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  1. Book ; Online: Beyond Antimicrobials: Non-Traditional Approaches to Combating Multidrug-Resistant Bacteria

    Kirienko, Natalia V. / Rahme, Laurence / Cho, You-Hee

    2019  

    Keywords Science: general issues ; Infectious & contagious diseases ; Drug discovery ; Infectious Disease ; Anti-Virulence ; Anti-Infectives ; Host-Microbe Interactions
    Size 1 electronic resource (281 pages)
    Publisher Frontiers Media SA
    Document type Book ; Online
    Note English ; Open Access
    HBZ-ID HT021230836
    ISBN 9782889632565 ; 2889632563
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  2. Article ; Online: Editorial: Role of microbial biofilm in infections.

    Kirienko, Natalia V / Di, Yuanpu Peter

    Frontiers in cellular and infection microbiology

    2023  Volume 13, Page(s) 1231607

    MeSH term(s) Biofilms ; Anti-Bacterial Agents
    Chemical Substances Anti-Bacterial Agents
    Language English
    Publishing date 2023-06-19
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 2619676-1
    ISSN 2235-2988 ; 2235-2988
    ISSN (online) 2235-2988
    ISSN 2235-2988
    DOI 10.3389/fcimb.2023.1231607
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: In vitro

    Kang, Donghoon / Xu, Qi / Kirienko, Natalia V

    Microbiology spectrum

    2024  Volume 12, Issue 3, Page(s) e0369323

    Abstract: The multidrug-resistant pathogen : Importance: Multidrug- ... ...

    Abstract The multidrug-resistant pathogen
    Importance: Multidrug-resistant
    MeSH term(s) Humans ; Animals ; Mice ; Siderophores/metabolism ; Pseudomonas aeruginosa/genetics ; Iron/metabolism ; Culture Media, Conditioned/metabolism ; Cystic Fibrosis/microbiology ; Iron Chelating Agents ; Pseudomonas Infections/microbiology ; Virulence Factors/genetics ; Virulence Factors/metabolism ; Epithelial Cells/metabolism ; Lung/metabolism ; Mammals ; Phenols ; Thiazoles
    Chemical Substances Siderophores ; pyochelin (69772-54-9) ; Iron (E1UOL152H7) ; Culture Media, Conditioned ; Iron Chelating Agents ; Virulence Factors ; Phenols ; Thiazoles
    Language English
    Publishing date 2024-02-05
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2807133-5
    ISSN 2165-0497 ; 2165-0497
    ISSN (online) 2165-0497
    ISSN 2165-0497
    DOI 10.1128/spectrum.03693-23
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: In vitro

    Kang, Donghoon / Xu, Qi / Kirienko, Natalia V

    bioRxiv : the preprint server for biology

    2023  

    Abstract: Multidrug- ... ...

    Abstract Multidrug-resistant
    Language English
    Publishing date 2023-10-16
    Publishing country United States
    Document type Preprint
    DOI 10.1101/2023.01.26.525796
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Pathogen-induced dormancy in liquid limits gastrointestinal colonization of

    Zhang, Liyang / Gade, Vyshnavi / Kirienko, Natalia V

    Virulence

    2023  Volume 14, Issue 1, Page(s) 2204004

    Abstract: Colonization is generally considered a prerequisite for infection, but this event is context-dependent, as evidenced by the differing ability of the human ... ...

    Abstract Colonization is generally considered a prerequisite for infection, but this event is context-dependent, as evidenced by the differing ability of the human pathogen
    MeSH term(s) Animals ; Humans ; Caenorhabditis elegans/microbiology ; Caenorhabditis elegans Proteins/metabolism ; Virulence ; Bacteria/metabolism ; Pseudomonas aeruginosa
    Chemical Substances Caenorhabditis elegans Proteins
    Language English
    Publishing date 2023-04-23
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 2657572-3
    ISSN 2150-5608 ; 2150-5594
    ISSN (online) 2150-5608
    ISSN 2150-5594
    DOI 10.1080/21505594.2023.2204004
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: The emergent role of mitochondrial surveillance in cellular health.

    Tjahjono, Elissa / Kirienko, Daniel R / Kirienko, Natalia V

    Aging cell

    2022  Volume 21, Issue 11, Page(s) e13710

    Abstract: Mitochondrial dysfunction is one of the primary causatives for many pathologies, including neurodegenerative diseases, cancer, metabolic disorders, and aging. Decline in mitochondrial functions leads to the loss of proteostasis, accumulation of ROS, and ... ...

