LIVIVO - Search results -

Search results

Result 1 - 10 of total 252

Search options

Article ; Online: Elevated plasma α1-antichymotrypsin is a biomarker candidate for malaria patients.

Bahk, Young Yil / Lee, Sang Bong / Kim, Jong Bo / Kim, Tong-Soo / Hong, Sung-Jong / Kim, Dong Min / Lee, Sungkeun

2022 Volume 55, Issue 11, Page(s) 571–576

Abstract: Advancements in the field of proteomics have provided opportunities to develop diagnostic and therapeutic strategies against various diseases. About half of the world's population remains at risk of malaria. Caused by protozoan parasites of the genus ... ...

Abstract	Advancements in the field of proteomics have provided opportunities to develop diagnostic and therapeutic strategies against various diseases. About half of the world's population remains at risk of malaria. Caused by protozoan parasites of the genus Plasmodium, malaria is one of the oldest and largest risk factors responsible for the global burden of infectious diseases with an estimated 3.2 billion persons at risk of infection. For epidemiological surveillance and appropriate treatment of individuals infected with Plasmodium spp., timely detection is critical. In this study, we used combinations of depletion of abundant plasma proteins, 2-dimensional gel electrophoresis (2-DE), image analysis, LC-MS/MS and western blot analysis on the plasma of healthy donors (100 individuals) and vivax and falciparum malaria patients (100 vivax malaria patients and 8 falciparum malaria patients). These analyses revealed that α1-antichymotrypsin (AACT) protein levels were elevated in vivax malaria patient plasma samples (mean fold-change ± standard error: 2.83 ± 0.11, based on band intensities), but not in plasma from patients with other mosquito-borne infectious diseases. The results of AACT immunoblot analyses showed that AACT protein was significantly elevated in vivax and falciparum malaria patient plasma samples (≥ 2-fold) compared to healthy control donor plasma samples, which has not been previously reported. [BMB Reports 2022; 55(11): 571-576].
MeSH term(s)	Animals ; Humans ; Malaria, Vivax/diagnosis ; Malaria, Vivax/epidemiology ; Malaria, Vivax/parasitology ; Plasmodium vivax ; Chromatography, Liquid ; Tandem Mass Spectrometry ; Malaria/drug therapy ; Malaria/epidemiology ; Malaria/parasitology ; Plasmodium ; Malaria, Falciparum/diagnosis ; Malaria, Falciparum/parasitology ; Biomarkers ; Communicable Diseases
Chemical Substances	Biomarkers
Language	English
Publishing date	2022-10-04
Publishing country	Korea (South)
Document type	News
ZDB-ID	2410389-5
ISSN	1976-670X ; 1976-6696
ISSN (online)	1976-670X
ISSN	1976-6696
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 4202: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (2.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

Details ▾
- See ZB MED holdings
- Order with fees

Article: Seroprevalence of Measles IgG Antibodies in Married Immigrant Women from Multicultural Families in Korea.

Lee, Woojoo / Shin, Mi Yeong / Go, Eunbyeul / Lim, Hyun-Cheol / Jeon, Ji-Yoon / Kwon, Yerim / Lee, Yerin / Kim, Tong-Soo / Lee, Sung-Keun / Bahk, Young Yil

Infection & chemotherapy

2023 Volume 55, Issue 3, Page(s) 368–376

Abstract: Background: Although an effective vaccine has been available, measles still causes mast morbidity and mortality world widely. In Korea, a small number of measles cases have been reported through exposure to imported cases among young people with vaccine- ...

