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  1. Book ; Online ; E-Book: My Thoughts on Biological Evolution

    Kimura, Motoo

    (Evolutionary Studies,)

    2020  

    Abstract: This book, written by Motoo Kimura (1924–94), is a classic in evolutionary biology. In 1968, Kimura proposed the “neutral theory of molecular evolution”, which became the theoretical basis of modern evolutionary studies. After publishing his work in 1983 ...

    Author's details by Motoo Kimura
    Series title Evolutionary Studies,
    Abstract This book, written by Motoo Kimura (1924–94), is a classic in evolutionary biology. In 1968, Kimura proposed the “neutral theory of molecular evolution”, which became the theoretical basis of modern evolutionary studies. After publishing his work in 1983 in the book “Neutral Theory of Molecular Evolution”, Kimura wrote this book in 1988 for the general public. It was originally written in Japanese and is translated here for the first time. In the book, Kimura first summarizes the development of evolutionary theory since Lamarck and Darwin. He then shows how the search for mechanisms of evolution developed into population genetics and describes how the study of molecular evolution matured by taking in the fruits of molecular biology. Kimura proceeds to carefully explain his neutral evolution theory at the molecular level. Finally, he presents his view of the world from an evolutionary perspective. The book has long served as an in-depth introduction to evolutionary biology for students and young researchers in Japan. There has been remarkably rapid progress in the field of bioscience at the molecular level over the past 30 years. Nevertheless, the book remains an important contribution that laid the foundations for what followed in molecular evolutionary studies.
    Keywords Life sciences ; Evolutionary biology ; Popular Life Sciences ; Evolutionary Biology ; Evolució (Biologia)
    Subject code 025.3357
    Language English
    Size 1 online resource (XII, 152 p. 24 illus., 2 illus. in color.)
    Edition 1st ed. 2020.
    Publisher Springer Singapore ; Imprint: Springer
    Publishing place Singapore
    Document type Book ; Online ; E-Book
    Remark Zugriff für angemeldete ZB MED-Nutzerinnen und -Nutzer
    ISBN 981-15-6165-6 ; 981-15-6164-8 ; 978-981-15-6165-8 ; 978-981-15-6164-1
    DOI 10.1007/978-981-15-6165-8
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  2. Article ; Online: Challenges of Catheter Ablation for Atrial Fibrillation in Hemodialysis Patients.

    Kimura, Masaomi

    Circulation journal : official journal of the Japanese Circulation Society

    2024  

    Language English
    Publishing date 2024-02-16
    Publishing country Japan
    Document type Journal Article
    ZDB-ID 2068090-9
    ISSN 1347-4820 ; 1346-9843
    ISSN (online) 1347-4820
    ISSN 1346-9843
    DOI 10.1253/circj.CJ-24-0041
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Role of the supinator muscle in the pathophysiological mechanism of a pulled elbow.

    Kimura, Masahiko

    Acta paediatrica (Oslo, Norway : 1992)

    2022  Volume 111, Issue 4, Page(s) 756–759

    Abstract: A pulled elbow is a common childhood orthopaedic injury that is usually caused by longitudinal traction on the hand. The pathophysiological mechanism of a pulled elbow involves interposition of the annular ligament into the radiohumeral joint. Recent ... ...

    Abstract A pulled elbow is a common childhood orthopaedic injury that is usually caused by longitudinal traction on the hand. The pathophysiological mechanism of a pulled elbow involves interposition of the annular ligament into the radiohumeral joint. Recent ultrasonographic studies have shown that both the supinator muscle and annular ligament were trapped into the radiohumeral joint. This paper discusses why pulled elbows can occur during pronation and how a pulled elbow can be reduced either by hyperpronation or supination followed by elbow flexion based on the function of the supinator muscle.
    MeSH term(s) Child ; Elbow ; Elbow Joint/diagnostic imaging ; Elbow Joint/injuries ; Humans ; Joint Dislocations/etiology ; Muscles ; Supination
    Language English
    Publishing date 2022-02-14
    Publishing country Norway
    Document type Journal Article
    ZDB-ID 203487-6
    ISSN 1651-2227 ; 0365-1436 ; 0803-5253
    ISSN (online) 1651-2227
    ISSN 0365-1436 ; 0803-5253
    DOI 10.1111/apa.16194
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Book ; Online: Generalization Bounds for Set-to-Set Matching with Negative Sampling

