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  1. Article: Impacts of Groundwater Pumping on Subterranean Microbial Communities in a Deep Aquifer Associated with an Accretionary Prism.

    Iso, Shinsei / Sato, Yu / Kimura, Hiroyuki

    Microorganisms

    2024  Volume 12, Issue 4

    Abstract: Accretionary prisms are composed mainly of ancient marine sediment scraped from the subducting oceanic plate at convergent plate boundaries. Anoxic groundwater is stored in deep aquifers associated with accretionary prisms and can be collected via deep ... ...

    Abstract Accretionary prisms are composed mainly of ancient marine sediment scraped from the subducting oceanic plate at convergent plate boundaries. Anoxic groundwater is stored in deep aquifers associated with accretionary prisms and can be collected via deep wells. We investigated how such groundwater pumping affects the microbial community in a deep aquifer. Groundwater samples were collected from a deep well drilled down to 1500 m every six months (five times in total) after completion of deep well construction and the start of groundwater pumping. Next-generation sequencing and clone-library analyses of 16S rRNA genes were used to describe the subterranean microbial communities in the samples. The archaea: the prokaryote ratio in groundwater increased significantly from 1 to 7% (0 and 7 months after initiating groundwater pumping) to 59 to 72% (13, 19, and 26 months after initiating groundwater pumping), and dominant prokaryotes changed from fermentative bacteria to sulfate-reducing archaea. The optimal growth temperature of the sulfate-reducing archaea, estimated based on the guanine-plus-cytosine contents of their 16S rRNA genes, was 48-52 °C, which agreed well with the groundwater temperature at the deep-well outflow. Our results indicated that, in deep aquifers, groundwater pumping enhances groundwater flow, and the supply of sulfate-containing seawater activates the metabolism of thermophilic sulfate-reducing archaea.
    Language English
    Publishing date 2024-03-28
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2720891-6
    ISSN 2076-2607
    ISSN 2076-2607
    DOI 10.3390/microorganisms12040679
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  2. Article ; Online: Pharmacokinetics of soy-derived lysophosphatidylcholine compared with that of glycerophosphocholine: a randomized controlled trial.

    Tanaka-Kanegae, Ryohei / Kimura, Hiroyuki / Hamada, Koichiro

    Bioscience, biotechnology, and biochemistry

    2024  

    Abstract: Lysophosphatidylcholine (LPC) is present in various foods and contains a choline moiety such as in glycerophosphocholine (GPC). However, the potential of LPC as a choline source remains unclear. This study investigated the single-dose pharmacokinetics of ...

    Abstract Lysophosphatidylcholine (LPC) is present in various foods and contains a choline moiety such as in glycerophosphocholine (GPC). However, the potential of LPC as a choline source remains unclear. This study investigated the single-dose pharmacokinetics of 480 mg soy-derived LPC in 12 healthy men compared with that of either soy oil with the same lipid amount (placebo) or GPC with the same choline amount. Both LPC and GPC supplementation increased plasma choline, serum phospholipid, and serum triglyceride concentrations, but neither of them significantly elevated plasma trimethylamine N-oxide concentration. In addition, although the intake of LPC slightly increased plasma LPC16:0, LPC18:2, and total LPC concentrations, their concentrations remained within physiological ranges. No adverse events were attributed to the LPC supplementation. To the best of our knowledge, this study is the first to compare LPC and GPC pharmacokinetics in humans and show that LPC can be a source of choline.
    Language English
    Publishing date 2024-03-15
    Publishing country England
    Document type Journal Article
    ZDB-ID 1106450-x
    ISSN 1347-6947 ; 0916-8451
    ISSN (online) 1347-6947
    ISSN 0916-8451
    DOI 10.1093/bbb/zbae031
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4647: Show issues Location:
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    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  3. Article ; Online: Oral Administration of Egg- and Soy-Derived Lysophosphatidylcholine Mitigated Acetylcholine Depletion in the Brain of Scopolamine-Treated Rats.

    Tanaka-Kanegae, Ryohei / Kimura, Hiroyuki / Hamada, Koichiro

    Nutrients

    2023  Volume 15, Issue 16

    Abstract: Enzyme-modified lecithin that contains lysophosphatidylcholine (LPC) is generally recognized as safe. However, its potential as a functional ingredient has been less investigated than other choline (Ch)-containing compounds, such as glycerophosphocholine ...

