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  1. Article ; Online: Impact on time to active antimicrobial therapy with 24-hour pharmacist review of Accelerate Pheno BC Kit results.

    Kinn, Patrick M / Ford, Bradley / Percival, Kelly M / Weiner, Lukasz / Ince, Dilek

    Antimicrobial stewardship & healthcare epidemiology : ASHE

    2022  Volume 2, Issue 1, Page(s) e132

    Abstract: The Accelerate Pheno platform provides rapid identification and susceptibility data. We demonstrate successful incorporation of 24-hour pharmacist review of Accelerate Pheno results that reduced the number of patients going >3 hours from result without ... ...

    Abstract The Accelerate Pheno platform provides rapid identification and susceptibility data. We demonstrate successful incorporation of 24-hour pharmacist review of Accelerate Pheno results that reduced the number of patients going >3 hours from result without an order for active antimicrobial therapy from 29 (2.8%) of 1,043 to 9 (0.85%) of 1,053 (
    Language English
    Publishing date 2022-08-05
    Publishing country England
    Document type Journal Article
    ISSN 2732-494X
    ISSN (online) 2732-494X
    DOI 10.1017/ash.2022.274
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: In vitro evaluation of meropenem-vaborbactam against clinical CRE isolates at a tertiary care center with low KPC-mediated carbapenem resistance.

    Kinn, Patrick M / Chen, Derrick J / Gihring, Thomas M / Schulz, Lucas T / Fox, Barry C / McCreary, Erin K / Lepak, Alexander J

    Diagnostic microbiology and infectious disease

    2018  Volume 93, Issue 3, Page(s) 258–260

    Abstract: The in vitro activity of meropenem-vaborbactam was examined against clinical carbapenem-resistant Enterobacteriaceae isolates collected over 3 years at our medical center. Only 3 KPC-producers were identified. Susceptibility to meropenem-vaborbactam was ... ...

    Abstract The in vitro activity of meropenem-vaborbactam was examined against clinical carbapenem-resistant Enterobacteriaceae isolates collected over 3 years at our medical center. Only 3 KPC-producers were identified. Susceptibility to meropenem-vaborbactam was noted in 15/16 (94%) isolates (MIC
    MeSH term(s) Anti-Bacterial Agents/pharmacology ; Bacterial Proteins/metabolism ; Boronic Acids/pharmacology ; Carbapenem-Resistant Enterobacteriaceae/drug effects ; Carbapenem-Resistant Enterobacteriaceae/enzymology ; Carbapenem-Resistant Enterobacteriaceae/isolation & purification ; Drug Combinations ; Drug Resistance, Bacterial/drug effects ; Enterobacteriaceae Infections/epidemiology ; Enterobacteriaceae Infections/microbiology ; Humans ; Meropenem/pharmacology ; Microbial Sensitivity Tests ; Tertiary Care Centers ; Wisconsin/epidemiology ; beta-Lactamase Inhibitors/pharmacology ; beta-Lactamases/metabolism
    Chemical Substances Anti-Bacterial Agents ; Bacterial Proteins ; Boronic Acids ; Drug Combinations ; beta-Lactamase Inhibitors ; vaborbactam (1C75676F8V) ; beta-Lactamases (EC 3.5.2.6) ; Meropenem (FV9J3JU8B1)
    Language English
    Publishing date 2018-10-04
    Publishing country United States
    Document type Journal Article
    ZDB-ID 604920-5
    ISSN 1879-0070 ; 0732-8893
    ISSN (online) 1879-0070
    ISSN 0732-8893
    DOI 10.1016/j.diagmicrobio.2018.09.017
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1845: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  3. Article ; Online: Real-World Impact of the Accelerate PhenoTest BC Kit on Patients With Bloodstream Infections in the Improving Outcomes and Antimicrobial Stewardship Study: A Quasiexperimental Multicenter Study.

    Bhalodi, Amira A / MacVane, Shawn H / Ford, Bradley / Ince, Dilek / Kinn, Patrick M / Percival, Kelly M / Bremmer, Derek N / Carr, Dustin R / Walsh, Thomas L / Bhatti, Micah M / Shelburne, Samuel A / Humphries, Romney M / Wolfe, Kaleb / Rosenbaum, Eric R / Dare, Ryan K / Kolev, Johann / Madhusudhan, Meghan / Ben-Aderet, Michael A / Morgan, Margie A

    Clinical infectious diseases : an official publication of the Infectious Diseases Society of America

    2021  Volume 75, Issue 2, Page(s) 269–277

    Abstract: Background: Bloodstream infections (BSIs) are a leading cause of morbidity and mortality. The Improving Outcomes and Antimicrobial Stewardship study seeks to evaluate the impact of the Accelerate PhenoTest BC Kit (AXDX) on antimicrobial use and clinical ...

