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Article ; Online: A Bee Trp-Arg Dense Peptide with Antiproliferation Efficacy against the Prostate Cancer Cell Line DU145.

Kim, Ye-Eun / Kim, Ki-Young

2024 Volume 46, Issue 3, Page(s) 2251–2262

Abstract: Prostate cancer accounts for 14% of male cancer-related fatalities in the UK. Given the challenges associated with hormone-based therapies in the context of androgen-independent prostate cancer, there is an imperative need for research into anticancer ... ...

Abstract	Prostate cancer accounts for 14% of male cancer-related fatalities in the UK. Given the challenges associated with hormone-based therapies in the context of androgen-independent prostate cancer, there is an imperative need for research into anticancer drugs. N0821, a peptide belonging to the Trp-Arg dense region and derived from the homologous region of various bee species, shows substantial potential for an anticancer effect. Both MTT assays and 3D spheroid assays were conducted to substantiate its antiproliferation potential and strongly indicated the antiproliferation effect of N0820 (WWWWRWWRKI) and N0821 (YWWWWRWWRKI). Notably, the mechanism underlying this effect is related to the downregulation of CCNA2 and the upregulation of CCNE1. Cell cycle arrest results from the reduction of CCNA2 in the S/G2 phase, leading to the accumulation of CCNE1. Our peptides were predicted to make an α-helix structure. This can act as an ion channel in the cell membrane. Therefore, we analyzed genes implicated in the influx of calcium ions into the mitochondria. Trp-Arg dense-region peptides are known for their antibacterial properties in targeting cell membranes, making the development of resistance less likely. Hence, further research in this area is essential and promising.
Language	English
Publishing date	2024-03-10
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2000024-8
ISSN	1467-3045 ; 1467-3037
ISSN (online)	1467-3045
ISSN	1467-3037
DOI	10.3390/cimb46030144
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Article ; Online: [Effects of a Nursing Simulation Learning Module on Clinical Reasoning Competence, Clinical Competence, Performance Confidence, and Anxiety in COVID-19 Patient-Care for Nursing Students].

Kim, Ye-Eun / Kang, Hee-Young

Journal of Korean Academy of Nursing

2023 Volume 53, Issue 1, Page(s) 87–100

Abstract: Purpose: This study aimed to develop a nursing simulation learning module for coronavirus disease 2019 (COVID-19) patient-care and examine its effects on clinical reasoning competence, clinical competence, performance confidence, and anxiety in COVID-19 ...

Abstract	Purpose: This study aimed to develop a nursing simulation learning module for coronavirus disease 2019 (COVID-19) patient-care and examine its effects on clinical reasoning competence, clinical competence, performance confidence, and anxiety in COVID-19 patient care for nursing students. Methods: A non-equivalent control group pre- and post-test design was employed. The study participants included 47 nursing students (23 in the experimental group and 24 in the control group) from G City. A simulation learning module for COVID-19 patient-care was developed based on the Jeffries simulation model. The module consisted of a briefing, simulation practice, and debriefing. The effects of the simulation module were measured using clinical reasoning competence, clinical competence, performance confidence, and anxiety in COVID-19 patient-care. Data were analyzed using χ²-test, Fisher's exact test, t-test, Wilcoxon signed-rank test, and Mann-Whitney U test. Results: The levels of clinical reasoning competence, clinical competence, and performance confidence of the experimental group were significantly higher than that of the control group, and the level of anxiety was significantly low after simulation learning. Conclusion: The nursing simulation learning module for COVID-19 patient-care is more effective than the traditional method in terms of improving students' clinical reasoning competence, clinical competence, and performance confidence, and reducing their anxiety. The module is expected to be useful for educational and clinical environments as an effective teaching and learning strategy to empower nursing competency and contribute to nursing education and clinical changes.
MeSH term(s)	Humans ; Clinical Competence ; Students, Nursing ; COVID-19 ; Anxiety ; Patient Care ; Education, Nursing, Baccalaureate/methods
Language	Korean
Publishing date	2023-03-10
Publishing country	Korea (South)
Document type	English Abstract ; Journal Article
ZDB-ID	2619665-7
ISSN	2093-758X ; 2093-758X
ISSN (online)	2093-758X
ISSN	2093-758X
DOI	10.4040/jkan.22130
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Article ; Online: The effect of supplementing the calcium phosphate cement containing poloxamer 407 on cellular activities.

