
DOI	10.1111/nan.12875
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Zs.A 1241: Show issues

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Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (1.OG)
ab Jg. 2022: Lesesaal (EG)

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Article ; Online: Abstinence-Dependent Effects of Long-Access Cocaine Self-Administration on Nucleus Accumbens Astrocytes Are Observed in Male, But Not Female, Rats.

Kim, Ronald / Testen, Anze / Harder, Eden V / Brown, Natalie E / Witt, Emily A / Bellinger, Tania J / Franklin, Janay P / Reissner, Kathryn J

eNeuro

2022 Volume 9, Issue 5

Abstract: Accumulating evidence indicates significant consequences for astrocytes associated with drug abuse. For example, reductions in structural features and synaptic colocalization of male rat nucleus accumbens (NAc) astrocytes are observed following short- ... ...

Abstract	Accumulating evidence indicates significant consequences for astrocytes associated with drug abuse. For example, reductions in structural features and synaptic colocalization of male rat nucleus accumbens (NAc) astrocytes are observed following short-access (ShA; 2 h/d) self-administration and extinction from cocaine, methamphetamine, and heroin. However, it is unknown whether these observations extend to other rodent models of drug abuse, how enduring these effects may be, and whether similar effects are observed in female rats. Here, we assess the effects of long-access (LgA; 6 h/d) cocaine self-administration and abstinence on NAc astrocytes separately in male and female rats, employing a commonly used behavioral approach to investigate the incubation of cocaine craving. NAc astrocytes from male rats exhibit extensive (∼40%) reductions in surface area, volume, and postsynaptic colocalization 45 d but not 24 h after the last self-administration session. In contrast, no effect of self-administration and abstinence was observed in astrocytes from female rats. Moreover, no effect of LgA self-administration and abstinence was observed on NAc GLT-1 expression in female rats, an effect that has been well described in males. These results indicate striking and sexually dimorphic effects of abstinence subsequent to LgA self-administration on astrocytes. Taken together, these results indicate a pivotal role of prolonged abstinence in the effects of cocaine self-administration on NAc astrocytes, and extend a growing body of evidence regarding sex differences in the cellular consequences of drug self-administration in the brain.
MeSH term(s)	Animals ; Astrocytes ; Cocaine/pharmacology ; Female ; Heroin/pharmacology ; Male ; Methamphetamine/pharmacology ; Nucleus Accumbens/metabolism ; Rats ; Self Administration
Chemical Substances	Methamphetamine (44RAL3456C) ; Heroin (70D95007SX) ; Cocaine (I5Y540LHVR)
Language	English
Publishing date	2022-09-21
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural
ZDB-ID	2800598-3
ISSN	2373-2822 ; 2373-2822
ISSN (online)	2373-2822
ISSN	2373-2822
DOI	10.1523/ENEURO.0310-22.2022
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Article ; Online: Functionally refined encoding of threat memory by distinct populations of basal forebrain cholinergic projection neurons.

Rajebhosale, Prithviraj / Ananth, Mala R / Kim, Ronald / Crouse, Richard / Jiang, Li / López-Hernández, Gretchen / Zhong, Chongbo / Arty, Christian / Wang, Shaohua / Jone, Alice / Desai, Niraj S / Li, Yulong / Picciotto, Marina R / Role, Lorna W / Talmage, David A

eLife

2024 Volume 13

Abstract: Neurons of the basal forebrain nucleus basalis and posterior substantia innominata (NBM/ ... ...

Abstract	Neurons of the basal forebrain nucleus basalis and posterior substantia innominata (NBM/SI
MeSH term(s)	Mice ; Animals ; Basal Forebrain/physiology ; Cholinergic Neurons/physiology ; Memory/physiology ; Learning/physiology ; Acetylcholine/metabolism ; Cholinergic Agents
Chemical Substances	Acetylcholine (N9YNS0M02X) ; Cholinergic Agents
Language	English
Publishing date	2024-02-16
Publishing country	England
Document type	Journal Article
ZDB-ID	2687154-3
ISSN	2050-084X ; 2050-084X
ISSN (online)	2050-084X
ISSN	2050-084X
DOI	10.7554/eLife.86581
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Article: Functionally refined encoding of threat memory by distinct populations of basal forebrain cholinergic projection neurons.

Research square

2024

Abstract: Neurons of the basal forebrain nucleus basalis and posterior substantia innominata (NBM/ ... ...

