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  1. Article ; Online: Zwitterionic Polymer Coatings Enhance Gold Nanoparticle Stability and Uptake in Various Biological Environments.

    King, Benjamin M / Fiegel, Jennifer

    The AAPS journal

    2022  Volume 24, Issue 1, Page(s) 18

    Abstract: Zwitterionic polymers are a class of materials that have demonstrated utility as non-fouling surfaces for medical devices and drug delivery vehicles. Here, we develop a synthesis protocol to produce zwitterionic polymers as coatings for gold ... ...

    Abstract Zwitterionic polymers are a class of materials that have demonstrated utility as non-fouling surfaces for medical devices and drug delivery vehicles. Here, we develop a synthesis protocol to produce zwitterionic polymers as coatings for gold nanoparticles and evaluate nanoparticle stability and biological function after exposure to various biological fluids. Thiol-functionalized polymethacryloyloxyethyl phosphorylcholine polymers (pMPC) were synthesized in nontoxic solvents via photoinitiated free radical polymerization with a radical addition-fragmentation chain transfer (RAFT) agent and coated onto gold nanoparticles. pMPC-coated nanoparticles exhibited reduced particle aggregation, improved suspension stability, and decreased protein adsorption upon exposure to serum and lung lavage fluid (BALF). Cell uptake in A549 cells was greater for pMPC-coated particles than uncoated particles after exposure to serum and BALF, with no observed cell toxicity, but pMPC-coated particles experienced higher levels of cell uptake after serum exposure than BALF exposure, suggesting that differences in the composition of the fluids result in differing impacts on particle fate. These zwitterionic polymers may serve as useful nanoparticle coatings to enhance particle stability and uptake in various biological environments.
    MeSH term(s) A549 Cells ; Adult ; Bronchoalveolar Lavage Fluid ; Drug Carriers/chemistry ; Drug Delivery Systems ; Gold ; Humans ; Male ; Metal Nanoparticles ; Phosphorylcholine/chemistry ; Polymers/chemistry ; Proteins/metabolism ; Sulfhydryl Compounds/chemistry
    Chemical Substances Drug Carriers ; Polymers ; Proteins ; Sulfhydryl Compounds ; Phosphorylcholine (107-73-3) ; Gold (7440-57-5)
    Language English
    Publishing date 2022-01-04
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S.
    ISSN 1550-7416
    ISSN (online) 1550-7416
    DOI 10.1208/s12248-021-00652-3
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Medical Treatment of Benign Prostatic Hyperplasia.

    Plochocki, Alexander / King, Benjamin

    The Urologic clinics of North America

    2022  Volume 49, Issue 2, Page(s) 231–238

    Abstract: In this article, we review the primary medical treatments of BPH-associated male LUTS, with a focus on physiology, indications, and side effects. We cover selective alpha-1 antagonists, anticholinergics, PDE5 inhibitors, 5-alpha reductase inhibitors, and ...

    Abstract In this article, we review the primary medical treatments of BPH-associated male LUTS, with a focus on physiology, indications, and side effects. We cover selective alpha-1 antagonists, anticholinergics, PDE5 inhibitors, 5-alpha reductase inhibitors, and beta-3 agonists. Through a review of the literature, we provide our clinical pathway for the medical management of BPH, generally starting with tamsulosin in most men and progressing to combination therapy based on patient's response and symptoms.
    MeSH term(s) 5-alpha Reductase Inhibitors/therapeutic use ; Adrenergic alpha-Antagonists/therapeutic use ; Drug Therapy, Combination ; Humans ; Lower Urinary Tract Symptoms/drug therapy ; Lower Urinary Tract Symptoms/etiology ; Male ; Prostatic Hyperplasia/complications ; Prostatic Hyperplasia/diagnosis ; Prostatic Hyperplasia/drug therapy ; Tamsulosin/therapeutic use
    Chemical Substances 5-alpha Reductase Inhibitors ; Adrenergic alpha-Antagonists ; Tamsulosin (G3P28OML5I)
    Language English
    Publishing date 2022-03-22
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 192293-2
    ISSN 1558-318X ; 0094-0143
    ISSN (online) 1558-318X
    ISSN 0094-0143
    DOI 10.1016/j.ucl.2021.12.003
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Se 269: Show issues Location:
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  3. Article ; Online: Paracentral acute middle maculopathy presenting as a sign of impending central retinal artery occlusion: a case report.

