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Article: Gender dynamics on Twitter during the 2020 U.S. Democratic presidential primary.

King, Catherine / Carley, Kathleen M

2023 Volume 13, Issue 1, Page(s) 50

Abstract: The Twitter social network for each of the top five U.S. Democratic presidential candidates in 2020 was analyzed to determine if there were any differences in the treatment of the candidates. This data set was collected from discussions of the ... ...

Abstract	The Twitter social network for each of the top five U.S. Democratic presidential candidates in 2020 was analyzed to determine if there were any differences in the treatment of the candidates. This data set was collected from discussions of the presidential primary between December 2019 through April 2020. It was then separated into five sets, one for each candidate. We found that the most discussed candidates, President Biden and Senator Sanders, received by far the most engagement from verified users and news agencies even before the Iowa caucuses, which was ultimately won by Mayor Buttigieg. The most popular candidates were also generally targeted more frequently by bots, trolls, and other aggressive users. However, the abusive language targeting the top two female candidates, Senators Warren and Klobuchar, included slightly more gendered and sexist language compared with the other candidates. Additionally, sexist slurs that ordinarily describe women were used more frequently than male slurs in all candidate data sets. Our results indicate that there may still be an undercurrent of sexist stereotypes permeating the social media conversation surrounding female U.S. presidential candidates.
Language	English
Publishing date	2023-03-15
Publishing country	Germany
Document type	Journal Article
ZDB-ID	2595306-0
ISSN	1869-5469 ; 1869-5450
ISSN (online)	1869-5469
ISSN	1869-5450
DOI	10.1007/s13278-023-01045-4
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Article ; Online: Experience of pediatric to adult transition in immunology services: patient experience questionnaire and micro-costing analysis.

King, Catherine / Ridge, Katie / Smyth, James / Flinn, Aisling M / Leahy, Timothy Ronan / Conlon, Niall

Frontiers in immunology

2024 Volume 15, Page(s) 1270451

Abstract: The effective transition from pediatric to adult care for individuals with chronic medical conditions should address the medical, psychosocial and educational needs of the cohort. The views and experiences of service users and their families are an ... ...

Abstract	The effective transition from pediatric to adult care for individuals with chronic medical conditions should address the medical, psychosocial and educational needs of the cohort. The views and experiences of service users and their families are an integral component of service development. This study sought to evaluate the current provision of transition services from pediatric immunology services to adult immunology services for patients with a diagnosis of an inborn error of immunity at St. James's Hospital, Dublin. We gathered patient perspectives on the experience of the transition process using a structured survey. In addition, we adopted a micro-costing technique to estimate the cost of implementing the current standard of care for these patients. Results of a micro-costing analysis suggest that the most significant component of cost in assessing these patients is on laboratory investigation, an area where there is likely significant duplication between pediatric and adult care. Perspectives from patients suggested that the transition period went well for the majority of the cohort and that they felt ready to move to adult services, but the transition was not without complications in areas such as self-advocacy and medication management. The transition process may benefit from enhanced communication and collaboration between pediatric and adult services.
MeSH term(s)	Adult ; Humans ; Child ; Transition to Adult Care ; Hospitals ; Surveys and Questionnaires ; Patient Outcome Assessment
Language	English
Publishing date	2024-03-05
Publishing country	Switzerland
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2606827-8
ISSN	1664-3224 ; 1664-3224
ISSN (online)	1664-3224
ISSN	1664-3224
DOI	10.3389/fimmu.2024.1270451
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Article ; Online: Linear mixed-effects models for predicting sarcoma local recurrence growth rates: Implications for optimal surveillance imaging frequency.

King, Catherine S / Sebro, Ronnie

European journal of radiology

2020 Volume 132, Page(s) 109308

Abstract: Purpose: Sarcomas are rare tumours of mesenchymal origin that are often treated with surgical resection and radiation to prevent local recurrence (LR). Surveillance for LR after surgical resection is often done with contrast-enhanced MRI, however, the ... ...