    Abstract Enzyme-modified lecithin that contains lysophosphatidylcholine (LPC) is generally recognized as safe. However, its potential as a functional ingredient has been less investigated than other choline (Ch)-containing compounds, such as glycerophosphocholine (GPC). Reports on the possibility of LPC functioning as a cholinergic precursor in vivo and on its kinetics are limited to docosahexaenoic acid-bound LPC. Herein, three experiments were performed to investigate these processes in scopolamine (SCO)-treated rats. First, an egg-derived LPC reagent was orally administered to rats, and brain acetylcholine (ACh), Ch, plasma Ch, and LPC were measured. Second, soy- and rapeseed-derived enzyme-modified lecithins and GPC were administered for comparison. Third, soy-derived enzyme-modified lecithins with different fat contents were administered for comparison. The LPC reagent mitigated SCO-induced ACh depletion at 500 mg/kg body weight and increased plasma Ch, but not LPC, concentrations. Additionally, soy-derived LPC-containing food additive counteracted brain ACh depletion similarly to GPC. Interestingly, plasma Ch and linoleoyl-LPC levels were higher when soy-derived LPC with a higher fat content was administered, whereas the plasma levels of palmitoyl-LPC decreased and those of total LPC remained constant. In conclusion, egg- and soy-derived LPC species function as cholinergic precursors in vivo, and future studies should explore this potential.
    MeSH term(s) Animals ; Rats ; Acetylcholine ; Lecithins ; Lysophosphatidylcholines ; Brain ; Choline ; Administration, Oral ; Scopolamine ; Cholinergic Agents
    Chemical Substances Acetylcholine (N9YNS0M02X) ; Lecithins ; Lysophosphatidylcholines ; Choline (N91BDP6H0X) ; Scopolamine (DL48G20X8X) ; Cholinergic Agents
    Language English
    Publishing date 2023-08-17
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2518386-2
    ISSN 2072-6643 ; 2072-6643
    ISSN (online) 2072-6643
    ISSN 2072-6643
    DOI 10.3390/nu15163618
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  4. Article ; Online: Genetic background of thrombocytosis in mice mimicking hereditary thrombocytosis in humans.

    Kimura, Hiroyuki / Onozawa, Masahiro / Teshima, Takanori

    Platelets

    2023  Volume 34, Issue 1, Page(s) 2276697

    MeSH term(s) Humans ; Mice ; Animals ; Thrombocytosis/diagnosis ; Thrombocytosis/genetics ; Genetic Background
    Language English
    Publishing date 2023-11-09
    Publishing country England
    Document type Journal Article
    ZDB-ID 1034283-7
    ISSN 1369-1635 ; 0953-7104
    ISSN (online) 1369-1635
    ISSN 0953-7104
    DOI 10.1080/09537104.2023.2276697
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2888: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  5. Article ; Online: Incorporation of backbone modifications in mRNA-displayable peptides.

    Kimura, Hiroyuki / Suga, Hiroaki

    Methods in enzymology

    2021  Volume 656, Page(s) 521–544

    Abstract: Here we comprehensively summarize the most recent efforts in our research team, aiming at installing N-methyl and azole backbones into peptides expressed in translation. The genetic code reprogramming using the Flexible In-vitro Translation system (FIT ... ...

    Abstract Here we comprehensively summarize the most recent efforts in our research team, aiming at installing N-methyl and azole backbones into peptides expressed in translation. The genetic code reprogramming using the Flexible In-vitro Translation system (FIT system) has proven to be the most reliable and versatile approach for ribosomally installing various exotic amino acids. However, it had been yet difficult in translating diverse kinds of multiple and consecutive sequences of N-methyl amino acids (
    MeSH term(s) Genetic Code ; Peptides/genetics ; RNA, Messenger/genetics ; RNA, Transfer ; Ribosomes/genetics
    Chemical Substances Peptides ; RNA, Messenger ; RNA, Transfer (9014-25-9)
    Language English
    Publishing date 2021-06-24
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ISSN 1557-7988
    ISSN (online) 1557-7988
    DOI 10.1016/bs.mie.2021.05.015
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  6. Article ; Online: One-pot two-step radioiodination based on copper-mediated iododeboronation and azide-alkyne cycloaddition reaction.

    Kondo, Yuto / Kimura, Hiroyuki / Chisaka, Ryota / Hattori, Yasunao / Kawashima, Hidekazu / Yasui, Hiroyuki

    Chemical communications (Cambridge, England)

    2024  Volume 60, Issue 6, Page(s) 714–717

    Abstract: This methodology demonstrates the ability to sequentially regulate copper-mediated radioiododeboronation and an azide-alkyne cycloaddition reaction, which facilitates the continuous incorporation of reagents into the reaction system and mediates the ... ...

