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  1. Book ; Online: Epstein-Barr Virus-associated T/NK-cell Lymphoproliferative Diseases

    Fujiwara, Shigeyoshi / Kimura, Hiroshi

    2019  

    Keywords Medicine ; Paediatric medicine ; Epstein-Barr virus (EBV) ; EBV-associated T/NK-cell lymphoproliferative diseases ; chronic active EBV infection (CAEBV) ; hydroa vacciniforme-like lymphoproliferative disorder ; severe mosquito bite allergy ; extranodal NK/T-cell lymphoma-nasal type (ENKTL) ; aggressive NK-cell leukemia (ANKL) ; systemic EBV-positive T-cell lymphoma of childhood ; EBV-associatedhemophagocytic lymphohistiocytosis (EBV-HLH)
    Size 1 electronic resource (102 pages)
    Publisher Frontiers Media SA
    Document type Book ; Online
    Note English ; Open Access
    HBZ-ID HT021230807
    ISBN 9782889630325 ; 2889630323
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  2. Article ; Online: The 100

    Kimura, Hiroshi

    Nagoya journal of medical science

    2023  Volume 85, Issue 1, Page(s) 5–6

    Language English
    Publishing date 2023-02-24
    Publishing country Japan
    Document type Editorial
    ZDB-ID 193148-9
    ISSN 2186-3326 ; 0027-7622
    ISSN (online) 2186-3326
    ISSN 0027-7622
    DOI 10.18999/nagjms.85.1.5
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Ua VI Zs.181: Show issues Location:
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  3. Book: Human Herpesviruses

    Kawaguchi, Yasushi / Mori, Yasuko / Kimura, Hiroshi

    (Advances in experimental medicine and biology ; 1045)

    2018  

    Series title Advances in experimental medicine and biology ; 1045
    Collection
    Keywords Herpes simplex virus ; Varicella zoster virus ; Human cytomegalovirus ; Human herpesvirus 6A ; Human herpesvirus 6B ; Kaposi’s sarcoma-associated virus ; Epstein–Barr virus ; Alphaherpesvirus ; Betaherpesvirus ; Gammaherpesvirus
    Subject code 570
    Language English
    Size viii, 501 Seiten, Illustrationen, 23.5 cm x 15.5 cm
    Publisher Springer
    Publishing place Singapore
    Publishing country Singapore
    Document type Book
    HBZ-ID HT019556196
    ISBN 978-981-10-7229-1 ; 981-10-7229-9 ; 9789811072307 ; 9811072302
    Database Catalogue ZB MED Medicine, Health

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    Shelf markLoan statusLocation
    Zs A 3192 -1045- not available for loan Zeitschriften-Lesesaal

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  4. Book ; Online ; E-Book: Human herpesviruses

    Kawaguchi, Yasushi / Mori, Yasuko / Kimura, Hiroshi

    (Advances in experimental medicine and biology ; 1045)

    2018  

    Series title Advances in experimental medicine and biology ; 1045
    Collection
    Language English
    Size 1 Online-Ressource (viii, 501 Seiten), Illustrationen, 23.5 cm x 15.5 cm
    Publisher Springer
    Publishing place Singapore
    Publishing country Singapore
    Document type Book ; Online ; E-Book
    Remark Zugriff für angemeldete ZB MED-Nutzerinnen und -Nutzer
    HBZ-ID HT019724844
    ISBN 978-981-10-7230-7 ; 9789811072291 ; 981-10-7230-2 ; 9811072299
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  5. Article ; Online: Decoding the cell nucleus.

    Kimura, Hiroshi / Lakadamyali, Melike

    Current opinion in cell biology

    2024  Volume 86, Page(s) 102319

    MeSH term(s) Cell Nucleus
    Language English
    Publishing date 2024-01-13
    Publishing country England
    Document type Editorial
    ZDB-ID 1026381-0
    ISSN 1879-0410 ; 0955-0674
    ISSN (online) 1879-0410
    ISSN 0955-0674
    DOI 10.1016/j.ceb.2023.102319
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2963: Show issues Location:
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  6. Article ; Online: Live-cell tracking of γ-H2AX kinetics reveals the distinct modes of ATM and DNA-PK in the immediate response to DNA damage.

    Trakarnphornsombat, Watanya / Kimura, Hiroshi

    Journal of cell science

    2023  Volume 136, Issue 8

    Abstract: DNA double-strand breaks (DSBs) are a serious form of DNA damage that can cause genetic mutation. On the induction of DSBs, histone H2AX becomes phosphorylated by kinases, including ataxia telangiectasia-mutated (ATM), ataxia telangiectasia and Rad3- ... ...

