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Article ; Online: Current Status of Diagnosis and Treatment of Irritable Bowel Syndrome in Korea.

Kim, You Sun

2023 Volume 38, Issue 16, Page(s) e113

MeSH term(s)	Humans ; Irritable Bowel Syndrome ; Korea ; Risk Factors ; Republic of Korea
Language	English
Publishing date	2023-04-24
Publishing country	Korea (South)
Document type	Editorial ; Comment
ZDB-ID	639262-3
ISSN	1598-6357 ; 1011-8934
ISSN (online)	1598-6357
ISSN	1011-8934
DOI	10.3346/jkms.2023.38.e113
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Article ; Online: [Diagnosis and Treatment of Colonic Diverticular Disease].

Kim, You Sun

The Korean journal of gastroenterology = Taehan Sohwagi Hakhoe chi

2022 Volume 79, Issue 6, Page(s) 233–243

Abstract: Colonic diverticulosis is one of the most common conditions of the digestive system and patients generally remain asymptomatic. However, about 20% of patients develop symptomatic diverticular disease such as acute diverticulitis or diverticular ... ...

Abstract	Colonic diverticulosis is one of the most common conditions of the digestive system and patients generally remain asymptomatic. However, about 20% of patients develop symptomatic diverticular disease such as acute diverticulitis or diverticular hemorrhage, and these have become a huge burden on healthcare systems worldwide. Recent understanding of the pathophysiology of diverticulosis and diverticular disease suggests the role of multiple factors including genetic and environment. Based on this understanding, a preventive strategy to reduce the risk factors of diverticulosis and diverticular disease is highly recommended. The diagnosis of the acute diverticulitis relies on imaging modalities such as an abdominal-pelvic CT scan together with symptoms and signs. Treatment of diverticular disease should be individualized and include modification of lifestyle, use of antibiotics, and surgery. Recent guidelines recommend pursuing less aggressive treatment for patients with acute diverticulitis. This review will provide an overview of both the existing and evolving understanding regarding colonic diverticulosis and diverticular disease and can help clinicians in the management of their patients with diverticular disease.
MeSH term(s)	Diverticular Diseases/complications ; Diverticular Diseases/diagnosis ; Diverticular Diseases/therapy ; Diverticulitis/complications ; Diverticulitis/diagnosis ; Diverticulitis/therapy ; Diverticulitis, Colonic/diagnosis ; Diverticulitis, Colonic/etiology ; Diverticulitis, Colonic/therapy ; Diverticulosis, Colonic/diagnosis ; Diverticulosis, Colonic/therapy ; Diverticulum ; Humans
Language	Korean
Publishing date	2022-06-17
Publishing country	Korea (South)
Document type	Journal Article ; Review
ZDB-ID	2611091-X
ISSN	2233-6869 ; 1598-9992
ISSN (online)	2233-6869
ISSN	1598-9992
DOI	10.4166/kjg.2022.072
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Article: Does cytomegalovirus load predict the outcome of acute severe ulcerative colitis?

Kim, You Sun

Intestinal research

2021 Volume 19, Issue 4, Page(s) 357–359

Language	English
Publishing date	2021-10-26
Publishing country	Korea (South)
Document type	Editorial ; Comment
ZDB-ID	3018469-1
ISSN	2288-1956 ; 1598-9100
ISSN (online)	2288-1956
ISSN	1598-9100
DOI	10.5217/ir.2021.00120
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Article ; Online: Roles of RIPK3 in necroptosis, cell signaling, and disease.

Morgan, Michael J / Kim, You-Sun

Experimental & molecular medicine

2022 Volume 54, Issue 10, Page(s) 1695–1704

Abstract: Receptor-interacting protein kinase-3 (RIPK3, or RIP3) is an essential protein in the "programmed" and "regulated" cell death pathway called necroptosis. Necroptosis is activated by the death receptor ligands and pattern recognition receptors of the ... ...