    Abstract Mitochondrial dysfunction is one of the primary causatives for many pathologies, including neurodegenerative diseases, cancer, metabolic disorders, and aging. Decline in mitochondrial functions leads to the loss of proteostasis, accumulation of ROS, and mitochondrial DNA damage, which further exacerbates mitochondrial deterioration in a vicious cycle. Surveillance mechanisms, in which mitochondrial functions are closely monitored for any sign of perturbations, exist to anticipate possible havoc within these multifunctional organelles with primitive origin. Various indicators of unhealthy mitochondria, including halted protein import, dissipated membrane potential, and increased loads of oxidative damage, are on the top of the lists for close monitoring. Recent research also indicates a possibility of reductive stress being monitored as part of a mitochondrial surveillance program. Upon detection of mitochondrial stress, multiple mitochondrial stress-responsive pathways are activated to promote the transcription of numerous nuclear genes to ameliorate mitochondrial damage and restore compromised cellular functions. Co-expression occurs through functionalization of transcription factors, allowing their binding to promoter elements to initiate transcription of target genes. This review provides a comprehensive summary of the intricacy of mitochondrial surveillance programs and highlights their roles in our cellular life. Ultimately, a better understanding of these surveillance mechanisms is expected to improve healthspan.
    MeSH term(s) Humans ; Mitochondria/metabolism ; DNA, Mitochondrial/genetics ; Oxidative Stress ; Aging ; Neurodegenerative Diseases/metabolism ; Reactive Oxygen Species/metabolism
    Chemical Substances DNA, Mitochondrial ; Reactive Oxygen Species
    Language English
    Publishing date 2022-09-11
    Publishing country England
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't ; Research Support, N.I.H., Extramural
    ZDB-ID 2113083-8
    ISSN 1474-9726 ; 1474-9718
    ISSN (online) 1474-9726
    ISSN 1474-9718
    DOI 10.1111/acel.13710
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 6581: Show issues Location:
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    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  7. Article ; Online: Box C/D small nucleolar ribonucleoproteins regulate mitochondrial surveillance and innate immunity.

    Tjahjono, Elissa / Revtovich, Alexey V / Kirienko, Natalia V

    PLoS genetics

    2022  Volume 18, Issue 3, Page(s) e1010103

    Abstract: Monitoring mitochondrial function is crucial for organismal survival. This task is performed by mitochondrial surveillance or quality control pathways, which are activated by signals originating from mitochondria and relayed to the nucleus (retrograde ... ...

    Abstract Monitoring mitochondrial function is crucial for organismal survival. This task is performed by mitochondrial surveillance or quality control pathways, which are activated by signals originating from mitochondria and relayed to the nucleus (retrograde response) to start transcription of protective genes. In Caenorhabditis elegans, several systems are known to play this role, including the UPRmt, MAPKmt, and the ESRE pathways. These pathways are highly conserved and their loss compromises survival following mitochondrial stress. In this study, we found a novel interaction between the box C/D snoRNA core proteins (snoRNPs) and mitochondrial surveillance and innate immune pathways. We showed that box C/D, but not box H/ACA, snoRNPs are required for the full function of UPRmt and ESRE upon stress. The loss of box C/D snoRNPs reduced mitochondrial mass, mitochondrial membrane potential, and oxygen consumption rate, indicating overall degradation of mitochondrial function. Concomitantly, the loss of C/D snoRNPs increased immune response and reduced host intestinal colonization by infectious bacteria, improving host resistance to pathogenesis. Our data may indicate a model wherein box C/D snoRNP machinery regulates a "switch" of the cell's activity between mitochondrial surveillance and innate immune activation. Understanding this mechanism is likely to be important for understanding multifactorial processes, including responses to infection and aging.
    MeSH term(s) Animals ; Caenorhabditis elegans/microbiology ; Immunity, Innate/genetics ; Mitochondria/genetics ; Mitochondria/metabolism ; RNA, Small Nucleolar ; Ribonucleoproteins, Small Nucleolar/genetics ; Ribonucleoproteins, Small Nucleolar/metabolism
    Chemical Substances RNA, Small Nucleolar ; Ribonucleoproteins, Small Nucleolar
    Language English
    Publishing date 2022-03-11
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 2186725-2
    ISSN 1553-7404 ; 1553-7390
    ISSN (online) 1553-7404
    ISSN 1553-7390
    DOI 10.1371/journal.pgen.1010103
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article: An In Vitro Cell Culture Model for Pyoverdine-Mediated Virulence.

