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  1. Article ; Online: Video Games-Cognitive Help or Hindrance?

    Welker, Kirk M

    JAMA network open

    2022  Volume 5, Issue 10, Page(s) e2235729

    MeSH term(s) Humans ; Video Games ; Cognition
    Language English
    Publishing date 2022-10-03
    Publishing country United States
    Document type Journal Article ; Comment
    ISSN 2574-3805
    ISSN (online) 2574-3805
    DOI 10.1001/jamanetworkopen.2022.35729
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  2. Article ; Online: Cross Talk Between Insulin and Glucagon Receptor Signaling in the Hepatocyte.

    Habegger, Kirk M

    Diabetes

    2022  Volume 71, Issue 9, Page(s) 1842–1851

    Abstract: While the consumption of external energy (i.e., feeding) is essential to life, this action induces a temporary disturbance of homeostasis in an animal. A primary example of this effect is found in the regulation of glycemia. In the fasted state, stored ... ...

    Abstract While the consumption of external energy (i.e., feeding) is essential to life, this action induces a temporary disturbance of homeostasis in an animal. A primary example of this effect is found in the regulation of glycemia. In the fasted state, stored energy is released to maintain physiological glycemic levels. Liver glycogen is liberated to glucose, glycerol and (glucogenic) amino acids are used to build new glucose molecules (i.e., gluconeogenesis), and fatty acids are oxidized to fuel long-term energetic demands. This regulation is driven primarily by the counterregulatory hormones epinephrine, growth hormone, cortisol, and glucagon. Conversely, feeding induces a rapid influx of diverse nutrients, including glucose, that disrupt homeostasis. Consistently, a host of hormonal and neural systems under the coordination of insulin are engaged in the transition from fasting to prandial states to reduce this disruption. The ultimate action of these systems is to appropriately store the newly acquired energy and to return to the homeostatic norm. Thus, at first glance it is tempting to assume that glucagon is solely antagonistic regarding the anabolic effects of insulin. We have been intrigued by the role of glucagon in the prandial transition and have attempted to delineate its role as beneficial or inhibitory to glycemic control. The following review highlights this long-known yet poorly understood hormone.
    MeSH term(s) Animals ; Blood Glucose/metabolism ; Glucagon/metabolism ; Glucose/metabolism ; Hepatocytes/metabolism ; Insulin/metabolism ; Insulin, Regular, Human ; Liver/metabolism ; Receptors, Glucagon/metabolism
    Chemical Substances Blood Glucose ; Insulin ; Insulin, Regular, Human ; Receptors, Glucagon ; Glucagon (9007-92-5) ; Glucose (IY9XDZ35W2)
    Language English
    Publishing date 2022-06-06
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Review
    ZDB-ID 80085-5
    ISSN 1939-327X ; 0012-1797
    ISSN (online) 1939-327X
    ISSN 0012-1797
    DOI 10.2337/dbi22-0002
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  3. Article ; Online: Fluorescent ratiometric supramolecular tandem assays for phosphatase and phytase enzymes.

    Atkinson, Kirk M / Smith, Bradley D

    Organic & biomolecular chemistry

    2024  Volume 22, Issue 8, Page(s) 1714–1720

    Abstract: Ratiometric fluorescent assays have a built-in correction factor which enhances assay accuracy and reliability. We have developed fluorescent ratiometric supramolecular tandem assays for phosphatase and phytase enzymes using a mixture of three molecular ... ...

