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  1. Artikel ; Online: Effectiveness of Shugan Jieyu capsules for psychiatric symptoms of epilepsy: a systematic review and meta-analysis.

    Kim, Sejin / Kim, Yunna / Cho, Seung-Hun

    BMC complementary medicine and therapies

    2024  Band 24, Heft 1, Seite(n) 63

    Abstract: Background: The relationship between epilepsy and depression is bidirectional. One condition exacerbates the other. However, there are no current guidelines for treating depression in epilepsy patients. In some cases, seizures worsen when ... ...

    Abstract Background: The relationship between epilepsy and depression is bidirectional. One condition exacerbates the other. However, there are no current guidelines for treating depression in epilepsy patients. In some cases, seizures worsen when antidepressants (AD) are prescribed or when they are discontinued due to adverse events. The Shugan Jieyu capsule, composed of Acanthopanax senticosus and Hypericum perforatum, is a widely used herbal medicine for treating depression. This study aimed to explore the effectiveness and safety of Shugan Jieyu capsules (SJC) in relieving depression in patients with epilepsy.
    Methods: We searched English, Korean, Japanese, and Chinese databases in October 2023 to collect all relevant randomized clinical trials (RCTs). The primary outcomes were the depression scale scores and seizure frequency. The secondary outcomes were quality of life (QoL) and adverse events.
    Results: Nine RCTs were included in this meta-analysis. Compared with AD, SJC showed significant differences in the improvement of depression (SMD: 3.82, 95% CI: 3.25, 4.39) and reduction in seizure frequency (MD: 0.39 times/month, 95% CI: 0.28, 0.50). SJC showed more beneficial results than antiepileptic drugs (AED) in terms of antidepressant effects (SMD: 1.10, 95% CI: 0.69, 1.51) and QoL (MD: 11.75, 95% CI: 10.55, 12.95). When patients were prescribed AED, the additional administration of SJC improved depression symptoms (SMD: 0.96, 95% CI: 0.28, 1.63). The SJC treatment group had a lower incidence of side effects than the control group. However, the difference was not statistically significant.
    Conclusions: Our results suggest that SJC may be effective in treating depression in patients with epilepsy. Additionally, SJC has the potential to help reduce seizure frequency in epilepsy patients with depression.
    Mesh-Begriff(e) Humans ; Epilepsy/drug therapy ; Antidepressive Agents/therapeutic use ; Anticonvulsants/therapeutic use ; Seizures/drug therapy ; Seizures/chemically induced
    Chemische Substanzen Antidepressive Agents ; Anticonvulsants
    Sprache Englisch
    Erscheinungsdatum 2024-01-29
    Erscheinungsland England
    Dokumenttyp Meta-Analysis ; Systematic Review ; Journal Article
    ISSN 2662-7671
    ISSN (online) 2662-7671
    DOI 10.1186/s12906-024-04361-0
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  2. Artikel ; Online: MR1- and HLA-E-Dependent Antigen Presentation of

    Kim, Se-Jin / Karamooz, Elham

    International journal of molecular sciences

    2022  Band 23, Heft 22

    Abstract: MR1 and HLA-E are highly conserved nonclassical antigen-presenting molecules. They can present antigens derived ... ...

    Abstract MR1 and HLA-E are highly conserved nonclassical antigen-presenting molecules. They can present antigens derived from
    Mesh-Begriff(e) Mycobacterium tuberculosis/metabolism ; Antigen Presentation ; Minor Histocompatibility Antigens/metabolism ; Histocompatibility Antigens Class I ; Antigens ; HLA-E Antigens
    Chemische Substanzen Minor Histocompatibility Antigens ; Histocompatibility Antigens Class I ; Antigens
    Sprache Englisch
    Erscheinungsdatum 2022-11-19
    Erscheinungsland Switzerland
    Dokumenttyp Journal Article ; Review
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms232214412
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  3. Artikel ; Online: Extracurricular activities in medical education: an integrative literature review.

    Kim, Sejin / Jeong, Hyeyoon / Cho, Hyena / Yu, Jihye

    BMC medical education

    2023  Band 23, Heft 1, Seite(n) 278

    Abstract: Background: The importance of extracurricular activities (EAs) has been emphasized in medical education. These activities could enhance medical students' emotional and physical health and afford them developmental opportunities. Despite the growing ... ...

