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  1. Article ; Online: Contextual drive of neuronal responses in mouse V1 in the absence of feedforward input.

    Kirchberger, Lisa / Mukherjee, Sreedeep / Self, Matthew W / Roelfsema, Pieter R

    Science advances

    2023  Volume 9, Issue 3, Page(s) eadd2498

    Abstract: Neurons in the primary visual cortex (V1) respond to stimuli in their receptive field (RF), which is defined by the feedforward input from the retina. However, V1 neurons are also sensitive to contextual information outside their RF, even if the RF ... ...

    Abstract Neurons in the primary visual cortex (V1) respond to stimuli in their receptive field (RF), which is defined by the feedforward input from the retina. However, V1 neurons are also sensitive to contextual information outside their RF, even if the RF itself is unstimulated. Here, we examined the cortical circuits for V1 contextual responses to gray disks superimposed on different backgrounds. Contextual responses began late and were strongest in the feedback-recipient layers of V1. They differed between the three main classes of inhibitory neurons, with particularly strong contextual drive of VIP neurons, indicating a contribution of disinhibitory circuits to contextual drive. Contextual drive was strongest when the gray disk was perceived as figure, occluding its background, rather than a hole. Our results link contextual drive in V1 to perceptual organization and provide previously unknown insight into how recurrent processing shapes the response of sensory neurons to facilitate figure perception.
    MeSH term(s) Mice ; Animals ; Visual Cortex/physiology ; Neurons/physiology ; Retina ; Neurons, Afferent ; Orientation/physiology ; Visual Perception/physiology ; Photic Stimulation/methods
    Language English
    Publishing date 2023-01-20
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2810933-8
    ISSN 2375-2548 ; 2375-2548
    ISSN (online) 2375-2548
    ISSN 2375-2548
    DOI 10.1126/sciadv.add2498
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Involvement of superior colliculus in complex figure detection of mice.

    Cazemier, J Leonie / Haak, Robin / Tran, T K Loan / Hsu, Ann T Y / Husic, Medina / Peri, Brandon D / Kirchberger, Lisa / Self, Matthew W / Roelfsema, Pieter / Heimel, J Alexander

    eLife

    2024  Volume 13

    Abstract: Object detection is an essential function of the visual system. Although the visual cortex plays an important role in object detection, the superior colliculus can support detection when the visual cortex is ablated or silenced. Moreover, it has been ... ...

    Abstract Object detection is an essential function of the visual system. Although the visual cortex plays an important role in object detection, the superior colliculus can support detection when the visual cortex is ablated or silenced. Moreover, it has been shown that superficial layers of mouse SC (sSC) encode visual features of complex objects, and that this code is not inherited from the primary visual cortex. This suggests that mouse sSC may provide a significant contribution to complex object vision. Here, we use optogenetics to show that mouse sSC is involved in figure detection based on differences in figure contrast, orientation, and phase. Additionally, our neural recordings show that in mouse sSC, image elements that belong to a figure elicit stronger activity than those same elements when they are part of the background. The discriminability of this neural code is higher for correct trials than for incorrect trials. Our results provide new insight into the behavioral relevance of the visual processing that takes place in sSC.
    MeSH term(s) Animals ; Mice ; Superior Colliculi ; Optogenetics ; Visual Cortex ; Visual Perception
    Language English
    Publishing date 2024-01-25
    Publishing country England
    Document type Journal Article
    ZDB-ID 2687154-3
    ISSN 2050-084X ; 2050-084X
    ISSN (online) 2050-084X
    ISSN 2050-084X
    DOI 10.7554/eLife.83708
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Mouse visual cortex contains a region of enhanced spatial resolution.

    van Beest, Enny H / Mukherjee, Sreedeep / Kirchberger, Lisa / Schnabel, Ulf H / van der Togt, Chris / Teeuwen, Rob R M / Barsegyan, Areg / Meyer, Arne F / Poort, Jasper / Roelfsema, Pieter R / Self, Matthew W

    Nature communications

    2021  Volume 12, Issue 1, Page(s) 4029

    Abstract: The representation of space in mouse visual cortex was thought to be relatively uniform. Here we reveal, using population receptive-field (pRF) mapping techniques, that mouse visual cortex contains a region in which pRFs are considerably smaller. This ... ...

    Abstract The representation of space in mouse visual cortex was thought to be relatively uniform. Here we reveal, using population receptive-field (pRF) mapping techniques, that mouse visual cortex contains a region in which pRFs are considerably smaller. This region, the "focea," represents a location in space in front of, and slightly above, the mouse. Using two-photon imaging we show that the smaller pRFs are due to lower scatter of receptive-fields at the focea and an over-representation of binocular regions of space. We show that receptive-fields of single-neurons in areas LM and AL are smaller at the focea and that mice have improved visual resolution in this region of space. Furthermore, freely moving mice make compensatory eye-movements to hold this region in front of them. Our results indicate that mice have spatial biases in their visual processing, a finding that has important implications for the use of the mouse model of vision.
    MeSH term(s) Animals ; Eye Movements/physiology ; Female ; Head Movements/physiology ; Male ; Mice ; Mice, Inbred C57BL ; Photic Stimulation ; Visual Cortex/physiology ; Visual Fields/physiology ; Visual Perception/physiology
    Language English
    Publishing date 2021-06-29
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2553671-0
    ISSN 2041-1723 ; 2041-1723
    ISSN (online) 2041-1723
    ISSN 2041-1723
    DOI 10.1038/s41467-021-24311-5
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: The essential role of recurrent processing for figure-ground perception in mice.

