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  1. Book ; Online: Evolving Mechanisms of Disease Tolerance

    Divangahi, Maziar / King, Irah L.

    2020  

    Keywords Medicine ; Immunology ; host defense ; infection ; immunity ; disease tolerance ; tissue damage
    Size 1 electronic resource (183 pages)
    Publisher Frontiers Media SA
    Document type Book ; Online
    Note English ; Open Access
    HBZ-ID HT021230590
    ISBN 9782889634583 ; 2889634582
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  2. Article ; Online: Dangerous liaisons: how helminths manipulate the intestinal epithelium.

    Karo-Atar, Danielle / Gregorieff, Alex / King, Irah L

    Trends in parasitology

    2023  Volume 39, Issue 6, Page(s) 414–422

    Abstract: Intestinal helminths remain highly pervasive throughout the animal kingdom by modulating multiple aspects of the host immune response. The intestinal epithelium functions as a physical barrier as well as a sentinel innate immune tissue with the ability ... ...

    Abstract Intestinal helminths remain highly pervasive throughout the animal kingdom by modulating multiple aspects of the host immune response. The intestinal epithelium functions as a physical barrier as well as a sentinel innate immune tissue with the ability to sense and respond to infectious agents. Although helminths form intimate interactions with the epithelium, comprehensive knowledge about host-helminth interactions at this dynamic interface is lacking. In addition, little is known about the ability of helminths to directly shape the fate of this barrier tissue. Here, we review the diverse pathways by which helminths regulate the epithelium and highlight the emerging field of direct helminth regulation of intestinal stem cell (ISC) fate and function.
    MeSH term(s) Animals ; Intestinal Mucosa ; Helminths ; Intestines/parasitology ; Helminthiasis ; Intestinal Diseases, Parasitic
    Language English
    Publishing date 2023-04-17
    Publishing country England
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 2036227-4
    ISSN 1471-5007 ; 1471-4922
    ISSN (online) 1471-5007
    ISSN 1471-4922
    DOI 10.1016/j.pt.2023.03.012
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Training the metaorganism: the microbial counterpart.

    King, Irah L / Divangahi, Maziar

    Cell

    2021  Volume 184, Issue 3, Page(s) 574–576

    Abstract: Infection or immunization can reprogram innate immune cells generating memory responses with broad protection against subsequent infection, a process referred to as "trained immunity." A new study by Stacy and colleagues demonstrates that, following ... ...

    Abstract Infection or immunization can reprogram innate immune cells generating memory responses with broad protection against subsequent infection, a process referred to as "trained immunity." A new study by Stacy and colleagues demonstrates that, following acute infection, the commensal microbiota can also be "trained" to enhance colonization resistance against heterologous infection.
    MeSH term(s) Humans ; Immunity, Innate ; Immunization ; Infections ; Microbiota ; Symbiosis
    Language English
    Publishing date 2021-02-05
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Comment
    ZDB-ID 187009-9
    ISSN 1097-4172 ; 0092-8674
    ISSN (online) 1097-4172
    ISSN 0092-8674
    DOI 10.1016/j.cell.2021.01.009
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Dangerous liaisons: how helminths manipulate the intestinal epithelium

    Karo-Atar, Danielle / Gregorieff, Alex / King, Irah L.

    Trends in Parasitology. 2023 Apr. 17,

    2023  

    Abstract: Intestinal helminths remain highly pervasive throughout the animal kingdom by modulating multiple aspects of the host immune response. The intestinal epithelium functions as a physical barrier as well as a sentinel innate immune tissue with the ability ... ...

    Abstract Intestinal helminths remain highly pervasive throughout the animal kingdom by modulating multiple aspects of the host immune response. The intestinal epithelium functions as a physical barrier as well as a sentinel innate immune tissue with the ability to sense and respond to infectious agents. Although helminths form intimate interactions with the epithelium, comprehensive knowledge about host–helminth interactions at this dynamic interface is lacking. In addition, little is known about the ability of helminths to directly shape the fate of this barrier tissue. Here, we review the diverse pathways by which helminths regulate the epithelium and highlight the emerging field of direct helminth regulation of intestinal stem cell (ISC) fate and function.
    Keywords animals ; helminths ; immune response ; intestinal mucosa ; parasitology ; stem cells ; intestinal epithelium ; epithelial regeneration ; intestinal organoids ; host defense
    Language English
    Dates of publication 2023-0417
    Publishing place Elsevier Ltd
    Document type Article ; Online
    Note Pre-press version
    ZDB-ID 2036227-4
    ISSN 1471-5007 ; 1471-4922
    ISSN (online) 1471-5007
    ISSN 1471-4922
    DOI 10.1016/j.pt.2023.03.012
    Database NAL-Catalogue (AGRICOLA)

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  5. Article ; Online: Editorial: Evolving Mechanisms of Disease Tolerance.

