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Article ; Online: Impact of overweight or obesity trajectory on health expenditure in Korea.

Kim, T H / Han, E

Journal of public health (Oxford, England)

2021 Volume 42, Issue 2, Page(s) e165–e173

Abstract: Background: This study aimed to identify the effect of the overweight or obesity (OWOB) trajectory on current health care expenditure in South Korea.: Methods: Ten years of publicly released data (2002-12) were obtained in 2016 from a retrospective ... ...

Abstract	Background: This study aimed to identify the effect of the overweight or obesity (OWOB) trajectory on current health care expenditure in South Korea. Methods: Ten years of publicly released data (2002-12) were obtained in 2016 from a retrospective cohort of National Health Insurance System claims. This study included 51,844 adults (aged 30-59 years in 2002) and 21,196 elderly adults (aged ≥ 60 years in 2002). Results: Compared with adults who maintained normal weight (NW), higher yearly total health expenditures were estimated for adults who lost weight over the 10-year period: by 11.5% (95% confidence interval (CI): 0.18-22.96%) when changing from NW to underweight (UW) and 6.2% (95% CI: 0.47-12.01%) from OWOB to UW/NW. Elderly adults had higher health expenditures when they lost weight by 14.0% (95% CI: 0.37-27.70%) from NW to UW and 6.8% (95% CI: 0.13-13.51%) from OWOB to UW/NW compared with when they maintained NW. Conclusions: These findings indicate the importance of early intervention to control OWOB, particularly because people in late adulthood have greater health care needs for reasons other than OWOB.
MeSH term(s)	Adult ; Aged ; Body Mass Index ; Health Expenditures ; Humans ; Obesity/epidemiology ; Overweight/epidemiology ; Republic of Korea/epidemiology ; Retrospective Studies
Language	English
Publishing date	2021-01-15
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2142082-8
ISSN	1741-3850 ; 1741-3842
ISSN (online)	1741-3850
ISSN	1741-3842
DOI	10.1093/pubmed/fdz068
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Article ; Online: Digital coincidence counting with 4πβ(PPC)-γ for the standardization of

Han, Minji / Hwang, Sanghoon / Agusbudiman, Agung / Lee, J M / Lee, K B / Kim, B C / Heo, D H / Kim, T H

Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine

2024 Volume 205, Page(s) 111173

Abstract: A 4πβ(PPC)-γ coincidence system has been made at KRISS based on a digital DAQ. ...

Abstract	A 4πβ(PPC)-γ coincidence system has been made at KRISS based on a digital DAQ.
Language	English
Publishing date	2024-01-03
Publishing country	England
Document type	Journal Article
ZDB-ID	1142596-9
ISSN	1872-9800 ; 0883-2889 ; 0969-8043
ISSN (online)	1872-9800
ISSN	0883-2889 ; 0969-8043
DOI	10.1016/j.apradiso.2024.111173
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Article ; Online: Correction to: Bioconversion of arachidonic acid into human 14,15-hepoxilin B

Lee, J / Kim, T-H / Oh, D-K

Biotechnology letters

2020 Volume 42, Issue 10, Page(s) 2011–2012

Abstract: In the original publication of the article, some chirality of Fig. 1 was published incorrectly. The corrected figure is provided below. ...

Abstract	In the original publication of the article, some chirality of Fig. 1 was published incorrectly. The corrected figure is provided below.
Language	English
Publishing date	2020-06-20
Publishing country	Netherlands
Document type	Journal Article ; Published Erratum
ZDB-ID	423853-9
ISSN	1573-6776 ; 0141-5492
ISSN (online)	1573-6776
ISSN	0141-5492
DOI	10.1007/s10529-020-02947-5
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Article ; Online: Bioconversion of arachidonic acid into human 14,15-hepoxilin B

Lee, J / Kim, T-H / Oh, D-K

Biotechnology letters

2020 Volume 42, Issue 10, Page(s) 2001–2009

Abstract: Objective: To produce high concentrations of 13-hydroxy-14,15-epoxy-eicosatrienoic acid (14,15-hepoxilin B: Results: The products obtained from the bioconversion of ARA by recombinant Escherichia coli cells containing Archangium violaceum 15-LOX ... ...

