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Article ; Online: Narirutin-Rich Celluclast Extract from Mandarin (

Im, Seung Tae / Kang, Heejoo / Kim, Jusang / Kim, Song-Rae / Kim, Kil-Nam / Lee, Seung-Hong

International journal of molecular sciences

2024 Volume 25, Issue 8

Abstract: Mandarin peel, a main by-product from the processing of citrus juice, has been highlighted for its various bioactivities and functional ingredients. Our previous study proved the inhibitory effects of Celluclast extract from mandarin peel (MPCE) on lipid ...

Abstract	Mandarin peel, a main by-product from the processing of citrus juice, has been highlighted for its various bioactivities and functional ingredients. Our previous study proved the inhibitory effects of Celluclast extract from mandarin peel (MPCE) on lipid accumulation and differentiation in 3T3-L1 adipocytes. Therefore, the current study aimed to evaluate the anti-obesity effect of MPCE in high-fat diet (HFD)-induced obese mice. The high-performance liquid chromatography (HPLC) analysis exhibited that narirutin and hesperidin are the main active components of MPCE. Our current results showed that MPCE supplementation decreased adiposity by reducing body and organ weights in HFD-induced obese mice. MPCE also reduced triglyceride (TG), alanine transaminase (ALT), aspartate transaminase (AST), and leptin contents in the serum of HFD-fed mice. Moreover, MPCE significantly inhibited hepatic lipid accumulation by regulating the expression levels of proteins associated with lipid metabolism, including sterol regulatory element-binding protein (SREBP1c), fatty acid synthase (FAS), and acetyl-CoA carboxylase (ACC). Furthermore, MPCE administration significantly inhibited both adipogenesis and lipogenesis, with modulation of energy metabolism by activating 5' adenosine monophosphate-activated protein kinase (AMPK) and lipolytic enzymes such as hormone-sensitive lipase (HSL) in the white adipose tissue (WAT). Altogether, our findings indicate that MPCE improves HFD-induced obesity and can be used as a curative agent in pharmaceuticals and nutraceuticals to alleviate obesity and related disorders.
MeSH term(s)	Animals ; Diet, High-Fat/adverse effects ; Obesity/metabolism ; Obesity/drug therapy ; Obesity/etiology ; Citrus/chemistry ; Mice ; Energy Metabolism/drug effects ; Plant Extracts/pharmacology ; Male ; Mice, Inbred C57BL ; Adipogenesis/drug effects ; Lipid Metabolism/drug effects ; 3T3-L1 Cells ; Anti-Obesity Agents/pharmacology ; Liver/metabolism ; Liver/drug effects ; Lipogenesis/drug effects ; Triglycerides/metabolism ; Triglycerides/blood ; Disaccharides ; Flavanones
Chemical Substances	Plant Extracts ; narirutin (06M5EAT0YC) ; Anti-Obesity Agents ; Triglycerides ; Disaccharides ; Flavanones
Language	English
Publishing date	2024-04-19
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2019364-6
ISSN	1422-0067 ; 1422-0067 ; 1661-6596
ISSN (online)	1422-0067
ISSN	1422-0067 ; 1661-6596
DOI	10.3390/ijms25084475
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Surface-decorated nanoparticles clicked into nanoparticle clusters for oligonucleotide encapsulation

Mao, Wei / Kim, Song Rae / Yoo, Hyuk Sang

RSC advances. 2020 Oct. 07, v. 10, no. 61

2020

Abstract: Gold nanoparticles (AuNPs) are the predominant and representative metal nano-carriers used for the tumor-targeted delivery of therapeutics because they possess advantages such as biocompatibility, high drug loading efficiency, and enhanced accumulation ... ...