    King, Irah L / Divangahi, Maziar

    Frontiers in immunology

    2019  Volume 10, Page(s) 2974

    MeSH term(s) Animals ; Biological Evolution ; Disease Resistance/physiology ; Humans
    Language English
    Publishing date 2019-12-20
    Publishing country Switzerland
    Document type Editorial ; Research Support, Non-U.S. Gov't
    ZDB-ID 2606827-8
    ISSN 1664-3224 ; 1664-3224
    ISSN (online) 1664-3224
    ISSN 1664-3224
    DOI 10.3389/fimmu.2019.02974
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: LAG-3- and CXCR5-expressing CD4 T cells display progenitor-like properties during chronic visceral leishmaniasis.

    Swaminathan, Sharada / Mai, Linh Thuy / Meli, Alexandre P / Carmona-Pérez, Liseth / Charpentier, Tania / Lamarre, Alain / King, Irah L / Stäger, Simona

    Cell reports

    2024  Volume 43, Issue 3, Page(s) 113879

    Abstract: Maintenance of CD4 T cells during chronic infections is vital for limiting pathogen burden and disease recrudescence. Although inhibitory receptor expression by CD4 T cells is commonly associated with immune suppression and exhaustion, such cell- ... ...

    Abstract Maintenance of CD4 T cells during chronic infections is vital for limiting pathogen burden and disease recrudescence. Although inhibitory receptor expression by CD4 T cells is commonly associated with immune suppression and exhaustion, such cell-intrinsic mechanisms that control activation are also associated with cell survival. Using a mouse model of visceral leishmaniasis (VL), we discovered a subset of lymphocyte activation gene 3 (LAG-3)-expressing CD4 T cells that co-express CXCR5. Although LAG3
    MeSH term(s) Humans ; CD4-Positive T-Lymphocytes ; Leishmaniasis, Visceral ; T-Lymphocyte Subsets ; Transcription Factors ; Receptors, CXCR5
    Chemical Substances Transcription Factors ; Receptors, CXCR5 ; CXCR5 protein, human
    Language English
    Publishing date 2024-02-27
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2649101-1
    ISSN 2211-1247 ; 2211-1247
    ISSN (online) 2211-1247
    ISSN 2211-1247
    DOI 10.1016/j.celrep.2024.113879
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Host-Parasite Interactions Promote Disease Tolerance to Intestinal Helminth Infection.

    King, Irah L / Li, Yue

    Frontiers in immunology

    2018  Volume 9, Page(s) 2128

    Abstract: Parasitic helminths are among the most pervasive pathogens of the animal kingdom. To complete their life cycle, these intestinal worms migrate through host tissues causing significant damage in their wake. As a result, infection can lead to malnutrition, ...

