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  1. Article: Increased Serum-Immunoglobulin G4 Levels in a 12-Year-Old Male Patient With Central Diabetes Insipidus.

    Kimura, Takuro / Umino, Satoko / Kitamura, Miyuki / Yatsuga, Shuichi

    Cureus

    2021  Volume 13, Issue 8, Page(s) e17362

    Abstract: Immunoglobulin G4 (IgG4)-related disorders are characterized by tissue hypertrophy due to IgG4-positive cell infiltration and increased serum IgG4 levels. IgG4-related hypophysitis (IgG4-RH) is characterized by pituitary hypertrophy, IgG4-positive cell ... ...

    Abstract Immunoglobulin G4 (IgG4)-related disorders are characterized by tissue hypertrophy due to IgG4-positive cell infiltration and increased serum IgG4 levels. IgG4-related hypophysitis (IgG4-RH) is characterized by pituitary hypertrophy, IgG4-positive cell infiltration, central diabetes insipidus, and increased serum IgG4 levels. IgG4-RH is diagnosed through diagnostic criteria. A few cases of IgG4-RH in children have been reported. We report a case of CDI with increased serum IgG4 levels that failed to meet the diagnostic criteria of IgG4-RH. The patient developed polyuria and polydipsia at age 11 and was diagnosed as having idiopathic CDI at age 12. The patient was not treated with steroids and is well controlled with antidiuretic hormones. It has been reported that pediatric IgG4-RH differs from that of adults in several respects. We believe that the pediatric IgG4-RH may not fit the diagnostic criteria of adults. There may be also other cases of increased serum IgG4 levels in pediatric patients with idiopathic CDI. We do not know if they are subtypes of IgG4-RH or if serum IgG4 levels are by chance raised in CDI, however, we report them here because IgG4-RH in children may be different from that in adults.
    Language English
    Publishing date 2021-08-22
    Publishing country United States
    Document type Case Reports
    ZDB-ID 2747273-5
    ISSN 2168-8184
    ISSN 2168-8184
    DOI 10.7759/cureus.17362
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Multiaxial Stress Relaxation of Dual-Cross-Link Poly(vinyl alcohol) Hydrogels.

    Kimura, Takuro / Urayama, Kenji

    ACS macro letters

    2019  Volume 9, Issue 1, Page(s) 1–6

    Abstract: Dual-cross-link hydrogels, which are composed of poly(vinyl alcohol) chains cross-linked by covalent bonds and transient physical bonds via borate ions, have received considerable interest due to the high extensibility as well as the self-healing ... ...

    Abstract Dual-cross-link hydrogels, which are composed of poly(vinyl alcohol) chains cross-linked by covalent bonds and transient physical bonds via borate ions, have received considerable interest due to the high extensibility as well as the self-healing properties. The dual-cross-link gels exhibit pronounced stress relaxation after the imposition of step strain, reflecting the breaking dynamics of temporary chains which sustain the initial stress. Multiaxial stress relaxation experiments using equibiaxial, planar, and uniaxial stretching with various degrees of strain unambiguously validate the time-strain separability in relaxation stress for a general type of deformation. The time effect is satisfactorily described by an existing model, while the strain effect is well approximated by the neo-Hookean model. Furthermore, the magnitude of total stress relaxation to the initial stress is constant, independently of the type and degree of imposed strain. These simple features provide an important basis for formulating the constitutive models of the dual-cross-link gels and for molecular design of hydrogels with transient physical cross-links.
    Language English
    Publishing date 2019-12-09
    Publishing country United States
    Document type Journal Article
    ISSN 2161-1653
    ISSN (online) 2161-1653
    DOI 10.1021/acsmacrolett.9b00896
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Onasemnogene Abeparvovec Treatment after Nusinersen in an Infant with Spinal Muscular Atrophy Type 1.

    Nanri, Daiki / Yuge, Kotaro / Goto, Kohei / Kimura, Takuro / Yae, Yukako / Mizuochi, Tatsuki / Sato, Ryosuke / Itonaga, Tomoyo / Maeda, Tomoki / Yamashita, Yushiro

    The Kurume medical journal

    2024  

    Abstract: Background: Until recently, the treatment of spinal muscular atrophy (SMA) was limited to symptomatic treatment with no cure. Three innovative drugs, nusinersen, onasemnogene abeparvovec (OA), and risdiplam have been developed to treat SMA. Although the ...