Abstract	Receptor-interacting protein kinase-3 (RIPK3, or RIP3) is an essential protein in the "programmed" and "regulated" cell death pathway called necroptosis. Necroptosis is activated by the death receptor ligands and pattern recognition receptors of the innate immune system, and the findings of many reports have suggested that necroptosis is highly significant in health and human disease. This significance is largely because necroptosis is distinguished from other modes of cell death, especially apoptosis, in that it is highly proinflammatory given that cell membrane integrity is lost, triggering the activation of the immune system and inflammation. Here, we discuss the roles of RIPK3 in cell signaling, along with its role in necroptosis and various pathways that trigger RIPK3 activation and cell death. Lastly, we consider pathological situations in which RIPK3/necroptosis may play a role.
MeSH term(s)	Humans ; Necroptosis ; Apoptosis ; Signal Transduction ; Cell Death ; Inflammation/pathology ; Receptor-Interacting Protein Serine-Threonine Kinases
Chemical Substances	RIPK3 protein, human (EC 2.7.11.1) ; Receptor-Interacting Protein Serine-Threonine Kinases (EC 2.7.11.1)
Language	English
Publishing date	2022-10-12
Publishing country	United States
Document type	Journal Article ; Review ; Research Support, Non-U.S. Gov't
ZDB-ID	1328915-9
ISSN	2092-6413 ; 1226-3613 ; 0378-8512
ISSN (online)	2092-6413
ISSN	1226-3613 ; 0378-8512
DOI	10.1038/s12276-022-00868-z
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Article ; Online: Management of inflammatory bowel disease beyond tumor necrosis factor inhibitors: novel biologics and small-molecule drugs.

Na, Soo-Young / Kim, You Sun

The Korean journal of internal medicine

2022 Volume 37, Issue 5, Page(s) 906–919

Abstract: The incidence and prevalence of inflammatory bowel disease (IBD), comprising Crohn's disease and ulcerative colitis, have increased in Asia and developing countries. In the past two decades, anti-tumor necrosis factor (TNF) agents have revolutionized the ...

Abstract	The incidence and prevalence of inflammatory bowel disease (IBD), comprising Crohn's disease and ulcerative colitis, have increased in Asia and developing countries. In the past two decades, anti-tumor necrosis factor (TNF) agents have revolutionized the treatment of IBD, in part by decreasing the rates of complications and surgery. Although anti-TNF agents have changed the course of IBD, there are unmet needs in terms of primary and secondary non-responses and side effects such as infections and malignancies. Novel biologics and small-molecule drugs have been developed for IBD, and the medical treatment options have improved. These drugs include sphingosine-1-phosphate receptor modulators and anti-integrins to block immune cell migration, and cytokine and Janus kinase inhibitors to block immune cell communications. In this review, we discuss the approved novel biologics and small-molecule drugs, including several of those in the late stages of development, for the treatment of IBD.
MeSH term(s)	Biological Products/adverse effects ; Colitis, Ulcerative/diagnosis ; Colitis, Ulcerative/drug therapy ; Crohn Disease/diagnosis ; Crohn Disease/drug therapy ; Humans ; Inflammatory Bowel Diseases/drug therapy ; Tumor Necrosis Factor Inhibitors ; Tumor Necrosis Factor-alpha
Chemical Substances	Biological Products ; Tumor Necrosis Factor Inhibitors ; Tumor Necrosis Factor-alpha
Language	English
Publishing date	2022-08-10
Publishing country	Korea (South)
Document type	Journal Article ; Review
ZDB-ID	639023-7
ISSN	2005-6648 ; 1226-3303
ISSN (online)	2005-6648
ISSN	1226-3303
DOI	10.3904/kjim.2022.152
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Article ; Online: [How to Optimally Use Currently Available Drugs in a Therapeutic Algorithm?]

Kim, You Sun

The Korean journal of gastroenterology = Taehan Sohwagi Hakhoe chi

2018 Volume 71, Issue 2, Page(s) 74–80

Abstract: Recently, the incidence and prevalence of inflammatory bowel disease (IBD) have been increasing in worldwide, especially in Asian area. IBD is a chronic and progressive disease eventually causing bowel damage. The advance in the treatment of IBD over the ...

Abstract	Recently, the incidence and prevalence of inflammatory bowel disease (IBD) have been increasing in worldwide, especially in Asian area. IBD is a chronic and progressive disease eventually causing bowel damage. The advance in the treatment of IBD over the past several decades has been achieved with the development of biologics. Furthermore, goals for management of IBD have been evolving from symptom-based management to mucosal healing, which can reduce the surgery rate and hospitalization. To treat the patients with IBD properly, identification of risk factors of patients should be preceded. In addition, the knowledge of several drugs, which are available in current situation is essential. In this review, optimal therapeutic approach with drugs including 5-aminosalicylate, steroid, immunomodulators and anti-TNF antagonists is discussed.
MeSH term(s)	Algorithms ; Anti-Inflammatory Agents, Non-Steroidal/therapeutic use ; Colitis, Ulcerative/drug therapy ; Crohn Disease/drug therapy ; Gastrointestinal Agents/therapeutic use ; Glucocorticoids/therapeutic use ; Humans ; Immunosuppressive Agents/therapeutic use ; Inflammatory Bowel Diseases/drug therapy ; Infliximab/therapeutic use
Chemical Substances	Anti-Inflammatory Agents, Non-Steroidal ; Gastrointestinal Agents ; Glucocorticoids ; Immunosuppressive Agents ; Infliximab (B72HH48FLU)
Language	Korean
Publishing date	2018-02-19
Publishing country	Korea (South)
Document type	Journal Article ; Review
ZDB-ID	2611091-X
ISSN	2233-6869 ; 1598-9992
ISSN (online)	2233-6869
ISSN	1598-9992
DOI	10.4166/kjg.2018.71.2.74
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Article ; Online: Development of a deep learning model that predicts critical events of pediatric patients admitted to general wards.