Abstract	Background: Although an effective vaccine has been available, measles still causes mast morbidity and mortality world widely. In Korea, a small number of measles cases have been reported through exposure to imported cases among young people with vaccine-induced measles immunity. Recently due to international migration including marriage, marriage migrants were the second-largest group of foreign population in Korea. Our study was carried out to obtain positive rate of measles antibody among married immigrant women from 12 countries in 10 Gun-Counties and 6 Cities, Korea. Materials and methods: A total of 547 blood samples were collected from maternal multicultural members from 12 countries. The measles-specific IgG antibody was measured by ELISA (Enzyme-linked immunosorbent assay; Enzygnost Results: Overall positive measles seroprevalence was 75.3% (95% confidence interval: 71.7 - 78.9). Participants aged 20 - 24 years, 25 - 29 years, and 30 - 63 years has respective seropositivities of 52.5%, 55.3%, and 82.7%. In this study, the geometric mean titers of participants aged 21 - 29 years were slightly lower than those of participants aged over 30 years, which were 1,372 mIU/ml and 2,261 mIU/ml, respectively (average of total participants: 2,027 mIU/ml). Conclusion: The study provides detailed information about seroimmunity of the married immigrant population in Korea, which is important for measles elimination. Since the 1980s, most vaccine-preventable diseases including measles have been well-controlled. Nevertheless, sporadic measles outbreaks are still reported. Thus, special attention should be paid to the possible importation of infectious diseases such as measles by immigration.
Language	English
Publishing date	2023-06-14
Publishing country	Korea (South)
Document type	Journal Article
ZDB-ID	2573798-3
ISSN	2093-2340
ISSN	2093-2340
DOI	10.3947/ic.2023.0026
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 6842: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article: The Overactivation of NADPH Oxidase during

Jeong, Ji Hoon / Yi, Junyeong / Hwang, Myung Ki / Hong, Sung-Jong / Sohn, Woon-Mok / Kim, Tong-Soo / Pak, Jhang Ho

Antioxidants (Basel, Switzerland)

2021 Volume 10, Issue 6

Abstract: Clonorchis ... ...

Abstract	Clonorchis sinensis
Language	English
Publishing date	2021-05-28
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2704216-9
ISSN	2076-3921
ISSN	2076-3921
DOI	10.3390/antiox10060869
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article ; Online: Transcriptomic profiling of three-dimensional cholangiocyte spheroids long term exposed to repetitive Clonorchis sinensis excretory-secretory products.

Kim, Jung-Woong / Yi, Junyeong / Park, Jinhong / Jeong, Ji Hoon / Kim, Jinho / Won, Jihee / Chung, Seok / Kim, Tong-Soo / Pak, Jhang Ho

Parasites & vectors

2021 Volume 14, Issue 1, Page(s) 213

Abstract: Background: Biliary tract infection with the carcinogenic human liver fluke, Clonorchis sinensis, provokes chronic inflammation, epithelial hyperplasia, periductal fibrosis, and even cholangiocarcinoma. Complications are proportional to the intensity ... ...