Kim, Yeeun / Hamada, Kenichi / Sekine, Kazumitsu

Journal of biomedical materials research. Part B, Applied biomaterials

2023 Volume 112, Issue 1, Page(s) e35335

Abstract: Calcium phosphate cement (CPC) is generally used for bone repair and augmentation. Poloxamers are tri-block copolymers that are used as surfactants but have applications in drug and antibiotic delivery. However, their biological effects on bone ... ...

Abstract	Calcium phosphate cement (CPC) is generally used for bone repair and augmentation. Poloxamers are tri-block copolymers that are used as surfactants but have applications in drug and antibiotic delivery. However, their biological effects on bone regeneration systems remain unelucidated. Here, we aimed to understand how supplementing the prototype CPC with poloxamer would impact cellular activity and its function as a bone-grafting material. A novel CPC, modified beta-tricalcium phosphate (mβ-TCP) powder, was developed through a planetary ball-milling process using a beta-tricalcium phosphate (β-TCP). The mβ-TCP dissolves rapidly and accelerates hydroxyapatite precipitation; successfully shortening the cement setting time and enhancing the strength. Furthermore, the addition of poloxamer 407 to mβ-TCP could reduce the risk of leakage from bone defects and improve fracture toughness while maintaining mechanical properties. In this study, the poloxamer addition effects (0.05 and 0.1 g/mL) on the cellular activities of MC3T3-E1 cells cultured in vitro were investigated. The cell viability of mβ-TCP containing poloxamer 407 was similar to that of mβ-TCP. All specimens showed effective cell attachment and healthy polygonal extension of the cytoplasm firmly attached to hydroxyapatite (HA) crystals. Therefore, even with the addition of poloxamer to mβ-TCP, it does not have a negative effect to osteoblast growth. These data demonstrated that the addition of poloxamer 407 to mβ-TCP might be considered a potential therapeutic application for the repair and regeneration of bone defects.
MeSH term(s)	Poloxamer/pharmacology ; Calcium Phosphates/pharmacology ; Calcium Phosphates/chemistry ; Bone Cements/pharmacology ; Bone Cements/chemistry ; Hydroxyapatites
Chemical Substances	Poloxamer (106392-12-5) ; beta-tricalcium phosphate ; calcium phosphate (97Z1WI3NDX) ; Calcium Phosphates ; Bone Cements ; Hydroxyapatites
Language	English
Publishing date	2023-09-29
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2099992-6
ISSN	1552-4981 ; 1552-4973 ; 0021-9304
ISSN (online)	1552-4981
ISSN	1552-4973 ; 0021-9304
DOI	10.1002/jbm.b.35335
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Article ; Online: Systems biology approaches to unravel lymphocyte subsets and function.

Kim, YeEun / Greenleaf, William J / Bendall, Sean C

Current opinion in immunology

2023 Volume 82, Page(s) 102323

Abstract: Single-cell technologies have revealed the extensive heterogeneity and complexity of the immune system. Systems biology approaches in immunology have taken advantage of the high-parameter, high-throughput data and analyzed immune cell types in a 'bottom- ... ...

Abstract	Single-cell technologies have revealed the extensive heterogeneity and complexity of the immune system. Systems biology approaches in immunology have taken advantage of the high-parameter, high-throughput data and analyzed immune cell types in a 'bottom-up' data-driven method. This approach has discovered previously unrecognized cell types and functions. Especially for human immunology, in which experimental manipulations are challenging, systems approach has become a successful means to investigate physiologically relevant contexts. This review focuses on the recent findings in lymphocyte biology, from their development, differentiation into subsets, and heterogeneity in their functions, enabled by these systems approaches. Furthermore, we review examples of the application of findings from systems approach studies and discuss how now to leave the rich dataset in the curse of high dimensionality.
MeSH term(s)	Humans ; Systems Biology ; Immune System ; Lymphocyte Subsets ; Cell Differentiation ; Lymphocyte Count
Language	English
Publishing date	2023-04-05
Publishing country	England
Document type	Journal Article ; Review ; Research Support, N.I.H., Extramural
ZDB-ID	1035767-1
ISSN	1879-0372 ; 0952-7915
ISSN (online)	1879-0372
ISSN	0952-7915
DOI	10.1016/j.coi.2023.102323
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Zs.A 2773: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG)
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Article ; Online: Erigeron annuus