Abstract	Purpose: Sarcomas are rare tumours of mesenchymal origin that are often treated with surgical resection and radiation to prevent local recurrence (LR). Surveillance for LR after surgical resection is often done with contrast-enhanced MRI, however, the optimal frequency of surveillance imaging is unknown. The aims of this study are to calculate LR growth, and to evaluate the factors that affect LR growth and to use this data to predict the optimal imaging surveillance frequency. Method: Retrospective cohort study of patients with sarcoma who were treated at a tertiary care academic institution between 01/01/2007 and 01/03/2020 identified 34 patients with 60 histologically confirmed LRs. The maximum LR length was measured on each surveillance MRI. Linear mixed-effects models were used to calculate the maximum LR length growth rate. We evaluated whether age, sex, primary sarcoma tumour size, sarcoma grade, margins, chemotherapy or radiation therapy affected the growth rate of the maximum LR length. Results: One patient had 6 LRs (2.9 %), two patients (5.9 %) had 5 LRs, two patients (5.9 %) had 4 LRs, two patients (5.9 %) had 3 LRs, three patients (8.8 %) had 2 LRs, and twenty-four patients (70.6 %) had 1 LR. Most patients had high grade (Grade II/III) disease (88.2 %). 41.2 % of the patients had microscopically positive surgical margins. The median time (range) from surgery to LR was 264 days (17 - 8013) days, and 90 % occurred within 42.8 months (1284 days). Microscopically positive margins were associated with faster growth of the maximum LR length (P = 0.036). Assuming that a 1 cm sarcoma LR is actionable and that the previous surveillance MRI was negative, the data predicts that patients with microscopically positive margins should have surveillance MRIs every 6.2 months when LRs are expected to achieve a length of 1.0 cm (95 % CI (0.4-2.3 cm)). Conclusions: Patients with microscopically positive resection margins had LRs that grew faster than patients with negative margins. Surveillance imaging with contrast-enhanced MRI could be conservatively performed every 6 months when LRs are expected to be just less than 1.0 cm in length.
MeSH term(s)	Humans ; Margins of Excision ; Neoplasm Recurrence, Local/diagnostic imaging ; Retrospective Studies ; Sarcoma/diagnostic imaging ; Soft Tissue Neoplasms
Language	English
Publishing date	2020-09-28
Publishing country	Ireland
Document type	Journal Article
ZDB-ID	138815-0
ISSN	1872-7727 ; 0720-048X
ISSN (online)	1872-7727
ISSN	0720-048X
DOI	10.1016/j.ejrad.2020.109308
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Article ; Online: A qualitative study on COVID-19 pandemic impacts on parental attitudes and intentions for routine adolescent vaccinations: The role of trust

Bolsewicz, Katarzyna T. / Steffens, Maryke S. / King, Catherine / ʻAbdī, Ikrām / Bullivant, Bianca / Beard, Frank

Vaccine. 2023 May 22,

2023

Abstract: The COVID-19 pandemic has contributed to declines in routine childhood and adolescent vaccination coverage globally. While the declines in Australia have been less, they are a concern, given steady increases in coverage prior to the pandemic. Given ... ...