Abstract	Background: Biliary tract infection with the carcinogenic human liver fluke, Clonorchis sinensis, provokes chronic inflammation, epithelial hyperplasia, periductal fibrosis, and even cholangiocarcinoma. Complications are proportional to the intensity and duration of the infection. In addition to mechanical irritation of the biliary epithelia from worms, their excretory-secretory products (ESPs) cause chemical irritation, which leads to inflammation, proliferation, and free radical generation. Methods: A three-dimensional in vitro cholangiocyte spheroid culture model was established, followed by ESP treatment. This allowed us to examine the intrinsic pathological mechanisms of clonorchiasis via the imitation of prolonged and repetitive in vivo infection. Results: Microarray and RNA-Seq analysis revealed that ESP-treated cholangiocyte H69 spheroids displayed global changes in gene expression compared to untreated spheroids. In ESP-treated H69 spheroids, 185 and 63 probes were found to be significantly upregulated and downregulated, respectively, corresponding to 209 genes (p < 0.01, fold change > 2). RNA-Seq was performed for the validation of the microarray results, and the gene expression patterns in both transcriptome platforms were well matched for 209 significant genes. Gene ontology analysis demonstrated that differentially expressed genes were mainly classified into immune system processes, the extracellular region, and the extracellular matrix. Among the upregulated genes, four genes (XAF1, TRIM22, CXCL10, and BST2) were selected for confirmation using quantitative RT-PCR, resulting in 100% similar expression patterns in microarray and RNA-Seq. Conclusions: These findings broaden our understanding of the pathological pathways of liver fluke-associated hepatobiliary disorders and suggest a novel therapeutic strategy for this infectious cancer.
MeSH term(s)	Animals ; Bile Ducts/cytology ; Bile Ducts/parasitology ; Clonorchiasis/genetics ; Clonorchiasis/metabolism ; Clonorchiasis/parasitology ; Clonorchis sinensis/genetics ; Clonorchis sinensis/metabolism ; Epithelial Cells/metabolism ; Epithelial Cells/parasitology ; Gene Expression Profiling ; Helminth Proteins/genetics ; Helminth Proteins/metabolism ; Humans ; Male ; Rabbits ; Spheroids, Cellular/cytology ; Spheroids, Cellular/metabolism ; Spheroids, Cellular/parasitology
Chemical Substances	Helminth Proteins
Language	English
Publishing date	2021-04-20
Publishing country	England
Document type	Journal Article
ZDB-ID	2409480-8
ISSN	1756-3305 ; 1756-3305
ISSN (online)	1756-3305
ISSN	1756-3305
DOI	10.1186/s13071-021-04717-2
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article ; Online: Clusters of Toxoplasmosis in Ganghwa-gun, Cheorwon-gun, and Goseong-gun, Korea.

Yu, Jihye / Kim, Woojin / Chang, Yoon Kyung / Kim, Tong-Soo / Hong, Sung-Jong / Ahn, Hye-Jin / Nam, Ho-Woo / Kim, Dongjae

The Korean journal of parasitology

2021 Volume 59, Issue 3, Page(s) 251–256

Abstract: We find out the clusters with high toxoplasmosis risk to discuss the geographical pattern in Gyodong-myeon and Samsan-myeon of Ganghwa-gun, Cheorwon-gun, and Goseong-gun, Korea. Seroepidemiological data of toxoplasmosis surveyed using rapid diagnostic ... ...

Abstract	We find out the clusters with high toxoplasmosis risk to discuss the geographical pattern in Gyodong-myeon and Samsan-myeon of Ganghwa-gun, Cheorwon-gun, and Goseong-gun, Korea. Seroepidemiological data of toxoplasmosis surveyed using rapid diagnostic tests for the residents in the areas in 2019 were analyzed to detect clusters of the infection. The cluster was investigated using the SaTScan program which is based on Kulldorff's scan statistic. The clusters were found with P-values in each region analyzed in the program, and the risk and patient incidence of specific areas can be examined by the values such as relative risk and log likelihood ratio. Jiseok-ri and Insa-ri were found to be a cluster in Gyodong-myeon and Seokmo-ri was the cluster in Samsan-myeon. Yangji-ri and Igil-ri were found to be a cluster in Cheorwon-gun and Madal-ri and Baebong-ri were the cluster in Goseong-gun. This findings can be used to monitor and prevent toxoplasmosis infections occurring in vulnerable areas.
MeSH term(s)	Diagnostic Tests, Routine ; Humans ; Incidence ; Republic of Korea/epidemiology ; Risk ; Toxoplasmosis/diagnosis ; Toxoplasmosis/epidemiology
Language	English
Publishing date	2021-06-21
Publishing country	Korea (South)
Document type	Journal Article
ZDB-ID	286875-1
ISSN	1738-0006 ; 0023-4001
ISSN (online)	1738-0006
ISSN	0023-4001
DOI	10.3347/kjp.2021.59.3.251
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 3476: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (2.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: Recent Spatial and Temporal Trends of Malaria in Korea.