    Louie, Emily / Tang, Anthony / King, Benjamin

    BMC ophthalmology

    2023  Volume 23, Issue 1, Page(s) 268

    Abstract: Background: To report a case of paracentral acute middle maculopathy (PAMM) that progressed to central retinal artery occlusion (CRAO) on spectral domain-optical coherence tomography (SD-OCT).: Case presentation: A 63-year-old male presented with a ... ...

    Abstract Background: To report a case of paracentral acute middle maculopathy (PAMM) that progressed to central retinal artery occlusion (CRAO) on spectral domain-optical coherence tomography (SD-OCT).
    Case presentation: A 63-year-old male presented with a paracentral scotoma that began several days ago. His past medical history consisted of third-degree atrioventricular heart block requiring a pacemaker. Giant cell arteritis was unlikely given the patient's labs, demographics and review of systems. SD-OCT revealed a characteristic hyperreflective band in the inner nuclear layer consistent with PAMM in his left eye. Fluorescein angiography was obtained and was unremarkable. Five days later, the patient developed no light perception in the left eye. SD-OCT showed a diffuse inner retinal hyperreflectivity consistent with CRAO.
    Conclusion: PAMM can be a harbinger event for complete CRAO. Complete stroke evaluation should be performed to prevent a cerebrovascular event or progression to complete blindness in the involved eye.
    MeSH term(s) Male ; Humans ; Middle Aged ; Retinal Artery Occlusion/diagnosis ; Retinal Artery Occlusion/etiology ; Retina ; Blindness ; Fluorescein Angiography ; Macular Degeneration
    Language English
    Publishing date 2023-06-13
    Publishing country England
    Document type Case Reports ; Journal Article
    ZDB-ID 2050436-6
    ISSN 1471-2415 ; 1471-2415
    ISSN (online) 1471-2415
    ISSN 1471-2415
    DOI 10.1186/s12886-023-02990-6
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  4. Article: Editorial: Zebrafish: An emerging model to study the cellular dynamics of inflammation in development, regeneration, and disease.

    Sullivan, Con / de Oliveira, Sofia / Kikuchi, Kazu / King, Benjamin L

    Frontiers in cell and developmental biology

    2023  Volume 10, Page(s) 1102381

    Language English
    Publishing date 2023-01-09
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 2737824-X
    ISSN 2296-634X
    ISSN 2296-634X
    DOI 10.3389/fcell.2022.1102381
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: Particle-Induced Electrostatic Repulsion within an Electric Curtain Operating below the Paschen Limit.

    Williams, Stuart J / Schneider, Joseph D / King, Benjamin C / Green, Nicolas G

    Micromachines

    2022  Volume 13, Issue 2

    Abstract: The electric curtain is a platform developed to lift and transport charged particles in air. Its premise is the manipulation of charged particles; however, fewer investigations isolate dielectric forces that are observed at lower voltages (i.e., less ... ...