    Kirchberger, Lisa / Mukherjee, Sreedeep / Schnabel, Ulf H / van Beest, Enny H / Barsegyan, Areg / Levelt, Christiaan N / Heimel, J Alexander / Lorteije, Jeannette A M / van der Togt, Chris / Self, Matthew W / Roelfsema, Pieter R

    Science advances

    2021  Volume 7, Issue 27

    Abstract: The segregation of figures from the background is an important step in visual perception. In primary visual cortex, figures evoke stronger activity than backgrounds during a delayed phase of the neuronal responses, but it is unknown how this figure- ... ...

    Abstract The segregation of figures from the background is an important step in visual perception. In primary visual cortex, figures evoke stronger activity than backgrounds during a delayed phase of the neuronal responses, but it is unknown how this figure-ground modulation (FGM) arises and whether it is necessary for perception. Here, we show, using optogenetic silencing in mice, that the delayed V1 response phase is necessary for figure-ground segregation. Neurons in higher visual areas also exhibit FGM and optogenetic silencing of higher areas reduced FGM in V1. In V1, figures elicited higher activity of vasoactive intestinal peptide-expressing (VIP) interneurons than the background, whereas figures suppressed somatostatin-positive interneurons, resulting in an increased activation of pyramidal cells. Optogenetic silencing of VIP neurons reduced FGM in V1, indicating that disinhibitory circuits contribute to FGM. Our results provide insight into how lower and higher areas of the visual cortex interact to shape visual perception.
    Language English
    Publishing date 2021-06-30
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2810933-8
    ISSN 2375-2548 ; 2375-2548
    ISSN (online) 2375-2548
    ISSN 2375-2548
    DOI 10.1126/sciadv.abe1833
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Activity in Lateral Visual Areas Contributes to Surround Suppression in Awake Mouse V1.

    Vangeneugden, Joris / van Beest, Enny H / Cohen, Michael X / Lorteije, Jeannette A M / Mukherjee, Sreedeep / Kirchberger, Lisa / Montijn, Jorrit S / Thamizharasu, Premnath / Camillo, Daniela / Levelt, Christiaan N / Roelfsema, Pieter R / Self, Matthew W / Heimel, J Alexander

    Current biology : CB

    2019  Volume 29, Issue 24, Page(s) 4268–4275.e7

    Abstract: Neuronal response to sensory stimuli depends on the context. The response in primary visual cortex (V1), for instance, is reduced when a stimulus is surrounded by a similar stimulus [1-3]. The source of this surround suppression is partially known. In ... ...

    Abstract Neuronal response to sensory stimuli depends on the context. The response in primary visual cortex (V1), for instance, is reduced when a stimulus is surrounded by a similar stimulus [1-3]. The source of this surround suppression is partially known. In mouse, local horizontal integration by somatostatin-expressing interneurons contributes to surround suppression [4]. In primates, however, surround suppression arises too quickly to come from local horizontal integration alone, and myelinated axons from higher visual areas, where cells have larger receptive fields, are thought to provide additional surround suppression [5, 6]. Silencing higher visual areas indeed decreased surround suppression in the awake primate by increasing responses to large stimuli [7, 8], although not under anesthesia [9, 10]. In smaller mammals, like mice, fast surround suppression could be possible without feedback. Recent studies revealed a small reduction in V1 responses when silencing higher areas [11, 12] but have not investigated surround suppression. To determine whether higher visual areas contribute to V1 surround suppression, even when this is not necessary for fast processing, we inhibited the areas lateral to V1, particularly the lateromedial area (LM), a possible homolog of primate V2 [13], while recording in V1 of awake and anesthetized mice. We found that part of the surround suppression depends on activity from lateral visual areas in the awake, but not anesthetized, mouse. Inhibiting the lateral visual areas specifically increased responses in V1 to large stimuli. We present a model explaining how excitatory feedback to V1 can have these suppressive effects for large stimuli.
    MeSH term(s) Animals ; Male ; Mice ; Mice, Transgenic ; Neural Inhibition/physiology ; Neurons/physiology ; Orientation/physiology ; Photic Stimulation/methods ; Visual Cortex/metabolism ; Visual Cortex/physiology ; Visual Fields ; Visual Pathways/physiology ; Visual Perception/physiology ; Wakefulness/physiology
    Language English
    Publishing date 2019-11-27
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1071731-6
    ISSN 1879-0445 ; 0960-9822
    ISSN (online) 1879-0445
    ISSN 0960-9822
    DOI 10.1016/j.cub.2019.10.037
    Database MEDical Literature Analysis and Retrieval System OnLINE

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