    Abstract Ratiometric fluorescent assays have a built-in correction factor which enhances assay accuracy and reliability. We have developed fluorescent ratiometric supramolecular tandem assays for phosphatase and phytase enzymes using a mixture of three molecular components. One of the molecules is a tetra-cationic fluorescence quencher called CalixPyr which can bind and quench the polyanionic pyrene fluorophore, CMP, that emits at 430 nm. Polyphosphates can disrupt the CMP/CalixPyr complex and alter the fluorescence intensity (responsive signal). CalixPyr has no effect on the fluorescence emission of cationic pentamethine cyanine fluorophore, cCy5, which emits at 665 nm and acts as a non-responsive reference signal. The continuous ratiometric fluorescent assay for alkaline phosphatase monitored hydrolytic consumption of adenosine triphosphate (ATP). The continuous ratiometric fluorescent assay for phytase activity monitored hydrolytic consumption of phytate. With further development this latter assay may be useful for high throughput assessment of phytase activity in individual batches of fortified animal feed. It is likely that the three-molecule mixture (CMP, CalixPyr, cCy5) can become a general assay platform for other enzymes that catalyse addition/removal of phosphate groups from appropriate molecular substrates.
    MeSH term(s) Animals ; Phosphoric Monoester Hydrolases ; 6-Phytase/metabolism ; Reproducibility of Results ; Alkaline Phosphatase/metabolism ; Hydrolysis ; Fluorescent Dyes/chemistry
    Chemical Substances Phosphoric Monoester Hydrolases (EC 3.1.3.2) ; 6-Phytase (EC 3.1.3.26) ; Alkaline Phosphatase (EC 3.1.3.1) ; Fluorescent Dyes
    Language English
    Publishing date 2024-02-21
    Publishing country England
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 2097583-1
    ISSN 1477-0539 ; 1477-0520
    ISSN (online) 1477-0539
    ISSN 1477-0520
    DOI 10.1039/d3ob02014b
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  4. Article ; Online: The days we never forget: Flashbulb memories across the life span in Alzheimer's disease.

    Rasmussen, Katrine W / Kirk, Marie / Overgaard, Susanne B / Berntsen, Dorthe

    Memory & cognition

    2024  

    Abstract: Alzheimer's disease (AD) is characterized by autobiographical memory deficits, with the ability to retrieve episodic-rich memories being particularly affected. Here, we investigated the influence of AD on a specific subtype of episodic memories known as ... ...

    Abstract Alzheimer's disease (AD) is characterized by autobiographical memory deficits, with the ability to retrieve episodic-rich memories being particularly affected. Here, we investigated the influence of AD on a specific subtype of episodic memories known as flashbulb memories (i.e., the ability to remember the personal circumstances for the reception of important news events). We examined the frequency, characteristics, and the temporal distribution of flashbulb memories across the life span. To this aim, 28 older adults diagnosed with AD and a matched sample of 29 healthy older controls were probed for flashbulb memories for two historical events from each decade of their lives. They also estimated the subjective degree of reexperiencing for the memories reported. AD participants showed impaired access to flashbulb memories, the frequency of reported memories being lower than for healthy older adults. However, qualitative aspects of AD participants' flashbulb memories were quite similar to those of the controls, as no group differences were obtained with respect to the canonical categories or degree of reexperience. AD participants' flashbulb memories clustered during the early years of their life, consistent with a reminiscence bump, whereas healthy controls also reported memories dated to later lifetime periods. Our results suggest that probing for personal memories of important public events may serve as a powerful cue for detailed episodic memories in AD.
    Language English
    Publishing date 2024-04-16
    Publishing country United States
    Document type Journal Article
    ZDB-ID 185691-1
    ISSN 1532-5946 ; 0090-502X
    ISSN (online) 1532-5946
    ISSN 0090-502X
    DOI 10.3758/s13421-024-01558-z
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4560: Show issues Location:
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  5. Book ; Thesis: Land tenure, technological change and resource use