    Abstract The electric curtain is a platform developed to lift and transport charged particles in air. Its premise is the manipulation of charged particles; however, fewer investigations isolate dielectric forces that are observed at lower voltages (i.e., less than the Paschen limit). This work focuses on observations of simultaneous dielectrophoretic and electrostatic forces. The electric curtain was a printed circuit board with interdigitated electrodes (0.020 inch width and spacing) coated with a layer of polypropylene, where a standing wave or travelling wave AC signal was applied (50 Hz) to produce an electric field below the Paschen limit. Soda lime glass beads (180-212 µm) demonstrated oscillatory rolling via dielectrophoretic forces. In addition, several particles simultaneously experienced rapid projectile repulsion, a behavior consistent with electrostatic phenomena. This second result is discussed as a particle-induced local increase in the electric field, with simulations demonstrating that a particle in close proximity to the curtain's surface produces a local field enhancement of over 2.5 times. The significance of this is that individual particles themselves can trigger electrostatic repulsion in an otherwise dielectric system. These results could be used for advanced applications where particles themselves provided triggered responses, perhaps for selective sorting of micrometer particles in air.
    Language English
    Publishing date 2022-02-11
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2620864-7
    ISSN 2072-666X
    ISSN 2072-666X
    DOI 10.3390/mi13020288
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  6. Article ; Online: Retraction Notice to: Modulation of TNFa Activity by the microRNA Let-7 Coordinates Zebrafish Heart Regeneration.

    Smith, Ashley M / Dykeman, Christina A / King, Benjamin L / Yin, Viravuth P

    iScience

    2022  Volume 25, Issue 6, Page(s) 104362

    Abstract: This retracts the article DOI: 10.1016/j.isci.2019.04.009.]. ...

    Abstract [This retracts the article DOI: 10.1016/j.isci.2019.04.009.].
    Language English
    Publishing date 2022-05-24
    Publishing country United States
    Document type Retraction of Publication
    ISSN 2589-0042
    ISSN (online) 2589-0042
    DOI 10.1016/j.isci.2022.104362
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Retraction Notice to: Modulation of TNFα Activity by the microRNA Let-7 Coordinates Zebrafish Heart Regeneration.

    Smith, Ashley M / Dykeman, Christina A / King, Benjamin L / Yin, Viravuth P

    iScience

    2022  Volume 25, Issue 6, Page(s) 104363

    Abstract: This retracts the article DOI: 10.1016/j.isci.2019.06.017.]. ...

    Abstract [This retracts the article DOI: 10.1016/j.isci.2019.06.017.].
    Language English
    Publishing date 2022-05-24
    Publishing country United States
    Document type Retraction of Publication
    ISSN 2589-0042
    ISSN (online) 2589-0042
    DOI 10.1016/j.isci.2022.104363
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  8. Article ; Online: Tautomerisation Mechanisms in the Adenine-Thymine Nucleobase Pair during DNA Strand Separation.

    King, Benjamin / Winokan, Max / Stevenson, Paul / Al-Khalili, Jim / Slocombe, Louie / Sacchi, Marco

    The journal of physical chemistry. B

    2023  Volume 127, Issue 19, Page(s) 4220–4228

    Abstract: The adenine-thymine tautomer (A*-T*) has previously been discounted as a spontaneous mutagenesis mechanism due to the energetic instability of the tautomeric configuration. We study the stability of A*-T* while the nucleobases undergo DNA strand ... ...

    Abstract The adenine-thymine tautomer (A*-T*) has previously been discounted as a spontaneous mutagenesis mechanism due to the energetic instability of the tautomeric configuration. We study the stability of A*-T* while the nucleobases undergo DNA strand separation. Our calculations indicate an increase in the stability of A*-T* as the DNA strands unzip and the hydrogen bonds between the bases stretch. Molecular Dynamics simulations reveal the time scales and dynamics of DNA strand separation and the statistical ensemble of opening angles present in a biological environment. Our results demonstrate that the unwinding of DNA, an inherently out-of-equilibrium process facilitated by helicase, will change the energy landscape of the adenine-thymine tautomerization reaction. We propose that DNA strand separation allows the stable tautomerization of adenine-thymine, providing a feasible pathway for genetic point mutations via proton transfer between the A-T bases.
    MeSH term(s) Thymine/chemistry ; Adenine/chemistry ; Base Pairing ; DNA/chemistry ; Protons
    Chemical Substances Thymine (QR26YLT7LT) ; Adenine (JAC85A2161) ; DNA (9007-49-2) ; Protons
    Language English
    Publishing date 2023-03-20
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ISSN 1520-5207
    ISSN (online) 1520-5207
    DOI 10.1021/acs.jpcb.2c08631
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  9. Article ; Online: Assessing appropriate panel size and optimization of quality metrics for ambulatory care pharmacists in the primary care setting.