Jeon, Yonghyuk / Kim, You Sun / Jang, Wonjin / Park, June Dong / Lee, Bongjin

Scientific reports

2024 Volume 14, Issue 1, Page(s) 4707

Abstract: Early detection of deteriorating patients is important to prevent life-threatening events and improve clinical outcomes. Efforts have been made to detect or prevent major events such as cardiopulmonary resuscitation, but previously developed tools are ... ...

Abstract	Early detection of deteriorating patients is important to prevent life-threatening events and improve clinical outcomes. Efforts have been made to detect or prevent major events such as cardiopulmonary resuscitation, but previously developed tools are often complicated and time-consuming, rendering them impractical. To overcome this problem, we designed this study to create a deep learning prediction model that predicts critical events with simplified variables. This retrospective observational study included patients under the age of 18 who were admitted to the general ward of a tertiary children's hospital between 2020 and 2022. A critical event was defined as cardiopulmonary resuscitation, unplanned transfer to the intensive care unit, or mortality. The vital signs measured during hospitalization, their measurement intervals, sex, and age were used to train a critical event prediction model. Age-specific z-scores were used to normalize the variability of the normal range by age. The entire dataset was classified into a training dataset and a test dataset at an 8:2 ratio, and model learning and testing were performed on each dataset. The predictive performance of the developed model showed excellent results, with an area under the receiver operating characteristics curve of 0.986 and an area under the precision-recall curve of 0.896. We developed a deep learning model with outstanding predictive power using simplified variables to effectively predict critical events while reducing the workload of medical staff. Nevertheless, because this was a single-center trial, no external validation was carried out, prompting further investigation.
MeSH term(s)	Child ; Female ; Humans ; Male ; Deep Learning ; Hospitalization ; Intensive Care Units ; Patients' Rooms ; Retrospective Studies ; ROC Curve ; Adolescent
Language	English
Publishing date	2024-02-27
Publishing country	England
Document type	Observational Study ; Journal Article
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-024-55528-1
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Article ; Online: Association between the COVID-19 pandemic and childhood development aged 30 to 36 months in South Korea, based on the National health screening program for infants and children database.

Lee, Kyung-Shin / Choi, Youn Young / Kim, You Sun / Kim, Yeonjae / Kim, Myoung-Hee / Lee, Nami

BMC public health

2024 Volume 24, Issue 1, Page(s) 989

Abstract: Background: The coronavirus disease 2019 (COVID-19) pandemic has had a significant impact on the neurodevelopment of children. However, the precise effects of the virus and the social consequences of the pandemic on pediatric neurodevelopment are not ... ...

Abstract	Background: The coronavirus disease 2019 (COVID-19) pandemic has had a significant impact on the neurodevelopment of children. However, the precise effects of the virus and the social consequences of the pandemic on pediatric neurodevelopment are not yet fully understood. We aimed to compare the neurodevelopment of children between before and during the COVID-19 pandemic, as well as examine the impact of socioeconomic status (SES) and regional differences on the development. Methods: The study used the Korean Developmental Screening Test to compare the difference in the risk of neurodevelopmental delay between before and during the COVID-19 pandemic. Multivariable logistic regression analysis was conducted to identify the relationship between experiencing the COVID-19 pandemic and the risk of neurodevelopmental delay. Stratified analyses were performed to determine whether the developmental delays caused by the pandemic's impact varied depending on SES or regional inequality. Results: This study found an association between the experience of COVID-19 and a higher risk of neurodevelopmental delay in communication (adjusted OR [aOR]: 1.21, 95% confidence interval [CI]: 1.19, 1.22; P-value: < 0.0001) and social interaction (aOR: 1.15, 95% CI: 1.13, 1.17; P-value: < 0.0001) domains among children of 30-36 months' ages. Notably, the observed association in the Medicaid group of children indicates a higher risk of neurodevelopmental delay compared to those in the non-Medicaid group. Conclusions: These findings highlight the need to be concerned about the neurodevelopment of children who experienced the COVID-19 pandemic. The study also calls for increased training and support for Medicaid children, parents, teachers, and healthcare practitioners. Additionally, policy programs focused on groups vulnerable to developmental delays are required.
MeSH term(s)	Infant ; Humans ; Child ; Pandemics ; Developmental Disabilities/epidemiology ; Developmental Disabilities/etiology ; COVID-19/epidemiology ; Child Development ; Parents
Language	English
Publishing date	2024-04-09
Publishing country	England
Document type	Journal Article
ZDB-ID	2041338-5
ISSN	1471-2458 ; 1471-2458
ISSN (online)	1471-2458
ISSN	1471-2458
DOI	10.1186/s12889-024-18361-9
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Article: Treatment of primary sclerosing cholangitis combined with inflammatory bowel disease.

