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  1. Book ; Thesis: Analyse der Antigenpräsentation und der spezifischen T-Helfer-Zell-Reaktion bei intestinalen Immunantworten

    Kirchhoff, Dennis

    2009  

    Author's details von Dennis Kirchhoff
    Language German
    Size 102 S. : graph. Darst.
    Publishing country Germany
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Berlin, Humboldt-Univ., Diss., 2009
    HBZ-ID HT016365931
    Database Catalogue ZB MED Medicine, Health

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    Shelf markLoan statusLocation
    2010 D 364 order for loan Magazin

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  2. Book ; Thesis: Analyse der Antigenpräsentation und der spezifischen T Helfer Zell-Reaktion bei intestinalen Immunantworten

    Kirchhoff, Dennis

    2009  

    Author's details von Dennis Kirchhoff
    Language German
    Size 102 S., Ill., graph. Darst., 21 cm
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Humboldt-Univ., Diss.--Berlin, 2009
    Database Former special subject collection: coastal and deep sea fishing

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  3. Book ; Thesis: Bewertung von betrieblichen Pensionszusagen

    Kirchhoff, Dennis

    bei besonderer Beachtung stochastischer Lebenserwartung

    (Schriftenreihe QM ; 19)

    2009  

    Author's details Dennis Kirchhoff
    Series title Schriftenreihe QM ; 19
    Keywords Pensionsrückstellung ; Lebenserwartung ; Teilwert ; Versicherungsmathematik ; Bilanz ; Betriebliche Altersversorgung ; Bilanzielle Bewertung ; Sterblichkeit ; Stochastischer Prozess ; Pensionsverpflichtungen ; Simulation ; Theorie ; Deutschland
    Language German
    Size XXIX, 403 S., graph. Darst., 210 mm x 148 mm, 534 gr.
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Zugl.: Bielefeld, Univ., Diss., 2009
    ISBN 9783830045069 ; 3830045069
    Database ECONomics Information System

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  4. Article ; Online: Parallel single-cell and bulk transcriptome analyses reveal key features of the gastric tumor microenvironment.

    Kang, Boxi / Camps, Jordi / Fan, Biao / Jiang, Hongpeng / Ibrahim, Mahmoud M / Hu, Xueda / Qin, Shishang / Kirchhoff, Dennis / Chiang, Derek Y / Wang, Shan / Ye, Yingjiang / Shen, Zhanlong / Bu, Zhaode / Zhang, Zemin / Roider, Helge G

    Genome biology

    2022  Volume 23, Issue 1, Page(s) 265

    Abstract: Background: The tumor microenvironment (TME) has been shown to strongly influence treatment outcome for cancer patients in various indications and to influence the overall survival. However, the cells forming the TME in gastric cancer have not been ... ...

    Abstract Background: The tumor microenvironment (TME) has been shown to strongly influence treatment outcome for cancer patients in various indications and to influence the overall survival. However, the cells forming the TME in gastric cancer have not been extensively characterized.
    Results: We combine bulk and single-cell RNA sequencing from tumors and matched normal tissue of 24 treatment-naïve GC patients to better understand which cell types and transcriptional programs are associated with malignant transformation of the stomach. Clustering 96,623 cells of non-epithelial origin reveals 81 well-defined TME cell types. We find that activated fibroblasts and endothelial cells are most prominently overrepresented in tumors. Intercellular network reconstruction and survival analysis of an independent cohort imply the importance of these cell types together with immunosuppressive myeloid cell subsets and regulatory T cells in establishing an immunosuppressive microenvironment that correlates with worsened prognosis and lack of response in anti-PD1-treated patients. In contrast, we find a subset of IFNγ activated T cells and HLA-II expressing macrophages that are linked to treatment response and increased overall survival.
    Conclusions: Our gastric cancer single-cell TME compendium together with the matched bulk transcriptome data provides a unique resource for the identification of new potential biomarkers for patient stratification. This study helps further to elucidate the mechanism of gastric cancer and provides insights for therapy.
    MeSH term(s) Humans ; Stomach Neoplasms/genetics ; Endothelial Cells ; Tumor Microenvironment ; Gene Expression Profiling ; Transcriptome ; Single-Cell Analysis
    Language English
    Publishing date 2022-12-22
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2040529-7
    ISSN 1474-760X ; 1474-760X
    ISSN (online) 1474-760X
    ISSN 1474-760X
    DOI 10.1186/s13059-022-02828-2
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: IL3RA-Targeting Antibody-Drug Conjugate BAY-943 with a Kinesin Spindle Protein Inhibitor Payload Shows Efficacy in Preclinical Models of Hematologic Malignancies.

