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  1. Article ; Online: No Stone Left Unturned: Pediatric Pancreatic Stones Presenting With Obstructive Jaundice.

    deVries, Jonathan M / Sidhu, Sarah / Kimsey, Kathryn M / Barnett, Grafton S / Wilsey, Michael

    JPGN reports

    2022  Volume 3, Issue 3, Page(s) e217

    Abstract: Pancreatic lithiasis, the formation of calcifications in the pancreatic duct, occurs uncommonly in pediatric patients but can occur more frequently with chronic pancreatitis (CP). Cystic fibrosis (CF) is one of the major causes of pancreatic lithiasis in ...

    Abstract Pancreatic lithiasis, the formation of calcifications in the pancreatic duct, occurs uncommonly in pediatric patients but can occur more frequently with chronic pancreatitis (CP). Cystic fibrosis (CF) is one of the major causes of pancreatic lithiasis in pediatric patients, with mutations in the CF transmembrane conductance regulator (CFTR) gene reported in up to 23% of pediatric CP patients. Mutations in the CFTR gene can lead to mild cases of CF, which may delay diagnosis and treatment. In such cases, pancreatitis can be the presenting symptom in children with CF. We report a unique case of a 10-year-old female with previously undiagnosed and untreated CF presenting with abdominal pain, vomiting, and obstructive jaundice. Her pancreatic lithiasis and biliary obstruction were successfully treated with endoscopic retrograde cholangiopancreatography (ERCP).
    Language English
    Publishing date 2022-06-21
    Publishing country United States
    Document type Case Reports
    ISSN 2691-171X
    ISSN (online) 2691-171X
    DOI 10.1097/PG9.0000000000000217
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Esophageal Heterotopic Pancreas in an Asymptomatic 2-Year-Old With VACTERL Association.

    Kimsey, Kathryn M / Barnett, Grafton S / Keup, Christopher / Nguyen, Johnny / Wilsey, Michael J / Smithers, Charles J / González, Raquel

    JPGN reports

    2023  Volume 4, Issue 4, Page(s) e350

    Abstract: A 2-year-old male with VACTERL association and asthma presented to the emergency room due to asthma exacerbation. Chest radiography revealed lingular pneumonia and thickening of the left paraspinal line of the gastroesophageal junction. Chest computed ... ...

    Abstract A 2-year-old male with VACTERL association and asthma presented to the emergency room due to asthma exacerbation. Chest radiography revealed lingular pneumonia and thickening of the left paraspinal line of the gastroesophageal junction. Chest computed tomography confirmed a heterogeneous fluid- and gas-filled structure at the left posterior lateral posterolateral aspect of the esophagus, which was suspected to be an esophageal diverticulum on an upper gastrointestinal series. The esophageal diverticulum was excised via left thoracoscopy, and pathological examination revealed pancreatic tissue. Heterotopic pancreas lacks anatomical, vascular, or ductal continuity with the native pancreas. It is usually asymptomatic, but when discovered, it usually occurs later in life. It has been described in the foregut, but is not as common in the esophagus, especially in the pediatric population. This case report highlights the rare occurrence, and importance of considering, esophageal heterotopic pancreas within an esophageal diverticulum in an asymptomatic patient with VACTERL association.
    Language English
    Publishing date 2023-08-16
    Publishing country United States
    Document type Case Reports
    ISSN 2691-171X
    ISSN (online) 2691-171X
    DOI 10.1097/PG9.0000000000000350
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Treatment of Esophageal Perforation: Endoscopic Vacuum-Assisted Closure.

    Barnett, Grafton S / Kimsey, Kathryn M / Shieh, Hester F / Smithers, C Jason / de Vries, Jonathan M / Mouch, Jack / Wilsey, Michael

    JPGN reports

    2023  Volume 4, Issue 2, Page(s) e314

    Abstract: Surgical repair of type C esophageal atresia (EA) with distal tracheoesophageal fistula (TEF) is complicated by an anastomotic leak in 10%-30% of cases with associated morbidity. A novel procedure in the pediatric population, endoscopic vacuum-assisted ... ...