Abstract	Objective: To produce high concentrations of 13-hydroxy-14,15-epoxy-eicosatrienoic acid (14,15-hepoxilin B Results: The products obtained from the bioconversion of ARA by recombinant Escherichia coli cells containing Archangium violaceum 15-LOX without and with Myxococcus xanthus EH were identified as 14,15-HXB Conclusion: These are the highest concentrations, productivities, and yields of hepoxilin and trioxilin from ARA reported thus far.
MeSH term(s)	8,11,14-Eicosatrienoic Acid/analogs & derivatives ; 8,11,14-Eicosatrienoic Acid/chemistry ; 8,11,14-Eicosatrienoic Acid/metabolism ; Arachidonate 15-Lipoxygenase/genetics ; Arachidonate 15-Lipoxygenase/metabolism ; Arachidonic Acids/chemistry ; Arachidonic Acids/metabolism ; Bacterial Proteins/genetics ; Bacterial Proteins/metabolism ; Epoxide Hydrolases/genetics ; Epoxide Hydrolases/metabolism ; Myxococcales/enzymology ; Myxococcales/genetics ; Myxococcus xanthus/enzymology ; Myxococcus xanthus/genetics
Chemical Substances	Arachidonic Acids ; Bacterial Proteins ; 10-hydroxy-11,12-epoxyeicosa-5,8,14-trienoic acid (71799-95-6) ; Arachidonate 15-Lipoxygenase (EC 1.13.11.33) ; Epoxide Hydrolases (EC 3.3.2.-) ; 8,11,14-Eicosatrienoic Acid (FC398RK06S)
Language	English
Publishing date	2020-06-01
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	423853-9
ISSN	1573-6776 ; 0141-5492
ISSN (online)	1573-6776
ISSN	0141-5492
DOI	10.1007/s10529-020-02932-y
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Article ; Online: Percentage volume of delayed kinetics in computer-aided diagnosis of MRI of the breast to reduce false-positive results and unnecessary biopsies.

Ha, T / Kang, D K / Kim, T H

Clinical radiology

2020 Volume 75, Issue 12, Page(s) 962.e1–962.e8

Abstract: Aim: To investigate the best cut-off percentage volume of delayed kinetics using magnetic resonance imaging (MRI) with computer-aided diagnosis (CAD) to reduce unnecessary biopsies in patients with newly diagnosed breast cancer.: Materials and methods! ...

Abstract	Aim: To investigate the best cut-off percentage volume of delayed kinetics using magnetic resonance imaging (MRI) with computer-aided diagnosis (CAD) to reduce unnecessary biopsies in patients with newly diagnosed breast cancer. Materials and methods: Between January 2017 and December 2018, 94 malignant and 56 benign masses were analysed using MRI CAD. All malignant and benign masses measured <2 cm and were confirmed histopathologically. The optimal cut-off values for washout, plateau, and persistent components were determined using the maximum Youden Index. The positive predictive value (PPV) was analysed using morphological descriptors and combining the percentage volume of delayed kinetics. Results: The area under the curve (AUC) was highest at ≤73% persistent component (AUC=0.759). In the subgroup analyses of masses <1 cm, the AUC was highest a plateau of >26% (AUC=0.697). When the persistent ≤73% criterion was applied to the lesions of C4a, the positive predictive value (PPV) increased from 61.9% to 72.44% with reduced false-negative cases and when applied to the lesions of C4a and C4b, the PPV increased from 61.9% to 78.1% with slightly increased false-negative cases. For subcentimetre lesions, the PPV increased from 46.77% to 54.72% with the same number of false-negative cases, when a plateau of >26% was applied to C4a, and the PPV increased from 46.77% to 61.36% with five false-negative cases when applied to C4a and C4b. Conclusion: The percentage volume of delayed kinetics has the potential to improve the PPV of breast MRI. When suspicious masses <2 cm do not show ≤73% persistence, follow-up rather than biopsy could be considered; however, to avoid increasing false-negative cases, delayed kinetic information should be used with caution and accurate margin assessment is essential.
MeSH term(s)	Adult ; Aged ; Biopsy/statistics & numerical data ; Breast Neoplasms/diagnostic imaging ; Breast Neoplasms/pathology ; Diagnosis, Computer-Assisted ; False Positive Reactions ; Female ; Humans ; Kinetics ; Magnetic Resonance Imaging/methods ; Middle Aged ; Retrospective Studies ; Tumor Burden ; Unnecessary Procedures/statistics & numerical data
Language	English
Publishing date	2020-09-01
Publishing country	England
Document type	Journal Article
ZDB-ID	391227-9
ISSN	1365-229X ; 0009-9260
ISSN (online)	1365-229X
ISSN	0009-9260
DOI	10.1016/j.crad.2020.08.005
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Article: Bioconversion of arachidonic acid into human 14,15-hepoxilin B3 and 13,14,15-trioxilin B3 by recombinant cells expressing microbial 15-lipoxygenase without and with epoxide hydrolase