    Abstract Background: Until recently, the treatment of spinal muscular atrophy (SMA) was limited to symptomatic treatment with no cure. Three innovative drugs, nusinersen, onasemnogene abeparvovec (OA), and risdiplam have been developed to treat SMA. Although the clinical trials for these drugs have demonstrated their efficacy, there is limited information on real world treatment strategies. In this study, we present a case of a male infant with SMA type 1 who underwent OA treatment after nusinersen treatment.
    Case presentation: At 4 months of age, the patient was diagnosed with SMA type 1. At 6 months of age, nusinersen treatment was initiated. His motor function improved, but the effect was limited; therefore, his parents requested gene replacement therapy. During the preparation for OA treatment, anti-adeno-associated virus 9 (AAV9) antibody tests repeatedly showed non-specific reactions, which delayed initiation of treatment. The patient was put on ventilator management after he caught a common cold. During this management, the anti-AAV9 antibody test results were negative. Furthermore, the patient showed increased transaminase levels just before OA treatment; however, since these gradually decreased without signs of liver failure, we started OA treatment at 13 months of age. Four months later, the patient began to sit without support and was weaned from non-invasive positive pressure ventilation, although nasogastric tube feeding remained partially necessary.
    Conclusion: We believe that the management of unstable SMA type 1 symptoms, anti-AAV9 antibody testing, and changes in transaminase levels will be helpful for other patients with SMA who require treatment.
    Language English
    Publishing date 2024-01-16
    Publishing country Japan
    Document type Journal Article
    ZDB-ID 603905-4
    ISSN 1881-2090 ; 0023-5679
    ISSN (online) 1881-2090
    ISSN 0023-5679
    DOI 10.2739/kurumemedj.MS6934008
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 704: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  4. Article: Estimated Gestational Age From Infant's Foot Length in Japanese.

    Niimi, Shingo / Kimura, Takuro / Saiki, Reo / Kanda, Hiroshi / Okamatsu, Yuki / Goto, Maki / Yatsuga, Shuichi

    Cureus

    2022  Volume 14, Issue 12, Page(s) e32991

    Abstract: Aim In developed countries including Japan, gestational age (GA) is predicted by the last menstrual period (LMP) and/or fetal ultrasound. In some developing countries, GA is predicted by infant's foot length (FL). Pregnant women who did not have ... ...

    Abstract Aim In developed countries including Japan, gestational age (GA) is predicted by the last menstrual period (LMP) and/or fetal ultrasound. In some developing countries, GA is predicted by infant's foot length (FL). Pregnant women who did not have pregnancy check-up is not infrequent in Japan, therefore there are sometimes opportunities to estimate the GA from infants after the delivery. The aim of this study is to determine the estimated GA formula from infant's FL in Japanese. Methods This study was a prospective cohort study. Infants between May 2021 and August 2021 at Iizuka Hospital and Tagawa Hospital or transferred from other hospitals within 24 hours of birth were collected. GA was determined using LMP and/or fetal ultrasound. The infant's FL was measured with a digital caliper within 24 hours of birth. The relationship between FL and GA was analyzed by simple regression analysis to determine the coefficient of determination (R
    Language English
    Publishing date 2022-12-27
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2747273-5
    ISSN 2168-8184
    ISSN 2168-8184
    DOI 10.7759/cureus.32991
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Time-strain inseparability in multiaxial stress relaxation of supramolecular gels formed

    Kimura, Takuro / Aoyama, Takuma / Nakahata, Masaki / Takashima, Yoshinori / Tanaka, Motomu / Harada, Akira / Urayama, Kenji

    Soft matter

    2022  Volume 18, Issue 26, Page(s) 4953–4962

    Abstract: Supramolecular hydrogels utilizing host-guest interactions (HG gels) exhibit large deformability and pronounced viscoelasticity. The inclusion complexes between β-cyclodextrin (host) and adamantane (guest) units on the water-soluble polymers form ... ...

    Abstract Supramolecular hydrogels utilizing host-guest interactions (HG gels) exhibit large deformability and pronounced viscoelasticity. The inclusion complexes between β-cyclodextrin (host) and adamantane (guest) units on the water-soluble polymers form transient bonds. The HG gels show significant stress relaxation with finite equilibrium stress following the step strain. The stress relaxation process reflects the detachment dynamics of the transient bonds which sustain the initial stress, while the finite equilibrium stress is preserved by the permanent topological cross-links with a rotaxane structure. Nonlinear stress relaxation experiments in biaxial stretching with various combinations of two orthogonal strains unambiguously reveal that time and strain effects on stress are not separable. The relaxation is accelerated for a short time frame (<10
    Language English
    Publishing date 2022-07-06
    Publishing country England
    Document type Journal Article
    ZDB-ID 2191476-X
    ISSN 1744-6848 ; 1744-683X
    ISSN (online) 1744-6848
    ISSN 1744-683X
    DOI 10.1039/d2sm00285j
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: Temple syndrome diagnosed in an adult patient with clinical autism spectrum disorder.