    Abstract DNA double-strand breaks (DSBs) are a serious form of DNA damage that can cause genetic mutation. On the induction of DSBs, histone H2AX becomes phosphorylated by kinases, including ataxia telangiectasia-mutated (ATM), ataxia telangiectasia and Rad3-related (ATR) and DNA-dependent protein kinase (DNA-PK). Phosphorylated H2AX (γ-H2AX) can be a platform to recruit DNA repair machinery. Here, we analyzed the immediate early kinetics of γ-H2AX upon laser-induced DNA damage in ATM-proficient and -deficient living cells by using fluorescently labeled antigen-binding fragments specific for γ-H2AX. The accumulation kinetics of γ-H2AX were similar in both ATM-proficient and -deficient cells. However, γ-H2AX accumulation was delayed when the cells were treated with a DNA-PK inhibitor, suggesting that DNA-PK rapidly phosphorylates H2AX at DSB sites. Ku80 (also known as XRCC5), a DNA-PK subunit, diffuses freely in the nucleus without DNA damage, whereas ATM repeatedly binds to and dissociates from chromatin. The accumulation of ATM at damage sites was regulated by the histone H4K16 acetyltransferase MOF (also known as KAT8 in mammals), but its accumulation was not necessarily reflected in the γ-H2AX level. These results suggest distinct actions of ATM and DNA-PK in immediate γ-H2AX accumulation.
    MeSH term(s) Animals ; Humans ; Histones/metabolism ; DNA-Activated Protein Kinase ; Protein Serine-Threonine Kinases/metabolism ; Cell Cycle Proteins/metabolism ; Ataxia Telangiectasia ; Tumor Suppressor Proteins/genetics ; Tumor Suppressor Proteins/metabolism ; Ataxia Telangiectasia Mutated Proteins/genetics ; Ataxia Telangiectasia Mutated Proteins/metabolism ; Cell Tracking ; Phosphorylation ; DNA-Binding Proteins/genetics ; DNA-Binding Proteins/metabolism ; DNA Damage ; DNA/metabolism ; Mammals/metabolism
    Chemical Substances Histones ; DNA-Activated Protein Kinase (EC 2.7.11.1) ; Protein Serine-Threonine Kinases (EC 2.7.11.1) ; Cell Cycle Proteins ; Tumor Suppressor Proteins ; Ataxia Telangiectasia Mutated Proteins (EC 2.7.11.1) ; DNA-Binding Proteins ; DNA (9007-49-2) ; ATM protein, human (EC 2.7.11.1)
    Language English
    Publishing date 2023-04-27
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2993-2
    ISSN 1477-9137 ; 0021-9533
    ISSN (online) 1477-9137
    ISSN 0021-9533
    DOI 10.1242/jcs.260698
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1200: Show issues Location:
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    Zs.MG 14: Show issues

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  7. Article ; Online: An expanded view of transcription.

    Stasevich, Timothy J / Kimura, Hiroshi

    Science (New York, N.Y.)

    2023  Volume 381, Issue 6653, Page(s) 26–27

    Abstract: A new method expands chromatin to provide detailed images of transcription sites. ...

    Abstract A new method expands chromatin to provide detailed images of transcription sites.
    MeSH term(s) Chromatin ; Transcription, Genetic ; Animals ; Microscopy, Fluorescence/methods ; Molecular Imaging/methods
    Chemical Substances Chromatin
    Language English
    Publishing date 2023-07-06
    Publishing country United States
    Document type Journal Article
    ZDB-ID 128410-1
    ISSN 1095-9203 ; 0036-8075
    ISSN (online) 1095-9203
    ISSN 0036-8075
    DOI 10.1126/science.adi8187
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 27: Show issues Location:
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    Zs.MG 77: Show issues

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  8. Article ; Online: Independent mesenchymal progenitor pools respectively produce and maintain osteogenic and chondrogenic cells in zebrafish.

    Komiya, Hiroaki / Sato, Yuko / Kimura, Hiroshi / Kawakami, Atsushi

    Development, growth & differentiation

    2024  Volume 66, Issue 2, Page(s) 161–171

    Abstract: Skeletal tissues including cartilage and bones are characteristic features of vertebrates that are crucial for supporting body morphology and locomotion. Studies mainly in mice have shown that osteoblasts and chondroblasts are supplied from several ... ...

