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Article ; Online: Soluble klotho induces the heat shock factor 1 through EGR1 expression.

Kim, Soo-A / Toan, Nguyen Khanh / Ahn, Sang-Gun

2024

Abstract: Klotho is an antiaging protein that has multiple functions. The purpose of this study is to investigate whether soluble klotho plays a role in cellular stress response pathways. We found that klotho deficiency ( ... ...

Abstract	Klotho is an antiaging protein that has multiple functions. The purpose of this study is to investigate whether soluble klotho plays a role in cellular stress response pathways. We found that klotho deficiency (kl
Language	English
Publishing date	2024-04-04
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	59230-4
ISSN	1872-8081 ; 0951-6433
ISSN (online)	1872-8081
ISSN	0951-6433
DOI	10.1002/biof.2056
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Article: Toe Grip Strength Is Associated with Improving Gait Function in Patients with Subacute Stroke.

Ryu, Jin-Whan / Hwang, In-Su / Jin, Sol / Kim, Soo-A / Kim, Min-Su

Brain sciences

2024 Volume 14, Issue 3

Abstract: Toe grip strength has recently been suggested to play an essential role in maintaining balance and postural stability for ambulatory function in older populations. This study aimed to investigate its association with improving gait function three months ... ...

Abstract	Toe grip strength has recently been suggested to play an essential role in maintaining balance and postural stability for ambulatory function in older populations. This study aimed to investigate its association with improving gait function three months after onset in patients with subacute stroke. This longitudinal cohort study included 98 first-ever stroke patients (67 ± 9 years, 56% female) within one month from the onset who could not ambulate independently. Functional outcome indicators, including toe grip strength, hand grip strength, knee extensor strength, Fugl-Meyer Assessment of Lower Extremity (FMA_LE), and the Postural Assessment Scale for Stroke (PASS), were assessed before and three months after the intervention. We analyzed the correlation between participants' gait function using a 10-meter walk test time and various functional indicators. Then, multiple linear regression analysis was used to investigate whether toe grip strength was related to the improvement of gait function. Correlation analysis revealed a significant positive correlation between the 10MWT time and toe grip strength ratio (affected/unaffected side), with a moderate effect size (r = -0.61,
Language	English
Publishing date	2024-02-26
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2651993-8
ISSN	2076-3425
ISSN	2076-3425
DOI	10.3390/brainsci14030215
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Article ; Online: Ascorbic acid induces salivary gland function through TET2/acetylcholine receptor signaling in aging SAMP1/Klotho (-/-) mice.

Toan, Nguyen Khanh / Kim, Soo-A / Ahn, Sang-Gun

Aging

2022 Volume 14, Issue 15, Page(s) 6028–6046

Abstract: Aging affects salivary gland function and alters saliva production and excretion. This study aimed to investigate whether ascorbic acid can be used to treat salivary gland dysfunction in an extensive aging mouse model of SAMP1/Klotho-/- mice. In our ... ...

Abstract	Aging affects salivary gland function and alters saliva production and excretion. This study aimed to investigate whether ascorbic acid can be used to treat salivary gland dysfunction in an extensive aging mouse model of SAMP1/Klotho-/- mice. In our previous study, we found that ascorbic acid biosynthesis was disrupted in the salivary glands of SAMP1/Klotho (-/-) mice subjected to metabolomic profiling analysis. In SAMP1/Klotho -/- mice, daily supplementation with ascorbic acid (100 mg/kg for 18 days) significantly increased saliva secretion compared with the control. The expression of salivary gland functional markers (α-amylase, ZO-1, and Aqua5) is upregulated. Additionally, acetylcholine and/or beta-adrenergic receptors (M1AchR, M3AchR, and Adrb1) were increased by ascorbic acid in the salivary glands of aging mice, and treatment with ascorbic acid upregulated the expression of acetylcholine receptors through the DNA demethylation protein TET2. These results suggest that ascorbic acid could overcome the lack caused by dysfunction of ascorbic acid biosynthesis and induce the recovery of salivary gland function.
MeSH term(s)	Acetylcholine ; Aging/physiology ; Animals ; Ascorbic Acid/metabolism ; Ascorbic Acid/pharmacology ; DNA-Binding Proteins/genetics ; DNA-Binding Proteins/metabolism ; Dioxygenases/metabolism ; Klotho Proteins/metabolism ; Membrane Proteins/metabolism ; Mice ; Nuclear Proteins/metabolism ; Receptors, Cholinergic/metabolism ; Salivary Glands/physiology
Chemical Substances	DNA-Binding Proteins ; Membrane Proteins ; Nuclear Proteins ; Receptors, Cholinergic ; Samp1 protein, mouse ; Dioxygenases (EC 1.13.11.-) ; Tet2 protein, mouse (EC 1.13.11.-) ; Klotho Proteins (EC 3.2.1.31) ; Acetylcholine (N9YNS0M02X) ; Ascorbic Acid (PQ6CK8PD0R)
Language	English
Publishing date	2022-08-11
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ISSN	1945-4589
ISSN (online)	1945-4589
DOI	10.18632/aging.204213
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Article ; Online: HOXC6-Mediated miR-188-5p Expression Induces Cell Migration through the Inhibition of the Tumor Suppressor FOXN2.