    Abstract Parasitic helminths are among the most pervasive pathogens of the animal kingdom. To complete their life cycle, these intestinal worms migrate through host tissues causing significant damage in their wake. As a result, infection can lead to malnutrition, anemia and increased susceptibility to co-infection. Despite repeated deworming treatment, individuals living in endemic regions remain highly susceptible to re-infection by helminths, but rarely succumb to excessive tissue damage. The chronicity of infection and inability to resist numerous species of parasitic helminths that have co-evolved with their hosts over millenia suggests that mammals have developed mechanisms to tolerate this infectious disease. Distinct from resistance where the goal is to destroy and eliminate the pathogen, disease tolerance is an active process whereby immune and structural cells restrict tissue damage to maintain host fitness without directly affecting pathogen burden. Although disease tolerance is evolutionary conserved and has been well-described in plant systems, only recently has this mode of host defense, in its strictest sense, begun to be explored in mammals. In this review, we will examine the inter- and intracellular networks that support disease tolerance during enteric stages of parasitic helminth infection and why this alternative host defense strategy may have evolved to endure the presence of non-replicating pathogens and maintain the essential functions of the intestine.
    MeSH term(s) Animals ; Asymptomatic Infections/mortality ; Biological Evolution ; Chronic Disease/mortality ; Disease Resistance/immunology ; Disease Susceptibility/immunology ; Disease Susceptibility/parasitology ; Gastrointestinal Microbiome/immunology ; Helminthiasis/immunology ; Helminthiasis/mortality ; Helminthiasis/parasitology ; Helminths/immunology ; Helminths/isolation & purification ; Host-Parasite Interactions/immunology ; Humans ; Intestinal Diseases, Parasitic/immunology ; Intestinal Diseases, Parasitic/mortality ; Intestinal Diseases, Parasitic/parasitology ; Intestines/immunology ; Intestines/microbiology ; Intestines/parasitology ; Parasite Load ; Survival Rate
    Language English
    Publishing date 2018-09-20
    Publishing country Switzerland
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 2606827-8
    ISSN 1664-3224 ; 1664-3224
    ISSN (online) 1664-3224
    ISSN 1664-3224
    DOI 10.3389/fimmu.2018.02128
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Blood and guts: The intestinal vasculature during health and helminth infection.

    Gentile, Maria E / King, Irah L

    PLoS pathogens

    2018  Volume 14, Issue 7, Page(s) e1007045

    MeSH term(s) Animals ; Gastrointestinal Tract/blood supply ; Gastrointestinal Tract/physiology ; Helminthiasis/physiopathology ; Humans ; Intestinal Diseases, Parasitic/physiopathology
    Language English
    Publishing date 2018-07-19
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2205412-1
    ISSN 1553-7374 ; 1553-7366
    ISSN (online) 1553-7374
    ISSN 1553-7366
    DOI 10.1371/journal.ppat.1007045
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: An introduction to the microbiome and MS.

    Trott, Sebastien / King, Irah L

    Multiple sclerosis (Houndmills, Basingstoke, England)

    2018  Volume 24, Issue 1, Page(s) 53–57

    Abstract: The human microbiota is composed of diverse forms of microorganisms that live on or in us and plays a crucial role in the health and development. Commensal species that reside in the intestine particularly influence host physiology at local and systemic ... ...

    Abstract The human microbiota is composed of diverse forms of microorganisms that live on or in us and plays a crucial role in the health and development. Commensal species that reside in the intestine particularly influence host physiology at local and systemic levels. Multiple sclerosis (MS) is a debilitating autoimmune disorder of the central nervous system for which there is currently no cure. While the cause of MS is unknown, there is a growing body of evidence suggesting that the microbiota can play both pathogenic and protective roles in disease progression. In this review, we provide a brief overview, based on both animal and clinical studies, of the current understanding by which the microbiota may influence MS and discuss opportunities for therapeutic intervention that may alleviate the symptoms associated with this debilitating neuroimmunological disease.
    MeSH term(s) Animals ; Gastrointestinal Microbiome/immunology ; Humans ; Multiple Sclerosis/microbiology
    Language English
    Publishing date 2018-01-05
    Publishing country England
    Document type Journal Article
    ZDB-ID 1290669-4
    ISSN 1477-0970 ; 1352-4585
    ISSN (online) 1477-0970
    ISSN 1352-4585
    DOI 10.1177/1352458517737391
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Helminth-mediated disease tolerance in TB: A role for microbiota?

    Karo-Atar, Danielle / Khan, Nargis / Divangahi, Maziar / King, Irah L

    PLoS pathogens

    2021  Volume 17, Issue 7, Page(s) e1009690

    MeSH term(s) Animals ; Coinfection ; Gastrointestinal Microbiome ; Helminthiasis/complications ; Helminthiasis/microbiology ; Humans ; Tuberculosis/complications ; Tuberculosis/microbiology
    Language English
    Publishing date 2021-07-15
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 2205412-1
    ISSN 1553-7374 ; 1553-7366
    ISSN (online) 1553-7374
    ISSN 1553-7366
    DOI 10.1371/journal.ppat.1009690
    Database MEDical Literature Analysis and Retrieval System OnLINE

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