Kim, Yeong Hoon / Ahn, Hye-Jin / Kim, Dongjae / Hong, Sung-Jong / Kim, Tong-Soo / Nam, Ho-Woo

The Korean journal of parasitology

2021 Volume 59, Issue 6, Page(s) 585–593

Abstract: This study was done to provide an analytical overview on the latest malaria infection clusters by evaluating temporal trends during 2010-2019 in Korea. Incheon was the most likely cluster (MLC) for all cases of malaria during the total period. MLCs for P. ...

Abstract	This study was done to provide an analytical overview on the latest malaria infection clusters by evaluating temporal trends during 2010-2019 in Korea. Incheon was the most likely cluster (MLC) for all cases of malaria during the total period. MLCs for P. falciparum, vivax, malariae, ovale, and clinically diagnosed malaria without parasitological confirmation were Jeollanam-do, Incheon, Gangwon-do, Gyeongsangnam-do, and Jeollabuk-do, respectively. Malaria was decreasing in most significant clusters, but Gwangju showed an increase for all cases of malaria, P. vivax and clinically diagnosed cases. Malaria overall, P. falciparum and P. vivax seem to be under control thanks to aggressive health measures. This study might provide a sound scientific basis for future control measures against malaria in Korea.
MeSH term(s)	Humans ; Malaria/epidemiology ; Malaria, Falciparum/epidemiology ; Malaria, Vivax/epidemiology ; Plasmodium falciparum ; Plasmodium vivax ; Republic of Korea/epidemiology
Language	English
Publishing date	2021-12-22
Publishing country	Korea (South)
Document type	Journal Article
ZDB-ID	286875-1
ISSN	1738-0006 ; 0023-4001
ISSN (online)	1738-0006
ISSN	0023-4001
DOI	10.3347/kjp.2021.59.6.585
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 3476: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (2.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: Seroprevalence of Plasmodium vivax Circumsporozoite Protein Antibody in High-Risk Malaria Areas in Korea.

Lee, Jinyoung / Jin, Kyoung / Ahn, Seong Kyu / Lee, Sung-Keun / Kwon, Hyung Wook / Na, Byoung-Kuk / Kim, Tong-Soo

The Korean journal of parasitology

2021 Volume 59, Issue 4, Page(s) 415–419

Abstract: The circumsporozoite protein (CSP) of Plasmodium spp. is a diagnostic antigen and useful biomarker for monitoring short-term/seasonal changes to malaria transmission. Using P. vivax CSP antibody ELISA, epidemiological characteristics were analyzed in the ...

Abstract	The circumsporozoite protein (CSP) of Plasmodium spp. is a diagnostic antigen and useful biomarker for monitoring short-term/seasonal changes to malaria transmission. Using P. vivax CSP antibody ELISA, epidemiological characteristics were analyzed in the residents of Ganghwa, Cheorwon, Paju, and Goseong from 2017 to 2018. In Ganghwa and Cheorwon, 1.6% and 1.2% of residents, respectively, were PvCSP-antibody-positive in 2018, which indicates a decrease of 0.4% in the positive rate compared to 2017. The annual parasite incidence (API) in Ganghwa and Cheorwon was 24.9 and 10.5 in 2017 and 20.3 and 10.7 in 2018, respectively. Although the changes were not significant, the API in Ganghwa decreased slightly by 4.5 in 2018 compared to the previous year. In Paju and Goseong, 3.9% and 2.0% of residents were positive for the PvCSP antibody. The API in Paju was 13.1 in 2017 and 16.0 in 2018, although no malaria patients were reported for the 2 years. Therefore, the results suggest that PvCSP is a useful antigen for confirming initial malaria infection. Additionally, considering that the antibody is relatively transient, it can be employed for sero-epidemiological studies to determine the extent of malaria transmission in the current year.
MeSH term(s)	Antibodies, Protozoan ; Humans ; Malaria ; Malaria, Vivax/epidemiology ; Plasmodium vivax ; Protozoan Proteins ; Republic of Korea/epidemiology ; Seroepidemiologic Studies
Chemical Substances	Antibodies, Protozoan ; Protozoan Proteins
Language	English
Publishing date	2021-08-18
Publishing country	Korea (South)
Document type	Journal Article
ZDB-ID	286875-1
ISSN	1738-0006 ; 0023-4001
ISSN (online)	1738-0006
ISSN	0023-4001
DOI	10.3347/kjp.2021.59.4.415
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 3476: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (2.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: Awareness and Opinions of Inhabitants on Vivax Malaria in Two Endemic Areas, Gyeonggi-do, Korea.

