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Article ; Online: Natural product drug discovery and drug design: two approaches shaping new pharmaceutical development.

Tzvetkov, Nikolay T / Kirilov, Kiril / Matin, Maima / Atanasov, Atanas G

Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association

2023 Volume 39, Issue 3, Page(s) 375–378

MeSH term(s)	Humans ; Drug Design ; Drug Discovery ; Drug Development ; Biological Products/therapeutic use ; Pharmaceutical Preparations
Chemical Substances	Biological Products ; Pharmaceutical Preparations
Language	English
Publishing date	2023-07-05
Publishing country	England
Document type	Journal Article
ZDB-ID	90594-x
ISSN	1460-2385 ; 0931-0509
ISSN (online)	1460-2385
ISSN	0931-0509
DOI	10.1093/ndt/gfad208
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Article ; Online: Deglycation activity of the Escherichia coli glycolytic enzyme phosphoglucose isomerase.

Boteva, Elitsa / Doychev, Konstantin / Kirilov, Kiril / Handzhiyski, Yordan / Tsekovska, Rositsa / Gatev, Evan / Mironova, Roumyana

International journal of biological macromolecules

2023 Volume 257, Issue Pt 1, Page(s) 128541

Abstract: Glycation is a spontaneous chemical reaction, which affects the structure and function of proteins under normal physiological conditions. Therefore, organisms have evolved diverse mechanisms to combat glycation. In this study, we show that the ... ...

Abstract	Glycation is a spontaneous chemical reaction, which affects the structure and function of proteins under normal physiological conditions. Therefore, organisms have evolved diverse mechanisms to combat glycation. In this study, we show that the Escherichia coli glycolytic enzyme phosphoglucose isomerase (Pgi) exhibits deglycation activity. We found that E. coli Pgi catalyzes the breakdown of glucose 6-phosphate (G6P)-derived Amadori products (APs) in chicken lysozyme. The affinity of Pgi to the glycated lysozyme (K
MeSH term(s)	Glucose-6-Phosphate Isomerase/chemistry ; Glucose-6-Phosphate Isomerase/metabolism ; Escherichia coli/metabolism ; Muramidase ; Escherichia coli Proteins ; Phosphates
Chemical Substances	Glucose-6-Phosphate Isomerase (EC 5.3.1.9) ; Muramidase (EC 3.2.1.17) ; Escherichia coli Proteins ; Phosphates
Language	English
Publishing date	2023-12-04
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	282732-3
ISSN	1879-0003 ; 0141-8130
ISSN (online)	1879-0003
ISSN	0141-8130
DOI	10.1016/j.ijbiomac.2023.128541
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Article ; Online: Surface Photovoltage Study of Metal Halide Perovskites Deposited Directly on Crystalline Silicon.

Donchev, Vesselin / Regaldo, Davide / Georgiev, Stefan / Bojar, Aleksandra / da Lisca, Mattia / Kirilov, Kiril / Alvarez, José / Schulz, Philip / Kleider, Jean-Paul

ACS omega

2023 Volume 8, Issue 9, Page(s) 8125–8133

Abstract: Perovskite (PVK) films deposited directly on n-type crystalline Si substrates were investigated by two operating modes of the surface photovoltage (SPV) method: (i) the metal-insulator-semiconductor (MIS) mode and (ii) the Kelvin probe force microscopy ( ... ...

Abstract	Perovskite (PVK) films deposited directly on n-type crystalline Si substrates were investigated by two operating modes of the surface photovoltage (SPV) method: (i) the metal-insulator-semiconductor (MIS) mode and (ii) the Kelvin probe force microscopy (KPFM). By scanning from 900 to 600 nm in the MIS mode, we consecutively studied the relatively fast processes of carrier generation, transport, and recombination first in Si, then on both sides of the PVK/Si interface, and finally in the PVK layer and its surface. The PVK optical absorption edge was observed in the range of 1.61-1.65 eV in good agreement with the band gap of 1.63 eV found from photoluminescence spectra. Both SPV methods evidenced an upward energy band bending at the PVK/n-Si interface generating positive SPV. Drift-diffusion modeling allowed us to analyze the shape of the wavelength dependence of the SPV. It was also observed that the intense illumination in the KPFM measurements induces slow SPV transients which were explained by the creation and migration of negative ions and their trapping at the PVK surface. Finally, aging effects were studied by measuring again SPV spectra after one-year storage in air, and an increase in the concentration of shallow defect states at the PVK/n-Si interface was found.
Language	English
Publishing date	2023-02-24
Publishing country	United States
Document type	Journal Article ; Review
ISSN	2470-1343
ISSN (online)	2470-1343
DOI	10.1021/acsomega.2c07664
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Article: Real-World Effectiveness and Safety of Insulin Glargine 300 U/mL in Patients with T2D Uncontrolled on NPH or Premixed Insulins as Part of Routine Clinical Practice in Bulgaria: ToUPGRADE Study.