    Kimura, Masanari

    2023  

    Abstract: The problem of matching two sets of multiple elements, namely set-to-set matching, has received a great deal of attention in recent years. In particular, it has been reported that good experimental results can be obtained by preparing a neural network as ...

    Abstract The problem of matching two sets of multiple elements, namely set-to-set matching, has received a great deal of attention in recent years. In particular, it has been reported that good experimental results can be obtained by preparing a neural network as a matching function, especially in complex cases where, for example, each element of the set is an image. However, theoretical analysis of set-to-set matching with such black-box functions is lacking. This paper aims to perform a generalization error analysis in set-to-set matching to reveal the behavior of the model in that task.

    Comment: This paper is accepted at the International Conference on Neural Information Processing (ICONIP2022)
    Keywords Statistics - Machine Learning ; Computer Science - Machine Learning
    Publishing date 2023-02-25
    Publishing country us
    Document type Book ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  5. Article ; Online: Comprehensive Molecular Dynamics Study of Oxygen Diffusion in Carbon Mesopores: Insights for Designing Fuel-Cell Catalyst Supports.

    Kikkawa, Nobuaki / Kimura, Masayuki

    Langmuir : the ACS journal of surfaces and colloids

    2024  Volume 40, Issue 3, Page(s) 1674–1687

    Abstract: Mesoporous carbon is often used as a support for platinum catalysts in polymer electrolyte fuel-cell catalyst layers. Mesopores in the carbon support improve the performance of fuel cells by inhibiting the adsorption of ionomer onto the catalyst ... ...

    Abstract Mesoporous carbon is often used as a support for platinum catalysts in polymer electrolyte fuel-cell catalyst layers. Mesopores in the carbon support improve the performance of fuel cells by inhibiting the adsorption of ionomer onto the catalyst particles. However, the mesopores may impair mass transport. Hence, understanding molecular behaviors in the pores is essential to optimizing the mesopore structures. Specifically, it is crucial to understand the oxygen transport in the high-current region. In this study, the diffusion coefficients of oxygen molecules in carbon mesopores were calculated for various pore lengths, pore diameters, filling rates, and water contents in the ionomer via molecular dynamics simulations. The results show that oxygen diffusion slows by 2 orders of magnitude because of pore occlusion, and it slows down by an additional 1 or 2 orders of magnitude if ionomers are present in the pores. The occlusion can be theoretically predicted by considering the surface free energy. This theory provides some insight into mesoporous carbon designs; for instance, the theory suggests that narrow pores should be shortened to prevent occlusion. Slow diffusion in the presence of ionomers was attributed to the localization of oxygen at the dense ionomer-carbon interface. Thus, to improve oxygen transport properties, carbon surfaces and ionomer structures may be designed in such a manner as to prevent densification at the interface.
    Language English
    Publishing date 2024-01-10
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2005937-1
    ISSN 1520-5827 ; 0743-7463
    ISSN (online) 1520-5827
    ISSN 0743-7463
    DOI 10.1021/acs.langmuir.3c02627
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: Prediction, Suppression of Visual Response, and Modulation of Visual Perception: Insights From Visual Evoked Potentials and Representational Momentum.

    Kimura, Motohiro

    Frontiers in human neuroscience

    2021  Volume 15, Page(s) 730962

    Abstract: When a visual object changes its position along with certain sequential regularities, the visual system rapidly and automatically forms a prediction regarding the future position of the object based on the regularities. Such prediction can drastically ... ...