    Abstract Surgical repair of type C esophageal atresia (EA) with distal tracheoesophageal fistula (TEF) is complicated by an anastomotic leak in 10%-30% of cases with associated morbidity. A novel procedure in the pediatric population, endoscopic vacuum-assisted closure (EVAC), accelerates the healing of esophageal leaks by using the effects of VAC therapy, including fluid removal and stimulation of granulation tissue formation. We report 2 additional cases of chronic esophageal leak treated with EVAC in EA patients. The first is a patient with a previously repaired type C EA/TEF and left congenital diaphragmatic hernia complicated by an infected diaphragmatic hernia patch erosion into the esophagus and colon. Additionally, we discuss a second case using EVAC for early anastomotic leak following type C EA/TEF repair in a patient who was later found to have a distal congenital esophageal stricture.
    Language English
    Publishing date 2023-04-26
    Publishing country United States
    Document type Case Reports
    ISSN 2691-171X
    ISSN (online) 2691-171X
    DOI 10.1097/PG9.0000000000000314
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: Solitary Duodenal Ulcer Causing Biliary Obstruction Requiring Rendezvous Procedure in a Pediatric Patient With Eosinophilic Gastroenteritis.

    Peck, Jacquelin / Kimsey, Kathryn M / Harris, Evan / Monforte, Hector / Wilsey, Michael

    Cureus

    2020  Volume 12, Issue 7, Page(s) e9377

    Abstract: Eosinophilic gastroenteritis (EGE) is an uncommon disease characterized by immune cell-mediated inflammation of the gastrointestinal (GI) tract resulting in vague abdominal symptoms, most commonly nausea, vomiting, diarrhea, and abdominal pain. We report ...

    Abstract Eosinophilic gastroenteritis (EGE) is an uncommon disease characterized by immune cell-mediated inflammation of the gastrointestinal (GI) tract resulting in vague abdominal symptoms, most commonly nausea, vomiting, diarrhea, and abdominal pain. We report the case of a 16-year-old male presenting with a six-week history of progressive pruritus, jaundice, fatigue, abdominal pain, acholic stools, and dark-colored urine. This patient was diagnosed via endoscopy with biliary obstruction caused by a large, solitary, duodenal ulcer secondary to EGE. This is a severe complication of EGE and to our knowledge, this is the first reported case of biliary obstruction caused by a duodenal ulcer in a pediatric patient with EGE. Additionally, we describe the first pediatric combined percutaneous-endoscopic rendezvous technique after failed therapeutic endoscopic retrograde cholangiography (ERCP) to relieve the biliary obstruction.
    Language English
    Publishing date 2020-07-24
    Publishing country United States
    Document type Case Reports
    ZDB-ID 2747273-5
    ISSN 2168-8184
    ISSN 2168-8184
    DOI 10.7759/cureus.9377
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: Effectiveness and Complication Rate of Percutaneous Endoscopic Gastrostomy Placement in Pediatric Oncology Patients.

    Kidder, Molly / Phen, Claudia / Brown, Jerry / Kimsey, Kathryn / Oshrine, Benjamin / Ghazarian, Sharon / Mateus, Jazmine / Amankwah, Ernest / Wilsey, Michael

    Pediatric gastroenterology, hepatology & nutrition

    2021  Volume 24, Issue 6, Page(s) 546–554

    Abstract: Purpose: Malnutrition is a significant issue for pediatric patients with cancer. We sought to evaluate the effectiveness and complication rate of percutaneous endoscopic gastrostomy (PEG) placement in pediatric oncology patients.: Methods: A ... ...

    Abstract Purpose: Malnutrition is a significant issue for pediatric patients with cancer. We sought to evaluate the effectiveness and complication rate of percutaneous endoscopic gastrostomy (PEG) placement in pediatric oncology patients.
    Methods: A retrospective chart review was performed on 49 pediatric oncology patients undergoing PEG placement at Johns Hopkins All Children's Hospital between 2000 and 2016. Demographic and clinical characteristics, complications, absolute neutrophil count at time of PEG placement and at time of complications, length of stay, and mortality were identified. Weight-for-age Z-scores were evaluated at time of- and six months post-PEG placement.
    Results: The overall mean weight-for-age Z-score improved by 0.73 (
    Conclusion: Consistent with previous studies, our data suggests a relationship between site complications (superficial wound infection, buried bumper syndrome) and neutropenia. Additionally, PEG placement appears to be an effective modality for improving nutritional status in malnourished pediatric oncology patients. However, larger prospective studies with appropriate controls and adjustment for potential confounders are warranted to confirm these findings.
    Language English
    Publishing date 2021-11-05
    Publishing country Korea (South)
    Document type Journal Article
    ZDB-ID 3032413-0
    ISSN 2234-8840 ; 2234-8646
    ISSN (online) 2234-8840
    ISSN 2234-8646
    DOI 10.5223/pghn.2021.24.6.546
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Advanced age has dissociable effects on hippocampal CA1 ripples and CA3 high frequency events in male rats.