Abstract	Gold nanoparticles (AuNPs) are the predominant and representative metal nano-carriers used for the tumor-targeted delivery of therapeutics because they possess advantages such as biocompatibility, high drug loading efficiency, and enhanced accumulation at tumor sites via the size-dependent enhanced permeability and retention (EPR) effect. In this study, we designed an AuNP functionalized with block polymers comprising polyethylenimine and azide group-functionalized poly(ethyl glycol) for the electrostatic incorporation of cytosine–guanine oligonucleotide (CpG ODN) on the surface. The ODN-incorporated AuNPs were cross-linked to gold nanoparticle clusters (AuNCs) via click chemistry using a matrix metalloproteinase (MMP)-2 cleavable peptide linker modified with alkyne groups at both ends. In the presence of Cu(i), azide groups and alkyne groups spontaneously cyclize to form a triazole ring with high fidelity and efficiency, and therefore allow single AuNPs to stack to larger AuNCs for increased EPR effect-mediated tumor targeting. ¹H-NMR and Fourier transform infrared spectroscopy revealed the successful synthesis of an azide–PEG-grafted branched polyethylenimine, and the size and morphology of AuNPs fabricated by the synthesized polymer were confirmed to be 4.02 ± 0.45 nm by field emission-transmission electron microscopy. Raman spectroscopy characterization demonstrated the introduction of azide groups on the surface of the synthesized AuNPs. Zeta-potential and gel-retardation analysis of CpG-loaded AuNPs indicated complete CpG sequestration by AuNPs when the CpG : AuNP weight ratio was higher than 1 : 2.5. The clustering process of the CpG-loaded AuNPs was monitored and was demonstrated to be dependent on the alkyne linker-to-AuNP ratio. Thus, the clicked AuNC can be tailored as a gene carrier where a high accumulation of therapeutics is required.
Keywords	Fourier transform infrared spectroscopy ; Raman spectroscopy ; alkynes ; azides ; biocompatibility ; crosslinking ; drugs ; electron microscopy ; encapsulation ; genes ; nanocarriers ; nanogold ; neoplasms ; oligodeoxyribonucleotides ; peptides ; permeability ; polyethyleneimine ; triazoles ; zeta potential
Language	English
Dates of publication	2020-1007
Size	p. 37040-37049.
Publishing place	The Royal Society of Chemistry
Document type	Article
Note	NAL-AP-2-clean
ISSN	2046-2069
DOI	10.1039/d0ra06622b
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Surface-decorated nanoparticles clicked into nanoparticle clusters for oligonucleotide encapsulation.

Mao, Wei / Kim, Song Rae / Yoo, Hyuk Sang

RSC advances

2020 Volume 10, Issue 61, Page(s) 37040–37049

Abstract	Gold nanoparticles (AuNPs) are the predominant and representative metal nano-carriers used for the tumor-targeted delivery of therapeutics because they possess advantages such as biocompatibility, high drug loading efficiency, and enhanced accumulation at tumor sites
Language	English
Publishing date	2020-10-07
Publishing country	England
Document type	Journal Article
ISSN	2046-2069
ISSN (online)	2046-2069
DOI	10.1039/d0ra06622b
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Monoclonal Antibody Functionalized, and L-lysine α-Oxidase Loaded PEGylated-Chitosan Nanoparticle for HER2/Neu Targeted Breast Cancer Therapy.

Saravanakumar, Kandasamy / Sathiyaseelan, Anbazhagan / Park, Soyoung / Kim, Song-Rae / Priya, Veeraraghavan Vishnu / Wang, Myeong-Hyeon

Pharmaceutics

2022 Volume 14, Issue 5

Abstract: Herein, we designed a nanocarrier to deliver the LO specifically to HER2+ breast cancer (BC) cells, where functionalization of mAb (anti-HER2+) with PEGylated chitosan enabled it to target the HER2+ BC cells. Taking advantage of overexpression of HER2+ ... ...

Abstract	Herein, we designed a nanocarrier to deliver the LO specifically to HER2+ breast cancer (BC) cells, where functionalization of mAb (anti-HER2+) with PEGylated chitosan enabled it to target the HER2+ BC cells. Taking advantage of overexpression of HER2+ in cancer cells, our nanocarrier (CS-LO-PEG-HER NPs) exhibited promising potency and selectivity against HER2+ BC cells (BT474). The CS-LO-PEG-HER NPs demonstrated the cytotoxicity in BT474 cells by promoting reactive oxygen species, mitochondrial membrane potential loss, and nucleus damage. The biocompatibility of CS-LO-PEG-HER NPs was evidenced by the hemolysis assay and H & E staining of major organs. The CS-LO-PEG-HER NPs showed anticancer potency against the BT474-xenograft tumor-bearing mice, as evident by the reduction of tumor size and cell density. These results indicate that CS-LO-PEG-HER NPs are biocompatible with mice while inhibiting tumor growth through alter the oxidative stress. Overall, this work provides a promising approach for the delivery of LO for good therapeutic effect in combination with mAb.
Language	English
Publishing date	2022-04-24
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2527217-2
ISSN	1999-4923
ISSN	1999-4923
DOI	10.3390/pharmaceutics14050927
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Dual irradiation-triggered anticancer therapeutics composed of polydopamine-coated gold nanoparticles.