Abstract	The COVID-19 pandemic has contributed to declines in routine childhood and adolescent vaccination coverage globally. While the declines in Australia have been less, they are a concern, given steady increases in coverage prior to the pandemic. Given limited evidence on how the experiences of parents during the pandemic affected their attitudes about and intentions towards adolescent vaccinations, with this study we aimed to explore these. This was a qualitative study. We invited parents of adolescents eligible for school-based vaccinations in 2021 from metropolitan, regional and rural areas of New South Wales and Victoria (the most affected States) and South Australia (less affected) to half hour-long online semi-structured interviews. We analysed data thematically and applied a conceptual model of trust in vaccination. In July 2022 we interviewed 15 accepting, 4 hesitant and two parents who refused adolescent vaccinations. We identified three themes: 1. Pandemic impacting on professional and personal lives and routine immunisations; 2. Pandemic strengthening preexisting vaccine hesitancy, with perceived lack of clarity in governmental information about vaccination and stigma around non-vaccinating as contributing factors; 3. Pandemic raising awareness of the benefits of COVID-19 and routine vaccinations, with communication campaigns and one’s trusted doctor’s vaccination recommendations as contributing factors. For some parents, experiences of poor system readiness and growing distrust towards health and vaccination systems strengthened their pre-existing vaccine hesitancy. We offer recommendations on how trust in the health system and immunisation can be optimised post-pandemic to increase uptake of routine vaccines. These include improving access to vaccination services and clear, timely information about vaccines; supporting immunisation providers in their immunisation consultations; working alongside communities, and building capacity of vaccine champions.
Keywords	COVID-19 infection ; adolescents ; childhood ; models ; pandemic ; qualitative analysis ; stigma ; vaccination ; vaccines ; South Australia
Language	English
Dates of publication	2023-0522
Publishing place	Elsevier Ltd
Document type	Article ; Online
Note	Pre-press version
ZDB-ID	605674-x
ISSN	1873-2518 ; 0264-410X
ISSN (online)	1873-2518
ISSN	0264-410X
DOI	10.1016/j.vaccine.2023.05.037
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Article ; Online: Involvement of endoplasmic reticulum and histone proteins in immunomodulation by TLR4-interacting SPA4 peptide against

Awasthi, Shanjana / Singh, Bhupinder / Ramani, Vijay / Godbole, Nachiket M / King, Catherine

Infection and immunity

2023 Volume 91, Issue 12, Page(s) e0031123

Abstract: Pulmonary host defense is critical for the control of lung infection and inflammation. An increased expression and activity of Toll-like receptor 4 (TLR4) induce phagocytic uptake/clearance and inflammation against Gram-negative bacteria. In this study, ... ...

Abstract	Pulmonary host defense is critical for the control of lung infection and inflammation. An increased expression and activity of Toll-like receptor 4 (TLR4) induce phagocytic uptake/clearance and inflammation against Gram-negative bacteria. In this study, we addressed the mechanistic aspect of the immunomodulatory activity of the TLR4-interacting SPA4 peptide (amino acid sequence GDFRYSDGTPVNYTNWYRGE) against
MeSH term(s)	Humans ; Toll-Like Receptor 4/metabolism ; Escherichia coli/metabolism ; Histones ; Tumor Necrosis Factor-alpha/metabolism ; Calnexin/metabolism ; Inflammation/metabolism ; Endoplasmic Reticulum/metabolism ; Lipopolysaccharides/pharmacology
Chemical Substances	Toll-Like Receptor 4 ; Histones ; Tumor Necrosis Factor-alpha ; Calnexin (139873-08-8) ; Lipopolysaccharides ; TLR4 protein, human
Language	English
Publishing date	2023-11-01
Publishing country	United States
Document type	Journal Article
ZDB-ID	218698-6
ISSN	1098-5522 ; 0019-9567
ISSN (online)	1098-5522
ISSN	0019-9567
DOI	10.1128/iai.00311-23
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Article ; Online: The association between tacrolimus exposure and tremor, headache and insomnia in adult kidney transplant recipients: A systematic review.

King, Catherine P / Cossart, Amelia R / Isbel, Nicole M / Campbell, Scott B / Staatz, Christine E

Transplantation reviews (Orlando, Fla.)

2023 Volume 38, Issue 1, Page(s) 100815

Abstract: Purpose: Tremor, headache and insomnia have been linked to the immunosuppressant, tacrolimus. The aim of this systematic review was to determine if there is a correlation between tacrolimus exposure and new-onset tremor, headache and insomnia ... ...

