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  1. Article ; Online: Sex blind: bridging the gap between drug exposure and sex-related gene expression in

    King, Alex C / Zenker, Armin K

    Frontiers in toxicology

    2023  Volume 5, Page(s) 1187302

    Abstract: The sex of both humans ... ...

    Abstract The sex of both humans and
    Language English
    Publishing date 2023-06-16
    Publishing country Switzerland
    Document type Journal Article
    ISSN 2673-3080
    ISSN (online) 2673-3080
    DOI 10.3389/ftox.2023.1187302
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Theory and Simulation of Metal-Insulator-Semiconductor (MIS) Photoelectrodes.

    King, Alex J / Weber, Adam Z / Bell, Alexis T

    ACS applied materials & interfaces

    2023  Volume 15, Issue 19, Page(s) 23024–23039

    Abstract: A metal-insulator-semiconductor (MIS) structure is an attractive photoelectrode-catalyst architecture for promoting photoelectrochemical reactions, such as the formation of ... ...

    Abstract A metal-insulator-semiconductor (MIS) structure is an attractive photoelectrode-catalyst architecture for promoting photoelectrochemical reactions, such as the formation of H
    Language English
    Publishing date 2023-05-08
    Publishing country United States
    Document type Journal Article
    ISSN 1944-8252
    ISSN (online) 1944-8252
    DOI 10.1021/acsami.2c21114
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Behind the bright headlines, mind the long shadows.

    King, Alex

    Psycho-oncology

    2017  Volume 26, Issue 5, Page(s) 588–592

    Language English
    Publishing date 2017
    Publishing country England
    Document type Journal Article
    ZDB-ID 1118536-3
    ISSN 1099-1611 ; 1057-9249
    ISSN (online) 1099-1611
    ISSN 1057-9249
    DOI 10.1002/pon.4419
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 3550: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
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  4. Article ; Online: The next challenge for psycho-oncology in the UK: targeting service quality and outcomes.

    King, Alex

    Future oncology (London, England)

    2016  Volume 12, Issue 24, Page(s) 2811–2816

    Abstract: The acceptance and provision of psychosocial cancer care in the UK is moving forward positively, aided by patient advocacy and psychologically minded healthcare policies. The unfolding challenge now is of targeting the quality and outcomes of clinical ... ...

    Abstract The acceptance and provision of psychosocial cancer care in the UK is moving forward positively, aided by patient advocacy and psychologically minded healthcare policies. The unfolding challenge now is of targeting the quality and outcomes of clinical psycho-oncology services. This report outlines the clinically led development of UK-focused guidance to challenge psycho-oncology services to achieve and demonstrate their potential. It discusses how the guidance was particularly framed to encourage small, low-resource services, and outlines the potential benefits for patients. Overall, setting ourselves the challenge of quality on the same terms as physical healthcare, we can shape a direct path to achieving parity of esteem in mental with physical healthcare.
    MeSH term(s) Delivery of Health Care ; Humans ; Medical Oncology ; Mental Health ; Neoplasms/psychology ; Outcome Assessment (Health Care) ; Practice Guidelines as Topic ; Psychology, Clinical ; Quality of Health Care ; United Kingdom
    Language English
    Publishing date 2016-12
    Publishing country England
    Document type Journal Article
    ZDB-ID 2184533-5
    ISSN 1744-8301 ; 1479-6694
    ISSN (online) 1744-8301
    ISSN 1479-6694
    DOI 10.2217/fon-2016-0395
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Making connections for a biopsychosocial future in cancer care.

    King, Alex

    Future oncology (London, England)

    2016  Volume 12, Issue 24, Page(s) 2767–2769

    MeSH term(s) Biobehavioral Sciences ; Humans ; Medical Oncology ; Mental Health ; Neoplasms/psychology ; Patient Care ; Psychology, Clinical
    Language English
    Publishing date 2016-12
    Publishing country England
    Document type Editorial ; Introductory Journal Article
    ZDB-ID 2184533-5
    ISSN 1744-8301 ; 1479-6694
    ISSN (online) 1744-8301
    ISSN 1479-6694
    DOI 10.2217/fon-2016-0463
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Theory and Simulation of Metal-Insulator-Semiconductor (MIS) Photoelectrodes

    King, Alex J. / Weber, Adam Z. / Bell, Alexis T.

    ACS Applied Materials & Interfaces. 2023 May 08, v. 15, no. 19 p.23024-23039

    2023  

    Abstract: A metal-insulator-semiconductor (MIS) structure is an attractive photoelectrode-catalyst architecture for promoting photoelectrochemical reactions, such as the formation of H₂ by proton reduction. The metal catalyzes the generation of H₂ using electrons ... ...

