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  1. Article: [Keyhole Craniotomy and Closure for Trigeminal Neuralgia and Facial Spasms].

    Kimura, Toshikazu

    No shinkei geka. Neurological surgery

    2024  Volume 52, Issue 1, Page(s) 38–45

    Abstract: Facial spasms and trigeminal neuralgia are functional diseases, which have alternative treatment options. The working space for each pathology can be obtained by a routine approach to the caudal and rostral sides of the cerebellum and can be provided ... ...

    Abstract Facial spasms and trigeminal neuralgia are functional diseases, which have alternative treatment options. The working space for each pathology can be obtained by a routine approach to the caudal and rostral sides of the cerebellum and can be provided through a small craniotomy, because CSF drainage provides sufficient space for manipulation. However, it is necessary to expose fully the structures that define the operative field, such as the margins of the venous sinuses. Familiarity with the muscular anatomy required for exposure is also important.
    MeSH term(s) Humans ; Trigeminal Neuralgia/surgery ; Drainage ; Cerebellum ; Craniotomy ; Spasm
    Language Japanese
    Publishing date 2024-01-22
    Publishing country Japan
    Document type English Abstract ; Journal Article
    ZDB-ID 197053-7
    ISSN 1882-1251 ; 0301-2603
    ISSN (online) 1882-1251
    ISSN 0301-2603
    DOI 10.11477/mf.1436204877
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Advancements in the Treatment Landscape of Hepatocellular Carcinoma.

    Kimura, Takefumi

    Cancers

    2024  Volume 16, Issue 5

    Abstract: The landscape of hepatocellular carcinoma (HCC) treatment has expanded significantly with the advent of multi-kinase inhibitors and immune checkpoint inhibitors [ ... ]. ...

    Abstract The landscape of hepatocellular carcinoma (HCC) treatment has expanded significantly with the advent of multi-kinase inhibitors and immune checkpoint inhibitors [...].
    Language English
    Publishing date 2024-03-05
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 2527080-1
    ISSN 2072-6694
    ISSN 2072-6694
    DOI 10.3390/cancers16051054
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Case report on successful treatment for brain abscess in a Japanese monkey (Macaca fuscata).

    Kimura, Tohru

    Laboratory animal research

    2023  Volume 39, Issue 1, Page(s) 13

    Abstract: Background: A brain abscess in human beings is a focal infection of the central nervous system frequently characterized by areas of localized cerebritis and central necrosis surrounded by a well vascularized capsule. A brain abscess, although ... ...

    Abstract Background: A brain abscess in human beings is a focal infection of the central nervous system frequently characterized by areas of localized cerebritis and central necrosis surrounded by a well vascularized capsule. A brain abscess, although sporadically reported, is relatively rare disease in domestic animals (horses, cattle, goats and alpacas), companion animals (dogs and cats) and laboratory nonhuman primates. Brain abscesses are life threatening disease that needs early and aggressive veterinary therapy.
    Case presentation: The purpose of this study on a brain abscess in a Japanese monkey was to report the investigational and therapeutic processes including clinical observations, hematological and serum biochemical profiles, and magnetic resonance imaging (MRI) features, probiotic and antibiotic therapy. In clinical observation, the monkey presented with slowly progressive gentle and depressed behavioral change. Hematological findings showed that slightly declined platelet counts gradually increased in the course of the treatment. Serum biochemical profiles revealed initial markedly elevated. A series of chemotherapy provide prominent relief from the influence of the brain abscess. MRI images illustrated that a brain abscess was located in the right frontal lobe and the mass was delineated by a thick rim, indicating the capsule formation stage. The lesion chronologically decreased in size over the course of treatment. Until 11 weeks after treatment of the brain abscess, the size of brain abscess continued to reduce, leaving an organized lesion trace. To the best of my knowledge, this is the first report on successful treatment for a brain abscess in a Japanese monkey (Macaca fuscata).
    Conclusions: Medical management of simian brain abscesses is possible based on the controlled and resolving nature of the lesions as determined by MRI and completion of a of chemical antibiotic treatment presented in this study.
    Language English
    Publishing date 2023-06-09
    Publishing country England
    Document type Journal Article
    ZDB-ID 2623220-0
    ISSN 2233-7660 ; 1738-6055
    ISSN (online) 2233-7660
    ISSN 1738-6055
    DOI 10.1186/s42826-023-00165-4
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Efficient use of peripheral information for temporal prediction.