Jeong, Myeongguk / Kwon, Hyeokjin / Kim, Yeeun / Jin, Hyunwoo / Choi, Go-Eun / Hyun, Kyung-Yae

Nutrients

2024 Volume 16, Issue 3

Abstract: Atopic dermatitis (AD) is a persistent inflammatory skin condition resulting from an intricate interplay among genetic, immunological, and environmental factors. ...

Abstract	Atopic dermatitis (AD) is a persistent inflammatory skin condition resulting from an intricate interplay among genetic, immunological, and environmental factors.
MeSH term(s)	Humans ; Animals ; Mice ; Dermatitis, Atopic/chemically induced ; Dermatitis, Atopic/drug therapy ; Skin/metabolism ; Dinitrochlorobenzene/toxicity ; Erigeron/metabolism ; NF-E2-Related Factor 2/metabolism ; Dinitrobenzenes/adverse effects ; Dinitrobenzenes/metabolism ; Heme Oxygenase-1/metabolism ; Hydrogen Peroxide/metabolism ; Tumor Necrosis Factor-alpha/metabolism ; Mice, Inbred BALB C ; Cytokines/metabolism
Chemical Substances	Dinitrochlorobenzene ; NF-E2-Related Factor 2 ; Dinitrobenzenes ; Heme Oxygenase-1 (EC 1.14.14.18) ; Hydrogen Peroxide (BBX060AN9V) ; Tumor Necrosis Factor-alpha ; Cytokines
Language	English
Publishing date	2024-02-03
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2518386-2
ISSN	2072-6643 ; 2072-6643
ISSN (online)	2072-6643
ISSN	2072-6643
DOI	10.3390/nu16030451
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Article ; Online: Capacitance Contribution of NIH/3T3 Cells Existing on and between Electrodes of an Impedance Biosensor.

Kim, Yeeun / Kang, Dahyun / Kim, Seokgyu / Hong, Eunchae / Jang, Moongyu

Biosensors

2023 Volume 13, Issue 11

Abstract: In this study, an impedance biosensor capable of real-time monitoring of the growth and drug reactions using NIH/3T3 cells was fabricated through a semiconductor process. With the fabricated impedance biosensor, the cell growth and drug reaction states ... ...

Abstract	In this study, an impedance biosensor capable of real-time monitoring of the growth and drug reactions using NIH/3T3 cells was fabricated through a semiconductor process. With the fabricated impedance biosensor, the cell growth and drug reaction states are monitored in real-time, showing the validness of the developed biosensor. By using the developed impedance biosensor, we have investigated the capacitance contribution of NIH/3T3 cells existing on electrodes and between electrodes. To compare the capacitance value contributions of the cells on and between electrodes, wide- and narrow-gap electrode patterns are manufactured with 3.7 and 0.3 mm electrode gap spacings, respectively. From the detailed analysis, the capacitance contributions of NIH/3T3 cells existing on electrodes are estimated around less than 20 percent compared to the cells existing between electrodes. In other words, a minimized electrode area with maximized electrode spacing is the promising impedance biosensor design guide for accurate cell capacitance measurements.
MeSH term(s)	Animals ; Mice ; Electric Impedance ; Electrodes ; Biosensing Techniques ; Electric Capacitance ; 3T3 Cells
Language	English
Publishing date	2023-11-06
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2662125-3
ISSN	2079-6374 ; 2079-6374
ISSN (online)	2079-6374
ISSN	2079-6374
DOI	10.3390/bios13110970
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Article ; Online: Effective Feature Selection Methods to Detect IoT DDoS Attack in 5G Core Network.