Kamenov, Zdravko / Pehlivanova, Veselina / Kuneva, Tsvetodara / Kirilov, Kiril / Bobeva, Roza / Stoykova, Julija / Mihalevska, Svetla

Diabetes therapy : research, treatment and education of diabetes and related disorders

2021 Volume 12, Issue 3, Page(s) 913–930

Abstract: Introduction: The aim of this study is to demonstrate the real-life effectiveness and safety of insulin glargine 300 U/mL (Gla-300) in patients with type 2 diabetes (T2D) previously uncontrolled on NPH ± prandial insulin or premixed insulins in routine ... ...

Abstract	Introduction: The aim of this study is to demonstrate the real-life effectiveness and safety of insulin glargine 300 U/mL (Gla-300) in patients with type 2 diabetes (T2D) previously uncontrolled on NPH ± prandial insulin or premixed insulins in routine clinical practice in Bulgaria. Methods: This was a 24-week prospective, observational study performed in 40 inpatient and outpatient sites across the country. Results: A total of 286 patients were included in the study. The mean age (± SD) was 61.2 ± 10.0 years with duration of diabetes of 11.64 ± 7.5 years and body mass index (BMI) of 32.1 ± 5.7 kg/m Conclusions: In real-life settings, Gla-300 significantly improved glycaemic control and insulin treatment satisfaction in people with T2D who were inadequately controlled with NPH ± prandial insulin or premixed insulin analogues. Improvement of glycaemic control was associated with a very low risk of hypoglycaemia and with significant weight loss irrespective of the previous insulin regimen.
Language	English
Publishing date	2021-02-19
Publishing country	United States
Document type	Journal Article
ZDB-ID	2566702-6
ISSN	1869-6961 ; 1869-6953
ISSN (online)	1869-6961
ISSN	1869-6953
DOI	10.1007/s13300-021-01022-0
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Article ; Online: Neurotensin(8-13) analogs as dual NTS1 and NTS2 receptor ligands with enhanced effects on a mouse model of Parkinson's disease.

Kühl, Toni / Georgieva, Maya G / Hübner, Harald / Lazarova, Maria / Vogel, Matthias / Haas, Bodo / Peeva, Martina I / Balacheva, Aneliya A / Bogdanov, Ivan P / Milella, Luigi / Ponticelli, Maria / Garev, Tsvetomir / Faraone, Immacolata / Detcheva, Roumyana / Minchev, Borislav / Petkova-Kirova, Polina / Tancheva, Lyubka / Kalfin, Reni / Atanasov, Atanas G /

Antonov, Liudmil / Pajpanova, Tamara I / Kirilov, Kiril / Gastreich, Marcus / Gmeiner, Peter / Imhof, Diana / Tzvetkov, Nikolay T

European journal of medicinal chemistry

2023 Volume 254, Page(s) 115386

Abstract: The modulatory interactions between neurotensin (NT) and the dopaminergic neurotransmitter system in the brain suggest that NT may be associated with the progression of Parkinson's disease (PD). NT exerts its neurophysiological effects by interactions ... ...

Abstract	The modulatory interactions between neurotensin (NT) and the dopaminergic neurotransmitter system in the brain suggest that NT may be associated with the progression of Parkinson's disease (PD). NT exerts its neurophysiological effects by interactions with the human NT receptors type 1 (hNTS1) and 2 (hNTS2). Therefore, both receptor subtypes are promising targets for the development of novel NT-based analogs for the treatment of PD. In this study, we used a virtually guided molecular modeling approach to predict the activity of NT(8-13) analogs by investigating the docking models of ligands designed for binding to the human NTS1 and NTS2 receptors. The importance of the residues at positions 8 and/or 9 for hNTS1 and hNTS2 receptor binding affinity was experimentally confirmed by radioligand binding assays. Further in vitro ADME profiling and in vivo studies revealed that, compared to the parent peptide NT(8-13), compound 10 exhibited improved stability and BBB permeability combined with a significant enhancement of the motor function and memory in a mouse model of PD. The herein reported NTS1/NTS2 dual-specific NT(8-13) analogs represent an attractive tool for the development of therapeutic strategies against PD and potentially other CNS disorders.
MeSH term(s)	Animals ; Humans ; Mice ; Dopamine ; Ligands ; Neurotensin/pharmacology ; Neurotensin/metabolism ; Parkinson Disease/drug therapy ; Protein Binding ; Receptors, Neurotensin/metabolism
Chemical Substances	Dopamine (VTD58H1Z2X) ; Ligands ; Neurotensin (39379-15-2) ; Receptors, Neurotensin ; NTSR2 protein, human
Language	English
Publishing date	2023-04-17
Publishing country	France
Document type	Journal Article
ZDB-ID	188597-2
ISSN	1768-3254 ; 0009-4374 ; 0223-5234
ISSN (online)	1768-3254
ISSN	0009-4374 ; 0223-5234
DOI	10.1016/j.ejmech.2023.115386
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Article ; Online: New Galantamine Derivatives with Inhibitory Effect on Acetylcholinesterase Activity.