    Kimura, Tsukasa

    Biological psychology

    2023  Volume 177, Page(s) 108484

    Abstract: We adapt to the environment by predicting subsequent events. Generally, intervals between predictions and events make it difficult to predict the events accurately. Previous studies reported that using peripheral information is useful for maintaining ... ...

    Abstract We adapt to the environment by predicting subsequent events. Generally, intervals between predictions and events make it difficult to predict the events accurately. Previous studies reported that using peripheral information is useful for maintaining predictions of subsequent events; however, it remains unclear how this information maintains the accuracy of the prediction. I presented peripheral visual stimuli in a discrimination task and manipulated the number of times these stimuli were presented while participants were waiting for a task-relevant visual stimulus, and compared participants' response times and event-related brain potentials in Experiment 1. In addition, the influence of the difficulty of predicting the task-relevant visual stimulus was examined in Experiment 2. In both experiments, contingent negative variation (CNV) amplitude immediately before the task-relevant visual stimulus appeared was larger under the condition where many peripheral visual stimuli were presented, and the response time was shorter under this condition. In addition, the largest CNV amplitude under this condition was elicited by the third peripheral visual stimulus, followed in order by the first and second peripheral visual stimuli. These results show that we can predict the timing of events that occur with a delay after the prediction by using peripheral information. Moreover, this peripheral information is processed according to the importance of predicting a task-relevant stimulus, and attentional resources are allocated efficiently. These results provide evidence of the predictive function for temporal prediction of using peripheral information and the allocation of cognitive resources.
    MeSH term(s) Humans ; Electroencephalography ; Photic Stimulation ; Reaction Time/physiology ; Evoked Potentials/physiology ; Brain/physiology ; Visual Perception/physiology
    Language English
    Publishing date 2023-01-05
    Publishing country Netherlands
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 185105-6
    ISSN 1873-6246 ; 0301-0511
    ISSN (online) 1873-6246
    ISSN 0301-0511
    DOI 10.1016/j.biopsycho.2023.108484
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  5. Article ; Online: Letter to the Editor. Clazosentan was superior to placebo, but was the comparison appropriate?

    Kimura, Toshikazu

    Journal of neurosurgery

    2023  Volume 139, Issue 1, Page(s) 299–300

    MeSH term(s) Humans ; Dioxanes/therapeutic use ; Pyridines/therapeutic use ; Pyrimidines/therapeutic use ; Sulfonamides/therapeutic use ; Tetrazoles/therapeutic use
    Chemical Substances clazosentan (3DRR0X4728) ; Dioxanes ; Pyridines ; Pyrimidines ; Sulfonamides ; Tetrazoles
    Language English
    Publishing date 2023-03-24
    Publishing country United States
    Document type Clinical Trial ; Journal Article ; Letter ; Comment
    ZDB-ID 3089-2
    ISSN 1933-0693 ; 0022-3085
    ISSN (online) 1933-0693
    ISSN 0022-3085
    DOI 10.3171/2023.1.JNS2316
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  6. Article ; Online: Recanalized Aneurysms: Is Rupture Further Preventable?

    Kimura, T

    AJNR. American journal of neuroradiology

    2020  Volume 41, Issue 10, Page(s) E85

    MeSH term(s) Blood Vessel Prosthesis ; Embolization, Therapeutic ; Humans ; Intracranial Aneurysm/diagnostic imaging ; Intracranial Aneurysm/therapy
    Language English
    Publishing date 2020-09-10
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 603808-6
    ISSN 1936-959X ; 0195-6108
    ISSN (online) 1936-959X
    ISSN 0195-6108
    DOI 10.3174/ajnr.A6734
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  7. Article ; Online: Letter to the Editor Regarding "Clinical Features of Ruptured Very Small Intracranial Aneurysms (<3 mm) in Patients with Subarachnoid Hemorrhage".