Abstract	Purpose: Tremor, headache and insomnia have been linked to the immunosuppressant, tacrolimus. The aim of this systematic review was to determine if there is a correlation between tacrolimus exposure and new-onset tremor, headache and insomnia experienced by adult kidney transplant recipients. Methods: PubMed, Embase, Cochrane Library and CINAHL databases were searched up to 11 April 2023 for published studies which reported on tacrolimus exposure in adult kidney transplant recipients, alongside information on treatment-emergent neurologic manifestations, including tremor, headache and insomnia. Review articles, case studies, conference abstracts and articles not published in English in peer-reviewed journals were excluded. The Physiotherapy Evidence Database and Newcastle-Ottawa Quality Assessment Scales were used to assess risk of bias. Extracted data was analysed via a narrative synthesis. Results: Eighteen studies involving 4030 patients in total were included in the final analysis. These comprised five randomised control trials and thirteen observational studies. Studies failed to find significant association between tacrolimus trough concentrations in whole blood and the incidence of neurologic side effects such as tremor, headache and insomnia; however, in one study the incidence of toxicity requiring a dose reduction increased with increasing, supratherapeutic targeted levels. Females, especially Black females, and older age were positively associated with the prevalence of neurologic adverse effects. Results were conflicting regarding whether extended-release formulations were associated with fewer neurologic complications than immediate-release formulations. Conclusion: The varied study designs and criteria for reporting tremor, headache and insomnia impacted on the quality of the data for exploring the relationship between tacrolimus exposure and the onset of neurologic manifestations experienced after kidney transplantation. Studies that examine defined neurologic complications as the primary outcome, and that consider novel markers of tacrolimus exposure while assessing the potential contribution of multiple covariate factors, are required.
MeSH term(s)	Adult ; Female ; Humans ; Headache/chemically induced ; Headache/epidemiology ; Immunosuppressive Agents/adverse effects ; Kidney Transplantation ; Sleep Initiation and Maintenance Disorders/epidemiology ; Sleep Initiation and Maintenance Disorders/chemically induced ; Sleep Initiation and Maintenance Disorders/drug therapy ; Tacrolimus/adverse effects ; Transplant Recipients ; Tremor/chemically induced ; Tremor/epidemiology ; Tremor/drug therapy ; Male
Chemical Substances	Immunosuppressive Agents ; Tacrolimus (WM0HAQ4WNM)
Language	English
Publishing date	2023-12-07
Publishing country	United States
Document type	Systematic Review ; Journal Article ; Review
ZDB-ID	639400-0
ISSN	1557-9816 ; 0955-470X
ISSN (online)	1557-9816
ISSN	0955-470X
DOI	10.1016/j.trre.2023.100815
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Article ; Online: A qualitative study on COVID-19 pandemic impacts on parental attitudes and intentions for routine adolescent vaccinations: The role of trust.

Bolsewicz, Katarzyna T / Steffens, Maryke S / King, Catherine / Abdi, Ikram / Bullivant, Bianca / Beard, Frank

Vaccine

2023 Volume 41, Issue 28, Page(s) 4138–4143

Abstract: Introduction: The COVID-19 pandemic has contributed to declines in routine childhood and adolescent vaccination coverage globally. While the declines in Australia have been less, they are a concern, given steady increases in coverage prior to the ... ...