    Abstract Background: The importance of extracurricular activities (EAs) has been emphasized in medical education. These activities could enhance medical students' emotional and physical health and afford them developmental opportunities. Despite the growing amount of research related to this theme, few studies review and synthesize the existing literature. This study aims to provide an understanding of the educational implications of EAs in medical colleges and constructs an integrated conceptual framework concerning their types and learning outcomes by literature review.
    Methods: An integrative literature review was conducted following Torraco's method, with the aim to generate a new framework for the given topic. The authors utilized Scopus and PubMed as databases, using search terms "extracurricular," "medical," and "students." Initially, titles and abstracts were screened to include relevant studies, and the researchers verified the eligibility of the articles by following the inclusion and exclusion criteria. Of the 263 articles identified, 64 empirical studies were selected for further review.
    Results: EAs in undergraduate medical education can be classified into direct extracurricular activities and indirect extracurricular activities, the latter of which is sorted into nine sub-categories. We identified seven main categories regarding the learning outcomes of EAs. In addition to general activities (e.g., pro-social activities, team sports), some distinctive activities such as research have been largely addressed in previous studies. The results of EAs were discussed in relation to academic growth, career development, and psychological experiences.
    Conclusions: This review identified the types and learning outcomes of EAs in the context of medical education, thereby suggesting ways to improve the quality of EAs and maximize their educational effects.
    Mesh-Begriff(e) Humans ; Education, Medical ; Education, Medical, Undergraduate ; Learning ; Sports ; Social Behavior
    Sprache Englisch
    Erscheinungsdatum 2023-04-22
    Erscheinungsland England
    Dokumenttyp Review ; Journal Article
    ZDB-ID 2044473-4
    ISSN 1472-6920 ; 1472-6920
    ISSN (online) 1472-6920
    ISSN 1472-6920
    DOI 10.1186/s12909-023-04245-w
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  4. Artikel ; Online: Visual display terminal syndrome and its associated factors among university students during the COVID-19 pandemic.

    Kim, Hyojin / Kim, Se-Jin / Hwang, Sujin

    Work (Reading, Mass.)

    2023  Band 77, Heft 1, Seite(n) 23–36

    Abstract: Background: Ever since the start of the coronavirus disease 2019 (COVID-19) pandemic, students have been spending an increasingly longer time staring at electrical devices to take online courses.: Objective: This study aimed to investigate the effect ...

    Abstract Background: Ever since the start of the coronavirus disease 2019 (COVID-19) pandemic, students have been spending an increasingly longer time staring at electrical devices to take online courses.
    Objective: This study aimed to investigate the effect of the virtual class environment on eye and musculoskeletal problems in university students during the COVID-19 pandemic.
    Methods: A total of 365 university students were enrolled in this study. They completed an online survey to examine the effects of online learning on eye and musculoskeletal health during the COVID-19 pandemic. The questionnaires consisted of four sections: demographic and general information, environmental and work factors, device-related factors, and visual display terminal syndrome (VDTS).
    Results: Participants have been taking online classes of 14.5 hours per week during the COVID-19 pandemic. They reported the mean daily usage of digital devices of 4.8±2.2 hours before the pandemic but this increased to 8.1±2.9 during the pandemic. Eye fatigue and neck, shoulder, and back pain have also been reported. The mean VDTS score was significantly influenced by gender, obesity, daily exercise, regular breaks, wear of blue light-blocking glasses, daily hours of electronic device use, and illumination of room.
    Conclusion: The results of this study showed that university students taking online classes suffered more from VDTS, especially in eye fatigue and neck, lower back, and shoulder pain during COVID-19 pandemic than prior. This study suggests that it is necessary to take breaks in online classes and regularly provide appropriate eye exercise and physical activity to prevent VDTS.
    Mesh-Begriff(e) Humans ; Asthenopia/epidemiology ; Asthenopia/etiology ; COVID-19/epidemiology ; Pandemics ; Universities ; Students
    Sprache Englisch
    Erscheinungsdatum 2023-07-21
    Erscheinungsland Netherlands
    Dokumenttyp Journal Article
    ZDB-ID 1394194-x
    ISSN 1875-9270 ; 1051-9815
    ISSN (online) 1875-9270
    ISSN 1051-9815
    DOI 10.3233/WOR-220265
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  5. Artikel ; Online: A novel paper-based lysis strip for SARS-CoV-2 RNA detection at low resource settings.

    Lee, Songhyun / Kim, SeJin / Kim, Sanghyo

    Analytical biochemistry

    2023  Band 664, Seite(n) 115037

    Abstract: Infectious respiratory diseases such as COVID-19 are serious and global concerns from the past to the present. To isolate the spread of infectious diseases even in the absence of a health system, a simple, inexpensive, reliable, sensitive, and selective ... ...