Lee, J / Kim, T.-H / Oh, D.-K

Biotechnology letters. 2020 Oct., v. 42, no. 10

2020

Abstract: OBJECTIVE: To produce high concentrations of 13-hydroxy-14,15-epoxy-eicosatrienoic acid (14,15-hepoxilin B₃, 14,15-HXB₃) and 13,14,15-trihydroxy-eicosatrienoic acid (13,14,15-trioxilin B₃, 13,14,15-TrXB₃) from arachidonic acid (ARA) using microbial 15- ... ...

Abstract	OBJECTIVE: To produce high concentrations of 13-hydroxy-14,15-epoxy-eicosatrienoic acid (14,15-hepoxilin B₃, 14,15-HXB₃) and 13,14,15-trihydroxy-eicosatrienoic acid (13,14,15-trioxilin B₃, 13,14,15-TrXB₃) from arachidonic acid (ARA) using microbial 15-lipoxygenase (15-LOX) without and with epoxide hydrolase (EH), respectively. RESULTS: The products obtained from the bioconversion of ARA by recombinant Escherichia coli cells containing Archangium violaceum 15-LOX without and with Myxococcus xanthus EH were identified as 14,15-HXB₃ and 13,14,15-TrXB₃, respectively. Under the optimal conditions of 30 g cells L⁻¹, 200 mM ARA, 25 °C, and initial pH 7.5, the cells converted 200 mM ARA into 192 mM 14,15-HXB₃ and 100 mM 13,14,15-TrXB₃ for 150 min, with conversion yields of 96 and 51% and productivities of 77 and 40 mM h⁻¹, respectively. CONCLUSION: These are the highest concentrations, productivities, and yields of hepoxilin and trioxilin from ARA reported thus far.
Keywords	Archangium ; Escherichia coli ; Myxococcus xanthus ; arachidonate 15-lipoxygenase ; arachidonic acid ; biotechnology ; biotransformation ; epoxide hydrolase ; humans ; pH
Language	English
Dates of publication	2020-10
Size	p. 2001-2009.
Publishing place	Springer Netherlands
Document type	Article
Note	NAL-AP-2-clean
ZDB-ID	423853-9
ISSN	1573-6776 ; 0141-5492
ISSN (online)	1573-6776
ISSN	0141-5492
DOI	10.1007/s10529-020-02932-y
Database	NAL-Catalogue (AGRICOLA)

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Article: Association between body composition indices and prevalence of chronic rhinosinusitis in Koreans.

Lee, K / Kim, K / Lee, S H / Kim, T H

Rhinology

2021 Volume 59, Issue 4, Page(s) 405–408

MeSH term(s)	Body Composition ; Chronic Disease ; Humans ; Prevalence ; Republic of Korea/epidemiology ; Rhinitis/epidemiology ; Sinusitis/epidemiology
Language	English
Publishing date	2021-07-31
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	80336-4
ISSN	0300-0729
ISSN	0300-0729
DOI	10.4193/Rhin20.665
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Article: Eosinophil-derived TGFβ1 controls the new bone formation in chronic rhinosinusitis with nasal polyps

Jo, S / Lee, S H / Jo, H-R / Weon, S / Jeon, C / Park, M K / Kim, T-H / Cho, S H

Rhinology

2023 Volume 61, Issue 4, Page(s) 338–347

Abstract: Background: Chronic rhinosinusitis with nasal polyps (CRSwNP) is characterized by chronic eosinophilic inflammation and new bone formation (NBF). These processes may be associated with each other in the pathogenesis and influence the severity and ... ...