Abstract	Introduction: The COVID-19 pandemic has contributed to declines in routine childhood and adolescent vaccination coverage globally. While the declines in Australia have been less, they are a concern, given steady increases in coverage prior to the pandemic. Given limited evidence on how the experiences of parents during the pandemic affected their attitudes about and intentions towards adolescent vaccinations, with this study we aimed to explore these. Methods: This was a qualitative study. We invited parents of adolescents eligible for school-based vaccinations in 2021 from metropolitan, regional and rural areas of New South Wales and Victoria (the most affected States) and South Australia (less affected) to half hour-long online semi-structured interviews. We analysed data thematically and applied a conceptual model of trust in vaccination. Results: In July 2022 we interviewed 15 accepting, 4 hesitant and two parents who refused adolescent vaccinations. We identified three themes: 1. Pandemic impacting on professional and personal lives and routine immunisations; 2. Pandemic strengthening preexisting vaccine hesitancy, with perceived lack of clarity in governmental information about vaccination and stigma around non-vaccinating as contributing factors; 3. Pandemic raising awareness of the benefits of COVID-19 and routine vaccinations, with communication campaigns and one's trusted doctor's vaccination recommendations as contributing factors. Conclusions: For some parents, experiences of poor system readiness and growing distrust towards health and vaccination systems strengthened their pre-existing vaccine hesitancy. We offer recommendations on how trust in the health system and immunisation can be optimised post-pandemic to increase uptake of routine vaccines. These include improving access to vaccination services and clear, timely information about vaccines; supporting immunisation providers in their immunisation consultations; working alongside communities, and building capacity of vaccine champions.
MeSH term(s)	Humans ; Adolescent ; Child ; Pandemics/prevention & control ; Intention ; Trust ; COVID-19/prevention & control ; Vaccination ; Vaccines ; Parents ; Victoria ; Health Knowledge, Attitudes, Practice
Chemical Substances	Vaccines
Language	English
Publishing date	2023-05-22
Publishing country	Netherlands
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	605674-x
ISSN	1873-2518 ; 0264-410X
ISSN (online)	1873-2518
ISSN	0264-410X
DOI	10.1016/j.vaccine.2023.05.037
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Article ; Online: Anthropogenic petroleum signatures and biodegradation in subantarctic Macquarie Island soils.

Houlahan, Sarah B / Errington, Ingrid / Hose, Grant C / King, Catherine K / George, Simon C

Chemosphere

2023 Volume 325, Page(s) 138395

Abstract: Special Antarctic Blend (SAB) diesel is the main fuel used on Macquarie Island and has been identified as the primary contaminant in several past spill events. This study evaluates the environmental impact of petroleum spills at high latitudes, in the ... ...

Abstract	Special Antarctic Blend (SAB) diesel is the main fuel used on Macquarie Island and has been identified as the primary contaminant in several past spill events. This study evaluates the environmental impact of petroleum spills at high latitudes, in the soils of subantarctic Macquarie Island. Soil samples were collected from seven locations, including the "fuel farm" and main powerhouse that have been contaminated by petroleum in the past, and five reference locations, away from station infrastructure and from any obvious signs of contamination. Soils were solvent extracted and analysed using gas chromatography-mass spectrometry. The results show that both contaminated and uncontaminated sites contained a suite of different chain-length hydrocarbons. The more contaminated samples from the fuel farm and main powerhouse contained higher concentrations and a greater range of hydrocarbons that typically indicate numerous spills of varying ages. The hydrocarbon signature of samples collected near the fuel farm and at some of the main powerhouse sites was typical of SAB diesel. However, the hydrocarbon signature at other main powerhouse sites suggest contamination with a heavier fuel with different characteristics, including lower pristane/phytane ratios. Traces of C
MeSH term(s)	Petroleum ; Soil/chemistry ; Hydrocarbons/metabolism ; Biodegradation, Environmental ; Fuel Oils
Chemical Substances	Petroleum ; Soil ; Hydrocarbons ; Fuel Oils
Language	English
Publishing date	2023-03-16
Publishing country	England
Document type	Journal Article
ZDB-ID	120089-6
ISSN	1879-1298 ; 0045-6535 ; 0366-7111
ISSN (online)	1879-1298
ISSN	0045-6535 ; 0366-7111
DOI	10.1016/j.chemosphere.2023.138395
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Article ; Online: "I'm scared that if I have the vaccine, it's going to make my lung condition worse, not better." COVID-19 vaccine acceptance in adults with underlying health conditions - A qualitative investigation.