    Kimura, Toshikazu

    World neurosurgery

    2022  Volume 165, Page(s) 206

    MeSH term(s) Aneurysm, Ruptured/complications ; Aneurysm, Ruptured/surgery ; Humans ; Intracranial Aneurysm/complications ; Intracranial Aneurysm/diagnostic imaging ; Intracranial Aneurysm/surgery ; Subarachnoid Hemorrhage/diagnostic imaging ; Subarachnoid Hemorrhage/surgery
    Language English
    Publishing date 2022-10-03
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 2534351-8
    ISSN 1878-8769 ; 1878-8750
    ISSN (online) 1878-8769
    ISSN 1878-8750
    DOI 10.1016/j.wneu.2022.06.059
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  8. Article ; Online: Spontaneous Polycystic Kidneys with Chronic Renal Failure in an Aged House Musk Shrew (

    Kimura, Tohru

    Veterinary sciences

    2022  Volume 9, Issue 3

    Abstract: Polycystic kidney disease is one of the most common inheritable renal diseases, characterized by the formation of multiple fluid-filled renal cysts. This disease is a progressive and unfortunately incurable condition. A case of polycystic kidney with ... ...

    Abstract Polycystic kidney disease is one of the most common inheritable renal diseases, characterized by the formation of multiple fluid-filled renal cysts. This disease is a progressive and unfortunately incurable condition. A case of polycystic kidney with chronic renal failure in house musk shrew (
    Language English
    Publishing date 2022-03-08
    Publishing country Switzerland
    Document type Case Reports
    ZDB-ID 2768971-2
    ISSN 2306-7381 ; 2306-7381
    ISSN (online) 2306-7381
    ISSN 2306-7381
    DOI 10.3390/vetsci9030123
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  9. Article: Trichoblastomas derived from the facial skin with tactile hair in aged house musk shrews (Suncus murinus).

    Kimura, Tohru

    Laboratory animal research

    2022  Volume 38, Issue 1, Page(s) 38

    Abstract: Background: Benign hair follicle tumors are relatively rare cutaneous neoplasms arising from hair follicle differentiation. These tumors are slow-growing solitary papules or nodules in the head, face or neck. The aim of this study was to describe 2 ... ...

    Abstract Background: Benign hair follicle tumors are relatively rare cutaneous neoplasms arising from hair follicle differentiation. These tumors are slow-growing solitary papules or nodules in the head, face or neck. The aim of this study was to describe 2 cases of trichoblastomas in tactile hair skin incidentally encountered in aged house musk shrews (Suncus murinus). In addition, this case report clarifies whether the characteristics in the tactile hair skin of Suncus murinus are different from those in humans and other animals.
    Case presentation: The animals were investigated the characteristics of the clinical findings, hematological and serum biochemical profiles (particularly, serum amyloid A levels (vSAA)), and histopathological results. Suncus murinus with the facial tumor showed weight loss and coarse fur. Hematological examinations indicated microcytic and normochromic anemia. Although few apparent changes were serum biochemically found in Suncus murinus, vSAA levels moderately increased and revealed inflammatory reactions. These lesions histopathologically showed the basaloid islands comprising peripheral palisading and dilated microcysts containing variable admixtures of free-floating cells such as neoplasm cells, giant cells, clear cells, mononuclear cells and erythrocytes.
    Conclusions: The author concluded that trichoblastomas in Suncus murinus revealed growth and morphological characteristics that recapitulate part of embryological development in the tactile hair follicles. In the histological structure, their trichoblastomas in the tactile hair skin were different from those found in humans and animals such as cats, dogs and other wildlife.
    Language English
    Publishing date 2022-12-06
    Publishing country England
    Document type Journal Article
    ZDB-ID 2623220-0
    ISSN 2233-7660 ; 1738-6055
    ISSN (online) 2233-7660
    ISSN 1738-6055
    DOI 10.1186/s42826-022-00147-y
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  10. Article ; Online: Letter to the Editor Regarding "Efficacy and Safety of Emergency Extracranial-Intracranial Bypass for Revascularization Within 24 Hours in Resolving Large Artery Occlusion with Intracranial Stenosis".

    Kimura, Toshikazu

    World neurosurgery

    2022  Volume 158, Page(s) 332

    MeSH term(s) Arterial Occlusive Diseases/complications ; Arterial Occlusive Diseases/diagnostic imaging ; Arterial Occlusive Diseases/surgery ; Arteries/surgery ; Carotid Artery, Internal/surgery ; Cerebral Revascularization ; Constriction, Pathologic/surgery ; Humans ; Vascular Surgical Procedures
    Language English
    Publishing date 2022-08-04
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 2534351-8
    ISSN 1878-8769 ; 1878-8750
    ISSN (online) 1878-8769
    ISSN 1878-8750
    DOI 10.1016/j.wneu.2021.07.110
    Database MEDical Literature Analysis and Retrieval System OnLINE

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