    Abstract This methodology demonstrates the ability to sequentially regulate copper-mediated radioiododeboronation and an azide-alkyne cycloaddition reaction, which facilitates the continuous incorporation of reagents into the reaction system and mediates the integration of the purification steps into the final process. Additionally, this reaction is suited to be conducted under mild conditions and yields target compounds through potent radiochemical conversions.
    Language English
    Publishing date 2024-01-16
    Publishing country England
    Document type Journal Article
    ZDB-ID 1472881-3
    ISSN 1364-548X ; 1359-7345 ; 0009-241X
    ISSN (online) 1364-548X
    ISSN 1359-7345 ; 0009-241X
    DOI 10.1039/d3cc04787c
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  7. Article ; Online: Relative impact of THPO mutation causing hereditary thrombocythemia.

    Kimura, Hiroyuki / Onozawa, Masahiro / Matsukawa, Toshihiro / Goto, Hideki / Kondo, Takeshi / Teshima, Takanori

    Experimental hematology

    2024  , Page(s) 104208

    Abstract: Germline mutations of THPO were reported as causes of hereditary thrombocythemia. Six previously reported distinct sites of the mutation were clustered at the 5`-untranslated region or the exon 3 splicing donor site of the THPO gene. Each mutation was ... ...

    Abstract Germline mutations of THPO were reported as causes of hereditary thrombocythemia. Six previously reported distinct sites of the mutation were clustered at the 5`-untranslated region or the exon 3 splicing donor site of the THPO gene. Each mutation was identified in an independent pedigree, and the differences between the mutations were not compared. We cloned six distinct THPO mutations (THPO c.-47delG, THPO c.-31G>T, THPO c.13G>A, THPO c.13+1G>A, THPO c.13+2T>C, and THPO c.13+5G>A) and compared the molecular mechanisms that underlie the increased production of THPO protein. At the transcript level, all of the mutations except THPO c.-47delG showed an exon 3 skipping transcript, including two mutations (THPO c.-31G>T and THPO c.13+5G>A) that were distant from the splicing donor site. THPO c.-47delG showed the same full-length transcript as that of the wild-type transcript. At the protein level, all mutations resulted in a higher level of production of thrombopoietin (THPO) protein compared with wild-type THPO. There are only two distinct patterns of mechanisms for increased production of THPO: exon 3 skipping that deleted upstream suppressive open reading frame (ORF)7 and one base deletion that shifted ORF7 to connect to the initial codon of THPO in-frame. The common mechanisms of hereditary thrombocytosis due to THPO mutations are unleashed THPO translations, which are usually suppressed by upstream out-of-frame ORF7.
    Language English
    Publishing date 2024-03-26
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 185107-x
    ISSN 1873-2399 ; 0531-5573 ; 0301-472X
    ISSN (online) 1873-2399
    ISSN 0531-5573 ; 0301-472X
    DOI 10.1016/j.exphem.2024.104208
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 922: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  8. Article: Novel synthesis of an [18F]aryl boronic acid ester as a reagent for 18F-labeling via Suzuki coupling

    Yagi, Yusuke / Kimura, Hiroyuki / Kondo, Yuto / Higuchi, Takahiro

    Tetrahedron letters. 2022 July 05,

    2022  

    Abstract: Indirect ¹⁸F labeling methods using ¹⁸F-containing compounds such as N-succinimidyl-4-[¹⁸F]fluorobenzoate and 4-[¹⁸F]fluoroiodobenzene as labeling reagents have been reported because direct ¹⁸F labeling has difficulty in labeling aromatic compounds. In ... ...