    Ozbay, Nimet / King, Benjamin S / Gothard, M David / King, Cynthia A

    American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists

    2022  

    Abstract: Disclaimer: In an effort to expedite the publication of articles, AJHP is posting manuscripts online as soon as possible after acceptance. Accepted manuscripts have been peer-reviewed and copyedited, but are posted online before technical formatting and ...

    Abstract Disclaimer: In an effort to expedite the publication of articles, AJHP is posting manuscripts online as soon as possible after acceptance. Accepted manuscripts have been peer-reviewed and copyedited, but are posted online before technical formatting and author proofing. These manuscripts are not the final version of record and will be replaced with the final article (formatted per AJHP style and proofed by the authors) at a later time.
    Purpose: Chronic disease state management utilizing pharmacists improves quality metrics, allows providers to focus on acute issues, and decreases physician burnout risk. Minimal data exist on pharmacist panel size and its impact. This study aimed to determine appropriate pharmacist panel size based on workload, quality metrics, and patient access.
    Methods: This study was a retrospective, multiclinic cohort analysis of patients with diabetes managed by pharmacists at 7 outpatient clinics. The primary objective calculated panel size per full-time equivalent (FTE) utilizing the National Health Interview Survey. Secondary objectives calculated the ideal FTE based on provider to pharmacist ratio and determined the impact of pharmacist panel size on patient access and quality metrics.
    Results: A total of 4,399 patients were analyzed from 2017 through 2019, with age (range, 57.4 to 62.6 years), sex (52.5% to 63.5% female), race (41.2% to 93.7% African American), insurance type (13.3% to 41% Medicaid), and mean number of medications (13.1 to 20.3) significantly different between sites. Primary outcome results showed that actual panel sizes were less than calculated. However, secondary outcomes indicated that each site was understaffed (actual 0.2 to 0.5 FTE vs calculated 2.52 to 7.34 FTEs) and overbooked (95% to 122% capacity, 17 to 54.2 days for time to third next available appointment). Patients met the composite quality metric 35.1% to 56.3% of the time across sites.
    Conclusion: This study supports the use of patient access data to determine appropriate pharmacist panel size. Utilizing provider panel size to pharmacist ratio and time to third next available appointment is preferable for determining appropriate pharmacist panel size. Further research is needed to evaluate return times to help determine an ideal pharmacist panel size.
    Language English
    Publishing date 2022-09-27
    Publishing country England
    Document type Journal Article
    ZDB-ID 1224627-x
    ISSN 1535-2900 ; 1079-2082
    ISSN (online) 1535-2900
    ISSN 1079-2082
    DOI 10.1093/ajhp/zxac271
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  10. Article ; Online: Not Just Surface Energy: The Role of Bis(pentafluorophenoxy) Silicon Phthalocyanine Axial Functionalization and Molecular Orientation on Organic Thin-Film Transistor Performance.

    King, Benjamin / Radford, Chase L / Vebber, Mário C / Ronnasi, Bahar / Lessard, Benoît H

    ACS applied materials & interfaces

    2023  

    Abstract: Understanding the effect of surface chemistry on the dielectric-semiconductor interface, thin-film morphology, and molecular alignment enables the optimization of organic thin-film transistors (OTFTs). We explored the properties of thin films of bis( ... ...

    Abstract Understanding the effect of surface chemistry on the dielectric-semiconductor interface, thin-film morphology, and molecular alignment enables the optimization of organic thin-film transistors (OTFTs). We explored the properties of thin films of bis(pentafluorophenoxy) silicon phthalocyanine (
    Language English
    Publishing date 2023-03-10
    Publishing country United States
    Document type Journal Article
    ISSN 1944-8252
    ISSN (online) 1944-8252
    DOI 10.1021/acsami.2c22789
    Database MEDical Literature Analysis and Retrieval System OnLINE

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