Jeong, Seho / Kim, Soo-A / Ahn, Sang-Gun

International journal of molecular sciences

2021 Volume 23, Issue 1

Abstract: Homeobox C6 (HOXC6) is a transcription factor that plays a role in the malignant progression of various cancers. However, the roles of HOXC6 and its regulatory mechanism remain unclear. In this study, we used microRNA (miRNA) regulatory networks to ... ...

Abstract	Homeobox C6 (HOXC6) is a transcription factor that plays a role in the malignant progression of various cancers. However, the roles of HOXC6 and its regulatory mechanism remain unclear. In this study, we used microRNA (miRNA) regulatory networks to identify key regulatory interactions responsible for HOXC6-mediated cancer progression. In microarray profiling of miRNAs, the levels of miRNAs such as hsa-miR-188-5p, hsa-miR-8063, and hsa-miR-8064 were significantly increased in HOXC6-overexpressing cells. Higher positive expression rates of HOXC6 and miR-188-5p were observed in malignant cancer. We also found that HOXC6 significantly upregulated miR-188-5p expression. The underlying function of HOXC6-mediated miR-188-5p expression was predicted through TargetScan and the MiRNA Database. Overexpression of mir-188-5p inhibited the expression of forkhead box N2 (FOXN2), a tumor suppressor gene. Furthermore, in the luciferase assay, miR-188-5p bound to the 3'-UTR of FOXN2 and was mainly responsible for the dysregulation of FOXN2 expression. Silencing FOXN2 induced cell migration, and the effect of FOXN2 silencing was enhanced when the HOXC6/miR-188-5p axis was induced. These results suggest that HOXC6/miR-188-5p may induce malignant progression in cancer by inhibiting the activation of the FOXN2 signaling pathway.
MeSH term(s)	3' Untranslated Regions ; Cell Line, Tumor ; Cell Movement ; Cell Proliferation ; Forkhead Transcription Factors/genetics ; Gene Expression Profiling ; Gene Expression Regulation, Neoplastic ; HEK293 Cells ; Homeodomain Proteins/genetics ; Humans ; MicroRNAs/genetics ; Mouth Neoplasms/genetics ; Oligonucleotide Array Sequence Analysis ; Up-Regulation
Chemical Substances	3' Untranslated Regions ; FOXN2 protein, human ; Forkhead Transcription Factors ; HOXC6 protein, human ; Homeodomain Proteins ; MIRN188 microRNA, human ; MicroRNAs
Language	English
Publishing date	2021-12-21
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2019364-6
ISSN	1422-0067 ; 1422-0067 ; 1661-6596
ISSN (online)	1422-0067
ISSN	1422-0067 ; 1661-6596
DOI	10.3390/ijms23010009
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Article ; Online: Radiologic changes of long term foot insole use in symptomatic pediatric flatfoot.

Kim, Joon Yeop / Kim, Soo A / Kim, Yuntae / Hwang, Insu / Heo, Nam Hun

Medicine

2023 Volume 102, Issue 10, Page(s) e33152

Abstract: Clinically, flatfoot, known as pes planus, is quite prevalent. It is classified into 2 types: flexible and rigid, both of which may or may not have symptoms. If a flexible flatfoot is symptomatic, it must be treated to prevent subsequent complications. ... ...