    Kang, Donghoon / Kirienko, Natalia V

    Pathogens (Basel, Switzerland)

    2020  Volume 10, Issue 1

    Language English
    Publishing date 2020-12-24
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2695572-6
    ISSN 2076-0817
    ISSN 2076-0817
    DOI 10.3390/pathogens10010009
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Repurposing bioactive compounds for treating multidrug-resistant pathogens.

    Hummell, Nicholas A / Kirienko, Natalia V

    Journal of medical microbiology

    2020  Volume 69, Issue 6, Page(s) 881–894

    Abstract: Introduction. ...

    Abstract Introduction.
    MeSH term(s) Animals ; Anti-Bacterial Agents/pharmacology ; Bacteria/drug effects ; Bacteria/metabolism ; Bacterial Infections/drug therapy ; Biofilms/drug effects ; Caenorhabditis elegans/microbiology ; Cells, Cultured ; Drug Repositioning/methods ; Drug Resistance, Multiple, Bacterial/drug effects ; Mammals/microbiology ; Microbial Sensitivity Tests/methods ; Virulence Factors/metabolism
    Chemical Substances Anti-Bacterial Agents ; Virulence Factors
    Language English
    Publishing date 2020-03-23
    Publishing country England
    Document type Journal Article
    ZDB-ID 218356-0
    ISSN 1473-5644 ; 0022-2615
    ISSN (online) 1473-5644
    ISSN 0022-2615
    DOI 10.1099/jmm.0.001172
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 634: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  10. Article ; Online: Examining Sporadic Cancer Mutations Uncovers a Set of Genes Involved in Mitochondrial Maintenance

    Moreno, Armando / Taffet, Allison / Tjahjono, Elissa / Anderson, Quinton L. / Kirienko, Natalia V.

    Genes (Basel). 2023 Apr. 29, v. 14, no. 5

    2023  

    Abstract: Mitochondria are key organelles for cellular health and metabolism and the activation of programmed cell death processes. Although pathways for regulating and re-establishing mitochondrial homeostasis have been identified over the past twenty years, the ... ...

    Abstract Mitochondria are key organelles for cellular health and metabolism and the activation of programmed cell death processes. Although pathways for regulating and re-establishing mitochondrial homeostasis have been identified over the past twenty years, the consequences of disrupting genes that regulate other cellular processes, such as division and proliferation, on affecting mitochondrial function remain unclear. In this study, we leveraged insights about increased sensitivity to mitochondrial damage in certain cancers, or genes that are frequently mutated in multiple cancer types, to compile a list of candidates for study. RNAi was used to disrupt orthologous genes in the model organism Caenorhabditis elegans, and a series of assays were used to evaluate these genes’ importance for mitochondrial health. Iterative screening of ~1000 genes yielded a set of 139 genes predicted to play roles in mitochondrial maintenance or function. Bioinformatic analyses indicated that these genes are statistically interrelated. Functional validation of a sample of genes from this set indicated that disruption of each gene caused at least one phenotype consistent with mitochondrial dysfunction, including increased fragmentation of the mitochondrial network, abnormal steady-state levels of NADH or ROS, or altered oxygen consumption. Interestingly, RNAi-mediated knockdown of these genes often also exacerbated α-synuclein aggregation in a C. elegans model of Parkinson’s disease. Additionally, human orthologs of the gene set showed enrichment for roles in human disorders. This gene set provides a foundation for identifying new mechanisms that support mitochondrial and cellular homeostasis.
    Keywords Caenorhabditis elegans ; bioinformatics ; genes ; homeostasis ; humans ; metabolism ; mitochondria ; models ; oxygen consumption ; phenotype ; programmed cell death
    Language English
    Dates of publication 2023-0429
    Publishing place Multidisciplinary Digital Publishing Institute
    Document type Article ; Online
    ZDB-ID 2527218-4
    ISSN 2073-4425
    ISSN 2073-4425
    DOI 10.3390/genes14051009
    Database NAL-Catalogue (AGRICOLA)

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