    Abstract Skeletal tissues including cartilage and bones are characteristic features of vertebrates that are crucial for supporting body morphology and locomotion. Studies mainly in mice have shown that osteoblasts and chondroblasts are supplied from several progenitors like the sclerotome cells in the embryonic stage, osteo-chondroprogenitors in growing long bones, and skeletal stem cells of bone marrow in the postnatal period. However, the exact origins of progenitor cells, their lineage relationships, and their potential to differentiate into osteoblasts and chondroblasts from embryos to adult tissues are not well understood. In this study, we conducted clonal cell tracking in zebrafish and showed that sox9a
    MeSH term(s) Animals ; Mice ; Zebrafish ; Cell Differentiation ; Osteogenesis ; Bone and Bones ; Osteoblasts
    Language English
    Publishing date 2024-01-09
    Publishing country Japan
    Document type Journal Article
    ZDB-ID 280433-5
    ISSN 1440-169X ; 0012-1592
    ISSN (online) 1440-169X
    ISSN 0012-1592
    DOI 10.1111/dgd.12908
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 194: Show issues Location:
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  9. Article ; Online: Mode of SUV420H2 heterochromatin localization through multiple HP1 binding motifs in the heterochromatic targeting module.

    Nakao, Masaru / Sato, Yuko / Aizawa, Arisa / Kimura, Hiroshi

    Genes to cells : devoted to molecular & cellular mechanisms

    2024  Volume 29, Issue 5, Page(s) 361–379

    Abstract: Constitutive heterochromatin is transcriptionally repressed and densely packed chromatin, typically harboring histone H3 Lys9 trimethylation (H3K9me3) and heterochromatin protein 1 (HP1). SUV420H2, a histone H4 Lys20 methyltransferase, is recruited to ... ...

    Abstract Constitutive heterochromatin is transcriptionally repressed and densely packed chromatin, typically harboring histone H3 Lys9 trimethylation (H3K9me3) and heterochromatin protein 1 (HP1). SUV420H2, a histone H4 Lys20 methyltransferase, is recruited to heterochromatin by binding to HP1 through its Heterochromatic Targeting Module (HTM). Here, we have identified three HP1 binding motifs within the HTM. Both the full-length HTM and its N-terminal region (HTM-N), which contains the first and second motifs, stabilized HP1 on heterochromatin. The intervening region between the first and second HP1 binding motifs in HTM-N was also crucial for HP1 binding. In contrast, the C-terminal region of HTM (HTM-C), containing the third motif, destabilized HP1 on chromatin. An HTM V374D mutant, featuring a Val374 to Asp substitution in the second HP1 binding motif, localizes to heterochromatin without affecting HP1 stability. These data suggest that the second HP1 binding motif in the SUV420H2 HTM is critical for locking HP1 on H3K9me3-enriched heterochromatin. HTM V374D, tagged with a fluorescent protein, can serve as a live-cell probe to visualize HP1-bound heterochromatin.
    MeSH term(s) Heterochromatin/metabolism ; Chromosomal Proteins, Non-Histone/metabolism ; Chromobox Protein Homolog 5/metabolism ; Humans ; Histone-Lysine N-Methyltransferase/metabolism ; Histone-Lysine N-Methyltransferase/genetics ; Protein Binding ; Histones/metabolism ; Amino Acid Motifs ; HeLa Cells ; Binding Sites
    Chemical Substances Heterochromatin ; Chromosomal Proteins, Non-Histone ; Chromobox Protein Homolog 5 (107283-02-3) ; Histone-Lysine N-Methyltransferase (EC 2.1.1.43) ; Histones ; KMT5C protein, human (EC 2.1.1.43)
    Language English
    Publishing date 2024-02-25
    Publishing country England
    Document type Journal Article
    ZDB-ID 1330000-3
    ISSN 1365-2443 ; 1356-9597
    ISSN (online) 1365-2443
    ISSN 1356-9597
    DOI 10.1111/gtc.13109
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 4539: Show issues Location:
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  10. Article ; Online: JAK inhibitors for refractory lymphoma.

    Kimura, Hiroshi

    Oncotarget

    2018  Volume 9, Issue 68, Page(s) 32883–32884

    Language English
    Publishing date 2018-08-31
    Publishing country United States
    Document type News ; Comment
    ZDB-ID 2560162-3
    ISSN 1949-2553 ; 1949-2553
    ISSN (online) 1949-2553
    ISSN 1949-2553
    DOI 10.18632/oncotarget.26054
    Database MEDical Literature Analysis and Retrieval System OnLINE

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