Abstract	Clinically, flatfoot, known as pes planus, is quite prevalent. It is classified into 2 types: flexible and rigid, both of which may or may not have symptoms. If a flexible flatfoot is symptomatic, it must be treated to prevent subsequent complications. In principle, most physicians initially use conservative methods, such as foot insoles. This study aimed to demonstrate the effect of long term use of a foot insole using plain radiography as an objective measurement in children with symptomatic flexible flatfoot (SFFF) in large samples. This study analyzed the medical records of 292 children aged < 18 years who were diagnosed with SFFF. Of these, 200 children (62 boys and 138 girls, mean age: 6.49 ± 2.96 years) were selected and conservatively treated with foot insoles. They were periodically followed up within 3 to 4 months to modify the foot insole and perform radiologic evaluations, such as foot radiography. The calcaneal pitch angle (CPA) and talo first metatarsal angle were measured and compared individually using foot lateral radiographs, which were pictured in a bilateral barefoot state. The treatment was terminated by repeating the same procedure until the symptoms disappeared. A significant improvement (P < .001) was observed in the radiological indicators, both CPA and talo first metatarsal angle, regardless of age, after the application of soft foot insoles. However, the right foot CPA in the group with valgus deformity was an exception (P = .078). This study showed that in children diagnosed with SFFF under 18 years of age, wearing a periodically revised foot insole as conservative treatment could not only decrease the symptoms, but also improve the radiologic indices.
MeSH term(s)	Male ; Female ; Humans ; Child ; Adolescent ; Child, Preschool ; Flatfoot/diagnosis ; Foot ; Calcaneus ; Lower Extremity ; Radiography
Language	English
Publishing date	2023-03-10
Publishing country	United States
Document type	Journal Article
ZDB-ID	80184-7
ISSN	1536-5964 ; 0025-7974
ISSN (online)	1536-5964
ISSN	0025-7974
DOI	10.1097/MD.0000000000033152
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Ua VI Zs.171: Show issues

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Article ; Online: Modulus-tunable multifunctional hydrogel ink with nanofillers for 3D-Printed soft electronics.

Kang, Minkyong / Park, Jae / Kim, Soo A / Kim, Tae Young / Kim, Ju Yeon / Kim, Dae Woo / Park, Kijun / Seo, Jungmok

Biosensors & bioelectronics

2024 Volume 255, Page(s) 116257

Abstract: Seamless integration and conformal contact of soft electronics with tissue surfaces have emerged as major challenges in realizing accurate monitoring of biological signals. However, the mechanical mismatch between the electronics and biological tissues ... ...

Abstract	Seamless integration and conformal contact of soft electronics with tissue surfaces have emerged as major challenges in realizing accurate monitoring of biological signals. However, the mechanical mismatch between the electronics and biological tissues impedes the conformal interfacing between them. Attempts have been made to utilize soft hydrogels as the bioelectronic materials to realize tissue-comfortable bioelectronics. However, hydrogels have several limitations in terms of their electrical and mechanical properties. In this study, we present the development of a 3D-printable modulus-tunable hydrogel with multiple functionalities. The hydrogel has a cross-linked double network, which greatly improves its mechanical properties. Functional fillers such as XLG or functionalized carbon nanotubes (fCNT) can be incorporated into the hydrogel to provide tunable mechanics (Young's modulus of 10-300 kPa) and electrical conductivity (electrical conductivity of ∼20 S/m). The developed hydrogel exhibits stretchability (∼1000% strain), self-healing ability (within 5 min), toughness (400-731 kJ/m
MeSH term(s)	Hydrogels ; Ink ; Nanotubes, Carbon ; Biosensing Techniques ; Electric Conductivity ; Electronics ; Printing, Three-Dimensional
Chemical Substances	Hydrogels ; Nanotubes, Carbon
Language	English
Publishing date	2024-03-30
Publishing country	England
Document type	Journal Article
ZDB-ID	1011023-9
ISSN	1873-4235 ; 0956-5663
ISSN (online)	1873-4235
ISSN	0956-5663
DOI	10.1016/j.bios.2024.116257
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Zs.A 2275: Show issues

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Article ; Online: Choline Acetyltransferase Induces the Functional Regeneration of the Salivary Gland in Aging SAMP1/Kl -/- Mice.

Toan, Nguyen Khanh / Tai, Nguyen Chi / Kim, Soo-A / Ahn, Sang-Gun

International journal of molecular sciences

2021 Volume 22, Issue 1

Abstract: Salivary gland dysfunction induces salivary flow reduction and a dry mouth, and commonly involves oral dysfunction, tooth structure deterioration, and infection through reduced salivation. This study aimed to investigate the impact of aging on the ... ...