Bahk, Young Yil / Cho, Shin-Hyeong / Na, Byoung-Kuk / Hong, Sung Jong / Lee, Sung-Keun / Kim, Tong-Soo

The Korean journal of parasitology

2021 Volume 59, Issue 5, Page(s) 513–518

Abstract: The incidence of vivax malaria in Korea was reduced to a low plateau. For successful elimination of vivax malaria, socio-behavioral changes in the communities are essential. This study aimed to figure out awareness of the inhabitants on the vivax malaria ...

Abstract	The incidence of vivax malaria in Korea was reduced to a low plateau. For successful elimination of vivax malaria, socio-behavioral changes in the communities are essential. This study aimed to figure out awareness of the inhabitants on the vivax malaria endemicity. The 407 participants including vivax malaria patients and uninfected inhabitants in Gimpo- and Paju-si, Gyeonggi-do, known as high-risk areas in Korea. We used a community-based study design and non-probability sampling method using primary data. Except for the perception about the public health facilities' capability to cope with anti-malaria programs, the 2 groups of participants shared the same level of awareness about public promotional and educational measures and opinions for malaria elimination from the community. Thus, our future goals for malaria prevention and elimination are to develop more active and well-organized community-based education and evaluation programs collaborating with the community healthcare authorities and local governments.
MeSH term(s)	Antibodies, Protozoan ; Humans ; Malaria ; Malaria, Vivax/epidemiology ; Malaria, Vivax/prevention & control ; Plasmodium vivax ; Republic of Korea/epidemiology
Chemical Substances	Antibodies, Protozoan
Language	English
Publishing date	2021-10-22
Publishing country	Korea (South)
Document type	Journal Article
ZDB-ID	286875-1
ISSN	1738-0006 ; 0023-4001
ISSN (online)	1738-0006
ISSN	0023-4001
DOI	10.3347/kjp.2021.59.5.513
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 3476: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (2.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: Monitoring Chigger Mites for Orientia tsutsugamushi in Field Small Mammals in Hwaseong-si, Gyeonggi-do, Korea, 2019-2020.

Bahk, Young Yil / Ahn, Seong Kyu / Lee, Jinyoung / Kwon, Hyung Wook / Hong, Sung Jong / Kim, Tong-Soo

The Korean journal of parasitology

2021 Volume 59, Issue 3, Page(s) 319–324

Abstract: Incidence of tsutsugamushi disease (scrub typhus) caused by Orientia tsutsugamushi, is steadily increasing. It is a mite-borne disease transmitted by chigger mites. In this study, the chigger mites were collected from field small mammals in Hwaseong-si ( ... ...

Abstract	Incidence of tsutsugamushi disease (scrub typhus) caused by Orientia tsutsugamushi, is steadily increasing. It is a mite-borne disease transmitted by chigger mites. In this study, the chigger mites were collected from field small mammals in Hwaseong-si (city), Gyeonggi-do (province), Korea, 2019 and 2020. The field small mammals captured were 56 Apodemus agrarius (94.9%) and 3 Crocidura lasiura (5.1%). A total of 7,531 chigger mites were collected from the captured small mammals. Using PCR test, 153 chigger mite pools were examined and 17 pools were reported positive for O. tsutsugamushi. The O. tsutsugamushi were identified to 5 strains; Jecheon strain was most prevalent, followed by Boryong strain. The other strains were OI011, Taguchi, and Shimokoshi. Collectively, these results provide essential regional information on mite-borne tsutsugamushi disease in the Hwaseong-si, and further contribute to bring awareness and rapid diagnosis for the tsutsugamushi disease.
MeSH term(s)	Animals ; Mites ; Murinae ; Orientia ; Orientia tsutsugamushi ; Republic of Korea/epidemiology ; Rodentia ; Scrub Typhus/epidemiology ; Scrub Typhus/veterinary ; Trombiculidae
Language	English
Publishing date	2021-06-21
Publishing country	Korea (South)
Document type	Journal Article
ZDB-ID	286875-1
ISSN	1738-0006 ; 0023-4001
ISSN (online)	1738-0006
ISSN	0023-4001
DOI	10.3347/kjp.2021.59.3.319
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 3476: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (2.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article: Transcriptomic profiling of three-dimensional cholangiocyte spheroids long term exposed to repetitive Clonorchis sinensis excretory-secretory products