    Kirchhoff, Dennis / Stelte-Ludwig, Beatrix / Lerchen, Hans-Georg / Wengner, Antje Margret / Ahsen, Oliver von / Buchmann, Pascale / Märsch, Stephan / Mahlert, Christoph / Greven, Simone / Dietz, Lisa / Erkelenz, Michael / Zierz, Ruprecht / Johanssen, Sandra / Mumberg, Dominik / Sommer, Anette

    Cancers

    2020  Volume 12, Issue 11

    Abstract: IL3RA (CD123) is the alpha subunit of the interleukin 3 (IL-3) receptor, which regulates the proliferation, survival, and differentiation of hematopoietic cells. IL3RA is frequently expressed in acute myeloid leukemia (AML) and classical Hodgkin lymphoma ...

    Abstract IL3RA (CD123) is the alpha subunit of the interleukin 3 (IL-3) receptor, which regulates the proliferation, survival, and differentiation of hematopoietic cells. IL3RA is frequently expressed in acute myeloid leukemia (AML) and classical Hodgkin lymphoma (HL), presenting an opportunity to treat AML and HL with an IL3RA-directed antibody-drug conjugate (ADC). Here, we describe BAY-943 (IL3RA-ADC), a novel IL3RA-targeting ADC consisting of a humanized anti-IL3RA antibody conjugated to a potent proprietary kinesin spindle protein inhibitor (KSPi). In vitro, IL3RA-ADC showed potent and selective antiproliferative efficacy in a panel of IL3RA-expressing AML and HL cell lines. In vivo, IL3RA-ADC improved survival and reduced tumor burden in IL3RA-positive human AML cell line-derived (MOLM-13 and MV-4-11) as well as in patient-derived xenograft (PDX) models (AM7577 and AML11655) in mice. Furthermore, IL3RA-ADC induced complete tumor remission in 12 out of 13 mice in an IL3RA-positive HL cell line-derived xenograft model (HDLM-2). IL3RA-ADC was well-tolerated and showed no signs of thrombocytopenia, neutropenia, or liver toxicity in rats, or in cynomolgus monkeys when dosed up to 20 mg/kg. Overall, the preclinical results support the further development of BAY-943 as an innovative approach for the treatment of IL3RA-positive hematologic malignancies.
    Language English
    Publishing date 2020-11-20
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2527080-1
    ISSN 2072-6694
    ISSN 2072-6694
    DOI 10.3390/cancers12113464
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Mast cells in endometriosis: guilty or innocent bystanders?

    Kirchhoff, Dennis / Kaulfuss, Stefan / Fuhrmann, Ulrike / Maurer, Marcus / Zollner, Thomas M

    Expert opinion on therapeutic targets

    2012  Volume 16, Issue 3, Page(s) 237–241

    Abstract: Endometriosis (EMS) is a chronic, estrogen-dependent inflammatory disease characterized by growth of endometrial tissue outside the uterine cavity. Symptoms in EMS patients include severe pelvic pain, dysmenorrhea, dyspareunia and infertility. To date, ... ...