Abstract	Salivary gland dysfunction induces salivary flow reduction and a dry mouth, and commonly involves oral dysfunction, tooth structure deterioration, and infection through reduced salivation. This study aimed to investigate the impact of aging on the salivary gland by a metabolomics approach in an extensive aging mouse model, SAMP1/Klotho -/- mice. We found that the salivary secretion of SAMP1/Klotho -/- mice was dramatically decreased compared with that of SAMP1/Klotho WT (+/+) mice. Metabolomics profiling analysis showed that the level of acetylcholine was significantly decreased in SAMP1/Klotho -/- mice, although the corresponding levels of acetylcholine precursors, acetyl-CoA and choline, increased. Interestingly, the mRNA and protein expression of choline acetyltransferase (ChAT), which is responsible for catalyzing acetylcholine synthesis, was significantly decreased in SAMP1/Klotho -/- mice. The overexpression of ChAT induced the expression of salivary gland functional markers (α-amylase, ZO-1, and Aqua5) in primary cultured salivary gland cells from SAMP1/Klotho +/+ and -/- mice. In an in vivo study, adeno-associated virus (AAV)-ChAT transduction significantly increased saliva secretion compared with the control in SAMP1/Klotho -/- mice. These results suggest that the dysfunction in acetylcholine biosynthesis induced by ChAT reduction may cause impaired salivary gland function.
MeSH term(s)	Acetyl Coenzyme A/metabolism ; Acetylcholine/genetics ; Acetylcholine/metabolism ; Aging/genetics ; Aging/metabolism ; Animals ; Cell Line ; Choline/metabolism ; Choline O-Acetyltransferase/genetics ; Choline O-Acetyltransferase/metabolism ; Down-Regulation ; Gene Expression Regulation/genetics ; Gene Knockdown Techniques ; Glucuronidase/genetics ; Glucuronidase/metabolism ; Humans ; Membrane Proteins/genetics ; Membrane Proteins/metabolism ; Metabolomics ; Mice ; Mice, Knockout ; Nuclear Proteins/genetics ; Nuclear Proteins/metabolism ; Salivary Glands/enzymology ; Salivary Glands/metabolism ; Up-Regulation ; Zonula Occludens-1 Protein/genetics ; Zonula Occludens-1 Protein/metabolism ; alpha-Amylases/genetics ; alpha-Amylases/metabolism
Chemical Substances	Membrane Proteins ; Nuclear Proteins ; Samp1 protein, mouse ; Tjp1 protein, mouse ; Zonula Occludens-1 Protein ; Acetyl Coenzyme A (72-89-9) ; Choline O-Acetyltransferase (EC 2.3.1.6) ; alpha-Amylases (EC 3.2.1.1) ; Glucuronidase (EC 3.2.1.31) ; klotho protein (EC 3.2.1.31) ; Choline (N91BDP6H0X) ; Acetylcholine (N9YNS0M02X)
Language	English
Publishing date	2021-01-02
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2019364-6
ISSN	1422-0067 ; 1422-0067 ; 1661-6596
ISSN (online)	1422-0067
ISSN	1422-0067 ; 1661-6596
DOI	10.3390/ijms22010404
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Article ; Online: Utility of ultrasound as a promising diagnostic tool for stroke-related sarcopenia: A retrospective pilot study.

Park, Siha / Kim, Yuntae / Kim, Soo A / Hwang, Insu / Kim, Doh-Eui

Medicine

2022 Volume 101, Issue 36, Page(s) e30245

Abstract: Stroke patients undergo extensive changes in muscle mass which lead to stroke-related sarcopenia. Stroke-related sarcopenia has a significant impact on the functional outcome of stroke survivors. So, it is important to measure muscle mass in stroke ... ...