Abstract	Neurons of the basal forebrain nucleus basalis and posterior substantia innominata (NBM/SI
Language	English
Publishing date	2024-02-09
Publishing country	United States
Document type	Preprint
DOI	10.21203/rs.3.rs-3938016/v1
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Book ; Thesis: Ein Prozessmodell zur Kokserzeugung mit direkter Beheizung

Kim, Ronald

2010

Author's details	von Ronald Kim
Keywords	Prozessmodell ; Koksofen ; Verkokung
Language	German
Size	155 S., Ill., graph. Darst.
Edition	1. Aufl.
Publisher	Papierflieger
Publishing place	Clausthal-Zellerfeld
Document type	Book ; Thesis
Thesis / German Habilitation thesis	Techn. Univ., Diss. u.d.T.: Kim, Ronald: Untersuchungen zu den wärmetechnischen Grundlagen des Koksofens einer Non/Heat Recovery-Kokereianlage--Clausthal, 2010
ISBN	9783869481050 ; 3869481056
Database	Library catalogue of the German National Library of Science and Technology (TIB), Hannover

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Article ; Online: Evaluation of Opioid Prescribing Patterns and Drivers of Variation Following Endoscopic Procedures for Benign Prostatic Hyperplasia Across an Integrated Academic Health System.

Vo, Amanda X / Ko, Oliver S / Hofer, Matthias D / Kim, Ronald J / Benson, Jonas S / Halpern, Joshua A / Auffenberg, Gregory B

Urology

2021 Volume 153, Page(s) 132–138

Abstract: Objectives: To evaluate patient, provider, and facility factors associated with variation in opioid prescribing after endoscopic procedures for benign prostatic hyperplasia across a large academic health system to drive improvement efforts.: Methods: ...

Abstract	Objectives: To evaluate patient, provider, and facility factors associated with variation in opioid prescribing after endoscopic procedures for benign prostatic hyperplasia across a large academic health system to drive improvement efforts. Methods: Opioids prescribed at discharge for patients who underwent an endoscopic prostate procedure March 2018-November 2019 were analyzed. Multivariable logistic and linear regression were used to evaluate the relationship between patient, provider, and facility factors and the receipt of any opioid prescription and the quantity prescribed. Results: We included 724 patients who had surgery with one of 26 urologists across five facilities. 222 (30.7%) received an opioid prescription, and the average morphine milligram equivalents (MMEs) prescribed was 97.9±33.5. We found wide variation in the proportion of patients who received an opioid prescription across surgeons (range 0%-88.9%) and facilities (range 19.9%-66.7%) and the average MMEs prescribed (range 25-188.5). Outpatient surgery (OR 2.32; 95% confidence interval [CI] 1.22-4.40, P = .010) and preoperative opioid use (OR 15.04; CI 9.65-23.45, P < .001) were associated with higher rates of opioid prescribing, while prescribing decreased with increasing patient age (OR 0.97; CI 0.95-0.99, P = 0.016). Multivariable linear regression analysis demonstrated an association between surgery at satellite facilities, having a surgeon in practice for at least 20 years, and higher surgeon volume with increased MMEs prescribed. Conclusions: Opioid prescribing following endoscopic prostate procedures varied widely. Targeted interventions tailored to younger patients, those taking opioids preoperatively, recipients of outpatient surgery and those undergoing surgery at satellite facilities may be particularly high yield given the association between these factors and increased postoperative prescribing.
MeSH term(s)	Academic Medical Centers/statistics & numerical data ; Aged ; Ambulatory Surgical Procedures/statistics & numerical data ; Analgesics, Opioid/administration & dosage ; Analgesics, Opioid/classification ; Chicago/epidemiology ; Humans ; Male ; Pain, Postoperative/diagnosis ; Pain, Postoperative/drug therapy ; Pain, Postoperative/epidemiology ; Patient Discharge/statistics & numerical data ; Practice Patterns, Physicians' ; Prostatic Hyperplasia/epidemiology ; Prostatic Hyperplasia/surgery ; Retrospective Studies ; Surgeons/statistics & numerical data ; Urologic Surgical Procedures, Male/adverse effects ; Urologic Surgical Procedures, Male/methods ; Urologic Surgical Procedures, Male/statistics & numerical data
Chemical Substances	Analgesics, Opioid
Language	English
Publishing date	2021-01-19
Publishing country	United States
Document type	Journal Article
ZDB-ID	192062-5
ISSN	1527-9995 ; 0090-4295
ISSN (online)	1527-9995
ISSN	0090-4295
DOI	10.1016/j.urology.2020.10.079
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Zs.A 1142: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MO 275: Show issues

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