    Abstract When a visual object changes its position along with certain sequential regularities, the visual system rapidly and automatically forms a prediction regarding the future position of the object based on the regularities. Such prediction can drastically alter visual perception. A phenomenon called representational momentum (RM: a predictive displacement of the perceived final position of a visual object along its recent regular pattern) has provided extensive evidence for the predictive modulation of visual perception. The purpose of the present study was to identify neural effects that could explain individual differences in the strength of the predictive modulation of visual perception as measured by RM. For this purpose, in two experiments with a conventional RM paradigm where a bar was discretely presented in a regular rotation manner (with a step of 18° in Experiment 1 and a step of 20° in Experiment 2), visual evoked potentials (VEPs) in response to the regularly rotated bar were measured, and correlations between the magnitudes of RM and VEPs were examined. The results showed that the magnitudes of RM and central P2 were negatively correlated, consistently in both experiments; participants who showed a smaller central P2 tended to exhibit greater RM. Together with a previous proposal that central P2 would represent delayed reactivation of lower visual areas around the striate and prestriate cortices via reentrant feedback projections from higher areas, the present results suggest that greater suppression of delayed reactivation of lower visual areas (as indicated by smaller central P2) may underlie stronger predictive modulation of visual perception (as indicated by greater RM).
    Language English
    Publishing date 2021-08-25
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2425477-0
    ISSN 1662-5161
    ISSN 1662-5161
    DOI 10.3389/fnhum.2021.730962
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Proper Threshold of Low Voltage and Reduced Conduction Velocity in Atrial Fibrillation.

    Kimura, Masaomi

    Circulation journal : official journal of the Japanese Circulation Society

    2021  Volume 86, Issue 2, Page(s) 200–201

    MeSH term(s) Atrial Fibrillation/physiopathology ; Catheter Ablation ; Heart Atria/physiopathology ; Humans
    Language English
    Publishing date 2021-12-22
    Publishing country Japan
    Document type Editorial ; Comment
    ZDB-ID 2068090-9
    ISSN 1347-4820 ; 1346-9843
    ISSN (online) 1347-4820
    ISSN 1346-9843
    DOI 10.1253/circj.CJ-21-0975
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Cellotype-phenotype associations using 'organoid villages'.

    Kimura, Masaki / Takebe, Takanori

    Trends in endocrinology and metabolism: TEM

    2024  

    Abstract: En masse phenotyping technology, using massively mosaic donor-derived cells and organoids, can offer enriched insights for cellotype-phenotype association in a cell-type-specific regulatory context. This emerging approach will help to discover biomarkers, ...

    Abstract En masse phenotyping technology, using massively mosaic donor-derived cells and organoids, can offer enriched insights for cellotype-phenotype association in a cell-type-specific regulatory context. This emerging approach will help to discover biomarkers, inform genetic-epigenetic interactions and identify personalized therapeutic targets, offering hope for precision medicine against highly heterogeneous metabolic diseases.
    Language English
    Publishing date 2024-04-03
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1042384-9
    ISSN 1879-3061 ; 1043-2760
    ISSN (online) 1879-3061
    ISSN 1043-2760
    DOI 10.1016/j.tem.2024.03.001
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Negative social interactions and coping behaviors: experiences of Japanese mothers caring for children with special needs in disaster areas.

    Kimura, Miyako

    BMC research notes

    2020  Volume 13, Issue 1, Page(s) 247

    Abstract: Objective: This study aims to identify the challenging experiences pertaining negative social interactions and the coping behaviors of mothers of children with special needs after two major earthquakes in Japan. A qualitative content analysis was ... ...