    Abstract A metal-insulator-semiconductor (MIS) structure is an attractive photoelectrode-catalyst architecture for promoting photoelectrochemical reactions, such as the formation of H₂ by proton reduction. The metal catalyzes the generation of H₂ using electrons generated by photon absorption and charge separation in the semiconductor. The insulator layer between the metal and the semiconductor protects the latter element from photo-corrosion and, also, significantly impacts the photovoltage at the metal surface. Understanding how the insulator layer determines the photovoltage and what properties lead to high photovoltages is critical to the development of MIS structures for solar-to-chemical energy conversion. Herein, we present a continuum model for charge-carrier transport from the semiconductor to the metal with an emphasis on mechanisms of charge transport across the insulator. The polarization curves and photovoltages predicted by this model for a Pt/HfO₂/p-Si MIS structure at different HfO₂ thicknesses agree well with experimentally measured data. The simulations reveal how insulator properties (i.e., thickness and band structure) affect band bending near the semiconductor/insulator interface and how tuning them can lead to operation closer to the maximally attainable photovoltage, the flat-band potential. This phenomenon is understood by considering the change in tunneling resistance with insulator properties. The model shows that the best MIS performance is attained with highly symmetric semiconductor/insulator band offsets (e.g., BeO, MgO, SiO₂, HfO₂, or ZrO₂ deposited on Si) and a low to moderate insulator thickness (e.g., between 0.8 and 1.5 nm). Beyond 1.5 nm, the density of filled interfacial trap sites is high and significantly limits the photovoltage and the solar-to-chemical conversion rate. These conclusions are true for photocathodes and photoanodes. This understanding provides critical insight into the phenomena enhancing and limiting photoelectrode performance and how this phenomenon is influenced by insulator properties. The study gives guidance toward the development of next-generation insulators for MIS structures that achieve high performance.
    Keywords absorption ; cathodes ; energy conversion ; models ; photoelectrodes ; photons ; semiconductors ; photoelectrochemistry ; solar fuels ; photoelectrode ; metal−insulator−semiconductor ; theory ; modeling ; hydrogen evolution ; CO2 reduction
    Language English
    Dates of publication 2023-0508
    Size p. 23024-23039.
    Publishing place American Chemical Society
    Document type Article ; Online
    ISSN 1944-8252
    DOI 10.1021/acsami.2c21114
    Database NAL-Catalogue (AGRICOLA)

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  7. Book ; Conference proceedings: Materials for sustainable development

    King, Alex

    challenges and opportunities ; symposium held November 25 - 30, 2012, Boston, Massachusetts, U.S.A. ; [papers ... from two MRS fall 2012 symposia ; Symposium D "Energy Critical Materials" and Symposium G "Materials as Tools for Sustainability" were held ... at the 2012 MRS fall meeting]

    (Materials Research Society symposium proceedings ; 1492)

    2013  

    Event/congress Fall meeting. Materials Research Society (MRS) (2012.11.25-30, BostonMass.) ; Symposium D "Energy Critical Materials" (2012.11.25-30, BostonMass.) ; Symposium G "Materials as Tools for Sustainability" (2012.11.25-30, BostonMass.)
    Author's details ed.: Alex King
    Series title Materials Research Society symposium proceedings ; 1492
    Keywords Energy conversion ; Energy development/Environmental development ; Energy storage ; Photovoltaic power generation ; Power resources
    Language English
    Size XI, 197 S., Ill., graph. Darst.
    Publisher Cambridge Univ. Press
    Publishing place New York, NY
    Document type Book ; Conference proceedings
    Note Literaturangaben
    ISBN 9781605114699 ; 1605114693
    Database Library catalogue of the German National Library of Science and Technology (TIB), Hannover

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  8. Article ; Online: Improving personalised care and support planning for people living with treatable-but-not-curable cancer.

    Le Boutillier, Clair / Jeyasingh-Jacob, Julian / Jones, Lizzie / King, Alex / Archer, Stephanie / Urch, Catherine

    BMJ open quality

    2023  Volume 12, Issue 3

    Abstract: People living with treatable-but-not-curable (TbnC) cancer encounter cancer-related needs. While the NHS long-term plan commits to offering a Holistic Needs Assessment (HNA) and care plan to all people diagnosed with cancer, the content, delivery and ... ...