    Kirk, Michael

    transformation processes in African agrarian systems

    1999  

    Author's details Michael Kirk
    Keywords Afrika ; Agrarsystem ; Wandel ; Grundeigentum ; Ressourcenökonomie ; Technischer Fortschritt
    Subject Bodeneigentum ; Grundbesitz ; Grundstück ; Grundstückseigentum ; Liegenschaftseigentum ; Grundvermögen ; Immobiliareigentum ; Landbesitz ; Landeigentum ; Besitzung ; Wandlung ; Technische Entwicklung ; Technischer Wandel ; Technologischer Wandel ; Technikwandel ; Natürliche Ressourcen ; Ressourcenökonomik ; Landwirtschaft ; Farming system ; Betriebssystem ; Landwirtschaftliches Betriebssystem ; Agrarbetriebssystem
    Language English
    Size XX, 484 S.
    Publisher Lang
    Publishing place Frankfurt am Main u.a.
    Publishing country Germany
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Göttingen, Univ., Habil.-Schr., 1995
    HBZ-ID HT011157547
    ISBN 3-631-30037-9 ; 0-8204-3171-0 ; 978-3-631-30037-4 ; 978-0-8204-3171-0
    Database Catalogue ZB MED Nutrition, Environment, Agriculture

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    In stock of ZB MED Bonn / Germany

    Shelf markLoan statusLocation
    998/3591 available for loan (reading room) Freihandmagazin (U1)

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  6. Book: Genomics

    Kirk, Maggie

    setting an agenda for regional health care ; [targets 1, 27, 33]

    (Leading edge / Regions for Health Network in Europe ; 4)

    1998  

    Author's details Maggie Kirk
    Series title Leading edge / Regions for Health Network in Europe ; 4
    Collection
    Language English
    Size 30 S. : graph. Darst., Kt.
    Publisher WHO Regional Office for Europe
    Publishing place Copenhagen
    Publishing country Denmark
    Document type Book
    HBZ-ID HT014180007
    Database Catalogue ZB MED Medicine, Health

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    Shelf markLoan statusLocation
    2004 A 4162 order for loan Magazin

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  7. Article ; Online: RGS4 controls airway hyperresponsiveness through GAP-independent mechanisms.

    Joshi, Ilin V / Chan, Eunice C / Lack, Justin B / Liu, Chengyu / Druey, Kirk M

    The Journal of biological chemistry

    2024  Volume 300, Issue 4, Page(s) 107127

    Abstract: Regulators of G protein signaling (RGS) proteins constrain G protein-coupled receptor (GPCR)-mediated and other responses throughout the body primarily, but not exclusively, through their GTPase-activating protein activity. Asthma is a highly prevalent ... ...

    Abstract Regulators of G protein signaling (RGS) proteins constrain G protein-coupled receptor (GPCR)-mediated and other responses throughout the body primarily, but not exclusively, through their GTPase-activating protein activity. Asthma is a highly prevalent condition characterized by airway hyper-responsiveness (AHR) to environmental stimuli resulting in part from amplified GPCR-mediated airway smooth muscle contraction. Rgs2 or Rgs5 gene deletion in mice enhances AHR and airway smooth muscle contraction, whereas RGS4 KO mice unexpectedly have decreased AHR because of increased production of the bronchodilator prostaglandin E2 (PGE2) by lung epithelial cells. Here, we found that knockin mice harboring Rgs4 alleles encoding a point mutation (N128A) that sharply curtails RGS4 GTPase-activating protein activity had increased AHR, reduced airway PGE2 levels, and augmented GPCR-induced bronchoconstriction compared with either RGS4 KO mice or WT controls. RGS4 interacted with the p85α subunit of PI3K and inhibited PI3K-dependent PGE2 secretion elicited by transforming growth factor beta in airway epithelial cells. Together, these findings suggest that RGS4 affects asthma severity in part by regulating the airway inflammatory milieu in a G protein-independent manner.
    MeSH term(s) Animals ; RGS Proteins/metabolism ; RGS Proteins/genetics ; Mice ; Dinoprostone/metabolism ; Asthma/metabolism ; Asthma/genetics ; Asthma/pathology ; Mice, Knockout ; Phosphatidylinositol 3-Kinases/metabolism ; Phosphatidylinositol 3-Kinases/genetics ; GTPase-Activating Proteins/genetics ; GTPase-Activating Proteins/metabolism ; Humans ; Respiratory Hypersensitivity/metabolism ; Respiratory Hypersensitivity/genetics ; Respiratory Hypersensitivity/pathology ; Epithelial Cells/metabolism ; Epithelial Cells/pathology ; Bronchoconstriction
    Chemical Substances RGS Proteins ; RGS4 protein (175335-35-0) ; Dinoprostone (K7Q1JQR04M) ; Phosphatidylinositol 3-Kinases (EC 2.7.1.-) ; GTPase-Activating Proteins
    Language English
    Publishing date 2024-03-02
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 2997-x
    ISSN 1083-351X ; 0021-9258
    ISSN (online) 1083-351X
    ISSN 0021-9258
    DOI 10.1016/j.jbc.2024.107127
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    Uc I Zs.108: Show issues Location:
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  8. Article ; Online: Identification of a heterozygous pathogenic variant in IRAK4 in an adult patient with pneumococcal sepsis, monoclonal gammopathy of uncertain significance, and idiopathic systemic capillary leak syndrome.