Lee, Mi So / Park, Yeonju / Kim, Song Rae / Jung, Young Mee / Yoo, Hyuk Sang

Biomaterials advances

2022 Volume 136, Page(s) 212779

Abstract: The therapeutic efficacy of nanoparticles depends on their ability to release encapsulated photosensitizers. Here, surface-engineered metallic gold nanoparticles (AuNP) were irradiated with dual near-infrared (NIR) light to enhance the release of ... ...

Abstract	The therapeutic efficacy of nanoparticles depends on their ability to release encapsulated photosensitizers. Here, surface-engineered metallic gold nanoparticles (AuNP) were irradiated with dual near-infrared (NIR) light to enhance the release of photosensitizer. Dopamine hydrochloride was surface-polymerized to polydopamine (PDA) layers on AuNP, and chlorin-e6 (Ce6) was chemically tethered to primary amines of PDA. The resulting Ce6-conjugated AuNP were characterized by Raman and X-ray photoelectron spectroscopy and visualized by electron microscopy and light scattering. The generation of reactive oxygen species was increased following dual NIR irradiation at 650 nm and 808 nm, which was attributed to the increased liberation of Ce6. In vitro, dual NIR irradiation significantly enhanced the anticancer effect of Ce6-incorporating AuNP by increasing the population of apoptotic cells. In vivo, tumor xenografted animals exhibited much better tumor suppression when subjected to dual NIR irradiation. Thus, we propose the use of Ce6-incorporating AuNP coupled to dual NIR irradiation for future anticancer treatment of solid tumors.
MeSH term(s)	Animals ; Chlorophyllides ; Gold/pharmacology ; Indoles ; Metal Nanoparticles/therapeutic use ; Neoplasms/drug therapy ; Photochemotherapy/methods ; Photosensitizing Agents/pharmacology ; Polymers
Chemical Substances	Chlorophyllides ; Indoles ; Photosensitizing Agents ; Polymers ; polydopamine ; Gold (7440-57-5)
Language	English
Publishing date	2022-03-28
Publishing country	Netherlands
Document type	Journal Article
ISSN	2772-9508
ISSN (online)	2772-9508
DOI	10.1016/j.bioadv.2022.212779
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Article ; Online: Fluorescence-Shadowing Nanoparticle Clusters for Real-Time Monitoring of Tumor Progression.

Pham-Nguyen, Oanh-Vu / Shin, JiUn / Park, Yeonju / Jin, Sila / Kim, Song Rae / Jung, Young Mee / Yoo, Hyuk Sang

Biomacromolecules

2022 Volume 23, Issue 8, Page(s) 3130–3141

Abstract: Monitoring tumor progression is important for elucidating appropriate therapeutic strategies in response to anticancer therapeutics. To fluorescently monitor ... ...

Abstract	Monitoring tumor progression is important for elucidating appropriate therapeutic strategies in response to anticancer therapeutics. To fluorescently monitor the
MeSH term(s)	Fluorescence Resonance Energy Transfer/methods ; Gold ; Humans ; Metal Nanoparticles ; Neoplasms ; Quantum Dots ; Tumor Microenvironment
Chemical Substances	Gold (7440-57-5)
Language	English
Publishing date	2022-04-22
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ISSN	1526-4602
ISSN (online)	1526-4602
DOI	10.1021/acs.biomac.2c00169
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Fluorescence-Shadowing Nanoparticle Clusters for Real-Time Monitoring of Tumor Progression

Pham-Nguyen, Oanh-Vu / Shin, JiUn / Park, Yeonju / Jin, Sila / Kim, Song Rae / Jung, Young Mee / Yoo, Hyuk Sang

Biomacromolecules. 2022 Apr. 22, v. 23, no. 8

2022

Abstract: Monitoring tumor progression is important for elucidating appropriate therapeutic strategies in response to anticancer therapeutics. To fluorescently monitor the in vivo levels of tumor-specific enzymes, we prepared matrix metalloprotease (MMP)- ... ...