Abstract	Background: Chronic rhinosinusitis with nasal polyps (CRSwNP) is characterized by chronic eosinophilic inflammation and new bone formation (NBF). These processes may be associated with each other in the pathogenesis and influence the severity and prognosis of the disease. However, it is still unclear how eosinophilic inflammation is involved in the NBF. Methodology: Sinus bone cells were isolated from ethmoid bone tissues of patients with CRSwNP and controls. Transforming growth factor beta 1 (TGFβ1) and alkaline phosphatase (ALP) expression in sinus bone cells was determined using quantitative RT-PCR, immunoblotting, and immunohistochemistry. The co-localization of TGFβ1 with eosinophils was assessed by immunofluorescence staining. Sinus bone cells were co-cultured with eosinophils (Eol-1 cell line), which were differentiated with butyrate, to measure the osteoblast differentiation activity of sinus bone cells. Results: TGFβ1 expression was increased in sinus bone tissues and correlated with CT scores in CRSwNP. TGFβ1 was also increased in the submucosa of CRSwNP and co-localized predominantly with eosinophils compared with neutrophils Differentiated Eol-1 cells-derived TGFβ1 increased ALP expression in sinus bone cells. Treatment with a TGFβ inhibitor attenuated TGFβ1-induced ALP expression and staining in sinus bone cells of CRSwNP, leading to loss of bone formation. Conclusions: Eosinophil-derived TGFβ1 was enriched in the submucosa of CRSwNP, which induced ALP expression in sinus bone cells and NBF. Therefore, eosinophil-derived TGFβ1 may mediate aberrant bone remodeling in CRSwNP.
MeSH term(s)	Humans ; Eosinophils ; Rhinitis/complications ; Rhinitis/pathology ; Transforming Growth Factor beta ; Nasal Polyps/complications ; Nasal Polyps/pathology ; Osteogenesis ; Sinusitis/complications ; Sinusitis/pathology ; Inflammation/pathology ; Chronic Disease
Chemical Substances	Transforming Growth Factor beta
Language	English
Publishing date	2023-04-14
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	80336-4
ISSN	0300-0729
ISSN	0300-0729
DOI	10.4193/Rhin22.439
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Article ; Online: A collagen-based layered chronic wound biofilm model for testing antimicrobial wound products.

Thaarup, Ida C / Lichtenberg, Mads / Nørgaard, Kim T H / Xu, Yijuan / Lorenzen, Jan / Thomsen, Trine R / Bjarnsholt, Thomas

Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society

2023 Volume 31, Issue 4, Page(s) 500–515

Abstract: A new in vitro chronic wound biofilm model was recently published, which provided a layered scaffold simulating mammalian tissue composition on which topical wound care products could be tested. In this paper, we updated the model even further to mimic ... ...