Abstract	Stroke patients undergo extensive changes in muscle mass which lead to stroke-related sarcopenia. Stroke-related sarcopenia has a significant impact on the functional outcome of stroke survivors. So, it is important to measure muscle mass in stroke patients. This study aimed to examine the correlation between ultrasonographic quadriceps muscle thickness (QMT) and dual-energy X-ray absorptiometry (DXA) derived appendicular lean mass (ALM) in patients with acute hemiplegic stroke. Twenty five participants were included (13 men and 12 women) in this study, who were diagnosed with stroke within 1 month. For both paretic and non-paretic legs, QMT was measured by an ultrasound and ALM was obtained by performing DXA scan. We analyzed the difference and the correlation between ultrasonographic QMT and DXA-derived lean body mass of both paretic and non-paretic legs. Stroke patients were divided into 2 groups according to the paretic knee extensor power. Ultrasonographic QMT, DXA scan findings, and functional parameters were compared. There was a significant correlation between QMT and ALM index, and between QMT and site-specific lean mass (SSLM) of both the legs for both the sexes (P < .05). In multivariate linear regression model, we made adjustments for the confounding factors of age, sex, body mass index (BMI) and paretic knee extensor power. We observed a positive relationship between QMT and ALM index (P < .05), and between QMT and SSLM of both the legs (P < .05). The % QMT showed higher difference than % SSLM between paretic and non-paretic legs (10.25% vs 4.58%). The QMT measurements of ultrasound show a great relationship with DXA scan findings. Ultrasound better reflects the change of muscle mass between paretic and non-paretic legs than DXA scan at an acute phase of stroke. Ultrasound could be a useful tool to evaluate stroke-related sarcopenia.
MeSH term(s)	Female ; Humans ; Male ; Muscle, Skeletal/diagnostic imaging ; Pilot Projects ; Retrospective Studies ; Sarcopenia/diagnostic imaging ; Stroke/complications ; Stroke/diagnostic imaging
Language	English
Publishing date	2022-09-08
Publishing country	United States
Document type	Journal Article
ZDB-ID	80184-7
ISSN	1536-5964 ; 0025-7974
ISSN (online)	1536-5964
ISSN	0025-7974
DOI	10.1097/MD.0000000000030244
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Ua VI Zs.171: Show issues

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Article: Quercetin and Quercitrin from

Trinh, Nguyet-Tran / Nguyen, Thi Minh Ngoc / Yook, Jong-In / Ahn, Sang-Gun / Kim, Soo-A

Pharmaceuticals (Basel, Switzerland)

2022 Volume 15, Issue 3

Abstract: Considering the high metastatic potential of colorectal cancer (CRC), the inhibition of metastasis is important for anti-CRC therapy. ...

Abstract	Considering the high metastatic potential of colorectal cancer (CRC), the inhibition of metastasis is important for anti-CRC therapy.
Language	English
Publishing date	2022-03-17
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2193542-7
ISSN	1424-8247
ISSN	1424-8247
DOI	10.3390/ph15030364
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Article: Three-Dimensional Magnetic Rehabilitation, Robot-Enhanced Hand-Motor Recovery after Subacute Stroke: A Randomized Controlled Trial.

Kim, Sung-Hoon / Ji, Dong-Min / Hwang, In-Su / Ryu, Jinwhan / Jin, Sol / Kim, Soo-A / Kim, Min-Su

Brain sciences

2023 Volume 13, Issue 12

Abstract: We developed an end-effector-type rehabilitation robot that can uses electro- and permanent magnets to generate a three-way magnetic field to assist hand movements and perform rehabilitation therapy. This study aimed to investigate the therapeutic effect ...

Abstract	We developed an end-effector-type rehabilitation robot that can uses electro- and permanent magnets to generate a three-way magnetic field to assist hand movements and perform rehabilitation therapy. This study aimed to investigate the therapeutic effect of a rehabilitation program using a three-dimensional (3D) magnetic force-based hand rehabilitation robot on the motor function recovery of the paralyzed hands of patients with stroke. This was a double-blind randomized controlled trial in which 36 patients with subacute stroke were assigned to intervention and control groups of 18 patients each. The intervention group received 30 min of rehabilitation therapy per day for a month using a 3D magnetic force-driven hand rehabilitation robot, whereas the control group received 30 min of conventional occupational therapy to restore upper-limb function. The patients underwent three behavioral assessments at three time points: before starting treatment (T0), after 1 month of treatment (T1), and at the follow-up 1-month after treatment completion (T2). The primary outcome measure was the Wolf Motor Function Test (WMFT), and secondary outcome measures included the Fugl-Meyer Assessment of the Upper Limb (FMA_U), Modified Barthel Index (MBI), and European Quality of Life Five Dimensions (EQ-5D) questionnaire. No participant safety issues were reported during the intervention. Analysis using repeated measures analysis of variance showed significant interaction effects between time and group for both the WMFT score (
Language	English
Publishing date	2023-12-07
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2651993-8
ISSN	2076-3425
ISSN	2076-3425
DOI	10.3390/brainsci13121685
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