Lazarova, Maria I / Tsekova, Daniela S / Tancheva, Lyubka P / Kirilov, Kiril T / Uzunova, Diamara N / Vezenkov, Lyubomir T / Tsvetanova, Elina R / Alexandrova, Albena V / Georgieva, Almira P / Gavrilova, Petja T / Dragomanova, Stela T / Papazova, Maria G / Handzhiyski, Yordan S / Kalfin, Reni E

Journal of Alzheimer's disease : JAD

2021 Volume 83, Issue 3, Page(s) 1211–1220

Abstract: Background: Inhibitors of acetylcholinesterase (AChE) are used to treat many disorders, among which are neurodegenerative upsets, like Alzheimer's disease (AD). One of the limited licensed AChE inhibitors (AChEIs) used as drugs is the natural compound ... ...

Abstract	Background: Inhibitors of acetylcholinesterase (AChE) are used to treat many disorders, among which are neurodegenerative upsets, like Alzheimer's disease (AD). One of the limited licensed AChE inhibitors (AChEIs) used as drugs is the natural compound galantamine (Gal). Objective: As Gal is a toxic compound, here we expose data about its four derivatives in hybrid peptide-norgalantamine molecules, which have shown 100 times lower toxicity. Methods: Four newly synthesized galantamine derivatives have been involved in docking analysis made by Molegro Virtual Docker. Biological assessments were performed on ICR male mice. The change in short and long-term memory performance was evaluated by passive avoidance test. AChE activity and levels of main oxidative stress parameters: lipid peroxidation, total glutathione (GSH), enzyme activities of catalase (CAT), superoxide dismutase, and glutathione peroxidase were measured in brain homogenates. Results: Our experimental data revealed that the new hybrid molecules did not impair memory performance in healthy mice. Two of the compounds demonstrated better than Gal AChE inhibitory activity in the brain. None of them changed the level of lipid peroxidation products, one of the compounds increased GSH levels, and all of them increased CAT enzyme activity. Conclusion: The new galantamine-peptide hybrids demonstrated a potential for inhibition of AChE and antioxidant activity and deserve further attention.
MeSH term(s)	Alzheimer Disease/drug therapy ; Animals ; Antioxidants/therapeutic use ; Brain/metabolism ; Catalase/metabolism ; Cholinesterase Inhibitors/pharmacology ; Cholinesterase Inhibitors/therapeutic use ; Galantamine/pharmacology ; Galantamine/therapeutic use ; Glutathione Peroxidase/metabolism ; Humans ; Lipid Peroxidation ; Male ; Memory/drug effects ; Mice ; Mice, Inbred ICR ; Oxidative Stress/drug effects ; Superoxide Dismutase/metabolism
Chemical Substances	Antioxidants ; Cholinesterase Inhibitors ; Galantamine (0D3Q044KCA) ; Catalase (EC 1.11.1.6) ; Glutathione Peroxidase (EC 1.11.1.9) ; Superoxide Dismutase (EC 1.15.1.1)
Language	English
Publishing date	2021-08-19
Publishing country	Netherlands
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1440127-7
ISSN	1875-8908 ; 1387-2877
ISSN (online)	1875-8908
ISSN	1387-2877
DOI	10.3233/JAD-210577
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Article: Method calculates crude cut properties

Dinkov, Rosen / Kirilov, Kiril / Petkov, Krasimir / Stratiev, Dicho

Oil & gas journal : international petroleum news and technology Vol. 106, No. 1 , p. 48-53

2008 Volume 106, Issue 1, Page(s) 48–53

Author's details	Dicho Stratiev; Rosen Dinkov; Kiril Kirilov; Krasimir Petkov
Keywords	Erdöl ; Qualitätsmanagement
Language	English
Size	Ill., graph. Darst.
Publishing place	Tulsa, Okla. [u.a.]
Document type	Article
ZDB-ID	240957-4
Database	ECONomics Information System

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Article ; Online: Neurotensins and their therapeutic potential: research field study.