Abstract	A new in vitro chronic wound biofilm model was recently published, which provided a layered scaffold simulating mammalian tissue composition on which topical wound care products could be tested. In this paper, we updated the model even further to mimic the dynamic influx of nutrients from below as is the case in a chronic wound. The modified in vitro model was created using collagen instead of agar as the main matrix component and contained both Staphylococcus aureus and Pseudomonas aeruginosa. The model was cast in transwell inserts and then placed in wound simulating media, which allowed for an exchange of nutrients and waste products across a filter. Three potential wound care products and chlorhexidine digluconate 2% solution as a positive control were used to evaluate the model. The tested products were composed of hydrogels made from completely biodegradable starch microspheres carrying different active compounds. The compounds were applied topically and left for 2-4 days. Profiles of oxygen concentration and pH were measured to assess the effect of treatments on bacterial activity. Confocal microscope images were obtained of the models to visualise the existence of microcolonies. Results showed that the modified in vitro model maintained a stable number of the two bacterial species over 6 days. In untreated models, steep oxygen gradients developed and pH increased to >8.0. Hydrogels containing active compounds alleviated the high oxygen consumption and decreased pH drastically. Moreover, all three hydrogels reduced the colony forming units significantly and to a larger extent than the chlorhexidine control treatment. Overall, the modified model expressed several characteristics similar to in vivo chronic wounds.
MeSH term(s)	Animals ; Wound Healing ; Wound Infection/microbiology ; Anti-Infective Agents/pharmacology ; Collagen/pharmacology ; Bacteria ; Biofilms ; Oxygen ; Hydrogels/pharmacology ; Pseudomonas aeruginosa ; Anti-Bacterial Agents/pharmacology ; Mammals
Chemical Substances	Anti-Infective Agents ; chlorhexidine gluconate (MOR84MUD8E) ; Collagen (9007-34-5) ; Oxygen (S88TT14065) ; Hydrogels ; Anti-Bacterial Agents
Language	English
Publishing date	2023-05-23
Publishing country	United States
Document type	Journal Article
ZDB-ID	1174873-4
ISSN	1524-475X ; 1067-1927
ISSN (online)	1524-475X
ISSN	1067-1927
DOI	10.1111/wrr.13087
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Article ; Online: Applicability and limitations of quality indicator-based assessment of appropriateness in antimicrobial use: a comparison with expert opinion.

Park, S Y / Moon, S M / Kim, B / Lee, M J / Song, K-H / Kim, E S / Kim, T H / Kim, H B

The Journal of hospital infection

2023 Volume 139, Page(s) 93–98

Abstract: Background: The effective implementation of antimicrobial stewardship requires an a-priori assessment of the appropriateness of antimicrobial prescriptions.: Aim: To evaluate the effectiveness of quality indicators (QIs) in determining the ... ...

Abstract	Background: The effective implementation of antimicrobial stewardship requires an a-priori assessment of the appropriateness of antimicrobial prescriptions. Aim: To evaluate the effectiveness of quality indicators (QIs) in determining the appropriateness of antimicrobial prescriptions compared to that of expert opinions. Methods: The study assessed antimicrobial use in 20 hospitals in Korea, with infectious disease specialists rating the appropriateness based on QIs and expert opinions. The selected QIs were (1) taking two blood cultures, (2) taking cultures from suspected sites of infection, (3) prescribing empirical antimicrobials according to guidelines, and (4) changing from empirical to pathogen-directed therapy for hospitalized patients and (2, 3, and 4) for ambulatory patients. Applicability, compliance with QIs, and agreement between QIs and expert opinions were investigated. Findings: Overall, 7999 therapeutic uses of antimicrobials were investigated at the study hospitals. The experts rated 20.5% (1636/7999) as inappropriate use. For hospitalized patients, antimicrobial use was assessed based on all four QIs in 28.8% (1798/6234) of the cases. For ambulatory care patients, only 7.5% (102/1351) of the antimicrobial use cases were assessed using all three QIs. The agreement between expert opinions and all four QIs for hospitalized patients was minimal (κ = 0.332), whereas that between expert opinions and all three QIs for ambulatory patients was weak (κ = 0.598). Conclusion: QIs have limitations in determining the appropriateness of antimicrobial use, and the degree of agreement with expert opinions was low. Therefore, these QI limitations should be considered when determining the appropriateness of antimicrobial use.
MeSH term(s)	Humans ; Quality Indicators, Health Care ; Expert Testimony ; Anti-Infective Agents/therapeutic use ; Hospitals ; Antimicrobial Stewardship
Chemical Substances	Anti-Infective Agents
Language	English
Publishing date	2023-07-05
Publishing country	England
Document type	Journal Article
ZDB-ID	779366-2
ISSN	1532-2939 ; 0195-6701
ISSN (online)	1532-2939
ISSN	0195-6701
DOI	10.1016/j.jhin.2023.06.023
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