    Abstract People living with treatable-but-not-curable (TbnC) cancer encounter cancer-related needs. While the NHS long-term plan commits to offering a Holistic Needs Assessment (HNA) and care plan to all people diagnosed with cancer, the content, delivery and timing of this intervention differs across practice. Understanding how people make sense of their cancer experience can support personalised care. A conceptual framework based on personal narratives of living with and beyond cancer (across different cancer types and all stages of the disease trajectory), identified three interlinked themes: Adversity, Restoration and Compatibility, resulting in the ARC framework.Our aim was to use the ARC framework to underpin the HNA to improve the experience of personalised care and support planning for people living with TbnC cancer. We used clinical work experience to operationalise the ARC framework and develop the intervention, called the ARC HNA, and service-level structure, called the ARC clinic. We sought expert input on the proposed content and structure from patients and clinicians through involvement and engagement activities. Delivered alongside standard care, the ARC HNA was piloted with patients on the TbnC cancer (myeloma and metastatic breast, prostate or lung) pathway, who were 6-24 months into their treatment. Iterations were made to the content, delivery and timing of the intervention based on user feedback.Fifty-one patients received the intervention. An average of 12 new concerns were identified per patient, and 96% of patients achieved at least one of their goals. Patients valued the space for reflection and follow-up, and clinicians valued the collaborative approach to meeting patients' supportive care needs. Compared with routine initial HNA and care plan completion rates of 13%, ARC clinic achieved 90% with all care plans shared with general practitioners. The ARC clinic adopts a novel and proactive approach to delivering HNAs and care plans in a meaningful and personalised way.
    MeSH term(s) Humans ; Neoplasms/therapy ; Precision Medicine ; Holistic Health ; Needs Assessment ; Male ; Female ; Middle Aged
    Language English
    Publishing date 2023-09-04
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ISSN 2399-6641
    ISSN (online) 2399-6641
    DOI 10.1136/bmjoq-2023-002322
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Is personalised prehabilitation feasible to implement for patients undergoing oncological treatment for lung cancer at a London teaching hospital? Protocol of a feasibility trial.

    Wade-Mcbane, Kelly / King, Alex / Urch, Catherine / Johansson, Lina / Wells, Mary

    BMJ open

    2023  Volume 13, Issue 7, Page(s) e072367

    Abstract: Introduction: There is significant potential to improve outcomes for patients with lung cancer in terms of quality of life and survival. There is some evidence that prehabilitation can help, but, to date, this has only been tested in surgical ... ...

    Abstract Introduction: There is significant potential to improve outcomes for patients with lung cancer in terms of quality of life and survival. There is some evidence that prehabilitation can help, but, to date, this has only been tested in surgical populations, despite 70%-80% of patients with lung cancer in the UK receiving non-surgical treatment. The physiological and psychological benefits of prehabilitation seen in surgical patients could be extrapolated to those receiving non-surgical treatment, particularly in such a poor prognosis group. With patients and healthcare professionals, we have co-designed a personalised and evidence-based prehabilitation programme. This draws on a conceptual framework that aligns with patient values and needs as well as functional goals. We aim to investigate whether this programme is feasible to implement and evaluate in clinical practice.
    Methods and analysis: An open-label, single-group feasibility study incorporating quantitative assessments, a qualitative free text questionnaire and reflective field notes. Thirty participants will be recruited over an eight-month period from a single London teaching hospital. All recruited participants will receive a personalised prehabilitation programme during their oncological treatment. This includes a one-hour face-to-face appointment prior to, at week three and at week six of their treatment regimen as well as a weekly telephone call. Interventions including nutrition, physical activity and psychological well-being are stratified according to a patient's priorities, level of readiness and expressed needs. The primary outcome will be feasibility of the personalised prehabilitation programme in clinical practice by investigating areas of uncertainty regarding patient recruitment, attrition, treatment fidelity, intervention adherence and acceptability of study outcome measures. Secondary outcomes will include quality of life, functional capacity and grip strength.
    Ethics and dissemination: Ethical approval has been obtained from the Health Research Authority (reference number 22/PR/0390). Results of this study will be disseminated through publication in peer-reviewed articles, presentations at scientific conferences and in collaboration with patient and public involvement representatives.
    Trial registration number: NCT05318807.
    MeSH term(s) Humans ; Feasibility Studies ; Hospitals, Teaching ; London ; Lung Neoplasms/surgery ; Preoperative Exercise ; Quality of Life
    Language English
    Publishing date 2023-07-17
    Publishing country England
    Document type Clinical Trial Protocol ; Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2599832-8
    ISSN 2044-6055 ; 2044-6055
    ISSN (online) 2044-6055
    ISSN 2044-6055
    DOI 10.1136/bmjopen-2023-072367
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Role of Mass Transport in Electrochemical CO

    Chan, Thomas / Kong, Calton J / King, Alex J / Babbe, Finn / Prabhakar, Rajiv Ramanujam / Kubiak, Clifford P / Ager, Joel W

    ACS applied energy materials

    2024  Volume 7, Issue 8, Page(s) 3091–3098

    Abstract: Electrochemical ... ...

    Abstract Electrochemical CO
    Language English
    Publishing date 2024-04-04
    Publishing country United States
    Document type Journal Article
    ISSN 2574-0962
    ISSN (online) 2574-0962
    DOI 10.1021/acsaem.3c02979
    Database MEDical Literature Analysis and Retrieval System OnLINE

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