Kan Yeung, Andy Wai / Georgieva, Maya G / Kirilov, Kiril / Balacheva, Aneliya A / Peeva, Martina I / Horbańczuk, Olaf K / Horbańczuk, Jarosław O / Lucarini, Massimo / Durazzo, Alessandra / Santini, Antonello / Souto, Eliana B / Pajpanova, Tamara I / Milella, Luigi / Atanasov, Atanas G / Tzvetkov, Nikolay T

Future medicinal chemistry

2020 Volume 12, Issue 19, Page(s) 1779–1803

Abstract: The natural tridecapeptide neurotensin has been emerged as a promising therapeutic scaffold for the treatment of neurological diseases and cancer. In this work, we aimed to identify the top 100 most cited original research papers as well as recent key ... ...

Abstract	The natural tridecapeptide neurotensin has been emerged as a promising therapeutic scaffold for the treatment of neurological diseases and cancer. In this work, we aimed to identify the top 100 most cited original research papers as well as recent key studies related to neurotensins. The Web of Science Core Collection database was searched and the retrieved research articles were analyzed by using the VOSviewer software. The most cited original articles were published between 1973 and 2013. The top-cited article was by Carraway and Leeman reporting the discovery of neurotensin in 1973. The highly cited terms were associated with hypotension and angiotensin-converting-enzyme. The conducted analysis reveals the therapeutic potentials of neurotensin, and further impactful research toward its clinical development is warrantied.
MeSH term(s)	Animals ; Antineoplastic Agents/chemistry ; Antineoplastic Agents/therapeutic use ; Central Nervous System Agents/chemistry ; Central Nervous System Agents/therapeutic use ; Humans ; Neoplasms/drug therapy ; Nervous System Diseases/drug therapy ; Neurotensin/chemistry ; Neurotensin/therapeutic use
Chemical Substances	Antineoplastic Agents ; Central Nervous System Agents ; Neurotensin (39379-15-2)
Language	English
Publishing date	2020-10-09
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Review
ISSN	1756-8927
ISSN (online)	1756-8927
DOI	10.4155/fmc-2020-0124
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Article: Investigation of Relationships between Petroleum Properties and Their Impact on Crude Oil Compatibility

Energy & Fuels. 2015 Dec. 17, v. 29, no. 12

2015

Abstract: Twenty-two crude oils around the world, from which 19 are processed in the LUKOIL Neftohim Burgas (LNB) refinery, were characterized in the LNB research laboratory by measuring 67 properties. These 22 crude oils included light low sulfur, light sulfur, ... ...

Abstract	Twenty-two crude oils around the world, from which 19 are processed in the LUKOIL Neftohim Burgas (LNB) refinery, were characterized in the LNB research laboratory by measuring 67 properties. These 22 crude oils included light low sulfur, light sulfur, intermediate low sulfur, intermediate sulfur, intermediate high sulfur, heavy high sulfur, and extra heavy extra high sulfur crudes. A new mathematical approachî¸the intercriteria analysisî¸was employed to study the relations between the petroleum properties. It was found that the petroleum properties, density, and sulfur content, along with the crude oil simulated distillation, seem to be capable of providing the same information as that from the full assay of a crude oil. Crude oils containing insoluble asphaltenes (self-incompatible oils) were found to have a high content of low aromaticity naphtha and kerosene. It was found that the asphaltene solubility correlated with the asphaltene hydrogen content. The oil solubility power was found to correlate with the oil saturate content. The oil colloidal stability seems to be controlled by the following rule: âlike dissolves likeâ. The higher the aromaticity of the asphaltenes, the higher the aromaticity of the oil is required to keep the asphaltenes in solution. The processing of blends of oils which are incompatible or nearly incompatible may deteriorate the performance of the dewatering and desalting in the refinery, which consequently may damage the equipment due to accelerated corrosion, entailed by salt deposition. The processing of blends of oils, which are incompatible, not always can be related to an increased fouling.
Keywords	corrosion ; dewatering ; distillation ; equipment ; fouling ; hydrogen ; kerosene ; oils ; petroleum ; solubility ; sulfur
Language	English
Dates of publication	2015-1217
Size	p. 7836-7854.
Publishing place	American Chemical Society
Document type	Article
ZDB-ID	1483539-3
ISSN	1520-5029 ; 0887-0624
ISSN (online)	1520-5029
ISSN	0887-0624
DOI	10.1021%2Facs.energyfuels.5b01822
Database	NAL-Catalogue (AGRICOLA)

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Book: Pravni problemi na ikonomičeskija mechanizǔm v kapitalnoto stroitelstvo

Markov, Manuel / Kirilov, Kiril

1977

Author's details	Kiril Kirilov
Keywords	Wirtschaftsordnung ; Betriebsmaschinenpark ; Investitionstheorie ; Bulgarien
Language	Undetermined
Size	181 S
Document type	Book
Note	Rechtliche Probleme des ökonomischen Mechanismusʹ im Aufbau der Produktionsmittel
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