Steffens, Maryke S / Bullivant, Bianca / King, Catherine / Bolsewicz, Katarzyna

Vaccine: X

2022 Volume 12, Page(s) 100243

Abstract: Background: Sustained uptake of COVID-19 vaccines, including booster doses, will continue to be key to minimising morbidity and mortality caused by COVID-19. Because hesitancy can affect people's motivation to get vaccinated, understanding and ... ...

Abstract	Background: Sustained uptake of COVID-19 vaccines, including booster doses, will continue to be key to minimising morbidity and mortality caused by COVID-19. Because hesitancy can affect people's motivation to get vaccinated, understanding and addressing factors influencing acceptance is critical to achieving high uptake. This is especially the case for adults with underlying health conditions, who are at increased risk of severe illness from COVID-19. The aim of this study was to investigate barriers and facilitators of COVID-19 vaccine acceptance in adults with underlying health conditions during the initial rollout of COVID-19 vaccines in Australia. Methods: We conducted semi-structured, qualitative interviews with 15 adults with underlying health conditions in New South Wales (NSW) in April 2021, focusing on their previous vaccination experiences and feelings about COVID-19 vaccination. We categorised participants as accepting, hesitant or refusing. We analysed interviews thematically, informed by the World Health Organization (WHO) Behavioural and Social Drivers of Vaccination framework. Results: Most (12/15) participants were hesitant about COVID-19 vaccination. Barriers to COVID-19 vaccine acceptance included concerns about vaccine safety and effectiveness; heightened perceptions of risk regarding the vaccines; low perceptions of COVID-19 risk; and negative social influences. Facilitators included perceived benefits of vaccination and positive social influences. Conclusions: For some adults with underlying health conditions, perceptions of heightened vulnerability to COVID-19 vaccine side effects contributed to vaccine hesitancy during the initial rollout of COVID-19 vaccines. We recommend supporting GPs and specialists to proactively reach out and recommend COVID-19 vaccination to this population; encouraging chronic disease organisations to act as trusted advocates of COVID-19 vaccination; and actively communicating evolving knowledge about vaccine safety.
Language	English
Publishing date	2022-11-24
Publishing country	England
Document type	Journal Article
ISSN	2590-1362
ISSN (online)	2590-1362
DOI	10.1016/j.jvacx.2022.100243
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Article ; Online: Antimicrobial Resistance Following Prolonged Use of Hand Hygiene Products: A Systematic Review.

Banik, Gouri Rani / Durayb, Bandar / King, Catherine / Rashid, Harunor

Pharmacy (Basel, Switzerland)

2022 Volume 10, Issue 1

Abstract: Background: This systematic review aimed to establish whether antimicrobial resistance (AMR) occurs following prolonged use of antimicrobial hand hygiene (HH) products, and, if so, in what magnitude.: Methods: Key bibliographic databases were ... ...

Abstract	Background: This systematic review aimed to establish whether antimicrobial resistance (AMR) occurs following prolonged use of antimicrobial hand hygiene (HH) products, and, if so, in what magnitude. Methods: Key bibliographic databases were searched to locate items on HH use and AMR development from database inception to December 2020. Records were screened and full texts of all potentially eligible articles were retrieved and checked for inclusion. The following data from the included studies were abstracted: type of HH product used, including the name of antimicrobial agent, study setting, country, study year, duration of use and development of AMR including the organisms involved. Quality assessment was done using the Newcastle-Ottawa Scale (NOS). Results: Of 339 full-text articles assessed for eligibility, only four heterogeneous United States (US) studies conducted in the period between 1986 and 2015 were found eligible, and included. One hospital-based study showed evidence of AMR following long term use of HH products, two studies conducted in household settings showed no evidence of AMR, and another experimental study showed partial evidence of AMR. The overall certainty of the evidence was moderate. Conclusion: Prolonged use of HH products may cause AMR in health care settings, but perhaps not in other settings.
Language	English
Publishing date	2022-01-04
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2737194-3
ISSN	2226-4787 ; 2226-4787
ISSN (online)	2226-4787
ISSN	2226-4787
DOI	10.3390/pharmacy10010009
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