    Abstract Background: Bloodstream infections (BSIs) are a leading cause of morbidity and mortality. The Improving Outcomes and Antimicrobial Stewardship study seeks to evaluate the impact of the Accelerate PhenoTest BC Kit (AXDX) on antimicrobial use and clinical outcomes in BSIs.
    Methods: This multicenter, quasiexperimental study compared clinical and antimicrobial stewardship metrics, prior to and after implementation of AXDX, to evaluate the impact this technology has on patients with BSIs. Laboratory and clinical data from hospitalized patients with BSIs (excluding contaminants) were compared between 2 arms, 1 that underwent testing on AXDX (post-AXDX) and 1 that underwent alternative organism identification and susceptibility testing (pre-AXDX). The primary outcomes were time to optimal therapy (TTOT) and 30-day mortality.
    Results: A total of 854 patients with BSIs (435 pre-AXDX, 419 post-AXDX) were included. Median TTOT was 17.2 hours shorter in the post-AXDX arm (23.7 hours) compared with the pre-AXDX arm (40.9 hours; P<.0001). Compared with pre-AXDX, median time to first antimicrobial modification (24.2 vs 13.9 hours; P<.0001) and first antimicrobial deescalation (36.0 vs 27.2 hours; P=.0004) were shorter in the post-AXDX arm. Mortality (8.7% pre-AXDX vs 6.0% post-AXDX), length of stay (7.0 pre-AXDX vs 6.5 days post-AXDX), and adverse drug events were not significantly different between arms. Length of stay was shorter in the post-AXDX arm (5.4 vs 6.4 days; P=.03) among patients with gram-negative bacteremia.
    Conclusions: For BSIs, use of AXDX was associated with significant decreases in TTOT, first antimicrobial modification, and time to antimicrobial deescalation.
    MeSH term(s) Anti-Bacterial Agents/therapeutic use ; Anti-Infective Agents/therapeutic use ; Antimicrobial Stewardship ; Bacteremia/diagnosis ; Bacteremia/drug therapy ; Gram-Negative Bacterial Infections/drug therapy ; Humans
    Chemical Substances Anti-Bacterial Agents ; Anti-Infective Agents
    Language English
    Publishing date 2021-10-25
    Publishing country United States
    Document type Journal Article ; Multicenter Study ; Research Support, Non-U.S. Gov't
    ZDB-ID 1099781-7
    ISSN 1537-6591 ; 1058-4838
    ISSN (online) 1537-6591
    ISSN 1058-4838
    DOI 10.1093/cid/ciab921
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1505: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)
    Zs.MO 480: Show issues

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  4. Article ; Online: Age-dependent variation in cytokines, chemokines, and biologic analytes rinsed from the surface of healthy human skin.

    Kinn, Patrick M / Holdren, Grant O / Westermeyer, Brittney A / Abuissa, Mousa / Fischer, Carol L / Fairley, Janet A / Brogden, Kim A / Brogden, Nicole K

    Scientific reports

    2015  Volume 5, Page(s) 10472

    Abstract: In the skin, aging is associated with overall epidermal thinning, decreased barrier function, and gradual deterioration of the epidermal immune response. However, the presence and role of cytokines, chemokines, and biologic analytes (CCBAs) in ... ...

    Abstract In the skin, aging is associated with overall epidermal thinning, decreased barrier function, and gradual deterioration of the epidermal immune response. However, the presence and role of cytokines, chemokines, and biologic analytes (CCBAs) in immunosenescence are not known. Here we identified age-related changes in skin properties and CCBAs from stratum corneum of healthy human subjects, providing a means to utilize CCBAs as benchmarks for aging skin health. Transepidermal water loss and a(*) (skin redness) decreased in an age-dependent manner, and were significantly lower (p < 0.05) in Groups 2 (56.6 ± 4.6 years) and 3 (72.9 ± 3.0 years) vs. Group 1 (24.3 ± 2.8 years). In skin wash fluid, 48 CCBAs were detected; seven were significantly lower (p < 0.05) in Groups 2 and 3: EGF, FGF-2, IFNα2, IL-1RA, HSA, keratin-6, and involucrin; cortisol was significantly higher (p < 0.05) in Groups 2 and 3. Our results correspond with the pro-inflammatory shift that occurs with immunosenescence and also provides basis for understanding the inflammatory changes in normal aging skin.
    MeSH term(s) Adolescent ; Adult ; Age Factors ; Aged ; Aged, 80 and over ; Biological Products/metabolism ; Chemokines/metabolism ; Cytokines/metabolism ; Healthy Volunteers ; Humans ; Middle Aged ; Skin/metabolism ; Skin/pathology ; Skin Aging/pathology ; Skin Aging/physiology ; Young Adult
    Chemical Substances Biological Products ; Chemokines ; Cytokines
    Language English
    Publishing date 2015-06-02
    Publishing country England
    Document type Journal Article
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/srep10472
    Database MEDical Literature Analysis and Retrieval System OnLINE

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