Kim, You Sun / Hurley, Edward H / Park, Yoojeong / Ko, Sungjin

Intestinal research

2023 Volume 21, Issue 4, Page(s) 420–432

Abstract: Primary sclerosing cholangitis (PSC) is a progressive cholestatic, inflammatory, and fibrotic disease that is strongly associated with inflammatory bowel disease (IBD). PSC-IBD represents a unique disease entity and patients with this disease have an ... ...

Abstract	Primary sclerosing cholangitis (PSC) is a progressive cholestatic, inflammatory, and fibrotic disease that is strongly associated with inflammatory bowel disease (IBD). PSC-IBD represents a unique disease entity and patients with this disease have an increased risk of malignancy development, such as colorectal cancer and cholangiocarcinoma. The pathogenesis of PSC-IBD involves genetic and environmental factors such as gut dysbiosis and bile acids alteration. However, despite the advancement of disease characteristics, no effective medical therapy has proven to have a significant impact on the prognosis of PSC. The treatment options for patients with PSC-IBD do not differ from those for patients with PSC alone. Potential candidate drugs have been developed based on the pathogenesis of PSC-IBD, such as those that target modulation of bile acids, inflammation, fibrosis, and gut dysbiosis. In this review, we summarize the current medical treatments for PSC-IBD and the status of new emerging therapeutic agents.
Language	English
Publishing date	2023-09-01
Publishing country	Korea (South)
Document type	Journal Article ; Review
ZDB-ID	3018469-1
ISSN	2288-1956 ; 1598-9100
ISSN (online)	2288-1956
ISSN	1598-9100
DOI	10.5217/ir.2023.00039
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Article ; Online: Primary sclerosing cholangitis (PSC) and inflammatory bowel disease (IBD): a condition exemplifying the crosstalk of the gut-liver axis.

Kim, You Sun / Hurley, Edward H / Park, Yoojeong / Ko, Sungjin

Experimental & molecular medicine

2023 Volume 55, Issue 7, Page(s) 1380–1387

Abstract: The close relationship between primary sclerosing cholangitis (PSC) and inflammatory bowel disease (IBD) provides a good opportunity to comprehend the gut-liver axis. The gut and the liver have reciprocal interactions, including how gut inflammation ... ...

Abstract	The close relationship between primary sclerosing cholangitis (PSC) and inflammatory bowel disease (IBD) provides a good opportunity to comprehend the gut-liver axis. The gut and the liver have reciprocal interactions, including how gut inflammation influences the liver through immune cells and the microbiota and how the microbiota in the gut modifies bile acids, which are produced and secreted from the liver. PSC-IBD shows distinct clinical findings from classical IBD. In addition, a distinct genetic predisposition and unique microbiota composition suggest that PSC-IBD is an independent disease entity. Understanding the pathogenesis of PSC-IBD helps to develop novel and effective therapeutic agents. Given the high risk of malignancies associated with PSC-IBD, it is critical to identify patients at high risk and implement appropriate surveillance and monitoring strategies. In this review, we provide an overview of PSC-IBD, which exemplifies the gut-liver axis.
MeSH term(s)	Humans ; Cholangitis, Sclerosing/complications ; Cholangitis, Sclerosing/pathology ; Inflammatory Bowel Diseases/etiology ; Liver/pathology ; Inflammation/complications ; Microbiota
Language	English
Publishing date	2023-07-18
Publishing country	United States
Document type	Journal Article ; Review ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	1328915-9
ISSN	2092-6413 ; 1226-3613 ; 0378-8512
ISSN (online)	2092-6413
ISSN	1226-3613 ; 0378-8512
DOI	10.1038/s12276-023-01042-9
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