    Abstract Infectious respiratory diseases such as COVID-19 are serious and global concerns from the past to the present. To isolate the spread of infectious diseases even in the absence of a health system, a simple, inexpensive, reliable, sensitive, and selective molecular diagnosis platform for Point of Care Test (POCT) is required. Especially, the nucleic acid extraction step is difficult to perform out of laboratory. Here, we propose a paper-based lysis (PBL) strip for nucleic acid extraction, especially in low-resource settings (LRS). PBL strips are suitable for isolating RNA from viruses with biological interference and inhibitors. We optimized the buffer compositions and membranes of the strip. A simple preparation method using a PBL strip could obtain an eluent for downstream inspection within 20 min. Overall, 10
    Mesh-Begriff(e) Humans ; COVID-19/diagnosis ; SARS-CoV-2/genetics ; RNA, Viral/genetics ; COVID-19 Testing ; Nucleic Acids ; Nucleic Acid Amplification Techniques/methods ; Sensitivity and Specificity
    Chemische Substanzen RNA, Viral ; Nucleic Acids
    Sprache Englisch
    Erscheinungsdatum 2023-01-06
    Erscheinungsland United States
    Dokumenttyp Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1110-1
    ISSN 1096-0309 ; 0003-2697
    ISSN (online) 1096-0309
    ISSN 0003-2697
    DOI 10.1016/j.ab.2023.115037
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 389: Hefte anzeigen Standort:
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  6. Artikel ; Online: What if you have a humanoid AI robot doctor?

    Kim, Do Kyun David / Kim, Sejin

    Journal of communication in healthcare

    2021  Band 15, Heft 4, Seite(n) 276–285

    Abstract: Background: Humanoid robots with artificial intelligence have been implemented in many healthcare facilities including hospitals, nursing homes, and many others. Due to the development of technology and the increasing use of humanoid robots, it is ... ...

    Abstract Background: Humanoid robots with artificial intelligence have been implemented in many healthcare facilities including hospitals, nursing homes, and many others. Due to the development of technology and the increasing use of humanoid robots, it is expected that more advanced humanoid robots will be developed and implemented in healthcare facilities for better healthcare services. Based on this anticipation, this study proactively examined the public trust in humanoid AI robot (HAIR) doctors that we might have in the near future.
    Methods: This study employed two scales that have been predominantly used to measure patient-doctor trust through an extensive search across different scholarships. For data collection, online surveys were administered by posting a weblink to the online survey through social media, mostly Facebook, Twitter, and KakaoTalk, in South Korea.
    Results: Data analysis of 424 valid surveys found that the level of public trust in HAIR doctors as primary doctors was slightly higher than human doctors. For the data analysis using demographic variables, a series of t-test and ANOVA revealed that males showed a higher trust in HAIR doctors than females, while maintaining indifference in other demographic variables.
    Conclusion: Based on the rapid development of AI and robot technology, the implementation of HAIR doctors for our healthcare service would be a reality in the near future as the public also becomes more familiar with interacting with humanoid robots. Therefore, a proactive preparation for the future is urgently needed for effective use of future technology as well as patients' satisfaction.
    Mesh-Begriff(e) Male ; Female ; Humans ; Robotics ; Artificial Intelligence ; Trust ; Surveys and Questionnaires ; Republic of Korea
    Sprache Englisch
    Erscheinungsdatum 2021-11-02
    Erscheinungsland England
    Dokumenttyp Journal Article
    ISSN 1753-8076
    ISSN (online) 1753-8076
    DOI 10.1080/17538068.2021.1994825
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  7. Artikel ; Online: A novel approach for estimating initial sound level for speech reception threshold test.

    Lee, Heonzoo / Park, Rayoung / Kim, Sejin / Cho, Hyong-Ho / Won, Yonggwan

    Technology and health care : official journal of the European Society for Engineering and Medicine

    2024  

    Abstract: Background: The speech reception threshold (SRT), synonymous with the speech recognition threshold, denotes the minimum hearing level required for an individual to discern 50% of presented speech material. This threshold is measured independently in ... ...