Kim, Ye-Eun / Kim, Yea-Sul / Kim, Hwankuk

Sensors (Basel, Switzerland)

2022 Volume 22, Issue 10

Abstract: The 5G networks aim to realize a massive Internet of Things (IoT) environment with low latency. IoT devices with weak security can cause Tbps-level Distributed Denial of Service (DDoS) attacks on 5G mobile networks. Therefore, interest in automatic ... ...

Abstract	The 5G networks aim to realize a massive Internet of Things (IoT) environment with low latency. IoT devices with weak security can cause Tbps-level Distributed Denial of Service (DDoS) attacks on 5G mobile networks. Therefore, interest in automatic network intrusion detection using machine learning (ML) technology in 5G networks is increasing. ML-based DDoS attack detection in a 5G environment should provide ultra-low latency. To this end, utilizing a feature-selection process that reduces computational complexity and improves performance by identifying features important for learning in large datasets is possible. Existing ML-based DDoS detection technology mostly focuses on DDoS detection learning models on the wired Internet. In addition, studies on feature engineering related to 5G traffic are relatively insufficient. Therefore, this study performed feature selection experiments to reduce the time complexity of detecting and analyzing large-capacity DDoS attacks in real time based on ML in a 5G core network environment. The results of the experiment showed that the performance was maintained and improved when the feature selection process was used. In particular, as the size of the dataset increased, the difference in time complexity increased rapidly. The experiments show that the real-time detection of large-scale DDoS attacks in 5G core networks is possible using the feature selection process. This demonstrates the importance of the feature selection process for removing noisy features before training and detection. As this study conducted a feature study to detect network traffic passing through the 5G core with low latency using ML, it is expected to contribute to improving the performance of the 5G network DDoS attack automation detection technology using AI technology.
MeSH term(s)	Internet of Things ; Machine Learning
Language	English
Publishing date	2022-05-18
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2052857-7
ISSN	1424-8220 ; 1424-8220
ISSN (online)	1424-8220
ISSN	1424-8220
DOI	10.3390/s22103819
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Article ; Online: Cooperative Interaction between Acid and Copper Resistance in

Kim, Yeeun / Lee, Seohyeon / Park, Kyungah / Yoon, Hyunjin

Journal of microbiology and biotechnology

2022 Volume 32, Issue 5, Page(s) 602–611

Abstract: The persistence of ... ...

Abstract	The persistence of pathogenic
MeSH term(s)	Acids/metabolism ; Acids/pharmacology ; Copper/metabolism ; Copper/pharmacology ; Escherichia coli/genetics ; Escherichia coli/metabolism ; Escherichia coli Infections ; Escherichia coli Proteins/metabolism ; Gene Expression Regulation, Bacterial ; Humans ; Hydrogen-Ion Concentration ; Sigma Factor/genetics
Chemical Substances	Acids ; Escherichia coli Proteins ; Sigma Factor ; Copper (789U1901C5)
Language	English
Publishing date	2022-03-10
Publishing country	Korea (South)
Document type	Journal Article
ZDB-ID	2412195-2
ISSN	1738-8872 ; 1017-7825
ISSN (online)	1738-8872
ISSN	1017-7825
DOI	10.4014/jmb.2201.01034
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Article ; Online: Complete genome sequence of a novel porcine hemagglutinating encephalomyelitis virus strain identified in South Korea.

Kim, Yeeun / Lee, Kyung Min / Jang, Guehwan / Lee, Changhee

Archives of virology

2022 Volume 167, Issue 5, Page(s) 1381–1385

Abstract: Porcine hemagglutinating encephalomyelitis virus (PHEV) is a member of the subgenus Embecovirus of the genus Betacoronavirus, and it is ubiquitously distributed in most pig-farming countries worldwide with low clinical incidence. Here, we report the full- ...