    Kimura, Takuro / Kagami, Masayo / Matsubara, Keiko / Yatsuga, Shuichi / Mukasa, Rio / Yatsuga, Chiho / Matsumoto, Takako / Koga, Yasutoshi

    Clinical case reports

    2018  Volume 7, Issue 1, Page(s) 15–18

    Abstract: Temple syndrome (TS14) leads to growth failure, precocious puberty, and diabetes mellitus. However, the long-term prognosis, including the development of social behavior in TS14 patients, remains unclarified. We report the clinical course of a male ... ...

    Abstract Temple syndrome (TS14) leads to growth failure, precocious puberty, and diabetes mellitus. However, the long-term prognosis, including the development of social behavior in TS14 patients, remains unclarified. We report the clinical course of a male patient with autism spectrum disorder that received a diagnosis of TS14 at 33 years of age.
    Language English
    Publishing date 2018-11-08
    Publishing country England
    Document type Case Reports
    ZDB-ID 2740234-4
    ISSN 2050-0904
    ISSN 2050-0904
    DOI 10.1002/ccr3.1895
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article: Changes in body surface potential distributions induced by isoproterenol and Na channel blockers in patients with the Brugada syndrome.

    Izumida, Naomi / Asano, Yuh / Doi, Shouzaburoh / Wakimoto, Hiroko / Fukamizu, Seiji / Kimura, Takuro / Ueyama, Tsuyoshi / Sakurada, Harumizu / Kawano, Seiko / Sawanobori, Tohru / Hiraoka, Masayasu

    International journal of cardiology

    2004  Volume 95, Issue 2-3, Page(s) 261–268

    Abstract: Background: The characteristics of unique ECG findings in the Brugada syndrome have not been well explained.: Methods: To clarify their characteristics and mechanisms, body surface maps (BSM) were recorded from patients with the Brugada syndrome (13 ... ...

    Abstract Background: The characteristics of unique ECG findings in the Brugada syndrome have not been well explained.
    Methods: To clarify their characteristics and mechanisms, body surface maps (BSM) were recorded from patients with the Brugada syndrome (13 cases; a mean age of 48 years) before and after administration of isoproterenol (ISP) or Na channel blockers (12 cases).
    Results: ST elevation in V1-V3 was decreased by 0.1 mV or more after ISP infusion in 8 of 11 cases and elevated after Na channel blockers in 8 of 12. In ventricular activation time (VAT) isochronal map, delayed conduction was noted on upper anterior chest in 11 and on anterior left chest in two. Delayed conduction areas were decreased by ISP and expanded by Na channel blockers. QRST isointegral map showed normal findings in baseline with minimal changes after ISP or Na channel blockers. Activation recovery interval (ARI) isochronal map showed prolonged area on upper anterior chest in baseline, being reduced by ISP and expanded by Na channel blockers. ARI dispersion (ARI-d), defined as difference between the maximum and minimum value of ARI, was larger in Brugada patients than that of normal subjects in baseline, and decreased after ISP and increased after Na channel blockers.
    Conclusion: ST elevation in the Brugada syndrome is primarily caused by abnormality in depolarization rather than in repolarization. BSM can provide better information to clarify a mechanism of ECG changes adding its diagnostic value for this unique syndrome.
    MeSH term(s) Adrenergic beta-Agonists/pharmacology ; Adult ; Anti-Arrhythmia Agents/pharmacology ; Body Surface Potential Mapping/drug effects ; Bundle-Branch Block/diagnosis ; Bundle-Branch Block/physiopathology ; Calcium Channel Blockers/pharmacology ; Female ; Humans ; Isoproterenol/pharmacology ; Male ; Middle Aged ; Syndrome ; Ventricular Fibrillation/diagnosis ; Ventricular Fibrillation/physiopathology
    Chemical Substances Adrenergic beta-Agonists ; Anti-Arrhythmia Agents ; Calcium Channel Blockers ; Isoproterenol (L628TT009W)
    Language English
    Publishing date 2004-06
    Publishing country Netherlands
    Document type Evaluation Studies ; Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 779519-1
    ISSN 1874-1754 ; 0167-5273
    ISSN (online) 1874-1754
    ISSN 0167-5273
    DOI 10.1016/j.ijcard.2003.05.025
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1673: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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