Abstract	Monitoring tumor progression is important for elucidating appropriate therapeutic strategies in response to anticancer therapeutics. To fluorescently monitor the in vivo levels of tumor-specific enzymes, we prepared matrix metalloprotease (MMP)-responsive gold nanoparticle (AuNP) clusters to sense tumor microenvironments. Specifically, AuNPs and quantum dots (QDs) were surface-engineered with two poly(ethylene glycol) [PEG] shells and cyclooctyne moieties, respectively, for the copper-free click reaction. Upon “peeling off” of the secondary shell from the double-PEGylated AuNPs under MMP-rich conditions, shielded azide moieties of the AuNPs were displayed toward the QD, and those two particles were clicked into nanoparticle clusters. This consequently resulted in a dramatic size increase and fluorescence quenching of QDs via fluorescence energy transfer (FRET) due to the molecular proximity of the particles. We observed that FRET efficiency was modulated via changes in MMP levels and exposure time. Cancer cell numbers exhibited a strong correlation with FRET efficiency, and in vivo studies that employed solid tumor models accordingly showed that FRET efficiency was dependent on the tumor size. Thus, we envision that this platform can be tailored and optimized for tumor monitoring based on MMP levels in solid tumors.
Keywords	azides ; cancer therapy ; energy transfer ; exposure duration ; fluorescence ; metalloproteinases ; nanogold ; neoplasm cells ; neoplasm progression ; neoplasms
Language	English
Dates of publication	2022-0422
Size	p. 3130-3141.
Publishing place	American Chemical Society
Document type	Article
ISSN	1526-4602
DOI	10.1021/acs.biomac.2c00169
Database	NAL-Catalogue (AGRICOLA)

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Article: Menaquinone-7 ameliorates cerebrovascular calcification-associated memory decline in aged mice

Lee, Bombi / Choi, Gwang-Muk / Hong, Joon-Pyo / Cho, Da-Eun / Kim, Yoongeun / Yeom, Mijung / Han, Jeong Jun / Kim, Song-rae / Hahm, Dae-Hyun

Life sciences. 2022 Oct. 15, v. 307

2022

Abstract: Menaquinone (MK)-7 is a vitamin K2 analog that functions as a cofactor of γ-glutamyl carboxylase involved in the activation of vitamin K (VK)-dependent proteins. The present study aimed to evaluate the effect of MK-7 on memory and cognitive function in ... ...

Abstract	Menaquinone (MK)-7 is a vitamin K2 analog that functions as a cofactor of γ-glutamyl carboxylase involved in the activation of vitamin K (VK)-dependent proteins. The present study aimed to evaluate the effect of MK-7 on memory and cognitive function in aged C57BL/6 mice. Eighteen-month-old mice were raised for a further 4 months, fed on a standard or calcium-rich diet (3 % [w/w]), and were orally given MK-7 (40 and 400 μg/day/mouse) five times per week during the same period. The Morris water maze (MWM) test was performed at 19 and 22 months. The aged mice showed noticeable memory declines in the MWM test at all time points compared with 6-week-old mice, and this memory loss was significantly restored by the daily administration of high-dose MK-7 for 4 months. MK-7 administration also improved micro-computed tomography-based cerebrovascular calcification and aging-associated declines in growth arrest-specific 6, total and carboxylated matrix Gla proteins, and ganglioside levels in the brain of aged mice. It serologically reduced phosphorous levels in the blood, but not the urea, cholesterol, and calcium. Taken together, the long-term administration of MK-7 significantly improved age-related memory and cognitive impairments, possibly through inhibition of cerebrovascular calcification in aged mice, indicating that it can be used to develop new drugs for improving memory and cognitive function in older adults.
Keywords	blood ; brain ; calcification ; calcium ; carboxylation ; cholesterol ; cognition ; diet ; gangliosides ; memory ; memory disorders ; menaquinones ; mice ; phosphorus ; urea
Language	English
Dates of publication	2022-1015
Publishing place	Elsevier Inc.
Document type	Article
ZDB-ID	3378-9
ISSN	1879-0631 ; 0024-3205
ISSN (online)	1879-0631
ISSN	0024-3205
DOI	10.1016/j.lfs.2022.120912
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Role of gut-derived bacterial lipopolysaccharide and peripheral TLR4 in immobilization stress-induced itch aggravation in a mouse model of atopic dermatitis.