Kim, Jung-Woong / Yi, Junyeong / Park, Jinhong / Jeong, Ji Hoon / Kim, Jinho / Won, Jihee / Chung, Seok / Kim, Tong-Soo / Pak, Jhang Ho

Parasites & vectors. 2021 Dec., v. 14, no. 1

2021

Abstract: BACKGROUND: Biliary tract infection with the carcinogenic human liver fluke, Clonorchis sinensis, provokes chronic inflammation, epithelial hyperplasia, periductal fibrosis, and even cholangiocarcinoma. Complications are proportional to the intensity and ...

Abstract	BACKGROUND: Biliary tract infection with the carcinogenic human liver fluke, Clonorchis sinensis, provokes chronic inflammation, epithelial hyperplasia, periductal fibrosis, and even cholangiocarcinoma. Complications are proportional to the intensity and duration of the infection. In addition to mechanical irritation of the biliary epithelia from worms, their excretory-secretory products (ESPs) cause chemical irritation, which leads to inflammation, proliferation, and free radical generation. METHODS: A three-dimensional in vitro cholangiocyte spheroid culture model was established, followed by ESP treatment. This allowed us to examine the intrinsic pathological mechanisms of clonorchiasis via the imitation of prolonged and repetitive in vivo infection. RESULTS: Microarray and RNA-Seq analysis revealed that ESP-treated cholangiocyte H69 spheroids displayed global changes in gene expression compared to untreated spheroids. In ESP-treated H69 spheroids, 185 and 63 probes were found to be significantly upregulated and downregulated, respectively, corresponding to 209 genes (p < 0.01, fold change > 2). RNA-Seq was performed for the validation of the microarray results, and the gene expression patterns in both transcriptome platforms were well matched for 209 significant genes. Gene ontology analysis demonstrated that differentially expressed genes were mainly classified into immune system processes, the extracellular region, and the extracellular matrix. Among the upregulated genes, four genes (XAF1, TRIM22, CXCL10, and BST2) were selected for confirmation using quantitative RT-PCR, resulting in 100% similar expression patterns in microarray and RNA-Seq. CONCLUSIONS: These findings broaden our understanding of the pathological pathways of liver fluke-associated hepatobiliary disorders and suggest a novel therapeutic strategy for this infectious cancer.
Keywords	Clonorchis sinensis ; biliary tract ; carcinogenicity ; clonorchiasis ; epithelium ; extracellular matrix ; fibrosis ; free radicals ; gene expression ; gene expression regulation ; gene ontology ; humans ; hyperplasia ; immune system ; inflammation ; liver ; liver flukes ; microarray technology ; models ; sequence analysis ; therapeutics ; transcriptome ; transcriptomics
Language	English
Dates of publication	2021-12
Size	p. 213.
Publishing place	BioMed Central
Document type	Article
ZDB-ID	2409480-8
ISSN	1756-3305
ISSN	1756-3305
DOI	10.1186/s13071-021-04717-2
Database	NAL-Catalogue (AGRICOLA)

Order via subito

To top

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

Order via subito

More links

Kategorien

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

Order via subito