Article ; Online: C5aR
NPJ vaccines
2023 Volume 8, Issue 1, Page(s) 120
Abstract: The mucosal delivery route is considered ideal for immunization. However, induction of antigen-specific mucosal immunity is difficult due to the tolerogenic environment. Therefore, developing an immunogenic mucosal dendritic cell (DC)-targeting strategy ... ...
Abstract | The mucosal delivery route is considered ideal for immunization. However, induction of antigen-specific mucosal immunity is difficult due to the tolerogenic environment. Therefore, developing an immunogenic mucosal dendritic cell (DC)-targeting strategy is required. Herein, we investigated the characteristics and immunogenic potential of Peyer's patch (PP) DCs as an oral vaccination-targeting strategy. Single-cell RNA sequencing analysis of the PP DCs showed that complement C5a receptor- and lysozyme-expressing DCs exhibit increased expression of genes related to chemotaxis. Administration of the Co1 peptide, a C5aR ligand, increased CD8 |
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Language | English |
Publishing date | 2023-08-14 |
Publishing country | England |
Document type | Journal Article |
ISSN | 2059-0105 |
ISSN (online) | 2059-0105 |
DOI | 10.1038/s41541-023-00720-z |
Database | MEDical Literature Analysis and Retrieval System OnLINE |
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