Abstract	Porcine hemagglutinating encephalomyelitis virus (PHEV) is a member of the subgenus Embecovirus of the genus Betacoronavirus, and it is ubiquitously distributed in most pig-farming countries worldwide with low clinical incidence. Here, we report the full-length genome sequence and molecular characterization of a novel PHEV strain identified in diarrheic neonates in South Korea. The complete genome of the Korean PHEV strain GNU-2113 was sequenced and analyzed to characterize PHEV circulating in South Korea. The GNU-2113 genome was determined to be 29,982 nucleotides in length, with large unique deletions in the regions encoding nonstructural protein 3 and NS2. It was found to share 95.1-96.9% sequence identity with other global strains. Genetic and phylogenetic analysis indicated that the GNU-2113 strain is distantly related to the existing PHEV genotypes, implying that the virus appears to undergo substantial evolution under endemic pressure. This study provides important information about the genetic diversity of PHEV circulating subclinically in swine herds, which may ensure viral fitness in the enzootic environment.
MeSH term(s)	Animals ; Betacoronavirus 1/genetics ; Genome, Viral ; Genotype ; Phylogeny ; Republic of Korea ; Sequence Analysis, DNA ; Swine ; Swine Diseases
Language	English
Publishing date	2022-04-10
Publishing country	Austria
Document type	Journal Article
ZDB-ID	7491-3
ISSN	1432-8798 ; 0304-8608
ISSN (online)	1432-8798
ISSN	0304-8608
DOI	10.1007/s00705-022-05414-w
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Article ; Online: Effects of poloxamer additives on strength, injectability, and shape stability of beta-tricalcium phosphate cement modified using ball-milling.

Kim, Yeeun / Uyama, Emi / Sekine, Kazumitsu / Kawano, Fumiaki / Hamada, Kenichi

Journal of the mechanical behavior of biomedical materials

2022 Volume 130, Page(s) 105182

Abstract: A new CPC was developed in this study using a β-TCP powder mechano-chemically modified by ball-milling. The prototype CPC exhibits excellent fluidity for easy injection into bone defects; however, there is a risk of leakage from the defects immediately ... ...

Abstract	A new CPC was developed in this study using a β-TCP powder mechano-chemically modified by ball-milling. The prototype CPC exhibits excellent fluidity for easy injection into bone defects; however, there is a risk of leakage from the defects immediately after implantation due to its high fluidity. The addition of poloxamer, an inverse thermoresponsive gelling agent, into CPC optimizes the fluidity. At lower temperatures, it forms a sol and maintains good injectability, whereas at the human body temperature, it transforms to a gel, reducing the fluidity and risk of leakage. In this study, the effects of poloxamer addition of 3, 5, and 10 mass% on the injectability, shape stability, and strength of the prototype CPC were evaluated. The calculated injectability of the prototype CPC pastes containing three different poloxamer contents was higher than that of the CPC paste without poloxamer for 15 min at 37 °C. Furthermore, the shape stability immediately after injection of the three CPC pastes with poloxamer was higher than that of the CPC paste without poloxamer. After 1 week of storage at 37 °C, the compressive strength and diametral tensile strength of the CPC compacts containing 10 mass% poloxamer were similar to those of the CPC compact without poloxamer. Additionally, the CPC compacts containing 10 mass% poloxamer exhibited clear plastic deformation after fracture. These results indicate that the addition of poloxamer to the prototype CPC could reduce the risk of leakage from bone defects and improve the fracture toughness with maintaining the injectability and strength.
MeSH term(s)	Bone Cements/chemistry ; Calcium Phosphates/chemistry ; Compressive Strength ; Dental Materials ; Glass Ionomer Cements ; Humans ; Poloxamer
Chemical Substances	Bone Cements ; Calcium Phosphates ; Dental Materials ; Glass Ionomer Cements ; beta-tricalcium phosphate ; Poloxamer (106392-12-5)
Language	English
Publishing date	2022-03-16
Publishing country	Netherlands
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2378381-3
ISSN	1878-0180 ; 1751-6161
ISSN (online)	1878-0180
ISSN	1751-6161
DOI	10.1016/j.jmbbm.2022.105182
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