    Galant-Swafford, Jessica / Druey, Kirk M / Verma, Divya / Alam, Rafeul

    The journal of allergy and clinical immunology. Global

    2023  Volume 2, Issue 3

    Language English
    Publishing date 2023-05-18
    Publishing country United States
    Document type Journal Article
    ISSN 2772-8293
    ISSN (online) 2772-8293
    DOI 10.1016/j.jacig.2023.100116
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  9. Article ; Online: Emerging Roles of Regulators of G Protein Signaling (RGS) Proteins in the Immune System.

    Druey, Kirk M

    Advances in immunology

    2017  Volume 136, Page(s) 315–351

    Abstract: The regulators of G protein signaling (RGS) proteins are a large, evolutionarily conserved group of intracellular proteins expressed in every cell type and tissue throughout the body including the immune system. Through their signature GTPase-activating ... ...

    Abstract The regulators of G protein signaling (RGS) proteins are a large, evolutionarily conserved group of intracellular proteins expressed in every cell type and tissue throughout the body including the immune system. Through their signature GTPase-activating protein (GAP) activity on heterotrimeric G proteins and interactions with signaling complexes and membrane constituents (e.g., lipids), RGS proteins determine the intensity and duration of G protein-coupled receptor-induced responses. They may also have a function in generating intracellular signaling gradients necessary for the directional migration of leukocytes to inflamed tissues containing local accumulations of chemoattractants. Although physiological functions of most RGS proteins in leukocytes and lymphoid organs are largely unknown, it appears thus far that deficiency of individual RGS proteins in mice does not affect homeostatic immune responses in the absence of immunogenic challenge and/or microbial infection. Although aberrant expression of some RGS proteins has been linked to dysregulated immunity and/or neoplasia in humans, there are no human diseases attributed to specific RGS dysfunction. Here, we highlight mostly published work describing expression and functions of the core group of RGS proteins that were among the first discovered, in both innate and adaptive immune processes, with particular emphasis on cell trafficking.
    Language English
    Publishing date 2017
    Publishing country United States
    Document type Journal Article
    ZDB-ID 80226-8
    ISSN 1557-8445 ; 0065-2776
    ISSN (online) 1557-8445
    ISSN 0065-2776
    DOI 10.1016/bs.ai.2017.05.001
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  10. Article ; Online: Autologous hematopoietic stem cell transplantation in Clarkson disease.

    Druey, Kirk M / Eisch, A Robin / Cunningham-Rundles, Charlotte

    The journal of allergy and clinical immunology. In practice

    2022  Volume 11, Issue 1, Page(s) 347–349

    MeSH term(s) Humans ; Capillary Leak Syndrome ; Hematopoietic Stem Cell Transplantation ; Transplantation, Autologous
    Language English
    Publishing date 2022-10-27
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Intramural
    ZDB-ID 2843237-X
    ISSN 2213-2201 ; 2213-2198
    ISSN (online) 2213-2201
    ISSN 2213-2198
    DOI 10.1016/j.jaip.2022.10.023
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