    Abstract Indirect ¹⁸F labeling methods using ¹⁸F-containing compounds such as N-succinimidyl-4-[¹⁸F]fluorobenzoate and 4-[¹⁸F]fluoroiodobenzene as labeling reagents have been reported because direct ¹⁸F labeling has difficulty in labeling aromatic compounds. In this study, we synthesized the ¹⁸F-labeling reagent 4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl) [¹⁸F]fluorobenzene ([¹⁸F]TDBFB) using a resonant-type microwave reactor in the presence of (2,2,6,6-tetramethylpiperidine 1-oxyl and a copper catalyst. Compared with a previous report on [¹⁸F]fluorophenylboronic acid, [¹⁸F]TDBFB was synthesized simply. Moreover, we applied [¹⁸F]TDBFB for the Suzuki coupling with triflate and bromide precursors. The Suzuki coupling of [¹⁸F]TDBFB and precursors using resonant-type microwave reactor yielded 4-[¹⁸F]fluorobiphenyl and the [¹⁸F]pitavastatin derivative as the coupling products. These results show the potential of [¹⁸F]TDBFB obtained using rapid synthesis as an indirect ¹⁸F-labeling reagent.
    Keywords Suzuki reaction ; acids ; aromatic compounds ; boronic acids ; bromides ; catalysts ; copper ; couplings ; esters ; microwave radiation ; microwave treatment ; yields
    Language English
    Dates of publication 2022-0705
    Publishing place Elsevier Ltd
    Document type Article
    Note Pre-press version
    ZDB-ID 204287-3
    ISSN 1873-3581 ; 0040-4039
    ISSN (online) 1873-3581
    ISSN 0040-4039
    DOI 10.1016/j.tetlet.2022.154010
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2837: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (2.OG)
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  9. Article ; Online: Identification of significant residues for intermediate accumulation in phycocyanobilin synthesis.

    Miyake, Keita / Kimura, Hiroyuki / Narikawa, Rei

    Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology

    2022  Volume 21, Issue 4, Page(s) 437–446

    Abstract: Phycocyanobilin, the primary pigment of both light perception and light-harvesting in cyanobacteria, is synthesized from biliverdin IXα (BV) through intermediate ... ...

    Abstract Phycocyanobilin, the primary pigment of both light perception and light-harvesting in cyanobacteria, is synthesized from biliverdin IXα (BV) through intermediate 18
    MeSH term(s) Chlorophyll ; Chlorophyll A ; Isoleucine ; Oxidoreductases ; Phycobilins/chemistry ; Phycocyanin
    Chemical Substances Phycobilins ; Isoleucine (04Y7590D77) ; Phycocyanin (11016-15-2) ; Chlorophyll (1406-65-1) ; phycocyanobilin (36NUT04V2K) ; Oxidoreductases (EC 1.-) ; Chlorophyll A (YF5Q9EJC8Y)
    Language English
    Publishing date 2022-04-08
    Publishing country England
    Document type Journal Article
    ZDB-ID 2072584-X
    ISSN 1474-9092 ; 1474-905X
    ISSN (online) 1474-9092
    ISSN 1474-905X
    DOI 10.1007/s43630-022-00198-z
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  10. Article: Cation Dimerization in a 3d¹ Honeycomb Lattice System

    Yamamoto, Hajime / Kamiyama, Sachiko / Yamada, Ikuya / Kimura, Hiroyuki

    Journal of the American Chemical Society. 2021 Dec. 17, v. 144, no. 3

    2021  

    Abstract: In one-dimensional systems with partially filled valence bands, simultaneous changes occur in the electronic states and crystal structures. This is known as the Peierls transition. The Peierls transition (cation dimerization) in VO₂, which has a quasi- ... ...

    Abstract In one-dimensional systems with partially filled valence bands, simultaneous changes occur in the electronic states and crystal structures. This is known as the Peierls transition. The Peierls transition (cation dimerization) in VO₂, which has a quasi-one-dimensional structure, is well-known, and its mechanism has been extensively discussed. Honeycomb lattices exhibit the Peierls instability owing to their low dimensionality. However, cation dimerization is rare in the 3d¹ honeycomb lattice system. Here, we perform an in-depth examination of the V–V dimerization (formation of V–V direct bond) in ilmenite-type MgVO₃, which is a 3d¹ honeycomb lattice system. A ladderlike pattern was observed in the V–V dimers through synchrotron X-ray experiments at temperatures below 500 K. This dimerization was accompanied by a magnetic-to-nonmagnetic transition. Moreover, a valence bond liquid phase may exist at 500–600 K. Our results reveal the behavior of the valence electrons in the 3d¹ honeycomb lattice system.
    Keywords X-radiation ; cations ; dimerization ; liquids
    Language English
    Dates of publication 2021-1217
    Size p. 1082-1086.
    Publishing place American Chemical Society
    Document type Article
    ZDB-ID 3155-0
    ISSN 1520-5126 ; 0002-7863
    ISSN (online) 1520-5126
    ISSN 0002-7863
    DOI 10.1021/jacs.1c10977
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    In stock of ZB MED Bonn / Germany

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