Cho, Da-Eun / Hong, Joon-Pyo / Kim, Yoongeun / Sim, Ju Yeon / Kim, Heenam Stanley / Kim, Song-Rae / Lee, Bombi / Cho, Hyo-Sung / Cho, Ik-Hyun / Shin, Sooan / Yeom, Mijung / Kwon, Soon-Kyeong / Lee, In-Seon / Park, Hijoon / Kim, Kyuseok / Hahm, Dae-Hyun

Scientific reports

2024 Volume 14, Issue 1, Page(s) 6263

Abstract: Psychological stress and intestinal leakage are key factors in atopic dermatitis (AD) recurrence and exacerbation. Here, we demonstrate the mechanism underlying bacterial translocation across intestinal epithelial barrier damaged due to stress and ... ...

Abstract	Psychological stress and intestinal leakage are key factors in atopic dermatitis (AD) recurrence and exacerbation. Here, we demonstrate the mechanism underlying bacterial translocation across intestinal epithelial barrier damaged due to stress and further aggravation of trimellitic anhydride (TMA)-induced itch, which remain unclear, in AD mice. Immobilization (IMO) stress exacerbated scratching bouts and colon histological damage, and increased serum corticosterone and lipopolysaccharide (LPS). Orally administered fluorescein isothiocyanate (FITC)-dextran and surgically injected (into the colon) Cy5.5-conjugated LPS were detected in the serum and skin after IMO stress, respectively. The relative abundance of aerobic or facultative anaerobic bacteria was increased in the colon mucus layer, and Lactobacillus murinus, E. coli, Staphylococcus nepalensis, and several strains of Bacillus sp. were isolated from the spleens and mesenteric lymph nodes. Oral antibiotics or intestinal permeability blockers, such as lubiprostone (Lu), 2,4,6-triaminopyrimidine (TAP) and ML-7, inhibited IMO stress-associated itch; however, it was reinduced through intradermal or i.p. injection of LPS without IMO stress. I.p. injection of TAK-242 (resatorvid), a TLR4 inhibitor, abrogated IMO stress-associated itch, which was also confirmed in TLR4-KO mice. IMO stress alone did not cause itch in naïve mice. IMO stress-induced itch aggravation in TMA-treated AD mice might be attributed to the translocation of gut-derived bacterial cells and LPS, which activates peripheral TLR4 signaling.
MeSH term(s)	Animals ; Mice ; Dermatitis, Atopic/metabolism ; Dermatitis, Atopic/pathology ; Disease Models, Animal ; Escherichia coli ; Lipopolysaccharides/metabolism ; Pruritus/chemically induced ; Toll-Like Receptor 4/metabolism
Chemical Substances	Lipopolysaccharides ; Toll-Like Receptor 4
Language	English
Publishing date	2024-03-15
Publishing country	England
Document type	Journal Article
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-024-56936-z
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Article ; Online: Age-associated spinal stenosis in the turquoise killifish.

Cho, Su-Hyeon / Lee, Seongsin / Park, Jae-Il / La Yang, Yoon / Kim, Song-Rae / Ahn, Juhee / Jeong, Hoibin / Jung, Hye-Yeon / Gwak, Nayoung / Kim, Kil-Nam / Kim, Yumi

iScience

2023 Volume 26, Issue 10, Page(s) 107877

Abstract: Aging triggers spinal degeneration, including common spinal stenosis, which causes back and leg pain in older individuals, significantly impacting their quality of life. Here, we explored aging traits in turquoise killifish spines, potentially offering a ...

Abstract	Aging triggers spinal degeneration, including common spinal stenosis, which causes back and leg pain in older individuals, significantly impacting their quality of life. Here, we explored aging traits in turquoise killifish spines, potentially offering a model for age-linked spinal stenosis in humans. Aged turquoise killifish exhibited body shape deformation and increased vertebral collapse, which was further accelerated by spawning. High-resolution CT scans revealed suppressed cortical bone thickness and hemal arch area in vertebrae due to spawning, and osteophyte formation was observed in both aged and breeding fish populations. Scale mineralization mirrored these changes, increasing with age but being suppressed by spawning. The expression of
Language	English
Publishing date	2023-09-09
Publishing country	United States
Document type	Journal Article
ISSN	2589-0042
ISSN (online)	2589-0042
DOI	10.1016/j.isci.2023.107877
Database	MEDical Literature Analysis and Retrieval System OnLINE

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