    Abstract Endometriosis (EMS) is a chronic, estrogen-dependent inflammatory disease characterized by growth of endometrial tissue outside the uterine cavity. Symptoms in EMS patients include severe pelvic pain, dysmenorrhea, dyspareunia and infertility. To date, medical therapies are mostly based on hormonal suppressive drugs that induce a hypoestrogenic state. Although being effective regarding the reduction of endometriotic tissue masses and pelvic pain, this treatment is accompanied by severe side effects. Since EMS is associated with chronic inflammation, novel therapeutic strategies also focus on immune modulating drugs. However, little is known about how and to what extent immune cell subsets contribute to the network of locally produced cytokines, chemokines and other mitogenic factors that modulate the growth of ectopic endometrial implants and the inflammation associated with them. Mast cells (MCs) are known to be key players of the immune system, especially during allergic reactions. However, in recent years MCs have been identified to exhibit a far broader range of functions and to be involved in host defense and wound healing responses. Here, recent reports that imply an involvement of MCs in EMS has been reviewed, while the value of novel mouse models for clarifying their contribution to the pathology of this condition has been discussed.
    MeSH term(s) Animals ; Endometriosis/metabolism ; Estrogens/metabolism ; Female ; Humans ; Inflammation/metabolism ; Mast Cells/metabolism
    Chemical Substances Estrogens
    Language English
    Publishing date 2012-03
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2055208-7
    ISSN 1744-7631 ; 1472-8222
    ISSN (online) 1744-7631
    ISSN 1472-8222
    DOI 10.1517/14728222.2012.661415
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Jg. 1995 - 2021: Lesesall (2.OG)
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  7. Article ; Online: Mast cells in health and disease: from basic science to clinical application 4-5 July 2008, Stuttgart, Germany.

    Kirchhoff, Dennis / Bischoff, Stephan C / Maurer, Marcus / Zollner, Thomas M

    Expert opinion on therapeutic targets

    2008  Volume 12, Issue 12, Page(s) 1591–1594

    Abstract: In July 2008, the fifth and last meeting of the Mast Cells and Chronic Inflammatory Diseases (MCCID) network was hosted by Axel Lorentz and Stephan Bischoff at the University of Hohenheim, in the Aula of the Chateau Hohenheim, Stuttgart. The MCCID ... ...

    Abstract In July 2008, the fifth and last meeting of the Mast Cells and Chronic Inflammatory Diseases (MCCID) network was hosted by Axel Lorentz and Stephan Bischoff at the University of Hohenheim, in the Aula of the Chateau Hohenheim, Stuttgart. The MCCID initiative is a Marie Curie early stage research training (EST)-sponsored multi-partner project that fosters collaboration between fundamental research, clinics and industry. At the same time, this meeting was the founding meeting of the new European Mast Cell Research Network (EMCRN) initiated by SC Bischoff, U Blank, F Levi-Schaffer, M Mauer and G Nielsson (steering committee), in co-operation with P Valent from the European Competence Network on Mastocytosis (ECNM). A mixture of scientists from pharma, biotech and academic institutions attended the meeting, presenting recent data from the field with a special focus on novel therapeutic strategies and possible interactions between industry and research. The aim of this report is to briefly describe some of the most intriguing of these new findings and to discuss how they can be relevant for making use of mast cells as therapeutic targets.
    MeSH term(s) Animals ; Anti-Allergic Agents/pharmacology ; Humans ; Hypersensitivity/drug therapy ; Hypersensitivity/metabolism ; Mast Cells/cytology ; Mast Cells/drug effects ; Mast Cells/physiology ; Mastocytosis/drug therapy ; Mastocytosis/metabolism ; Mice
    Chemical Substances Anti-Allergic Agents
    Language English
    Publishing date 2008-08-11
    Publishing country England
    Document type Congress
    ZDB-ID 2055208-7
    ISSN 1744-7631 ; 1472-8222
    ISSN (online) 1744-7631
    ISSN 1472-8222
    DOI 10.1517/14728220802546512
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Publisher Correction: Global characterization of T cells in non-small-cell lung cancer by single-cell sequencing.

    Guo, Xinyi / Zhang, Yuanyuan / Zheng, Liangtao / Zheng, Chunhong / Song, Jintao / Zhang, Qiming / Kang, Boxi / Liu, Zhouzerui / Jin, Liang / Xing, Rui / Gao, Ranran / Zhang, Lei / Dong, Minghui / Hu, Xueda / Ren, Xianwen / Kirchhoff, Dennis / Roider, Helge Gottfried / Yan, Tiansheng / Zhang, Zemin

    Nature medicine

    2018  Volume 24, Issue 10, Page(s) 1628

    Abstract: In the version of this article originally published, the P statistic described in Fig. 3d was incorrect. It was described as "P < 22 × ... ...