    Abstract Objective: This study aims to identify the challenging experiences pertaining negative social interactions and the coping behaviors of mothers of children with special needs after two major earthquakes in Japan. A qualitative content analysis was conducted based on the interviews of 26 mothers of children with special needs who had experienced the Great East Japan Earthquake in 2011 or Kumamoto Earthquake in 2016.
    Results: The themes extracted were "perceiving pressures and unfairness," "failing to obtain support and deeper understanding," "realizing child's characteristics that are difficult for others to understand," and "tackling challenges on their own in different ways." The experienced negative social interactions and coping behaviors were found to be similar in both earthquakes. Although the Japanese legislation was amended 2 years after the Great East Japan Earthquake, it may not have had necessarily improved the mothers' situations. Thus, while it is important to provide specific support for families of children with special needs after natural disasters and organize food supplies with a focus on family units, it is also important to increase Japanese society's understanding of the varied characteristics of disabilities.
    MeSH term(s) Adaptation, Psychological ; Adolescent ; Adult ; Child ; Child, Preschool ; Developmental Disabilities/nursing ; Disabled Children ; Earthquakes ; Female ; Humans ; Intellectual Disability/nursing ; Japan ; Middle Aged ; Mothers/psychology ; Qualitative Research ; Social Interaction ; Social Support ; Young Adult
    Language English
    Publishing date 2020-05-20
    Publishing country England
    Document type Journal Article
    ZDB-ID 2413336-X
    ISSN 1756-0500 ; 1756-0500
    ISSN (online) 1756-0500
    ISSN 1756-0500
    DOI 10.1186/s13104-020-05087-1
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: [Consideration of Advanced Pharmaceutical Control Functions through Pharmacy-provided Home Pharmaceutical Care].

    Kimura, Masahiko

    Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan

    2020  Volume 140, Issue 7, Page(s) 841–850

    Abstract: In October 2015, the Ministry of Health, Labour and Welfare of Japan newly included "health support functions" and "advanced pharmaceutical control functions" as part of "primary-care pharmacy" in the pharmacy vision for patients. "Health support ... ...

    Abstract In October 2015, the Ministry of Health, Labour and Welfare of Japan newly included "health support functions" and "advanced pharmaceutical control functions" as part of "primary-care pharmacy" in the pharmacy vision for patients. "Health support functions" were defined as recommending that patients seek medical consultations, introducing them to relevant medical institutions, and contributing to disease prevention and health support among local residents, apart from health counseling and the consolidation of a framework for the appropriate selection and supply of and advice on pharmacist-only over-the-counter medications, etc. On the other hand, the term "advanced pharmaceutical control functions" is presumed to imply meeting the needs for advanced pharmaceutical control, e.g., cooperation with specialized medical institutions in addressing adverse reactions caused by anticancer drugs and support of the selection of anti-HIV drugs. However, the details remain unknown. Since the opening of the Akebono pharmacy group 22 years ago, our staff members have visited home-care patients, controlled and guided the use of pharmaceuticals, and supported all types of home-care patients including those with end-stage cancer and amyotrophic lateral sclerosis, undergoing home parenteral nutrition, and pediatric home-care patients. We have experienced many cases requiring sophisticated pharmaceutical control, e.g., pain control with opioids, sterile preparation of transfusions, and supply of special medical devices. We would like to consider the requirements for pharmacy-provided home healthcare that depends heavily on medical treatment as one advanced pharmaceutical control function.
    MeSH term(s) Community Pharmacy Services ; Delivery of Health Care ; Home Care Services ; Humans ; Japan ; Pharmacy
    Language Japanese
    Publishing date 2020-07-01
    Publishing country Japan
    Document type Journal Article ; Review
    ZDB-ID 200514-1
    ISSN 1347-5231 ; 0031-6903 ; 0372-7750 ; 0919-2085 ; 0919-2131
    ISSN (online) 1347-5231
    ISSN 0031-6903 ; 0372-7750 ; 0919-2085 ; 0919-2131
    DOI 10.1248/yakushi.19-00237-1
    Database MEDical Literature Analysis and Retrieval System OnLINE

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