    Abstract Background: The speech reception threshold (SRT), synonymous with the speech recognition threshold, denotes the minimum hearing level required for an individual to discern 50% of presented speech material. This threshold is measured independently in each ear with a repetitive up-down adjustment of stimulus level starting from the initial SRT value derived from pure tone thresholds (PTTs), measured via pure-tone audiometry (PTA). However, repetitive adjustments in the test contributes to increased fatigue for both patients and audiologists, compromising the reliability of the hearing tests.
    Objective: Determining the first (initial) sound level closer to the finally determined SRT value, is important to reduce the number of repetitions. The existing method to determine the initial sound level is to average the PTTs called pure tone average (PTAv).
    Methods: We propose a novel method using a machine learning approach to estimate a more optimal initial sound level for the SRT test. Specifically, a convolutional neural network with 1-dimensional filters (1D CNN) was implemented to predict a superior initial level than the conventional methods.
    Results: Our approach produced a reduction of 37.92% in the difference between the initial stimulus level and the final SRT value.
    Conclusions: This outcome substantiates that our approach can reduce the repetitions for finding the final SRT, and, as the result, the hearing test time can be reduced.
    Sprache Englisch
    Erscheinungsdatum 2024-04-25
    Erscheinungsland Netherlands
    Dokumenttyp Journal Article
    ZDB-ID 1159961-3
    ISSN 1878-7401 ; 0928-7329
    ISSN (online) 1878-7401
    ISSN 0928-7329
    DOI 10.3233/THC-248017
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    Verfügbar in ZB MED Köln/Königswinter

    Zs.A 3846: Hefte anzeigen Standort:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  8. Artikel: A novel variant of THRβ and its 4-year clinical course in a Korean boy with resistance to thyroid hormone.

    Kim, Sejin / Park, Soyun / Moon, Jungeun / Kim, Heungsik / Kang, Seokjin

    Annals of pediatric endocrinology & metabolism

    2023  Band 28, Heft 3, Seite(n) 219–224

    Abstract: Thyroid hormone resistance (RTH) is characterized by a decreased sensitivity of target tissues to thyroid hormones due to a defect in the THRα- and THRβ-encoded thyroid hormone receptors (THRs). The clinical manifestations range from no symptoms to ... ...

    Abstract Thyroid hormone resistance (RTH) is characterized by a decreased sensitivity of target tissues to thyroid hormones due to a defect in the THRα- and THRβ-encoded thyroid hormone receptors (THRs). The clinical manifestations range from no symptoms to simple goiter and hypo- or hyperthyroidism, depending on the receptor subtype distribution in the tissues. Here, we report the case of a thyroid hormone-resistant 12-month-old boy carrying a novel THRβ variant who was initially diagnosed with congenital hypothyroidism. An extensive evaluation revealed increased free T4 level and inappropriately increased thyroid-stimulating hormone (TSH) level; a normal lipid profile, sex hormone-binding globulin, and free alpha subunit of TSH; exaggerated TSH response to THR; and no radiological evidence of pituitary adenoma. A targeted next-generation sequencing panel identified a heterozygote c.993T>G (p.Asn331Lys) mutation in the THRβ gene. During the first year of life, a higher dose of levothyroxine was administered to the patient due to uncompensated RTH. Levothyroxine treatment was continued after 3 years to maintain TSH level <5 mIU/mL, but the observed weight gain was poor, height increase was insufficient, and bone development was delayed. However, neither hyperactivity nor developmental delay was observed. Patients with RTH exhibit various clinical features. Due to its heterogeneous nature, genetic test for accurate diagnosis is important to provide proper management.
    Sprache Englisch
    Erscheinungsdatum 2023-09-19
    Erscheinungsland Korea (South)
    Dokumenttyp Case Reports
    ZDB-ID 2800460-7
    ISSN 2287-1292 ; 2287-1012
    ISSN (online) 2287-1292
    ISSN 2287-1012
    DOI 10.6065/apem.2142246.123
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  9. Artikel: Effectiveness of the Shugan Jieyu Capsule against Psychiatric Symptoms in Epilepsy: a protocol for systematic review and meta-analysis.

    Kim, Sejin / Kim, Yunna / Cho, Seung-Hun

    Journal of pharmacopuncture

    2022  Band 26, Heft 1, Seite(n) 38–43

    Abstract: Objectives: Psychiatric symptoms in epilepsy are very common, and the most common symptoms are depression, insomnia, and anxiety. These symptoms not only lower the quality of life of epilepsy patients, but also elevate the risk of epileptic seizures. ... ...