    Abstract In the version of this article originally published, the P statistic described in Fig. 3d was incorrect. It was described as "P < 22 × 10
    Language English
    Publishing date 2018-08-13
    Publishing country United States
    Document type Published Erratum
    ZDB-ID 1220066-9
    ISSN 1546-170X ; 1078-8956
    ISSN (online) 1546-170X
    ISSN 1078-8956
    DOI 10.1038/s41591-018-0167-7
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Global characterization of T cells in non-small-cell lung cancer by single-cell sequencing.

    Guo, Xinyi / Zhang, Yuanyuan / Zheng, Liangtao / Zheng, Chunhong / Song, Jintao / Zhang, Qiming / Kang, Boxi / Liu, Zhouzerui / Jin, Liang / Xing, Rui / Gao, Ranran / Zhang, Lei / Dong, Minghui / Hu, Xueda / Ren, Xianwen / Kirchhoff, Dennis / Roider, Helge Gottfried / Yan, Tiansheng / Zhang, Zemin

    Nature medicine

    2018  Volume 24, Issue 7, Page(s) 978–985

    Abstract: Cancer immunotherapies have shown sustained clinical responses in treating non-small-cell lung ... ...

    Abstract Cancer immunotherapies have shown sustained clinical responses in treating non-small-cell lung cancer
    MeSH term(s) CD8-Positive T-Lymphocytes/immunology ; Carcinoma, Non-Small-Cell Lung/immunology ; Carcinoma, Non-Small-Cell Lung/pathology ; Cell Proliferation ; Humans ; Lung Neoplasms/immunology ; Lung Neoplasms/pathology ; Lymphocyte Activation/immunology ; Receptors, Antigen, T-Cell/metabolism ; Sequence Analysis, RNA/methods ; Single-Cell Analysis/methods ; T-Lymphocytes/immunology ; T-Lymphocytes, Regulatory/immunology
    Chemical Substances Receptors, Antigen, T-Cell
    Language English
    Publishing date 2018-06-25
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1220066-9
    ISSN 1546-170X ; 1078-8956
    ISSN (online) 1546-170X
    ISSN 1078-8956
    DOI 10.1038/s41591-018-0045-3
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article: Identification and isolation of murine antigen-reactive T cells according to CD154 expression

    Kirchhoff, Dennis / Frentsch, Marco / Leclerk, Patrick / Bumann, Dirk / Rausch, Sebastian / Hartmann, Susanne / Thiel, Andreas / Scheffold, Alexander

    European journal of immunology. 2007 Sept., v. 37, no. 9

    2007  

    Abstract: T helper (Th) cells are central regulators of adaptive immune responses. However, the detection of the small number of Th cells specific for a particular antigen or pathogen is still a major challenge. CD154 was recently introduced as a marker for ... ...

    Abstract T helper (Th) cells are central regulators of adaptive immune responses. However, the detection of the small number of Th cells specific for a particular antigen or pathogen is still a major challenge. CD154 was recently introduced as a marker for antigen-specific Th cells. To date, this technology was not applicable for mice - arguably the most important immunological model system. CD154 is difficult to detect due to its rapid removal from the cell surface upon binding to CD40 during antigen-specific activation by APC. We present an efficient strategy to block the degradation of murine CD154 by combined use of antibodies against CD40 and CD154. This strategy makes CD154 easily accessible for surface staining, which allows isolation and expansion of rare antigen specific T cells. Importantly, CD154 identified all specific T cells in strongly Th1- or Th2-polarized immune responses against pathogens like Salmonella typhimurium and Heligmosomoides polygyrus, independent of their potential to produce cytokines. We demonstrate that CD154 can in fact be used as a reliable marker for antigen-specific CD4 T cells in mice, offering a unique option to analyze, isolate and rapidly expand the entire pool of Th-cells generated during a physiological T cell response in vivo.
    Language English
    Dates of publication 2007-09
    Size p. 2370-2377.
    Publishing place Wiley-VCH Verlag
    Document type Article
    ZDB-ID 120108-6
    ISSN 1521-4141 ; 0014-2980
    ISSN (online) 1521-4141
    ISSN 0014-2980
    DOI 10.1002/eji.200737322
    Database NAL-Catalogue (AGRICOLA)

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