    DiCola, Nicholas M / Lacy, Alexa L / Bishr, Omar J / Kimsey, Kathryn M / Whitney, Jenna L / Lovett, Sarah D / Burke, Sara N / Maurer, Andrew P

    Neurobiology of aging

    2022  Volume 117, Page(s) 44–58

    Abstract: Sharp wave/ripples/high frequency events (HFEs) are transient bursts of depolarization in hippocampal subregions CA3 and CA1 that occur during rest and pauses in behavior. Previous studies have reported that CA1 ripples in aged rats have lower frequency ... ...

    Abstract Sharp wave/ripples/high frequency events (HFEs) are transient bursts of depolarization in hippocampal subregions CA3 and CA1 that occur during rest and pauses in behavior. Previous studies have reported that CA1 ripples in aged rats have lower frequency than those detected in young animals. While CA1 ripples are thought to be driven by CA3, HFEs in CA3 have not been examined in aged animals. The current study obtained simultaneous recordings from CA1 and CA3 in young and aged rats to examine sharp wave/ripples/HFEs in relation to age. While CA1 ripple frequency was reduced with age, there were no age differences in the frequency of CA3 HFEs, although power and length were lower in old animals. While there was a proportion of CA1 ripples that co-occurred with a CA3 HFE, none of the age-related differences in CA1 ripples could be explained by alterations in CA3 HFE characteristics. These findings suggest that age differences in CA1 are not due to altered CA3 activity, but instead reflect distinct mechanisms of ripple generation with age.
    MeSH term(s) Action Potentials ; Animals ; CA1 Region, Hippocampal ; Hippocampus ; Male ; Rats
    Language English
    Publishing date 2022-05-05
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 604505-4
    ISSN 1558-1497 ; 0197-4580
    ISSN (online) 1558-1497
    ISSN 0197-4580
    DOI 10.1016/j.neurobiolaging.2022.04.014
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Pediatric Cannabinoid Hyperemesis: A Single Institution 10-Year Case Series.

    Lonsdale, Hannah / Kimsey, Kathryn M / Brown, Jerry M / Dey, Aditi / Peck, Jacquelin / Son, Sorany / Wilsey, Michael

    The Journal of adolescent health : official publication of the Society for Adolescent Medicine

    2020  Volume 68, Issue 2, Page(s) 255–261

    Abstract: Purpose: Cannabis hyperemesis (CH) is an under-recognized condition in patients with chronic or cyclic vomiting and who regularly use cannabis. Once thought to be rare, it is now increasingly recognized in both adults and children. We report a case ... ...

    Abstract Purpose: Cannabis hyperemesis (CH) is an under-recognized condition in patients with chronic or cyclic vomiting and who regularly use cannabis. Once thought to be rare, it is now increasingly recognized in both adults and children. We report a case series of adolescent patients with CH who presented at a single institution over 10 years.
    Methods: Patients were included if they had a diagnosis code of cannabis-related or cyclic vomiting, experienced the onset of regular vomiting after starting to regularly use cannabis, and if no other diagnosis was found to better explain the presentation. Thirty-four patients aged 13-20 years (median 17 years) met the inclusion criteria.
    Results: The presenting clinical features were broadly similar to adult CH: cyclic nausea and emesis after at least 3 months of regular cannabis use, abdominal pain, change in bowel habit, and symptomatic relief from hot showers or baths. No antiemetic was found to be of particular benefit. Follow-up was recorded in under half of the patients; documentation of drug history was also frequently incomplete. Clinicians should consider CH when assessing any adolescent with cyclic or chronic vomiting.
    Conclusions: A detailed drug history, preferably taken in the absence of parents or other involved adults and corroborated by urine drug screening, is helpful in substantiating the diagnosis. Further prospective studies are needed to confirm the incidence, prevalence, presenting features, and the effectiveness of treatments, including drug counseling and cessation. Based on our findings, we propose pragmatic criteria to aid in the diagnosis of pediatric CH.
    MeSH term(s) Adolescent ; Adult ; Cannabinoids/adverse effects ; Child ; Humans ; Marijuana Abuse/complications ; Prospective Studies ; Syndrome ; Vomiting/chemically induced
    Chemical Substances Cannabinoids
    Language English
    Publishing date 2020-10-27
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1063374-1
    ISSN 1879-1972 ; 1054-139X
    ISSN (online) 1879-1972
    ISSN 1054-139X
    DOI 10.1016/j.jadohealth.2020.09.024
    Database MEDical Literature Analysis and Retrieval System OnLINE

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