    Abstract Objectives: Psychiatric symptoms in epilepsy are very common, and the most common symptoms are depression, insomnia, and anxiety. These symptoms not only lower the quality of life of epilepsy patients, but also elevate the risk of epileptic seizures. There are no specific criteria for the available antiepileptic drugs to ameliorate these symptoms in patients with epilepsy, and there is a lack of evidence to support the efficacy and safety of existing drugs. The Shugan Jieyu capsule (SJC) is a traditional herbal medicine composed of
    Methods: Electronic databases will be investigated for publications in English, Korean, Japanese, and Chinese. The participants of the study are epilepsy patients with psychiatric symptoms diagnosed using any validated criteria. All types of controls will be compared-placebo, conventional treatments, and no treatment-to groups treated with SJC or modified SJC. We will measure the degree of improvement in psychiatric symptoms and check epileptic symptoms, such as the frequency of seizures. The study selection and data extraction will be performed by two independent reviewers, who will also assess methodological quality using the risk-of-bias tool by Cochrane. We will use Review Manager software (RevMan) to carry out all statistical analyses.
    Results: This systematic review and meta-analysis will be performed in accordance with the PRISMA-P statement.
    Conclusion: This systematic review is the first study to assess the efficacy and safety of SJC for the treatment of psychiatric symptoms in epilepsy. We expect that this study will provide clinically applicable evidence for patients with epilepsy when selecting drug treatments.
    Sprache Englisch
    Erscheinungsdatum 2022-12-26
    Erscheinungsland Korea (South)
    Dokumenttyp Journal Article
    ZDB-ID 2747301-6
    ISSN 2234-6856 ; 2093-6966
    ISSN (online) 2234-6856
    ISSN 2093-6966
    DOI 10.3831/KPI.2023.26.1.38
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  10. Artikel ; Online: Construction of a thermally stable ZIF-8 membrane embedded inside a porous support for H2/CO2 separation: Close interlocking between membrane grains and porous support grains

    Ma, Qiang / Kim, Sejin / Jeong, Yanghwan / Jang, Eunhee / Choi, Jungkyu

    Journal of Membrane Science. 2023 July, v. 677 p.121654-

    2023  

    Abstract: Zeolitic imidazolate framework-8 (ZIF-8) membranes have emerged as promising wall candidates for use in membrane reactors. These membranes can improve the water gas shift (WGS) reaction performance because of their exceptional thermal stability and ... ...

    Abstract Zeolitic imidazolate framework-8 (ZIF-8) membranes have emerged as promising wall candidates for use in membrane reactors. These membranes can improve the water gas shift (WGS) reaction performance because of their exceptional thermal stability and marked H₂/CO₂ sieving ability. Here, we propose a modified counter diffusion scheme to form an unprecedented, thermally stable ZIF-8 membrane: Pre-deposition of a zinc precursor (zinc acetate dihydrate) and subsequent solvothermal reaction with a methanolic solution of the ligand (2-methylimidazole). It appears that the pre-deposition and drying of the Zn precursor on and inside a porous support were key to retarding the diffusion of the Zn source, thus leading to the primary contact between the Zn source and ligand molecules within the porous support. As a result, it is likely that a continuous ZIF-8 layer was formed on the top surface and, more preferentially, at the interface with the grains of the porous support, reaching an infiltration depth of approximately 80 μm. Accordingly, this allowed for the effective blocking of the support pores by ZIF-8 grains, as well as their high dispersion. Notably, the resulting ZIF-8 membrane exhibited a maximum H₂/CO₂ separation factor of ca. 8.7 at a WGS reaction temperature of 300 °C. Unlike the conventional membrane architecture, ZIF-8 grains were densely embedded inside the porous support, thus reducing the risk of mechanical damage. Furthermore, the unique membrane structure was desirable for securing superior thermal stability for reliable and sustainable H₂/CO₂ separation at 300 °C for up to 72 h.
    Schlagwörter ligands ; mechanical damage ; primary contact ; risk ; temperature ; thermal stability ; zinc ; ZIF-8 membrane ; H2/CO2 separation ; Embedded ZIF-8 layer ; Interlocking structure ; Thermal and mechanical stability
    Sprache Englisch
    Erscheinungsverlauf 2023-07
    Erscheinungsort Elsevier B.V.
    Dokumenttyp Artikel ; Online
    ZDB-ID 194516-6
    ISSN 0376-7388
    ISSN 0376-7388
    DOI 10.1016/j.memsci.2023.121654
    Datenquelle NAL Katalog (AGRICOLA)

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    Verfügbar in ZB MED Bonn

    Z 78/706: Hefte anzeigen

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